Fielding (cardiovascular physiology, University of California-San Francisco) offers a detailed overview of the biological role of high-density lipoproteins (HDLs), summarizing current knowledge on HDL turnover, regulation, and physiology. The first four chapters deal with the structures and properties of the HDL proteins apoA-I, -A-II, -E, and -M. This is followed by five chapters on HDL biochemistry and the catalytic factors driving its formation and metabolism. The next section deals with the secretion and removal of HDL, detailing the cell biological pathways that determine circulating HDL levels. The use of animal models in HDL research is also discussed. A section on the role of HDL in metabolism offers four chapters on nutrition, exercise, and the endothelium. The remaining five chapters review the rapid progress being made in the human pathology of HDL and in the treatment of HDL diseases. Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)
This book meets the long-awaited need for a comprehensive overview of the biological role of HDLs. Edited by one of the pioneers in HDL and cholesterol research, this monograph summarizes current knowledge on HDL turnover, regulation and physiology. Clearly structured, the various sections cover HDL structure, formation, secretion and removal, as well as plasma metabolic factors. The biological activities and clinical aspects are equally discussed, as is the impact of HDL on common diseases and their prevention.
