Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2) 20th edition [Paperback / softback]

(HARVARD MEDICAL SCHOOL BOSTON), (Univ of Calif - San Francisco), (NORTHWESTERN MEDICAL SCHL), (HARVARD MEDICAL SCHOOL BOSTON), ,
  • Formaat: Paperback / softback, kõrgus x laius x paksus: 285x226x109 mm, kaal: 5988 g, Contains 2 Hardbacks and 1 Other printed item
  • Ilmumisaeg: 13-Aug-2018
  • Kirjastus: McGraw-Hill Education
  • ISBN-10: 1259644030
  • ISBN-13: 9781259644030
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  • Formaat: Paperback / softback, kõrgus x laius x paksus: 285x226x109 mm, kaal: 5988 g, Contains 2 Hardbacks and 1 Other printed item
  • Ilmumisaeg: 13-Aug-2018
  • Kirjastus: McGraw-Hill Education
  • ISBN-10: 1259644030
  • ISBN-13: 9781259644030
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Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine  
 
The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms
 
Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Trusted by generations of students and clinicians, this cornerstone two-volume text maintains its accessible, standard-setting balance between the scientific foundations of signs and symptoms, and the clinical management of the patient. This 20th edition is more relevant—and essential—than ever, with a refreshed, user-friendly design and cutting-edge new content that reflects the latest foundational, bioscientific, and clinical insights across the full spectrum of medicine.  
 
 
Essential for practice and education, the landmark 20th Edition features: 
 
Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.
 
State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with a goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.
 
All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine—and contain knowledge-building chapters on increasingly vital, fast-evolving areas of medical science and clinical medicine. Plus, a new Part covering cutting edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.
 
Important and timely new chapters—such as Promoting Good Health, LGBT Heal
Contributors xix
Preface xl
Part 1 The Profession of Medicine
1 The Practice of Medicine
1(7)
The Editors
2 Promoting Good Health
8(5)
Donald M. Lloyd-Jones
Kathleen M. McKibbin
3 Decision-Making in Clinical Medicine
13(9)
Daniel B. Mark
John B. Wong
4 Screening and Prevention of Disease
22(5)
Katrina A. Armstrong
Gary J. Martin
5 Health Care Systems in Developed Countries
27(6)
Richard B. Saltman
6 The Safety and Quality of Health Care
33(4)
David W. Bates
7 Racial and Ethnic Disparities in Health Care
37(7)
Joseph R. Betancourt
Alexander R. Green
8 Ethical Issues in Clinical Medicine
44(3)
Bernard Lo
Christine Grady
9 Palliative and End-of-Life Care
47(18)
Ezekiel J. Emanuel
Part 2 Cardinal Manifestations and Presentation of Diseases
Section 1 Pain
10 Pain: Pathophysiology and Management
65(8)
James P. Rathmell
Howard L. Fields
11 Chest Discomfort
73(8)
David A. Morrow
12 Abdominal Pain
81(4)
Danny O. Jacobs
13 Headache
85(4)
Peter J. Goadsby
14 Back and Neck Pain
89(13)
John W. Engstrom
Section 2 Alterations in Body Temperature
15 Fever
102(3)
Charles A. Dinarello
Reuven Porat
16 Fever and Rash
105(9)
Elaine T. Kaye
Kenneth M. Kaye
17 Fever of Unknown Origin
114(8)
Chantal P. Bleeker-Rovers
Jos W.M. van der Meer
Section 3 Nervous System Dysfunction
18 Syncope
122(7)
Roy Freeman
19 Dizziness and Vertigo
129(3)
Mark F. Walker
Robert B. Daroff
20 Fatigue
132(3)
Jeffrey M. Gelfand
Vanja C. Douglas
21 Neurologic Causes of Weakness and Paralysis
135(4)
Michael J. Aminoff
22 Numbness, Tingling, and Sensory Loss
139(4)
Michael J. Aminoff
23 Gait Disorders, Imbalance and Falls
143(4)
Jessica M. Baker
Lewis R. Sudarsky
24 Confusion and Delirium
147(5)
S. Andrew Josephson
Bruce L. Miller
25 Dementia
152(5)
William W. Seeley
Bruce L. Miller
26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes and Other Cerebral Disorders
157(9)
M. Marsel Mesulam
27 Sleep Disorders
166(11)
Thomas E. Scammell
Clifford B. Saper
Charles A. Czeisler
Section 4 Disorders of Eyes, Ears, Nose and Throat
28 Disorders of the Eye
177(17)
Jonathan C. Horton
29 Disorders of Smell and Taste
194(6)
Richard L. Doty
Steven M. Bromley
30 Disorders of Hearing
200(8)
Anil K. Lalwani
31 Sore Throat, Earache and Upper Respiratory Symptoms
208(11)
Michael A. Rubin
Larry C. Ford
Ralph Gonzales
32 Oral Manifestations of Disease
219(7)
Samuel C. Durso
Section 5 Alterations in Circulatory and Respiratory Functions
33 Dyspnea
226(4)
Rebecca M. Baron
34 Cough
230(2)
Christopher H. Fanta
35 Hemoptysis
232(2)
Anna K. Brady
Patricia A. Kritek
36 Hypoxia and Cyanosis
234(3)
Joseph Loscalzo
37 Edema
237(3)
Eugene Braunwald
Joseph Loscalzo
38 Approach to the Patient with a Heart Murmur
240(9)
Patrick T. O'Gara
Joseph Loscalzo
39 Palpitations
249(1)
Joseph Loscalzo
Section 6 Alterations in Gastrointestinal Function
40 Dysphagia
249(4)
Ikuo Hirano
Peter J. Kahrilas
41 Nausea, Vomiting and Indigestion
253(6)
William L. Hasler
42 Diarrhea and Constipation
259(11)
Michael Camilleri
Joseph A. Murray
43 Unintentional Weight Loss
270(2)
J. Larry Jameson
44 Gastrointestinal Bleeding
272(4)
Loren Laine
45 Jaundice
276(5)
Savio John
Daniel S. Pratt
46 Abdominal Swelling and Ascites
281(4)
Kathleen E. Corey
Lawrence S. Friedman
Section 7 Alterations in Renal and Urinary Tract Function
47 Dysuria, Bladder Pain and the Interstitial Cystitis/Bladder Pain Syndrome
285(3)
John W. Warren
48 Azotemia and Urinary Abnormalities
288(7)
David B. Mount
49 Fluid and Electrolyte Disturbances
295(17)
David B. Mount
50 Hypercalcemia and Hypocalcemia
312(3)
Sundeep Khosla
51 Acidosis and Alkalosis
315(9)
Thomas D. DuBose Jr
Section 8 Alterations in the Skin
52 Approach to the Patient with a Skin Disorder
324(5)
Kim B. Yancey
Thomas J. Lawley
53 Eczema, Psoriasis, Cutaneous Infections, Acne and Other Common Skin Disorders
329(10)
Leslie P. Lawley
Calvin O. McCall
Thomas J. Lawley
54 Skin Manifestations of Internal Disease
339(16)
Jean L. Bolognia
Irwin M. Braverman
55 Immunologically Mediated Skin Diseases
355(7)
Kim B. Yancey
Thomas J. Lawley
56 Cutaneous Drug Reactions
362(10)
Robert G. Micheletti
Misha Rosenbach
Bruce U. Wintroub
Kanade Shinkai
57 Photosensitivity and Other Reactions to Light
372(7)
Alexander G. Marneros
David R. Bickers
Section 9 Hematologic Alterations
58 Interpreting Peripheral Blood Smears
379(6)
Dan L. Longo
59 Anemia and Polycythemia
385(9)
John W. Adamson
Dan L. Longo
60 Disorders of Granulocytes and Monocytes
394(10)
Steven M. Holland
John I. Gallin
61 Bleeding and Thrombosis
404(7)
Barbara A. Konkle
62 Enlargement of Lymph Nodes and Spleen
411(8)
Dan L. Longo
Part 3 Pharmacology
63 Principles of Clinical Pharmacology
419(10)
Dan M. Roden
64 Pharmacogenomics
429(6)
Dan M. Roden
Part 4 Oncology and Hematology
Section 1 Neoplastic Disorders
65 Approach to the Patient with Cancer
435(8)
Dan L. Longo
66 Prevention and Early Detection of Cancer
443(9)
Jennifer M. Croswell
Otis W. Brawley
Barnett S. Kramer
67 Cancer Genetics
452(9)
Fred Bunz
Bert Vogelstein
68 Cancer Cell Biology
461(19)
Jeffrey W. Clark
Dan L. Longo
69 Principles of Cancer Treatment
480(22)
Edward A. Sausville
Dan L. Longo
70 Infections in Patients with Cancer
502(9)
Robert W. Finberg
71 Oncologic Emergencies
511(11)
Rasim Gucalp
Janice P. Dutcher
72 Cancer of the Skin
522(10)
Brendan D. Curti
Sancy Leachman
Walter Urba
73 Head and Neck Cancer
532(5)
Everett E. Vokes
74 Neoplasms of the Lung
537(18)
Leora Horn
Christine M. Lovly
75 Breast Cancer
555(11)
Daniel F. Hayes
Marc E. Lippman
76 Upper Gastrointestinal Tract Cancers
566(6)
Robert J. Mayer
77 Lower Gastrointestinal Cancers
572(6)
Robert J. Mayer
78 Tumors of the Liver and Biliary Tree
578(13)
Josep M. Llovet
79 Pancreatic Cancer
591(5)
Daniel D. Von Hoff
80 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas
596(20)
Robert T. Jensen
81 Renal Cell Carcinoma
616(3)
Robert J. Motzer
82 Cancer of the Bladder and Urinary Tract
619(4)
Noah M. Hahn
83 Benign and Malignant Diseases of the Prostate
623(9)
Howard I. Scher
James A. Eastham
84 Testicular Cancer
632(5)
David J. Vaughn
85 Gynecologic Malignancies
637(6)
David Spriggs
86 Primary and Metastatic Tumors of the Nervous System
643(10)
Lisa M. DeAngelis
Patrick Y. Wen
87 Soft Tissue and Bone Sarcomas and Bone Metastases
653(4)
Shreyaskumar R. Patel
88 Carcinoma of Unknown Primary
657(5)
Gauri R. Varadhachary
James L. Abbruzzese
89 Paraneoplastic Syndromes: Endocrinologic/Hematologic
662(6)
J. Larry Jameson
Dan L. Longo
90 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis
668(6)
Josep Dalmau
Myrna R. Rosenfeld
91 Late Consequences of Cancer and Its Treatment
674(5)
Carl E. Freter
Dan L. Longo
Section 2 Hematopoietic Disorders
92 Hematopoietic Stem Cells
679(4)
David T. Scadden
Dan L. Longo
93 Iron Deficiency and Other Hypoproliferative Anemias
683(7)
John W. Adamson
94 Disorders of Hemoglobin
690(8)
Edward J. Benz Jr
95 Megaloblastic Anemias
698(10)
A. Victor Hoffbrand
96 Hemolytic Anemias
708(15)
Lucio Luzzatto
97 Anemia Due to Acute Blood Loss
723(1)
Dan L. Longo
98 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
723(10)
Neal S. Young
99 Polycythemia Vera and Other Myeloproliferative Neoplasms
733(6)
Jerry L. Spivak
100 Acute Myeloid Leukemia
739(9)
William Blum
Clara D. Bloomfield
101 Chronic Myeloid Leukemia
748(9)
Hagop Kantarjian
Jorge Cortes
102 Acute Lymphoid Leukemia
757(6)
Dieter Hoelzer
103 Chronic Lymphocytic Leukemia
763(6)
Jennifer A. Woyach
John C. Byrd
104 Non-Hodgkin's Lymphoma
769(11)
Caron A. Jacobson
Dan L. Longo
105 Hodgkin's Lymphoma
780(3)
Caron A. Jacobson
Dan L. Longo
106 Less Common Hematologic Malignancies
783(10)
Ayalew Tefferi
Dan L. Longo
107 Plasma Cell Disorders
793(10)
Nikhil C. Munshi
Dan L. Longo
Kenneth C. Anderson
108 Amyloidosis
803(6)
John L. Berk
Vaishali Sanchorawala
109 Transfusion Biology and Therapy
809(7)
Jeffery S. Dzieczkowski
Pierre Tiberghien
Kenneth C. Anderson
110 Hematopoietic Cell Transplantation
816(6)
Frederick R. Appelbaum
Section 3 Disorders of Hemostasis
111 Disorders of Platelets and Vessel Wall
822(8)
Barbara A. Konkle
112 Coagulation Disorders
830(9)
Valder R. Arruda
Katherine A. High
113 Arterial and Venous Thrombosis
839(4)
Jane E. Freedman
Joseph Loscalzo
114 Antiplatelet, Anticoagulant and Fibrinolytic Drugs
843(16)
Jeffrey I. Weitz
Part 5 Infectious Diseases
Section 1 Basic Considerations in Infectious Diseases
115 Approach to the Patient with an Infectious Disease
859(7)
Neeraj K. Surana
Dennis L. Kasper
116 Molecular Mechanisms of Microbial Pathogenesis
866(11)
Gerald B. Pier
117 Approach to the Acutely Ill Infected Febrile Patient
877(7)
Tamar F. Barlam
Dennis L. Kasper
118 Immunization Principles and Vaccine Use
884(8)
Nancy Messonnier
Anne Schuchat
Lisa A. Jackson
119 Health Recommendations for International Travel
892(8)
Jay S. Keystone
Phyllis E. Kozarsky
120 Climate Change and Infectious Disease
900(8)
Aaron S. Bernstein
Section 2 Clinical Syndromes: Community-Acquired Infections
121 Pneumonia
908(11)
Lionel A. Mandell
Richard Wunderink
122 Lung Abscess
919(2)
Rebecca M. Baron
Miriam Baron Barshak
123 Infective Endocarditis
921(12)
Adolf W. Karchmer
124 Infections of the Skin, Muscles and Soft Tissues
933(6)
Dennis L. Stevens
125 Infectious Arthritis
939(5)
Lawrence C. Madoff
126 Osteomyelitis
944(8)
Werner Zimmerli
127 Intraabdominal Infections and Abscesses
952(7)
Miriam Baron Barshak
Dennis L. Kasper
128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
959(5)
Richelle C. Charles
Stephen B. Calderwood
Regina C. LaRocque
129 Clostridium difficile Infection, Including Pseudomembranous Colitis
964(4)
Dale N. Gerding
Stuart Johnson
130 Urinary Tract Infections, Pyelonephritis and Prostatitis
968(8)
Kalpana Gupta
Barbara W. Trautner
131 Sexually Transmitted Infections: Overview and Clinical Approach
976(15)
Jeanne M. Marrazzo
King K. Holmes
132 Encephalitis
991(7)
Karen L. Roos
Kenneth L. Tyler
133 Acute Meningitis
998(9)
Karen L. Roos
Kenneth L. Tyler
134 Chronic and Recurrent Meningitis
1007(6)
Walter J. Koroshetz
Michael R. Wilson
Avindra Nath
135 Brain Abscess and Empyema
1013(6)
Karen L. Roos
Kenneth L. Tyler
136 Infectious Complications of Bites
1019(3)
Sandeep S. Jubbal
Florencia Pereyra
Lawrence C. Madoff
Section 3 Clinical Syndromes: Health Care-Associated Infections
137 Infections Acquired in Health Care Facilities
1022(8)
Robert A. Weinstein
138 Infections in Transplant Recipients
1030(12)
Robert W. Finberg
Joyce D. Fingeroth
Section 4 Therapy for Bacterial Diseases
139 Treatment and Prophylaxis of Bacterial Infections
1042(15)
David C. Hooper
Erica S. Shenoy
Christy A. Varughese
140 Bacterial Resistance to Antimicrobial Agents
1057(5)
David C. Hooper
Section 5 Diseases Caused by Gram-Positive Bacteria
141 Pneumococcal Infections
1062(9)
David Goldblatt
Katherine L. O'Brien
142 Staphylococcal Infections
1071(10)
Franklin D. Lowy
143 Streptococcal Infections
1081(8)
Michael R. Wessels
144 Enterococcal Infections
1089(6)
Cesar A. Arias
Barbara E. Murray
145 Diphtheria and Other Corynebacterial Infections
1095(5)
William R. Bishai
John R. Murphy
146 Listeria monocytogenes Infections
1100(2)
Elizabeth L. Hohmann
Daniel A. Portnoy
147 Tetanus
1102(3)
C. Louise Thwaites
Lam Minh Yen
148 Botulism
1105(4)
Agam K. Rao
Susan Maslanka
149 Gas Gangrene and Other Clostridial Infections
1109(5)
Amy E. Bryant
Dennis L. Stevens
Section 6 Diseases Caused by Gram-Negative Bacteria
150 Meningococcal Infections
1114(8)
Andrew J. Pollard
151 Gonococcal Infections
1122(7)
Sanjay Ram
Peter A. Rice
152 Haemophilus and Moraxella Infections
1129(5)
Timothy F. Murphy
153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
1134(3)
Tamar F. Barlam
Dennis L. Kasper
154 Legionella Infections
1137(5)
Victor L. Yu
M. Luisa Pedro-Botet
Yusen E. Lin
155 Pertussis and Other Bordetella Infections
1142(4)
Karina A. Top
Scott A. Halperin
156 Diseases Caused by Gram-Negative Enteric Bacilli
1146(12)
Thomas A. Russo
James R. Johnson
157 Acinetobacter Infections
1158(4)
Rossana Rosa
L. Silvia Munoz-Price
158 Helicobacter pylori Infections
1162(5)
John C. Atherton
Martin J. Blaser
159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species
1167(6)
Reuben Ramphal
160 Salmonellosis
1173(7)
David A. Pegues
Samuel I. Miller
161 Shigellosis
1180(4)
Philippe J. Sansonetti
Jean Bergounioux
162 Infections Due to Campylobacter and Related Organisms
1184(2)
Beth D. Kirkpatrick
Martin J. Blaser
163 Cholera and Other Vibrioses
1186(6)
Matthew K. Waldor
Edward T. Ryan
164 Brucellosis
1192(4)
Nicholas J. Beeching
165 Tularemia
1196(4)
Jeannine M. Petersen
Paul S. Mead
166 Plague and Other Yersinia Infections
1200(9)
Michael B. Prentice
167 Bartonella Infections, Including Cat-Scratch Disease
1209(5)
Michael Giladi
Moshe Ephros
168 Donovanosis
1214(1)
Nigel O'Farrell
Section 7 Miscellaneous Bacterial Infections
169 Nocardiosis
1215(5)
Gregory A. Filice
170 Actinomycosis
1220(3)
Thomas A. Russo
171 Whipple's Disease
1223(4)
Thomas A. Russo
172 Infections Due to Mixed Anaerobic Organisms
1227(9)
Neeraj K. Surana
Dennis L. Kasper
Section 8 Mycobacterial Diseases
173 Tuberculosis
1236(23)
Mario C. Raviglione
174 Leprosy
1259(7)
Robert H. Gelber
175 Nontuberculous Mycobacterial Infections
1266(4)
Steven M. Holland
176 Antimycobacterial Agents
1270(9)
Divya Reddy
Max R. O'Donnell
Section 9 Spirochetal Diseases
177 Syphilis
1279(7)
Sheila A. Lukehart
178 Endemic Treponematoses
1286(4)
Sheila A. Lukehart
179 Leptospirosis
1290(5)
P. Wagenaar
Marga G.A. Goris
180 Relapsing Fever
1295(3)
Alan G. Barbour
181 Lyme Borreliosis
1298(5)
Allen C. Steere
Section 10 Diseases Caused by Rickettsiae, Mycoplasmas and Chlamydiae
182 Rickettsial Diseases
1303(10)
David H. Walker
J. Stephen Dumler
Lucas S. Blanton
Thomas Marrie
183 Infections Due to Mycoplasmas
1313(3)
R. Doug Hardy
184 Chlamydial Infections
1316(9)
Charlotte A. Gaydos
Thomas C. Quinn
Section 11 Viral Diseases: General Considerations
185 Medical Virology
1325(9)
Fred Wang
Elliott Kieff
186 Antiviral Chemotherapy, Excluding Antiretroviral Drugs
1334(11)
Lindsey R. Baden
Section 12 Infections Due to DNA Viruses
187 Herpes Simplex Virus Infections
1345(9)
Lawrence Corey
188 Varicella-Zoster Virus Infections
1354(4)
Richard J. Whitley
189 Epstein-Barr Virus Infections, Including Infectious Mononucleosis
1358(3)
Jeffrey I. Cohen
190 Cytomegalovirus and Human Herpesvirus Types 6, 7 and 8
1361(5)
Camille Nelson Kotton
Martin S. Hirsch
191 Molluscum Contagiosum, Monkeypox and Other Poxvirus Infections
1366(1)
Fred Wang
192 Parvovirus Infections
1367(3)
Kevin E. Brown
193 Human Papillomavirus Infections
1370(5)
Darron R. Brown
Aaron Ermel
Section 13 Infections Due to DNA and RNA Respiratory Viruses
194 Common Viral Respiratory Infections
1375(7)
James E. Crowe Jr
195 Influenza
1382(6)
Peter F. Wright
Section 14 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
196 The Human Retroviruses
1388(5)
Dan L. Longo
Anthony S. Fauci
197 Human Immunodeficiency Virus Disease: AIDS and Related Disorders
1393(70)
Anthony S. Fauci
Gregory K. Folkers
H. Clifford Lane
Section 15 Infections Due to RNA Viruses
198 Viral Gastroenteritis
1463(5)
Umesh D. Parashar
Roger I. Glass
199 Enterovirus, Parechovirus and Reovirus Infections
1468(6)
Jeffrey I. Cohen
200 Measles (Rubeola)
1474(4)
Kaitlin Rainwater-Lovett
William J. Moss
201 Rubella (German Measles)
1478(3)
Laura A. Zimmerman
Susan E. Reef
202 Mumps
1481(3)
Steven A. Rubin
203 Rabies and Other Rhabdovirus Infections
1484(5)
Alan C. Jackson
204 Arthropod-Borne and Rodent-Borne Virus Infections
1489(20)
Jens H. Kuhn
Remi N. Charrel
205 Ebolavirus and Marburgvirus Infections
1509(6)
Jens H. Kuhn
Section 16 Fungal Infections
206 Diagnosis and Treatment of Fungal Infections
1515(3)
John E. Edwards Jr
207 Histoplasmosis
1518(3)
Chadi A. Hage
L. Joseph Wheat
208 Coccidioidomycosis
1521(3)
Neil M. Ampel
209 Blastomycosis
1524(2)
S. Travis King
Rathel L. Nolan III
210 Cryptococcosis
1526(3)
Arturo Casadevall
211 Candidiasis
1529(3)
John E. Edwards Jr
212 Aspergillosis
1532(5)
David W. Denning
213 Mucormycosis
1537(4)
Brad Spellberg
Ashraf S. Ibrahim
214 Superficial Mycoses and Less Common Systemic Mycoses
1541(6)
Carol A. Kauffman
215 Pneumocystis Infections
1547(4)
Alison Morris
Henry Masur
Section 17 Protozoal and Helminthic Infections: General Considerations
216 Introduction to Parasitic Infections
1551(5)
Sharon L. Reed
Charles E. Davis
217 Agents Used to Treat Parasitic Infections
1556(12)
Thomas A. Moore
Section 18 Protozoal Infections
218 Amebiasis and Infection with Free-Living Amebae
1568(7)
Rosa M. Andrade
Sharon L. Reed
219 Malaria
1575(15)
Nicholas I. White
Elizabeth A. Ashley
220 Babesiosis
1590(4)
Edouard Vannier
Peter J. Krause
221 Leishmaniasis
1594(7)
Shyam Sundar
222 Chagas Disease and African Trypanosomiasis
1601(8)
Francois Chappuis
Yves Jackson
223 Toxoplasma Infections
1609(6)
Kami Kim
224 Protozoal Intestinal Infections and Trichomoniasis
1615(5)
Peter F. Weller
Section 19 Helminthic Infections
225 Introduction to Helminthic Infections
1620(1)
Peter F. Weller
226 Trichinellosis and Other Tissue Nematode Infections
1621(4)
Peter F. Weller
227 Intestinal Nematode Infections
1625(4)
Peter F. Weller
Thomas B. Nutman
228 Filarial and Related Infections
1629(6)
Thomas B. Nutman
Peter F. Weller
229 Schistosomiasis and Other Trematode Infections
1635(6)
Birgitte Jyding Vennervald
230 Cestode Infections
1641(8)
A. Clinton White Jr
Peter F. Weller
Part 6 Disorders of the Cardiovascular System
Section 1 Introduction to Cardiovascular Disorders
231 Approach to the Patient with Possible Cardiovascular Disease
1649(2)
Joseph Loscalzo
232 Basic Biology of the Cardiovascular System
1651(11)
Joseph Loscalzo
Peter Libby
Calum A. MacRae
233 Epidemiology of Cardiovascular Disease
1662(4)
Thomas A. Gaziano
J. Michael Gaziano
Section 2 Diagnosis of Cardiovascular Disorders
234 Physical Examination of the Cardiovascular System
1666(9)
Patrick T. O'Gara
Joseph Loscalzo
235 Electrocardiography
1675(8)
Ary L. Goldberger
236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology and Magnetic Resonance/Computed Tomography Imaging
1683(26)
Marcelo F. Di Carli
Raymond Y. Kwong
Scott D. Solomon
237 Diagnostic Cardiac Catheterization and Coronary Angiography
1709(7)
Jane A. Leopold
David P. Faxon
Section 3 Disorders of Rhythm
238 Principles of Electrophysiology
1716(6)
David D. Spragg
Gordon F. Tomaselli
239 The Bradyarrhythmias: Disorders of the Sinoatrial Node
1722(5)
David D. Spragg
Gordon F. Tomaselli
240 The Bradyarrhythmias: Disorders of the Atrioventricular Node
1727(6)
David D. Spragg
Gordon F. Tomaselli
241 Approach to Supraventricular Tachyarrhythmias
1733(2)
Gregory F. Michaud
William G. Stevenson
242 Physiologic and Nonphysiologic Sinus Tachycardia
1735(1)
Gregory F. Michaud
William G. Stevenson
243 Focal Atrial Tachycardia
1736(3)
Gregory F. Michaud
William G. Stevenson
244 Paroxysmal Supraventricular Tachycardias
1739(4)
Gregory F. Michaud
William G. Stevenson
245 Common Atrial Flutter, Macroreentrant and Multifocal Atrial Tachycardias
1743(3)
Gregory F. Michaud
William G. Stevenson
246 Atrial Fibrillation
1746(4)
Gregory F. Michaud
William G. Stevenson
247 Approach to Ventricular Arrhythmias
1750(5)
Roy M. John
William G. Stevenson
248 Premature Ventricular Beats, Non-Sustained Ventricular Tachycardia and Idioventricular Rhythm
1755(2)
Roy M. John
William G. Stevenson
249 Sustained Ventricular Tachycardia
1757(2)
Roy M. John
William G. Stevenson
250 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation
1759(3)
Roy M. John
William G. Stevenson
251 Electrical Storm and Incessant VT
1762(1)
Roy M. John
William G. Stevenson
Section 4 Disorders of the Heart
252 Heart Failure: Pathophysiology and Diagnosis
1763(6)
Douglas L. Mann
Murali Chakinala
253 Heart Failure: Management
1769(10)
Mandeep R. Mehra
254 Cardiomyopathy and Myocarditis
1779(18)
Neal K. Lakdawala
Lynne Warner Stevenson
Joseph Loscalzo
255 Cardiac Transplantation and Prolonged Assisted Circulation
1797(5)
Mandeep R. Mehra
256 Aortic Valve Disease
1802(7)
Patrick T. O'Gara
Joseph Loscalzo
257 Aortic Regurgitation
1809(4)
Patrick T. O'Gara
Joseph Loscalzo
258 Mitral Stenosis
1813(5)
Patrick T. O'Gara
Joseph Loscalzo
259 Mitral Regurgitation
1818(3)
Patrick T. O'Gara
Joseph Loscalzo
260 Mitral Valve Prolapse
1821(2)
Patrick T. O'Gara
Joseph Loscalzo
261 Tricuspid Valve Disease
1823(3)
Patrick T. O'Gara
Joseph Loscalzo
262 Pulmonic Valve Disease
1826(1)
Patrick T. O'Gara
Joseph Loscalzo
263 Multiple and Mixed Valvular Heart Disease
1827(2)
Patrick T. O'Gara
Joseph Loscalzo
264 Congenital Heart Disease in the Adult
1829(12)
Anne Marie Valente
Michael J. Landzberg
265 Pericardial Disease
1841(6)
Eugene Braunwald
266 Atrial Myxoma and Other Cardiac Tumors
1847(3)
Eric H. Awtry
Section 5 Coronary and Peripheral Vascular Disease
267 Ischemic Heart Disease
1850(16)
Elliott M. Antman
Joseph Loscalzo
268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)
1866(6)
Robert P. Giugliano
Christopher P. Cannon
Eugene Braunwald
269 ST-Segment Elevation Myocardial Infarction
1872(13)
Elliott M. Antman
Joseph Loscalzo
270 Percutaneous Coronary Interventions and Other Interventional Procedures
1885(5)
David P. Faxon
Deepak L. Bhatt
271 Hypertensive Vascular Disease
1890(16)
Theodore A. Kotchen
272 Renovascular Disease
1906(4)
Stephen C. Textor
273 Deep Venous Thrombosis and Pulmonary Thromboembolism
1910(7)
Samuel Z. Goldhaber
274 Diseases of the Aorta
1917(6)
Mark A. Creager
Joseph Loscalzo
275 Arterial Diseases of the Extremities
1923(7)
Mark A. Creager
Joseph Loscalzo
276 Chronic Venous Disease and Lymphedema
1930(5)
Mark A. Creager
Joseph Loscalzo
277 Pulmonary Hypertension
1935(8)
Aaron B. Waxman
Joseph Loscalzo
Part 7 Disorders of the Respiratory System
Section 1 Diagnosis of Respiratory Disorders
278 Approach to the Patient with Disease of the Respiratory System
1943(2)
Patricia A. Kritek
Bruce D. Levy
279 Disturbances of Respiratory Function
1945(6)
Edward T. Naureckas
Julian Solway
280 Diagnostic Procedures in Respiratory Disease
1951(6)
Anne L. Fuhlbrigge
Augustine M.K. Choi
Section 2 Diseases of the Respiratory System
281 Asthma
1957(13)
Peter J. Barnes
282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
1970(6)
Praveen Akuthota
Michael E. Wechsler
283 Occupational and Environmental Lung Disease
1976(7)
John R. Balmes
284 Bronchiectasis
1983(3)
Rebecca M. Baron
Miriam Baron Barshak
285 Cystic Fibrosis
1986(4)
Eric J. Sorscher
286 Chronic Obstructive Pulmonary Disease
1990(9)
Edwin K. Silverman
James D. Crape
Barry J. Make
287 Interstitial Lung Disease
1999(7)
Gary M. Hunninghake
Ivan O. Rosas
288 Disorders of the Pleura
2006(3)
Richard W. Light
289 Disorders of the Mediastinum
2009(1)
Richard W. Light
290 Disorders of Ventilation
2010(3)
John F. McConville
Julian Solway
Babak Mokhlesi
291 Sleep Apnea
2013(5)
Andrew Wellman
Susan Redline
292 Lung Transplantation
2018(5)
Elbert P. Trulock III
Part 8 Critical Care Medicine
Section 1 Respiratory Critical Care
293 Approach to the Patient with Critical Illness
2023(7)
John P. Kress
Jesse B. Hall
294 Acute Respiratory Distress Syndrome
2030(5)
Rebecca M. Baron
Bruce D. Levy
295 Mechanical Ventilatory Support
2035(4)
Bartolome R. Celli
Section 2 Shock and Cardiac Arrest
296 Approach to the Patient with Shock
2039(5)
Anthony F. Massaro
297 Sepsis and Septic Shock
2044(8)
Christopher W. Seymour
Derek C. Angus
298 Cardiogenic Shock and Pulmonary Edema
2052(7)
David H. Ingbar
Holger Thiele
299 Cardiovascular Collapse, Cardiac Arrest and Sudden Cardiac Death
2059(9)
Christine M. Albert
William G. Stevenson
Section 3 Neurologic Critical Care
300 Coma
2068(6)
S. Andrew Josephson
Allan H. Rapper
Stephen L. Hauser
301 Severe Acute Encephalopathies and Critical Care Weakness
2074(10)
J. Claude Hemphill III
Wade S. Smith
S. Andrew Josephson
Daryl R. Gress
302 Subarachnoid Hemorrhage
2084(5)
J. Claude Hemphill III
Wade S. Smith
Daryl R. Gress
Part 9 Disorders of the Kidney and Urinary Tract
303 Cellular and Molecular Biology of the Kidney
2089(10)
Alfred L. George Jr
Eric G. Neilson
304 Acute Kidney Injury
2099(12)
Sushrut S. Waikar
Joseph V. Bonventre
305 Chronic Kidney Disease
2111(10)
Joanne M. Bargman
Karl L. Skorecki
306 Dialysis in the Treatment of Renal Failure
2121(5)
Kathleen D. Liu
Glenn M. Chertow
307 Transplantation in the Treatment of Renal Failure
2126(6)
Jamil Azzi
Edgar L. Milford
Mohamed H. Sayegh
Anil Chandraker
308 Glomerular Diseases
2132(18)
Julia B. Lewis
Eric G. Neilson
309 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development
2150(7)
Jing Zhou
Martin R. Pollak
310 Tubulointerstitial Diseases of the Kidney
2157(7)
Laurence H. Beck Jr
David J. Salant
311 Vascular Injury to the Kidney
2164(4)
Ronald S. Go
Nelson Leung
312 Nephrolithiasis
2168(5)
Gary C. Curhan
313 Urinary Tract Obstruction
2173(4)
Julian L. Seifter
Part 10 Disorders of the Gastrointestinal System
Section 1 Disorders of the Alimentary Tract
314 Approach to the Patient with Gastrointestinal Disease
2177(5)
William L. Hasler
Chung Owyang
315 Gastrointestinal Endoscopy
2182(27)
Louis Michel Wong Kee Song
Mark Topazian
316 Diseases of the Esophagus
2209(11)
Peter J. Kahrilas
Ikuo Hirano
317 Peptic Ulcer Disease and Related Disorders
2220(24)
John Del Valle
318 Disorders of Absorption
2244(14)
Henry J. Binder
319 Inflammatory Bowel Disease
2258(18)
Sonia Friedman
Richard S. Blumberg
320 Irritable Bowel Syndrome
2276(7)
Chung Owyang
321 Diverticular Disease and Common Anorectal Disorders
2283(8)
Rizwan Ahmed
Susan L. Gearhart
322 Mesenteric Vascular Insufficiency
2291(3)
Satinderjit Locham
Mahmoud Malas
323 Acute Intestinal Obstruction
2294(4)
Danny O. Jacobs
324 Acute Appendicitis and Peritonitis
2298(5)
Danny O. Jacobs
Section 2 Nutrition
325 Nutrient Requirements and Dietary Assessment
2303(6)
Johanna Dwyer
326 Vitamin and Trace Mineral Deficiency and Excess
2309(10)
Paolo M. Suter
Robert M. Russell
327 Malnutrition and Nutritional Assessment
2319(5)
Gordon L. Jensen
328 Enteral and Parenteral Nutrition
2324(8)
L. John Hoffer
Bruce R. Bistrian
David F. Driscoll
Section 3 Liver and Biliary Tract Disease
329 Approach to the Patient with Liver Disease
2332(6)
Marc G. Ghany
Jay H. Hoofnagle
330 Evaluation of Liver Function
2338(4)
Daniel S. Pratt
331 The Hyperbilirubinemias
2342(5)
Allan W. Wolkoff
332 Acute Viral Hepatitis
2347(19)
Jules L. Dienstag
333 Toxic and Drug-Induced Hepatitis
2366(9)
William M. Lee
Jules L. Dienstag
334 Chronic Hepatitis
2375(24)
Jules L. Dienstag
335 Alcoholic Liver Disease
2399(2)
Mark E. Mailliard
Michael F. Sorrell
336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis
2401(4)
Manal F. Abdelmalek
Anna Mae Diehl
337 Cirrhosis and Its Complications
2405(9)
Bruce R. Bacon
338 Liver Transplantation
2414(8)
Raymond T. Chung
Jules L. Dienstag
339 Diseases of the Gallbladder and Bile Ducts
2422(11)
Norton J. Greenberger
Gustav Paumgartner
Section 4 Disorders of the Pancreas
340 Approach to the Patient with Pancreatic Disease
2433(4)
Darwin L. Conwell
Norton J. Greenberger
Peter A. Banks
341 Acute and Chronic Pancreatitis
2437(14)
Darwin L. Conwell
Peter A. Banks
Norton J. Greenberger
Part 11 Immune-Mediated, Inflammatory and Rheumatologic Disorders
Section 1 The Immune System in Health and Disease
342 Introduction to the Immune System
2451(29)
Barton F. Haynes
Kelly A. Soderberg
Anthony S. Fauci
343 The Major Histocompatibility Complex
2480(8)
Gerald T. Nepom
344 Primary Immune Deficiency Diseases
2488(10)
Alain Fischer
Section 2 Disorders of Immune-Mediated Injury
345 Urticaria, Angioedema, and Allergic Rhinitis
2498(8)
Katherine N. Cahill
Joshua A. Boyce
346 Anaphylaxis
2506(2)
David Hong
Joshua A. Boyce
347 Mastocytosis
2508(2)
Cem Akin
Joshua A. Boyce
348 Autoimmunity and Autoimmune Diseases
2510(5)
Betty Diamond
Peter E. Lipsky
349 Systemic Lupus Erythematosus
2515(11)
Bevra Hannahs Hahn
350 Antiphospholipid Syndrome
2526(1)
Haralampos M. Moutsopoulos
351 Rheumatoid Arthritis
2527(14)
Ankoor Shah
E. William St. Clair
352 Acute Rheumatic Fever
2541(5)
Jonathan R. Carapetis
353 Systemic Sclerosis (Scleroderma) and Related Disorders
2546(14)
John Varga
354 Sjogren's Syndrome
2560(3)
Haralampos M. Moutsopoulos
355 The Spondyloarthritides
2563(11)
Joel D. Taurog
356 The Vasculitis Syndromes
2574(15)
Carol A. Langford
Anthony S. Fauci
357 Beficet's Syndrome
2589(1)
Haralampos M. Moutsopoulos
358 Inflammatory Myopathies
2590(7)
Steven A. Greenberg
Anthony A. Amato
359 Relapsing Polychondritis
2597(3)
Carol A. Langford
360 Sarcoidosis
2600(7)
Robert P. Baughman
Elyse E. Lower
361 IgG4-Related Disease
2607(3)
John H. Stone
362 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases
2610(4)
Daniel L. Kastner
Section 3 Disorders of the Joints and Adjacent Tissues
363 Approach to Articular and Musculoskeletal Disorders
2614(10)
John J. Cush
364 Osteoarthritis
2624(7)
David T. Felson
Tuhina Neogi
365 Gout and Other Crystal-Associated Arthropathies
2631(5)
H. Ralph Schumacher
Lan X. Chen
366 Fibromyalgia
2636(3)
Leslie J. Crofford
367 Arthritis Associated with Systemic Disease, and Other Arthritides
2639(7)
Carol A. Langford
Brian F. Mandell
368 Periarticular Disorders of the Extremities
2646(3)
Carol A. Langford
Part 12 Endocrinology and Metabolism
Section 1 Endocrinology
369 Approach to the Patient with Endocrine Disorders
2649(4)
J. Larry Jameson
370 Mechanisms of Hormone Action
2653(6)
J. Larry Jameson
371 Physiology of Anterior Pituitary Hormones
2659(5)
Shlomo Melmed
J. Larry Jameson
372 Hypopituitarism
2664(6)
Shlomo Melmed
J. Larry Jameson
373 Pituitary Tumor Syndromes
2670(14)
Shlomo Melmed
J. Larry Jameson
374 Disorders of the Neurohypophysis
2684(8)
Gary L. Robertson
375 Thyroid Gland Physiology and Testing
2692(6)
J. Larry Jameson
Susan J. Mandel
Anthony P. Weetman
376 Hypothyroidism
2698(5)
J. Larry Jameson
Susan J. Mandel
Anthony P. Weetman
377 Hyperthyroidism
2703(7)
J. Larry Jameson
Susan J. Mandel
Anthony P. Weetman
378 Thyroid Nodular Disease and Thyroid Cancer
2710(9)
J. Larry Jameson
Susan J. Mandel
Anthony P. Weetman
379 Disorders of the Adrenal Cortex
2719(20)
Wiebke Arlt
380 Pheochromocytoma
2739(7)
Hartmut P.H. Neumann
381 Multiple Endocrine Neoplasia
2746(10)
R. V. Thakker
382 Autoimmune Polyendocrine Syndromes
2756(4)
Peter A. Gottlieb
Aaron W. Michels
Section 2 Sex- and Gender-Based Medicine
383 Disorders of Sex Development
2760(9)
John C. Achermann
J. Larry Jameson
384 Disorders of the Testes and Male Reproductive System
2769(18)
Shalender Bhasin
J. Larry Jameson
385 Disorders of the Female Reproductive System
2787(7)
Janet E. Hall
386 Menstrual Disorders and Pelvic Pain
2794(5)
Janet E. Hall
387 Hirsutism
2799(4)
David A. Ehrmann
388 Menopause and Postmenopausal Hormone Therapy
2803(7)
JoAnn E. Manson
Shari S. Bassuk
389 Infertility and Contraception
2810(6)
Janet E. Hall
390 Sexual Dysfunction
2816(7)
Kevin T. Mc Vary
391 Women's Health
2823(5)
Andrea Dunaif
392 Men's Health
2828(7)
Shalender Bhasin
Shehzad Basaria
393 Lesbian, Gay, Bisexual and Transgender (LGBT) Health
2835(2)
Baligh R. Yehia
Harvey J. Makadon
Section 3 Obesity, Diabetes Mellitus and Metabolic Syndrome
394 Pathobiology of Obesity
2837(6)
Jeffrey S. Flier
Elef Iberia Maratos-Flier
395 Evaluation and Management of Obesity
2843(7)
Robert F. Kushner
396 Diabetes Mellitus: Diagnosis, Classification and Pathophysiology
2850(9)
Alvin C. Powers
Kevin D. Niswender
Carmella Evans-Molina
397 Diabetes Mellitus: Management and Therapies
2859(16)
Alvin C. Powers
Kevin D. Niswender
Michael R. Rickels
398 Diabetes Mellitus: Complications
2875(8)
Alvin C. Powers
John M. Stafford
Michael R. Rickels
399 Hypoglycemia
2883(6)
Philip E. Cryer
Stephen N. Davis
400 Disorders of Lipoprotein Metabolism
2889(14)
Daniel J. Rader
Sekar Kathiresan
401 The Metabolic Syndrome
2903(6)
Robert H. Eckel
Section 4 Disorders of Bone and Mineral Metabolism
402 Bone and Mineral Metabolism in Health and Disease
2909(12)
F. Richard Bringhurst
Marie B. Demay
Henry M. Kronenberg
403 Disorders of the Parathyroid Gland and Calcium Homeostasis
2921(21)
John T. Potts Jr
Harald W. Juppner
404 Osteoporosis
2942(17)
Robert Lindsay
Felicia Cosman
405 Paget's Disease and Other Dysplasias of Bone
2959(8)
Murray J. Favus
Tamara J. Vokes
Section 5 Disorders of Intermediary Metabolism
406 Heritable Disorders of Connective Tissue
2967(10)
Darwin J. Prockop
John F. Bateman
407 Hemochromatosis
2977(5)
Lawrie W. Powell
408 Wilson's Disease
2982(2)
George J. Brewer
409 The Porphyrias
2984(13)
Robert J. Desnick
Manisha Balwani
410 Disorders of Purine and Pyrimidine Metabolism
2997(6)
John N. Mecchella
Christopher M. Burns
411 Lysosomal Storage Diseases
3003(6)
Robert J. Hopkin
Gregory A. Grabowski
412 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism
3009(6)
Priya S. Kishnani
Yuan-Tsong Chen
413 Inherited Disorders of Amino Acid Metabolism in Adults
3015(5)
Nicola Longo
414 Inherited Defects of Membrane Transport
3020(5)
Nicola Longo
Part 13 Neurologic Disorders
Section 1 Diagnosis of Neurologic Disorders
415 Approach to the Patient with Neurologic Disease
3025(5)
Daniel H. Lowenstein
Joseph B. Martin
Stephen L. Hauser
416 Neuroimaging in Neurologic Disorders
3030(9)
William P. Dillon
417 Pathobiology of Neurologic Diseases
3039(11)
Stephen L. Hauser
Arnold R. Kriegstein
Stanley B. Prusiner
Section 2 Diseases of the Central Nervous System
418 Seizures and Epilepsy
3050(18)
Daniel H. Lowenstein
419 Cerebrovascular Diseases
3068(11)
Wade S. Smith
S. Claiborne Johnston
J. Claude Hemphill III
420 Ischemic Stroke
3079(12)
Wade S. Smith
S. Claiborne Johnston
J. Claude Hemphill III
421 Intracranial Hemorrhage
3091(5)
Wade S. Smith
J. Claude Hemphill III
S. Claiborne Johnston
422 Migraine and Other Primary Headache Disorders
3096(12)
Peter J. Goadsby
423 Alzheimer's Disease
3108(7)
William W. Seeley
Bruce L. Miller
424 Frontotemporal Dementia
3115(3)
William W. Seeley
Bruce L. Miller
425 Vascular Dementia
3118(1)
Joel Kramer
William W. Seeley
Bruce L. Miller
426 Dementia with Lewy Bodies
3119(1)
William W. Seeley
Caroline M. Tanner
Bruce L. Miller
427 Parkinson's Disease
3120(12)
C. Warren Olanow
Christine Klein
Anthony H.V. Schapira
428 Tremor, Chorea and Other Movement Disorders
3132(9)
C. Warren Olanow
Christine Klein
Jose A. Obeso
429 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
3141(7)
Robert H. Brown Jr
430 Prion Diseases
3148(6)
Stanley B. Prusiner
Bruce L. Miller
431 Ataxic Disorders
3154(4)
Roger N. Rosenberg
432 Disorders of the Autonomic Nervous System
3158(8)
Christopher H. Gibbons
John W. Engstrom
433 Trigeminal Neuralgia, Bell's Palsy and Other Cranial Nerve Disorders
3166(6)
M. Flint Beal
Stephen L. Hauser
434 Diseases of the Spinal Cord
3172(11)
Stephen L. Hauser
435 Concussion and Other Traumatic Brain Injuries
3183(5)
Geoffrey T. Manley
Stephen L. Hauser
Michael McCrea
436 Multiple Sclerosis
3188(14)
Bruce A.C. Cree
Stephen L. Hauser
437 Neuromyelitis Optica
3202(2)
Bruce A. C. Cree
Stephen L. Hauser
Section 3 Nerve and Muscle Disorders
438 Peripheral Neuropathy
3204(21)
Anthony A. Amato
Richard J. Barohn
439 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies
3225(7)
Stephen L. Hauser
Anthony A. Amato
440 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
3232(7)
Anthony A. Amato
441 Muscular Dystrophies and Other Muscle Diseases
3239(15)
Anthony A. Amato
Robert H. Brown Jr
Section 4 Chronic Fatigue Syndrome
442 Chronic Fatigue Syndrome
3254(2)
Gijs Bleijenberg
Jos W.M. van der Meer
Section 5 Psychiatric and Addiction Disorders
443 Biology of Psychiatric Disorders
3256(6)
Robert O. Messing
Eric J. Nestler
Matthew W. State
444 Psychiatric Disorders
3262(15)
Victor I. Reus
445 Alcohol and Alcohol Use Disorders
3277(7)
Marc A. Schuckit
446 Opioid-Related Disorders
3284(3)
Thomas R. Kosten
Colin N. Haile
447 Cocaine and Other Commonly Used Drugs
3287(5)
Karran A. Phillips
Antonello Bonci
448 Nicotine Addiction
3292(5)
David M. Burns
Part 14 Poisoning, Drug Overdose and Envenomation
449 Heavy Metal Poisoning
3297(3)
Howard Hu
450 Poisoning and Drug Overdose
3300(13)
Mark B. Mycyk
451 Disorders Caused by Venomous Snakebites and Marine Animal Exposures
3313(11)
Charles Lei
Kirsten B. Hornbeak
Paul S. Auerbach
Robert L. Norris
452 Ectoparasite Infestations and Arthropod Injuries
3324(9)
Richard J. Pollack
Scott A. Norton
Part 15 Disorders Associated with Environmental Exposures
453 Altitude Illness
3333(5)
Buddha Basnyat
Geoffrey Tabin
454 Hypothermia and Peripheral Cold Injuries
3338(5)
Daniel F. Danzl
455 Heat-Related Illnesses
3343(4)
Daniel F. Danzl
Part 16 Genes, the Environment and Disease
456 Principles of Human Genetics
3347(22)
J. Larry Jameson
Peter Kopp
457 The Practice of Genetics in Clinical Medicine
3369(6)
Susan M. Domchek
J. Larry Jameson
Susan Miesfeldt
458 Gene and Cell Based Therapy in Clinical Medicine
3375(4)
Katherine A. High
Malcolm K. Brenner
459 The Human Microbiome
3379(12)
Neeraj K. Surana
Dennis L. Kasper
Part 17 Global Medicine
460 Global Issues in Medicine
3391(10)
Joseph J. Rhatigan
Paul Farmer
461 Worldwide Changes in Patterns of Infectious Disease
3401(3)
George W. Rutherford
Jaime Sepulveda
462 Primary Care and Global Health
3404(9)
Tim Evans
Kumanan Rasanathan
Part 18 Aging
463 The Biology of Aging
3413(7)
Rafael de Cabo
David G. Le Couteur
464 Clinical Problems Associated with the Aging Process
3420(19)
Joseph G. Ouslander
Bernardo Reyes
Part 19 Consultative Medicine
465 Approach to Medical Consultation
3439(1)
Jack Ende
Jeffrey Berns
466 Medical Disorders During Pregnancy
3440(6)
Robert L. Barbieri
John T. Repke
467 Medical Evaluation of the Surgical Patient
3446(7)
Prashant Vaishnava
Kim A. Eagle
Part 20 Frontiers
468 Behavioral Economics and Health
3453(9)
Kevin G. Volpp
George Loewenstein
David A. Asch
469 Complementary, Alternative and Integrative Health Approaches
3462(4)
Josephine P. Briggs
470 Telomere Disease
3466(5)
Rodrigo T. Calado
Neal S. Young
471 The Role of Epigenetics in Disease and Treatment
3471(5)
Brian C. Capell
Shelley L. Berger
472 Mitochondrial DNA and Heritable Traits and Diseases
3476(12)
Karl L. Skorecki
Bruce H. Cohen
473 Applications of Stem Cell Biology in Clinical Medicine
3488(3)
John A. Kessler
474 Microbial Genomics and Infectious Disease
3491(13)
Roby P. Bhattacharyya
Yonatan H. Grad
Deborah T. Hung
475 The Role of Circadian Biology in Health and Disease
3504(11)
Jonathan Cedernaes
Kathryn Moynihan Ramsey
Joseph Bass
476 Network Medicine: Systems Biology in Health and Disease
3515(7)
Joseph Loscalzo
477 Emerging Neurotherapeutic Technologies
3522
Jyoti Mishra
Karunesh Ganguly
Index I-1
C.F. Kettering Professor of Medicine, Chief, Division of Endocrinology, Metabolism and Molecular Medicine Northwestern University Medical School, Chicago, IL. Dennis L. Kasper, MD, MA (Hon)William Ellery Channing Professor of MedicineProfessor of Microbiology and Molecular GeneticsExecutive Dean for Academic ProgramsHarvard Medical SchoolDirector, Channing LaboratoryDepartment of MedicineBrigham and Womens Hospital Stephen L. Hauser, MDChairman and Betty Anker Fife ProfessorDepartment of NeurologyUniversity of California, San Francisco Dan L. Longo, MDScientific DirectorNational Institute on AgingNational Institutes of HealthBethesda, Maryland Anthony S. Fauci, MDChief, Laboratory of ImmunoregulationDirector, National Institute of Allergy and Infectious DiseasesNational Institutes of Health. In 2008, Dr. Fauci was awarded the Presidential Medal of Freedom, the Nation's highest civil award. Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School; Chairman, Department of Medicine; Physician-in-Chief, Brigham and Womens Hospital, Boston, Massachusetts