Hemodiafiltration (HDF) for the treatment of end-stage renal disease patients is predominantly performed in European countries and in Japan, with some differences in technique such as rate of blood flow and dialysis fluid delivery systems. The main focus of this book is on the clinical importance of online HDF, the techniques of which have been re-evaluated with the introduction of super high-flux membrane dialyzers. After a brief introduction into the history of HDF, recent advances and clinical experiences of HDF are summarized, including water quality control for dialysis fluid, equipped system for safe use, clinical advantages, and theoretical aspects of HDF. Moreover, at the end of each chapter researchers and scientists discuss problems into which further research is needed. Clinicians and scientists involved in the treatment of end-stage renal disease patients will find this publication an essential source of information. Moreover, it may also serve as a textbook for those who are planning to start HDF in their clinics or who are studying blood purification therapies in medical schools, nursing schools and even in engineering schools related to medical technologies.
Preface: Kawanishi, H.; Yamashita, A.C.; History and Evolution of
Hemodiafiltration; Dawn of Hemodiafiltration: Ota, K.; Hemodiafiltration -
State of the Art: Locatelli, F. et al.; Hemodiafiltration: Evolution of a
Technique Towards Better Dialysis Care: Ronco, C.; Clinical Benefits of
Hemodiafiltration; Optimal Therapeutic Conditions for Online
Hemodiafiltration: Canaud, B. et al.; Effect of Hemodiafiltration on
Mortality, Inflammation and Quality of Life: den Hoedt, C.H. et al.; How to
Prescribe Hemodialysis or Hemodiafiltration in Order to Ameliorate
Dialysis-Related Symptoms and Complications: Masakane, I.; Optimizing Home
Dialysis: Role of Hemodiafiltration: Vilar, E. et al.; Management of Dialysis
Fluid and Dialysis System; Quality Management of Dialysis Fluid for Online
Convective Therapies: Ward, R.A.; Biocompatibility of Dialysis Fluid for
Online HDF: Tomo, T.; Shinoda, T.; Characteristics of Central Dialysis Fluid
Delivery System and Single Patient Dialysis Machine for HDF: Aoike, I.; Fully
Automated Dialysis System for Online Hemodiafiltration Built into the Central
Dialysis Fluid Delivery System: Kawanishi, H.; Moriishi, M.; Uremic Toxins;
New Uremic Toxins - Which Solutes Should Be Removed? Glorieux, G.; Vanholder,
R.; Beta-2-Microglobulin as a Uremic Toxin: the Japanese Experience:
Fujimori, A.; Markers and Possible Uremic Toxins: Japanese Experiences:
Kinugasa, E.; Dialysis Membranes for Hemodiafiltration; Biocompatibility of
the Dialysis Membrane: Takemoto, Y. et al.; Choice of Dialyzers for HDF:
Yamashita, A.C.; Sakurai, K.; Estimation of Internal Filtration Flow Rate in
High-Flux Dialyzers by Doppler Ultrasonography: Mineshima, M.; Clinical
Aspects of Hemodiafiltration; Management of Anemia by Convective Treatments:
Locatelli, F. et al.; Clinical Evaluation Indices for
Hemodialysis/Hemodiafiltration in Japan: Shinoda, T.; Koda, Y.; Effect of
Large-Size Dialysis Membrane and Hemofiltration/Hemodiafiltration Methods on
Long-Term Dialysis Patients: Tsuchida, K.; Minakuchi, J.; Who Needs
Acetate-Free Biofiltration? Kuno, T.; Improvement of Autonomic Nervous
Regulation by Blood Purification Therapy Using Acetate-Free Dialysis Fluid -
Clinical Evaluation by Laser Doppler Flowmetry: Sato, T. et al.; Preservation
of Residual Renal Function with HDF: Hyodo, T.; Koutoku, N.
