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Harrison's Principles of Internal Medicine, Twenty-First Edition (Vol.1 & Vol.2) 21st edition [Kõva köide]

  • Formaat: Hardback, 4384 pages, kõrgus x laius x paksus: 297x226x119 mm, kaal: 6468 g, Illustrations, unspecified
  • Ilmumisaeg: 09-May-2022
  • Kirjastus: McGraw-Hill Education
  • ISBN-10: 1264268505
  • ISBN-13: 9781264268504
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  • Formaat: Hardback, 4384 pages, kõrgus x laius x paksus: 297x226x119 mm, kaal: 6468 g, Illustrations, unspecified
  • Ilmumisaeg: 09-May-2022
  • Kirjastus: McGraw-Hill Education
  • ISBN-10: 1264268505
  • ISBN-13: 9781264268504
Teised raamatud teemal:

The Voice of Clinical Reason

Harrison’s Principles of Internal Medicine is the world's most trusted clinical medicine text—and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine. 

Written and edited by the world’s top experts in their respective fields, this landmark guide provides comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease. 

Harrison’s is world-renowned as the most authoritative source for: 

Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases
• The physiologic and etiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow
• Updated clinical trial results and recommended guidelines
• Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings
• Coverage of both therapeutic approaches and specific treatment regimens
• Practical clinical decision trees and algorithms
• Organ/system-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, and general and specific approaches to therapy

Harrison’s remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world’s top experts are featured in the 21st edition: 

Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer
• Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries
• More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes
• Numerous atlases featuring curated collections of important visual aspects of diagnosis and management
• Updated and time-saving curation and synthesis of established and new medical literature and studies
• Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms

Contributors xviii
Preface xxxix
Harrison's Related Resources xl
PART 1 The Profession of Medicine
1 The Practice of Medicine
1(7)
The Editors
2 Promoting Good Health
8(5)
Donald M. Lloyd-Jones
Kathleen M. McKibbin
3 Vaccine Opposition and Hesitancy
13(8)
Julie A. Bettinger
Hana Mitchell
4 Decision-Making in Clinical Medicine
21(9)
Daniel B. Mark
John B. Wong
5 Precision Medicine and Clinical Care
30(7)
The Editors
6 Screening and Prevention of Disease
37(5)
Katrina A. Armstrong
Gary J. Martin
7 Global Diversity of Health System Financing and Delivery
42(8)
Richard B. Saltman
8 The Safety and Quality of Health Care
50(4)
David W. Bates
9 Diagnosis: Reducing Errors and Improving Quality
54(5)
Gordon Schiff
10 Racial and Ethnic Disparities in Health Care
59(8)
Lenny Lopez
Joseph R. Betancourt
11 Ethical Issues in Clinical Medicine
67(5)
Christine Grady
Bernard Lo
12 Palliative and End-of-Life Care
72(19)
Ezekiel J. Emanuel
PART 2 Cardinal Manifestations and Presentation of Diseases
SECTION 1 Pain
13 Pain: Pathophysiology and Management
91(9)
James P. Rathmell
Howard L. Fields
14 Chest Discomfort
100(8)
David A. Morrow
15 Abdominal Pain
108(4)
Danny O. Jacobs
16 Headache
112(5)
Peter J. Goadsby
17 Back and Neck Pain
117(13)
John W. Engstrom
SECTION 2 Alterations in Body Temperature
18 Fever
130(3)
Neeraj K. Surana
Charles A. Dinarello
Reuven Porat
19 Fever and Rash
133(12)
Elaine T. Kaye
Kenneth M. Kaye
20 Fever of Unknown Origin
145(7)
Chantal P. Bleeker-Rovers
Catharina M. Mulders-Manders
Jos W. M. van der Meer
SECTION 3 Nervous System Dysfunction
21 Syncope
152(7)
Roy Freeman
22 Dizziness and Vertigo
159(3)
Mark F. Walker
Robert B. Daroff
23 Fatigue
162(3)
Jeffrey M. Gelfand
Vanja C. Douglas
24 Neurologic Causes of Weakness and Paralysis
165(3)
Stephen L. Hauser
25 Numbness, Tingling, and Sensory Loss
168(5)
Stephen L. Hauser
26 Gait Disorders, Imbalance, and Falls
173(5)
Jessica M. Baker
27 Confusion and Delirium
178(5)
S. Andrew Josephson
Bruce L. Miller
28 Coma
183(6)
S. Andrew Josephson
Allan H. Ropper
Stephen L. Hauser
29 Dementia
189(6)
William W. Seeley
Gil D. Rabinovici
Bruce L. Miller
30 Aphasia, Memory Loss, and Other Cognitive Disorders
195(9)
M.-Marsel Mesulam
31 Sleep Disorders
204(11)
Thomas E. Scammell
Clifford B. Saper
Charles A. Czeisler
SECTION 4 Disorders of Eyes, Ears, Nose, and Throat
32 Disorders of the Eye
215(17)
Jonathan C. Horton
33 Disorders of Smell and Taste
232(6)
Richard L. Doty
Steven M. Bromley
34 Disorders of Hearing
238(9)
Anil K. Lalwani
35 Upper Respiratory Symptoms, Including Earache, Sinus Symptoms, and Sore Throat
247(9)
Rachel L. Amdur
Jeffrey A. Linder
36 Oral Manifestations of Disease
256(7)
Samuel C. Durso
SECTION 5 Alterations in Circulatory and Respiratory Functions
37 Dyspnea
263(4)
Rebecca M. Baron
38 Cough
267(3)
Christopher H. Fanta
39 Hemoptysis
270(2)
Carolyn M. Dambrosio
40 Hypoxia and Cyanosis
272(3)
Joseph Loscalzo
41 Edema
275(3)
Joseph Loscalzo
42 Approach to the Patient with a Heart Murmur
278(8)
Patrick T. O'Gara
Joseph Loscalzo
43 Palpitations
286(1)
Joseph Loscalzo
SECTION 6 Alterations in Gastrointestinal Function
44 Dysphagia
287(4)
Ikuo Hirano
Peter J. Kahrilas
45 Nausea, Vomiting, and Indigestion
291(6)
William L. Hasler
46 Diarrhea and Constipation
297(12)
Michael Camilleri
Joseph A. Murray
47 Unintentional Weight Loss
309(2)
Larry Jameson
48 Gastrointestinal Bleeding
311(4)
Loren Laine
49 Jaundice
315(6)
Savio John
Daniel S. Pratt
50 Abdominal Swelling and Ascites
321(4)
Lawrence S. Friedman
SECTION 7 Alterations in Renal and Urinary Tract Function
51 Interstitial Cystitis/Bladder Pain Syndrome
325(6)
R. Christopher Doiron
J. Curtis Nickel
52 Azotemia and Urinary Abnormalities
331(7)
David B. Mount
53 Fluid and Electrolyte Disturbances
338(18)
L. David B. Mount
54 Hypercalcemia and Hypocalcemia
356(3)
Sundeep Khosla
55 Acidosis and Alkalosis
359(10)
Thomas D. DuBose Jr.
SECTION 8 Alterations in the Skin
56 Approach to the Patient with a Skin Disorder
369(5)
Kim B. Yancey
Thomas J. Lawley
57 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
374(9)
Leslie P. Lawley
Justin T. Cheeky
Robert A. Swerlick
58 Skin Manifestations of Internal Disease
383(17)
Jean L. Bolognia
Jonathan S. Leventhal
Irwin M. Braverman
59 Immunologically Mediated Skin Diseases
400(7)
Kim B. Yancey
Benjamin F. Chong
Thomas J. Lawley
60 Cutaneous Drug Reactions
407(10)
Robert G. Micheletti
Misha Rosenbach
Bruce U. Wintroub
Kanade Shinkai
61 Photosensitivity and Other Reactions to Sunlight
417(7)
Alexander G. Marneros
David R. Bickers
SECTION 9 Hematologic Alterations
62 Interpreting Peripheral Blood Smears
424(7)
Dan L. Longo
63 Anemia and Polycythemia
431(8)
John W. Adamson
Dan L. Longo
64 Disorders of Granulocytes and Monocytes
439(11)
Steven M. Holland
John I. Gallin
65 Bleeding and Thrombosis
450(7)
Barbara A. Konkle
66 Enlargement of Lymph Nodes and Spleen
457(8)
Dan L. Longo
PART 3 Pharmacology
67 Principles of Clinical Pharmacology
465(9)
Dan M. Roden
68 Pharmacogenomics
474(7)
Dan M. Roden
PART 4 Oncology and Hematology
SECTION 1 Neoplastic Disorders
69 Approach to the Patient with Cancer
481(9)
Dan L. Longo
70 Prevention and Early Detection of Cancer
490(8)
Jennifer M. Croswell
Otis W. Brawley
Barnett S. Kramer
71 Cancer Genetics
498(10)
Fred Bunz
Bert Vogelstein
72 Cancer Cell Biology
508(21)
Jeffrey W. Clark
Dan L. Longo
73 Principles of Cancer Treatment
529(27)
Edward A. Sausville
Dan L. Longo
74 Infections in Patients with Cancer
556(9)
Robert W. Finberg
75 Oncologic Emergencies
565(13)
Rasim Gucalp
Janice P. Dutcher
76 Cancer of the Skin
578(12)
Brendan D. Curti
John T. Vetto
Sancy A. Leachman
77 Head and Neck Cancer s
590(4)
Everett E. Vokes
78 Neoplasms of the Lung
594(17)
Leora Horn
Wade T. Jams
79 Breast Cancer
611(15)
Daniel F. Hayes
Marc E. Lippman
80 Upper Gastrointestinal Tract Cancers
626(10)
David Kelsen
81 Lower Gastrointestinal Cancers
636(7)
Robert J. Mayer
82 Tumors of the Liver and Biliary Tree
643(14)
Josep M. Llovet
83 Pancreatic Cancer
657(6)
Daniel D. VonHoff
84 Gastrointestinal Neuroendocrine Tumors
663(10)
Matthew H. Kulke
85 Renal Cell Carcinoma
673(3)
Robert J. Motzer
Martin H. Voss
86 Cancer of the Bladder and Urinary Tract
676(5)
Noah M. Hahn
87 Benign and Malignant Diseases of the Prostate
681(8)
Howard I. Scher
James A. Eastham
88 Testicular Cancer
689(6)
David J. Vaughn
89 Gynecologic Malignancies
695(6)
David Spriggs
90 Primary and Metastatic Tumors of the Nervous System
701(11)
Lisa M. DeAngelis
Patrick Y. Wen
91 Soft Tissue and Bone Sarcomas and Bone Metastases
712(4)
Shreyaskumar R. Patel
92 Carcinoma of Unknown Primary
716(5)
Kanwal Raghav
James L. Abbruzzese
Gauri R. Varadhachary
93 Paraneoplastic Syndromes: Endocrinologic/Hematologic
721(7)
J. Larry Jameson
Dan L. Longo
94 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis
728(8)
Josep Dalmau
Myrna R. Rosenfeld
Francesc Graus
95 Cancer Survivorship and the Long-Term Impact of Cancer and Its Treatment
736(7)
Mark Roschewski
Dan L. Longo
SECTION 2 Hematopoietic Disorders
96 Hematopoietic Stem Cells
743(4)
David T. Scadden
Dan L. Longo
97 Iron Deficiency and Other Hypoproliferative Anemias
747(7)
John W. Adamson
98 Disorders of Hemoglobin
754(12)
Martin H. Steinberg
99 Megaloblastic Anemias
766(10)
A. Victor Hoffbrand
100 Hemolytic Anemias
776(15)
Lucio Luzzatto
Lucia De Franceschi
101 Anemia Due to Acute Blood Loss
791(1)
Dan L. Longo
102 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
792(10)
Neal S. Young
103 Polycythemia Vera and Other Myeloproliferative Neoplasms
802(7)
Jerry L. Spivak
104 Acute Myeloid Leukemia
809(9)
William Blum
105 Chronic Myeloid Leukemia
818(10)
Hagop Kantarjian
Elias Jabbour
Jorge Cortes
106 Acute Lymphoid Leukemia
828(6)
Dieter Hoelzer
107 Chronic Lymphocytic Leukemia
834(7)
Jennifer A. Woyach
John C. Byrd
108 Non-Hodgkin's Lymphoma
841(11)
Caron A. Jacobson
Dan L. Longo
109 Hodgkin's Lymphoma
852(3)
Caron A. Jacobson
Dan L. Longo
110 Less Common Lymphoid and Myeloid Malignancies
855(11)
Ayalew Tefferi
Dan L. Longo
111 Plasma Cell Disorders
866(12)
Nikhil C. Munshi
Dan L. Longo
Kenneth C. Anderson
112 Amyloidosis
878(6)
John L. Berk
Vaishali Sanchorawala
113 Transfusion Therapy and Biology
884(13)
Pierre Tiberghien
Olivier Garraud
Jacques Chiaroni
114 Hematopoietic Cell Transplantation
897(6)
Frederick R. Appelbaum
SECTION 3 Disorders of Hemostasis
115 Disorders of Platelets and Vessel Wall
903(7)
Barbara A. Konkle
116 Coagulation Disorders
910(9)
Jean M. Connors
117 Arterial and Venous Thrombosis
919(5)
Jane E. Freedman
Joseph Loscalzo
118 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
924(17)
Jeffrey I. Weitz
PART 5 Infectious Diseases
SECTION 1 Basic Considerations in Infectious Diseases
119 Approach to the Patient with an Infectious Disease
941(7)
Neeraj K. Surana
Dennis L. Kasper
120 Molecular Mechanisms of Microbial Pathogenesis
948(12)
Thomas E. Wood
Marcia B. Goldberg
121 Microbial Genomics and Infectious Disease
960(13)
Roby P. Bhattacharyya
Yonatan H. Grad
Deborah T. Hung
122 Approach to the Acutely 111 Infected Febrile Patient
973(8)
Tamar F. Barlam
123 Immunization Principles and Vaccine Use
981(8)
Sarah Mbaeyi
Amanda Cohn
Nancy Messonnier
124 Health Recommendations for International Travel
989(12)
Jesse Waggoner
Henry M. Wu
125 Climate Change and Infectious Disease
1001(8)
Aaron S. Bernstein
SECTION 2 Clinical Syndromes: Community-Acquired Infections
126 Pneumonia
1009(11)
Lionel A. Mandell
Michael S. Niederman
127 Lung Abscess
1020(2)
Rebecca M. Baron
Beverly W. Baron
Miriam Baron Barshak
128 Infective Endocarditis
1022(12)
Sara E. Cosgrove
Adolf W. Karchmer
129 Infections of the Skin, Muscles, and Soft Tissues
1034(6)
Dennis L. Stevens
Amy E. Bryant
130 Infectious Arthritis
1040(6)
Lawrence C. Madoff
Nongnooch Poowanawittayakom
131 Osteomyelitis
1046(8)
Werner Zimmerli
132 Intraabdominal Infections and Abscesses
1054(7)
Miriam Baron Barshak
Dennis L. Kasper
133 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
1061(5)
Richelle C. Charles
Regina C. LaRocque
134 Clostridioides difficile Infection, Including Pseudomembranous Colitis
1066(4)
Dale N. Gerding
Stuart Johnson
135 Urinary Tract Infections, Pyelonephritis, and Prostatitis
1070(8)
Kalpana Gupta
Barbara W. Trautner
136 Sexually Transmitted Infections: Overview and Clinical Approach
1078(16)
Jeanne M. Marrazzo
King K. Holmes
137 Encephalitis
1094(6)
Karen L. Roos
Michael R. Wilson
Kenneth L. Tyler
138 Acute Meningitis
1100(10)
Karen L. Roos
Kenneth L. Tyler
139 Chronic and Recurrent Meningitis
1110(7)
Avindra Nath
Walter J. Koroshetz
Michael R. Wilson
140 Brain Abscess and Empyema
1117(7)
Karen L. Roos
Kenneth L. Tyler
141 Infectious Complications of Bites
1124(4)
Sandeep S. Jubbal
Florencia Pereyra Segal
Lawrence C. Madoff
SECTION 3 Clinical Syndromes: Health Care-Associated Infections
142 Infections Acquired in Health Care Facilities
1128(8)
Robert A. Weinstein
143 Infections in Transplant Recipients
1136(12)
Robert W. Finberg
SECTION 4 Therapy for Bacterial Diseases
144 Treatment and Prophylaxis of Bacterial Infections
1148(15)
David C. Hooper
Erica S. Shenoy
Ramy H. Elshaboury
145 Bacterial Resistance to Antimicrobial Agents
1163(6)
David C. Hooper
SECTION 5 Diseases Caused by Gram-Positive Bacteria
146 Pneumococcal Infections
1169(9)
David Goldblatt
Katherine L. O'Brien
147 Staphylococcal Infections
1178(10)
Franklin D. Lowy
148 Streptococcal Infections
1188(9)
Michael R. Wessels
149 Enterococcal Infections
1197(6)
William R. Miller
Cesar A. Arias
Barbara E. Murray
150 Diphtheria and Other Corynebacterial Infections
1203(5)
William R. Bishai
John R. Murphy
151 Listeria monocytogenes Infections
1208(3)
Jennifer P. Collins
Patricia M. Griffin
152 Tetanus
1211(3)
C. Louise Thwaites
Lam Minh Yen
153 Botulism
1214(6)
Carolina Luquez
Jeremy Sobel
154 Gas Gangrene and Other Clostridial Infections
1220(5)
Amy E. Bryant
Dennis L. Stevens
SECTION 6 Diseases Caused by Gram-Negative Bacteria
155 Meningococcal Infections
1225(9)
Manish Sadarangani
Andrew J. Pollard
156 Gonococcal Infections
1234(7)
Sanjay Ram
Peter A. Rice
157 Haemophilus and Moraxella Infections
1241(5)
Timothy F. Murphy
158 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
1246(3)
Tamar F. Barlam
159 Legionella Infections
1249(8)
Steven A. Pergam
Thomas R. Hawn
160 Pertussis and Other Bordetella Infections
1257(4)
Karina A. Top
Scott A. Halperin
161 Diseases Caused by Gram-Negative Enteric Bacilli
1261(14)
Thomas A. Russo
James R. Johnson
162 Acinetobacter Infections
1275(4)
Rossana Rosa
L. Silvia Munoz-Price
163 Helicobacter pylori Infections
1279(5)
John C. Atherton
Martin J. Blaser
164 Infections Due to Pseudomonas, Burkbolderia, and Stenotrophomonas Species
1284(7)
Reuben Ramphal
165 Salmonellosis
1291(7)
David A. Pegues
Samuel I. Miller
166 Shigellosis
1298(4)
Philippe J. Sansonetti
Jean Bergounioux
167 Infections Due to Campylobacter and Related Organisms
1302(3)
Martin J. Blaser
168 Cholera and Other Vibrioses
1305(5)
Matthew K. Waldor
Edward T. Ryan
169 Brucellosis
1310(4)
Nicholas J. Beeching
170 Tularemia
1314(6)
Max Maurin
Didier Raoult
171 Plague and Other Yersinia Infections
1320(8)
Michael B. Prentice
172 Bartonella Infections, Including Cat-Scratch Disease
1328(6)
Michael Giladi
Moshe Ephros
173 Donovanosis
1334(1)
Nigel O'Farrell
SECTION 7 Miscellaneous Bacterial Infections
174 Nocardiosis
1335(5)
Gregory A. Filice
175 Actinomycosis
1340(4)
Thomas A. Russo
176 Whipple's Disease
1344(3)
Thomas A. Russo
Seth R. Glassman
177 Infections Due to Mixed Anaerobic Organisms
1347(10)
Neeraj K. Surana
Dennis L. Kasper
SECTION 8 Mycobacterial Diseases
178 Tuberculosis
1357(25)
Mario C. Raviglione
Andrea Gori
179 Leprosy
1382(10)
Jan H. Richardus
Hemanta K. Kar
Zoica Bakirtzief
Wim H. van Brakel
180 Nontuberculous Mycobacterial Infections
1392(5)
Steven M. Holland
181 Antimycobacterial Agents
1397(9)
Divya Reddy
Sebastian G. Kurz
Max R. O'Donnell
SECTION 9 Spirochetal Diseases
182 Syphilis
1406(7)
Sheila A. Lukehart
183 Endemic Treponematoses
1413(4)
Sheila A. Lukehart
Lorenzo Giacani
184 Leptospirosis
1417(4)
Jiri F. P. Wagenaar
Marga G.A. Goris
185 Relapsing Fever and Borrelia miyamotoi Disease
1421(4)
Alan G. Barbour
186 Lyme Borreliosis
1425(6)
Allen C. Steere
SECTION 10 Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
187 Rickettsial Diseases
1431(10)
David H. Walker
J. Stephen Dumler
Lucas S. Blanton
Chantal P. Bleeker-Rovers
188 Infections Due to Mycoplasmas
1441(3)
R. Doug Hardy
189 Chlamydial Infections
1444(9)
Charlotte A. Gaydos
Thomas C. Quinn
SECTION 11 Viral Diseases: General Considerations
190 Principles of Medical Virology
1453(7)
David M. Knipe
191 Antiviral Chemotherapy, Excluding Antiretroviral Drugs
1460(10)
Jeffrey I. Cohen
Eleanor Wilson
SECTION 12 Infections Due to DNA Viruses
192 Herpes Simplex Virus Infections
1470(9)
Lawrence Corey
193 Varicella-Zoster Virus Infections
1479(4)
Richard J. Whitley
194 Epstein-Barr Virus Infections, Including Infectious Mononucleosis
1483(4)
Jeffrey I. Cohen
195 Cytomegalovirus and Human Herpesvirus Types 6,7, and 8
1487(5)
Camille Nelson Kotton
Martin S. Hirsch
196 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections
1492(3)
Inger K. Damon
197 Parvovirus Infections
1495(3)
Kevin E. Brown
198 Human Papillomavirus Infections
1498(6)
Darron R. Brown
Aaron C. Ermel
SECTION 13 Infections Due to DNA and RNA Respiratory Viruses
199 Common Viral Respiratory Infections, Including COVID-19
1504(11)
James E. Crowe Jr.
200 Influenza
1515(6)
Kathleen M. Neuzil
Peter F. Wright
SECTION 14 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
201 The Human Retroviruses
1521(6)
Dan L. Longo
Anthony S. Fauci
202 Human Immunodeficiency Virus Disease: AIDS and Related Disorders
1527(70)
Anthony S. Fauci
Gregory K. Folkers
H. Clifford Lane
SECTION 15 Infections Due to RNA Viruses
203 Viral Gastroenteritis
1597(5)
Umesh D. Parashar
Roger I. Glass
204 Enterovirus, Parechovirus, and Reovirus Infections
1602(6)
Jeffrey I. Cohen
205 Measles (Rubeola)
1608(4)
Kaitlin Rainwater-Lovett
William J. Moss
206 Rubella (German Measles)
1612(3)
Laura A. Zimmerman
Susan E. Reef
207 Mumps
1615(3)
Jessica Leung Mariel Marlow
208 Rabies and Other Rhabdovirus Infections
1618(6)
Alan C. Jackson
209 Arthropod-Borne and Rodent-Borne Virus Infections
1624(21)
Jens H. Kuhn
Ian Crozier
210 Ebolavirus and Marburgvirus Infections
1645(7)
Jens H. Kuhn
Ian Crozier
SECTION 16 Fungal Infections
211 Pathogenesis, Diagnosis, and Treatment of Fungal Infections
1652(6)
Michail S. Lionakis
John E. Edwards Jr.
212 Histoplasmosis
1658(3)
Chadi A. Hage
L. Joseph Wheat
213 Coccidioidomycosis
1661(3)
Neil M. Ampel
214 Blastomycosis
1664(4)
Gregory M. Gauthier
Bruce S. Klein
215 Cryptococcosis
1668(3)
Arturo Casadevall
216 Candidiasis
1671(6)
Michail S. Lionakis
Shakti Singh
Ashraf S. Ibrahim
John E. Edwards Jr.
217 Aspergillosis
1677(4)
David W. Denning
218 Mucormycosis
1681(5)
Brad Spellberg Ashraf S. Ibrahim
219 Less Common Systemic Mycoses and Superficial Mycoses
1686(5)
Carol A. Kauffman
220 Pneumocystis Infections
1691(5)
Alison Morris
Henry Masur
SECTION 17 Protozoal and Helminthic Infections: General Considerations
221 Introduction to Parasitic Infections
1696(5)
Sharon L. Reed
222 Agents Used to Treat Parasitic Infections
1701(13)
Thomas A. Moore
SECTION 18 Protozoal Infections
223 Amebiasis and Infection with Free-Living Amebae
1714(6)
Rosa M. Andrade
Sharon L. Reed
224 Malaria
1720(16)
Nicholas J. White
Elizabeth A. Ashley
225 Babesiosis
1736(5)
Edouard Vannier
Jeffrey A. Gelfand
226 Leishmaniasis
1741(7)
Shyam Sundar
227 Chagas Disease and African Trypanosomiasis
1748(9)
Francois Chappuis
Yves Jackson
228 Toxoplasma Infections
1757(7)
Kami Kim
229 Protozoal Intestinal Infections and Trichomoniasis
1764(4)
Peter F. Weller
SECTION 19 Helminthic Infections
230 Introduction to Helminthic Infections
1768(2)
Peter F. Weller
231 Trichinellosis and Other Tissue Nematode Infections
1770(3)
Peter F. Weller
232 Intestinal Nematode Infections
1773(5)
Thomas B. Nutman
Peter F. Weller
233 Filarial and Related Infections
1778(6)
Thomas B. Nutman
Peter F. Weller
234 Schistosomiasis and Other Trematode Infections
1784(6)
Birgitte Jyding Vennervald
235 Cestode Infections
1790(7)
A. Clinton White Jr.
Peter F. Weller
PART 6 Disorders of the Cardiovascular System
SECTION 1 Introduction to Cardiovascular Disorders
236 Approach to the Patient with Possible Cardiovascular Disease
1797(2)
Joseph Loscalzo
237 Basic Biology of the Cardiovascular System
1799(11)
Joseph Loscalzo
John F. Keaney Jr.
Calum A. MacRae
238 Epidemiology of Cardiovascular Disease
1810(5)
Thomas A. Gaziano
J. Michael Gaziano
SECTION 2 Diagnosis of Cardiovascular Disorders
239 Physical Examination of the Cardiovascular System
1815(9)
Patrick T. O'Gara
Joseph Loscalzo
240 Electrocardiography
1824(8)
Ary L. Goldberger
241 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging
1832(27)
Marcelo F. Di Carli
Raymond Y. Kwong Scott D. Solomon
242 Diagnostic Cardiac Catheterization and Coronary Angiography
1859(7)
Jane A. Leopold
David P. Faxon
SECTION 3 Disorders of Rhythm
243 Principles of Clinical Cardiac Electrophysiology
1866(7)
William H. Sauer
Bruce A. Koplan
Paul C. Lei
244 The Bradyarrhythmias: Disorders of the Sinoatrial Node
1873(7)
William H. Sauer
Bruce A. Koplan
245 The Bradyarrhythmias: Disorders of the Atrioventricular Node
1880(8)
William H. Sauer
Bruce A. Koplan
246 Approach to Supraventricular Tachyarrhythmias
1888(3)
William H. Sauer
Paul C. Zei
247 Physiologic and Nonphysiologic Sinus Tachycardia
1891(2)
William H. Sauer
Paul C. Zei
248 Focal Atrial Tachycardia
1893(1)
William H. Sauer
Paul C. Zei
249 Paroxysmal Supraventricular Tachycardias
1894(5)
William H. Sauer
Paul C. Zei
250 Common Atrial Flutter and Macroreentrant and Multifocal Atrial Tachycardias
1899(4)
William H. Sauer
Paul C. Zei
251 Atrial Fibrillation
1903(7)
William H. Sauer
Paul C. Zei
252 Approach to Ventricular Arrhythmias
1910(5)
William H. Sauer
Usha B. Tedrow
253 Premature Ventricular Contractions, Nonsustained Ventricular Tachycardia, and Accelerated Idioventricular Rhythm
1915(4)
William H. Sauer
Usha B. Tedrow
254 Sustained Ventricular Tachycardia
1919(4)
William H. Sauer
Usha B. Tedrow
255 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation
1923(4)
William H. Sauer
Usha B. Tedrow
256 Electrical Storm and Incessant Ventricular Tachycardia
1927(3)
William H. Sauer
Usha B. Tedrow
SECTION 4 Disorders of the Heart, Muscles, Valves, and Pericardium
257 Heart Failure: Pathophysiology and Diagnosis
1930(10)
Michael M. Givertz
Mandeep R. Mehra
258 Heart Failure: Management
1940(14)
Akshay S. Desai
Mandeep R. Mehra
259 Cardiomyopathy and Myocarditis
1954(19)
Neal K. Lakdawala
Lynne Warner Stevenson
Joseph Loscalzo
260 Cardiac Transplantation and Prolonged Assisted Circulation
1973(5)
Mandeep R. Mehra
261 Aortic Stenosis
1978(8)
Patrick T. O'Gara
Joseph Loscalzo
262 Aortic Regurgitation
1986(5)
Patrick T. O'Gara
Joseph Loscalzo
263 Mitral Stenosis
1991(4)
Patrick T. O'Gara
Joseph Loscalzo
264 Mitral Regurgitation
1995(4)
Patrick T. O'Gara
Joseph Loscalzo
265 Mitral Valve Prolapse
1999(2)
Patrick T. O'Gara
Joseph Loscalzo
266 Tricuspid Valve Disease
2001(3)
Patrick T. O'Gara
Joseph Loscalzo
267 Pulmonic Valve Disease
2004(1)
Patrick T. O'Gara
Joseph Loscalzo
268 Multiple and Mixed Valvular Heart Disease
2005(3)
Patrick T. O'Gara
Joseph Loscalzo
269 Congenital Heart Disease in the Adult
2008(11)
Anne Marie Valente
Michael J. Landzberg
270 Pericardial Disease
2019(6)
Joseph Loscalzo
271 Atrial Myxoma and Other Cardiac Tumors
2025(3)
Eric H. Awtry
272 Cardiac Trauma
2028(2)
Eric H. Awtry
SECTION 5 Coronary and Peripheral Vascular Disease
273 Ischemic Heart Disease
2030(16)
Elliott M. Antman
Joseph Loscalzo
274 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)
2046(7)
Robert P. Giugliano
Christopher P. Cannon
Eugene Braunwald
275 ST-Segment Elevation Myocardial Infarction
2053(13)
Elliott M. Antman
Joseph Loscalzo
276 Percutaneous Coronary Interventions and Other Interventional Procedures
2066(6)
David P. Faxon
Deepak L. Bhatt
277 Hypertension
2072(16)
Theodore A. Kotchen
278 Renovascular Disease
2088(3)
Stephen C. Textor
279 Deep-Venous Thrombosis and Pulmonary Thromboembolism
2091(10)
Samuel Z. Goldhaber
280 Diseases of the Aorta
2101(6)
Mark A. Creager
Joseph Loscalzo
281 Arterial Diseases of the Extremities
2107(8)
Mark A. Creager
Joseph Loscalzo
282 Chronic Venous Disease and Lymphedema
2115(6)
Mark A. Creager
Joseph Loscalzo
283 Pulmonary Hypertension
2121(10)
Bradley A. Maron
Joseph Loscalzo
PART 7 Disorders of the Respiratory System
SECTION 1 Diagnosis of Respiratory Disorders
284 Approach to the Patient with Disease of the Respiratory System
2131(2)
Bruce D. Levy
285 Disturbances of Respiratory Function
2133(7)
Edward T. Naureckas
Julian Solway
286 Diagnostic Procedures in Respiratory Disease
2140(7)
George R. Washko
Hilary J. Goldberg
Majid Shafiq
SECTION 2 Diseases of the Respiratory System
287 Asthma
2147(13)
Elliot Israel
288 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
2160(6)
Praveen Akuthota
Michael E. Wechsler
289 Occupational and Environmental Lung Disease
2166(7)
John R. Balmes
290 Bronchiectasis
2173(3)
Rebecca M. Baron
Beverly W. Baron
Miriam Baron Barshak
291 Cystic Fibrosis
2176(4)
Eric J. Sorscher
292 Chronic Obstructive Pulmonary Disease
2180(10)
Edwin K. Silverman
James D. Crapo
Barry J. Make
293 Interstitial Lung Disease
2190(7)
Gary M. Hunninghake
Ivan O. Rosas
294 Disorders of the Pleura
2197(3)
Richard W. Light
295 Disorders of the Mediastinum
2200(1)
Richard W. Light
296 Disorders of Ventilation
2201(3)
John F. McConville
Julian Solway
Babak Mokhlesi
297 Sleep Apnea
2204(5)
Andrew Wellman
Daniel J. Gottlieb
Susan Redline
298 Lung Transplantation
2209(5)
Hilary J. Goldberg Hari R. Mallidi
299 Interventional Pulmonary Medicine
2214(3)
Lonny Yarmus
David Feller-Kopman
PART 8 Critical Care Medicine
SECTION 1 Respiratory Critical Care
300 Approach to the Patient with Critical Illness
2217(8)
Rebecca M. Baron
Anthony F. Massaro
301 Acute Respiratory Distress Syndrome
2225(5)
Rebecca M. Baron
Bruce D. Levy
302 Mechanical Ventilatory Support
2230(5)
Scott Schissel
SECTION 2 Shock and Cardiac Arrest
303 Approach to the Patient with Shock
2235(6)
Anthony F. Massaro
304 Sepsis and Septic Shock
2241(9)
Emily B. Brant
Christopher W. Seymour
Derek C. Angus
305 Cardiogenic Shock and Pulmonary Edema
2250(7)
David H. Ingbar
Holger Thiele
306 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
2257(10)
Christine Albert
William H. Sauer
SECTION 3 Neurologic Critical Care
307 Nervous System Disorders in Critical Care
2267(12)
J. Claude Hemphill
Wade S. Smith
S. Andrew Josephson
Daryl R. Gress
PART 9 Disorders of the Kidney and Urinary Tract
308 Approach to the Patient with Renal Disease or Urinary Tract Disease
2279(8)
Julian L. Seifter
309 Cell Biology and Physiology of the Kidney
2287(9)
Alfred L. George Jr.
Eric G. Neilson
310 Acute Kidney Injury
2296(13)
Sushrut S. Waikar
Joseph V. Bonventre
311 Chronic Kidney Disease
2309(11)
Joanne M. Bargman
Karl Skorecki
312 Dialysis in the Treatment of Kidney Failure
2320(5)
Kathleen D. Liu
Glenn M. Chertow
313 Transplantation in the Treatment of Renal Failure
2325(6)
Jamil Azzi
Naoka Murakami
Anil Chandraker
314 Glomerular Diseases
2331(19)
Julia B. Lewis
Eric G. Neilson
315 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development
2350(7)
Jing Zhou
Martin R. Pollak
316 Tubulointerstitial Diseases of the Kidney
2357(7)
Laurence H. Beck Jr.
David J. Salant
317 Vascular Injury to the Kidney
2364(4)
Ronald S. Go
Nebon Leung
318 Nephrolithiasis
2368(5)
Gary C. Curhan
319 Urinary Tract Obstruction
2373(4)
Julian L. Seifter
320 Interventional Nephrology
2377(4)
Dirk M. Hentschel
PART 10 Disorders of the Gastrointestinal System
SECTION 1 Disorders of the Alimentary Tract
321 Approach to the Patient with Gastrointestinal Disease
2381(6)
William L. Hasler
Chung Owyang
322 Gastrointestinal Endoscopy
2387(36)
Louis Michel Wong Kee Song Mark Topazian
323 Diseases of the Esophagus
2423(11)
Peter J. Kahrilas
Ikuo Hirano
324 Peptic Ulcer Disease and Related Disorders
2434(24)
John Del Valle
325 Disorders of Absorption
2458(11)
Deborah C. Rubin
326 Inflammatory Bowel Disease
2469(21)
Sonia Friedman
Richard S. Blumberg
327 Irritable Bowel Syndrome
2490(7)
Chung Owyang
328 Diverticular Disease and Common Anorectal Disorders
2497(9)
Susan L. Gearhart
329 Mesenteric Vascular Insufficiency
2506(2)
Maryam Ali Khan
Jaideep Das Gupta
Mahmoud Malas
330 Acute Intestinal Obstruction
2508(5)
Danny O. Jacobs
331 Acute Appendicitis and Peritonitis
2513(4)
Danny O. Jacobs
SECTION 2 Nutrition
332 Nutrient Requirements and Dietary Assessment
2517(6)
Johanna T. Dwyer
333 Vitamin and Trace Mineral Deficiency and Excess
2523(11)
Paolo M. Suter
334 Malnutrition and Nutritional Assessment
2534(5)
Gordon L. Jensen
335 Enteral and Parenteral Nutrition
2539(7)
L. John Hoffer
Bruce R. Bistrian
David F. Driscoll
SECTION 3 Liver and Biliary Tract Disease
336 Approach to the Patient with Liver Disease
2546(7)
Marc G. Ghany
Jay H. Hoofnagle
337 Evaluation of Liver Function
2553(4)
Emily D. Bethea
Daniel S. Pratt
338 The Hyperbilirubinemias
2557(5)
Allan W. Wolkoff
339 Acute Viral Hepatitis
2562(22)
Jules L. Dienstag
340 Toxic and Drug-Induced Hepatitis
2584(7)
William M. Lee
Jules L. Dienstag
341 Chronic Hepatitis
2591(26)
Jules L. Dienstag
342 Alcohol-Associated Liver Disease
2617(2)
Bernd Schnabl
343 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis
2619(5)
Manal F. Abdelmalek
Anna Mae Diehl
344 Cirrhosis and Its Complications
2624(9)
Alex S. Befeler
Bruce R. Bacon
345 Liver Transplantation
2633(8)
Raymond T. Chung
Jules L. Dienstag
346 Diseases of the Gallbladder and Bile Ducts
2641(11)
Norton J. Greenberger
Gustav Paumgartner
Daniel S. Pratt
SECTION 4 Disorders of the Pancreas
347 Approach to the Patient with Pancreatic Disease
2652(5)
Somashekar G. Krishna
Darwin L. Conwell
Phil A. Hart
348 Acute and Chronic Pancreatitis
2657(14)
Phil A. Hart
Darwin L. Conwell
Somashekar G. Krishna
PART 11 Immune-Mediated, Inflammatory, and Rheumatologic Disorders
SECTION 1 The Immune System in Health and Disease
349 Introduction to the Immune System
2671(30)
Barton F. Haynes
Kelly A. Soderberg Anthony S. Fauci
350 Mechanisms of Regulation and Dysregulation of the Immune System
2701(8)
Barton F. Haynes
Kelly A. Soderberg Anthony S. Fauci
351 Primary Immune Deficiency Diseases
2709(10)
Alain Fischer
SECTION 2 Disorders of Immune-Mediated Injury
352 Urticaria, Angioedema, and Allergic Rhinitis
2719(8)
Katherine L. Tuttle
Joshua A. Boyce
353 Anaphylaxis
2727(2)
David Hong Joshua A. Boyce
354 Mastocytosis
2729(2)
Matthew P. Giannetti
Joshua A. Boyce
355 Autoimmunity and Autoimmune Diseases
2731(5)
Betty Diamond
Peter E. Lipsky
356 Systemic Lupus Erythematosus
2736(13)
Bevra Hannahs Hahn
Maureen McMahon
357 Antiphospholipid Syndrome
2749(2)
Haralampos M. Moutsopoulos
Clio P. Mavragani
358 Rheumatoid Arthritis
2751(15)
Ankoor Shah
E. William St. Clair
359 Acute Rheumatic Fever
2766(5)
Joseph Kado
Jonathan Carapetis
360 Systemic Sclerosis (Scleroderma) and Related Disorders
2771(16)
John Varga
361 Sjogren's Syndrome
2787(3)
Haralampos M. Moutsopoulos
Clio P. Mavragani
362 Spondyloarthritis
2790(12)
Joel D. Taurog
Lianne S. Gensler
Nigil Haroon
363 The Vasculitis Syndromes
2802(15)
Carol A. Langford
Anthony S. Fauci
364 Behcet Syndrome
2817(2)
365 Inflammatory Myopathies
2819(7)
Steven A. Greenberg
Anthony A. Amato
366 Relapsing Polychondritis
2826(3)
Carol A. Langford
367 Sarcoidosis
2829(8)
Robert P. Baughman
Elyse E. Lower
368 IgG4-Related Disease
2837(3)
John H. Stone
369 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases
2840(4)
Daniel L. Kastner
SECTION 3 Disorders of the Joints and Adjacent Tissues
370 Approach to Articular and Musculoskeletal Disorders
2844(10)
John J. Cash
371 Osteoarthritis
2854(8)
David T. Felson
Tuhina Neogi
372 Gout and Other Crystal-Associated Arthropathies
2862(6)
Hyon K. Choi
373 Fibromyalgia
2868(3)
Leslie J. Crofford
374 Arthritis Associated with Systemic Disease, and Other Arthritides
2871(7)
Carol A. Langford
Brian F. Mandell
375 Periarticular Disorders of the Extremities
2878(3)
Carol A. Langford
PART 12 Endocrinology and Metabolism
SECTION 1 Endocrinology
376 Approach to the Patient with Endocrine Disorders
2881(3)
J. Larry Jameson
377 Mechanisms of Hormone Action
2884(7)
J. Larry Jameson
378 Physiology of Anterior Pituitary Hormones
2891(5)
Shlomo Melmed
J. Larry Jameson
379 Hypopituitarism
2896(6)
Shlomo Melmed
J. Larry Jameson
380 Pituitary Tumor Syndromes
2902(16)
Shlomo Melmed
J. Larry Jameson
381 Disorders of the Neurohypophysis
2918(8)
Gary L. Robertson
Daniel G. Bichet
382 Thyroid Gland Physiology and Testing
2926(7)
J. Larry Jameson
Susan J. Mandel
Anthony P. Weetman
383 Hypothyroidism
2933(5)
J. Larry Jameson
Susan J. Mandel
Anthony P. Weetman
384 Hyperthyroidism and Other Causes of Thyrotoxicosis
2938(8)
J. Larry Jameson
Susan J. Mandel
Anthony P. Weetman
385 Thyroid Nodular Disease and Thyroid Cancer
2946(9)
J. Larry Jameson
Susan J. Mandel
Anthony P. Weetman
386 Disorders of the Adrenal Cortex
2955(21)
Wiebke Arlt
387 Pheochromocytoma
2976(7)
Hartmut P. H. Neumann
388 Multiple Endocrine Neoplasia Syndromes
2983(9)
R. V. Thakker
389 Autoimmune Polyendocrine Syndromes
2992(5)
Peter A. Gottlieb
Aaron W. Michels
SECTION 2 Sex- and Gender-Based Medicine
390 Sex Development
2997(9)
Courtney Finlayson
J. Larry Jameson
John C. Achermann
391 Disorders of the Testes and Male Reproductive System
3006(21)
Shalender Bhasin
J. Larry Jameson
392 Disorders of the Female Reproductive System
3027(6)
Janet E. Hall
Anuja Dokras
393 Menstrual Disorders and Pelvic Pain
3033(6)
Janet E. Hall
Anuja Dokras
394 Hirsutism
3039(4)
David A. Ehrmann
395 Menopause and Postmenopausal Hormone Therapy
3043(7)
JoAnn E. Manson
Shari S. Bassuk
396 Infertility and Contraception
3050(5)
Anuja Dokras
Janet E. Hall
397 Sexual Dysfunction
3055(8)
Kevin T. McVary
398 Women's Health
3063(6)
Emily Nosova
Andrea Dunaif
399 Men's Health
3069(9)
Shalender Bhasin
400 Lesbian, Gay, Bisexual, and Transgender (LGBT) Health
3078(2)
Baligh R. Yehia
Zachary B. R. McClain
SECTION 3 Obesity, Diabetes Mellitus, and Metabolic Syndrome
401 Pathobiology of Obesity
3080(7)
Stephen O'Rahilly
I. Sadaf Farooqi
402 Evaluation and Management of Obesity
3087(7)
Robert F. Kushner
403 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology
3094(10)
Alvin C. Powers
Kevin D. Niswender
Carmella Evans-Molina
404 Diabetes Mellitus: Management and Therapies
3104(16)
Alvin C. Powers
Michael J. Fowler
Michael R. Rickels
405 Diabetes Mellitus: Complications
3120(9)
Alvin C. Powers
John M. Stafford
Michael R. Rickels
406 Hypoglycemia
3129(6)
Stephen N. Davis
Philip E. Cryer
407 Disorders of Lipoprotein Metabolism
3135(15)
Daniel J. Rader
408 The Metabolic Syndrome
3150(7)
Robert H. Eckel
SECTION 4 Disorders of Bone and Mineral Metabolism
409 Bone and Mineral Metabolism in Health and Disease
3157(12)
F. Richard Bringhurst
Henry M. Kronenberg Eva S. Liu
410 Disorders of the Parathyroid Gland and Calcium Homeostasis
3169(22)
John T. Potts Jr.
Harold Juppner
411 Osteoporosis
3191(18)
Robert Lindsay
Blossom Samuels
412 Paget's Disease and Other Dysplasias of Bone
3209(8)
Rajesh K. Jain
Tamara J. Vokes
SECTION 5 Disorders of Intermediary Metabolism
413 Heritable Disorders of Connective Tissue
3217(13)
Joan C. Marini
Fransiska Malfait
414 Hemochromatosis
3230(5)
Lawrie W. Powell
David M. Frazer
415 Wilson's Disease
3235(2)
Stephen G. Kaler
416 The Porphyrias
3237(11)
Robert J. Desnick
Manisha Balwani
417 Disorders of Purine and Pyrimidine Metabolism
3248(6)
John N. Mecchella
Christopher M. Burns
418 Lysosomal Storage Diseases
3254(7)
Robert J. Hopkin
Gregory A. Grabowski
419 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism
3261(7)
Priya S. Kishnani
420 Inherited Disorders of Amino Acid Metabolism in Adults
3268(6)
Nicola Longo
421 Inherited Defects of Membrane Transport
3274(3)
Nicola Longo
PART 13 Neurologic Disorders
SECTION 1 Diagnosis of Neurologic Disorders
422 Approach to the Patient with Neurologic Disease
3277(5)
Daniel H. Lowenstein
S. Andrew Josephson
Stephen L. Hauser
423 Neuroimaging in Neurologic Disorders
3282(11)
William P. Dillon
424 Pathobiology of Neurologic Diseases
3293(12)
Stephen L. Hauser
Arnold R. Kriegstein
Stanley B. Prusiner
SECTION 2 Diseases of the Central Nervous System
425 Seizures and Epilepsy
3305(19)
Vikram R. Rao
Daniel H. Lowenstein
426 Introduction to Cerebrovascular Diseases
3324(11)
Wade S. Smith
S. Claiborne Johnston
J. Claude Hemphill
427 Ischemic Stroke
3335(13)
Wade S. Smith
S. Claiborne Johnston
J. Claude Hemphill
428 Intracranial Hemorrhage
3348(5)
Wade S. Smith
J. Claude Hemphill
S. Claiborne Johnston
429 Subarachnoid Hemorrhage
3353(4)
Claude Hemphill
Wade S. Smith
Daryl R. Gress
430 Migraine and Other Primary Headache Disorders
3357(13)
Peter J. Goadsby
431 Alzheimer's Disease
3370(8)
Gil D. Rabinovici
William W. Seeley
Bruce L. Miller
432 Frontotemporal Dementia
3378(3)
William W. Seeley
Bruce L. Miller
433 Vascular Dementia
3381(4)
Steven M. Greenberg
William W. Seeley
434 Dementia with Lewy Bodies
3385(1)
Irene Litvan
William W. Seeley
Bruce L. Miller
435 Parkinson's Disease
3386(14)
C. Warren Olanow
Anthony H.V. Schapira
436 Tremor, Chorea, and Other Movement Disorders
3400(10)
C. Warren Olanow
Christine Klein
437 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
3410(6)
Robert H. Brown Jr.
438 Prion Diseases
3416(6)
Stanley B. Prusiner
Michael Geschwind
439 Ataxic Disorders
3422(5)
Roger N. Rosenberg
440 Disorders of the Autonomic Nervous System
3427(9)
Richard J. Barohn
John W. Engstrom
441 Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders
3436(9)
Vanja C. Douglas
Stephen L. Hauser
442 Diseases of the Spinal Cord
3445(11)
Stephen L. Hauser
443 Concussion and Other Traumatic Brain Injuries
3456(6)
Geoffrey T. Manley
Benjamin L. Brett
Michael McCrea
444 Multiple Sclerosis
3462(15)
Bruce A. C. Cree
Stephen L. Hauser
445 Neuromyelitis Optica
3477(3)
Bruce A. C. Cree
Stephen L. Hauser
SECTION 3 Nerve and Muscle Disorders
446 Peripheral Neuropathy
3480(21)
Anthony A. Amato
Richard J. Barohn
447 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies
3501(8)
Stephen L. Hauser
Anthony A. Amato
448 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
3509(7)
Anthony A. Amato
449 Muscular Dystrophies and Other Muscle Diseases
3516(16)
Anthony A. Amato
Robert H. Brown Jr.
SECTION 4 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
450 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
3532(2)
Elizabeth R. Unger
Jin-Mann S. Lin
Jeanne Bertolli
SECTION 5 Psychiatric and Addiction Disorders
451 Biology of Psychiatric Disorders
3534(6)
Robert O. Messing Eric J. Nestler
Matthew W. State
452 Psychiatric Disorders
3540(16)
Victor I. Reus
453 Alcohol and Alcohol Use Disorders
3556(7)
Marc A. Schuckit
454 Nicotine Addiction
3563(4)
David M. Burns
455 Marijuana and Marijuana Use Disorders
3567(2)
Nora D. Volkow
Aidan Hampson
Ruben Baler
456 Opioid-Related Disorders
3569(4)
Thomas R. Kosten
Colin N. Haile
457 Cocaine, Other Psychostimulants, and Hallucinogens
3573(6)
Karran A. Phillips
Wilson M. Compton
PART 14 Poisoning, Drug Overdose, and Envenomation
458 Heavy Metal Poisoning
3579(3)
Howard Hu
459 Poisoning and Drug Overdose
3582(14)
Mark B. Mycyk
460 Disorders Caused by Venomous Snakebites and Marine Animal Exposures
3596(12)
Erik Fisher
Alex Chen
Charles Lei
461 Ectoparasite Infestations and Arthropod Injuries
3608(9)
Richard J. Pollack
Scott A. Norton
PART 15 Disorders Associated with Environmental Exposures
462 Altitude Illness
3617(6)
Buddha Basnyat
Geoffrey Tabin
463 Hyperbaric and Diving Medicine
3623(7)
Michael H. Bennett
Simon J. Mitchell
464 Hypothermia and Peripheral Cold Injuries
3630(5)
Daniel F. Danzl
465 Heat-Related Illnesses
3635(4)
Daniel F. Danzl
PART 16 Genes, the Environment, and Disease
466 Principles of Human Genetics
3639(23)
Larry Jameson
Peter Kopp
467 The Practice of Genetics in Clinical Medicine
3662(6)
Susan M. Domchek
J. Larry Jameson
Susan Miesfeldt
468 Mitochondrial DNA and Heritable Traits and Diseases
3668(12)
Karl L. Skorecki
Bruce H. Cohen
469 Telomere Disease
3680(5)
Rodrigo T. Calado
Neal S. Young
470 Gene- and Cell-Based Therapy in Clinical Medicine
3685(5)
Katherine A. High
Marcela V. Maus
471 The Human Microbiome
3690(13)
Neeraj K. Surana
Dennis L. Kasper
PART 17 Global Medicine
472 Global Issues in Medicine
3703(10)
Joseph J. Rhatigan
Paul Farmer
473 Emerging and Reemerging Infectious Diseases
3713(5)
George W. Rutherford
Jaime Sepiilveda
474 Primary Care and Global Health
3718(8)
Tim Evans
Kumanan Rasanathan
475 Health Effects of Climate Change
3726(7)
Eugene T. Richardson
Maxine A. Burkett
Paul E. Farmer
PART 18 Aging
476 Biology of Aging
3733(6)
Rafael de Cabo
David Le Couteur
477 Caring for the Geriatric Patient
3739(22)
Joseph G. Ouslander
Bernardo Reyes
PART 19 Consultative Medicine
478 Approach to Medical Consultation
3761(1)
Jeffrey Berns
Jack Ende
479 Medical Disorders During Pregnancy
3762(7)
Sarah Rae Easter
Robert L. Barbieri
480 Medical Evaluation of the Surgical Patient
3769(6)
Prashant Vaishnava
Kim A. Eagle
PART 20 Frontiers
481 Behavioral Economics and Health
3775(9)
Kevin G. Volpp
George Loewenstein
David A. Asch
482 Complementary and Integrative Therapies and Practices
3784(6)
Helene M. Langevin
483 The Role of Epigenetics in Disease and Treatment
3790(6)
Brian C. Capell
Shelley L. Berger
484 Applications of Stem Cell Biology in Clinical Medicine
3796(4)
John A. Kessler
485 The Role of Circadian Biology in Health and Disease
3800(12)
Jonathan Cedernaes
Kathryn Moynihan Ramsey
Joseph Bass
486 Network Medicine: Systems Biology in Health and Disease
3812(7)
Joseph Loscalzo
487 Emerging Neurotherapeutic Technologies
3819(7)
Jyoti Mishra
Karunesh Ganguly
488 Machine Learning and Augmented Intelligence in Clinical Medicine
3826(5)
Arjun K. Manrai
Isaac S. Kohane
489 Metabolomics
3831(5)
Jared R. Mayers
Mathew G. Wander Heiden
490 Circulating Nucleic Acids as Liquid Biopsies and Noninvasive Disease Biomarkers
3836(10)
Ash A. Alizadeh
Kiran K. Khush
Yair J. Blumenfeld
491 Protein Folding Disorders
3846(5)
Richard I. Morimoto
G. Scott Budinger
492 Novel Approaches to Diseases of Unknown Etiology
3851
David Adams
Camilo Tow
Joseph Loscalzo
Index 1
Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School; Chairman, Department of Medicine; Physician-in-Chief, Brigham and Womens Hospital, Boston, Massachusetts





Anthony S. Fauci, MDChief, Laboratory of ImmunoregulationDirector, National Institute of Allergy and Infectious DiseasesNational Institutes of Health. In 2008, Dr. Fauci was awarded the Presidential Medal of Freedom, the Nation's highest civil award.





Dennis L. Kasper, MD, MA (Hon)William Ellery Channing Professor of MedicineProfessor of Microbiology and Molecular GeneticsExecutive Dean for Academic ProgramsHarvard Medical SchoolDirector, Channing LaboratoryDepartment of MedicineBrigham and Womens Hospital





McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide





McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide