In anticipation of imminent benefits to understanding the role of histamine expected from the recent cloning of the H 3 receptor and developments in H 3 ligands and drugs and in knockout mice of genes related to histamine, the 105 papers discuss overviews of the central nervous system, the histamine H 3 receptor and its ligands, H 1 antagonists and their safety and efficiency, signal transduction, the hypothalamus and histamine neurons, H 2 receptors and diseases, new perspectives for histamine mediated central nervous system functions, mast cells and inflammation, histidine decarboxylase, allergic disease, molecular biology and its applications, immunology, and related topics. There is no subject index. Annotation c. Book News, Inc., Portland, OR (booknews.com)
These proceedings cover the most recent advances on histamine research from basic science to clinical medicine. Histamine is an endogenous compound that is synthesized, stored, and released primarily by mast cells and after release exerts profound effects on many tissues and organs. It is one of the cellular mediators of the immediate hypersensitivity reaction and the acute inflammatory responses, as well as primary stimulant of gastric acid secretion. A central neurotransmitter role for histamine has been also established. Histamine research has been very dynamic since it discovery in 1910. Among recent important advances are: Generation of Histamine H1, H2, H3 receptors and histidine decraboxylase (HDC) knockout mice; Clarification of the constitutive activity of the H1, H2 and H3 receptors; Characterisation of H3 receptor isoforms with distinct signaling properties; and Characterisation and cloning of the H4 receptor.
These proceedings cover the most recent advances on histamine research from basic science to clinical medicine. Histamine is an endogenous compound that is synthesized, stored, and released primarily by mast cells and after release exerts profound effects on many tissues and organs. It is one of the cellular mediators of the immediate hypersensitivity reaction and the acute inflammatory responses, as well as primary stimulant of gastric acid secretion. A central neurotransmitter role for histamine has been also established. Histamine research has been very dynamic since it discovery in 1910. Among recent important advances are: Generation of Histamine H1, H2, H3 receptors and histidine decraboxylase (HDC) knockout mice; Clarification of the constitutive activity of the H1, H2 and H3 receptors; Characterisation of H3 receptor isoforms with distinct signaling properties; and Characterisation and cloning of the H4 receptor.
Preface. Plenary lectures. Regulation of mast cell differentiation
(Y. Kitamura et al.). The histamine H3 receptor: gene organization, mutiple
isoforms, constitutive activity and molecular pharmacology (J.-M. Arrang et
al.). CNS overviews. The discovery of potent non-imidazole H3-receptor
histamine antagonists (C.R. Ganellin et al.). Histaminergic and cholinergic
transmission in cognitive processes (A. Philipu, H. Prast, M.M. Kraus).
Physiology and pharmacology of histaminergic neurons (H.L. Haas et al.).
Histaminergic modulation of basal forebrain cholinergic neurons (M.B. Passani
et al.). The interaction between the histaminergic system and the NO-cGMP
pathway: A functional neuroanatomical study in the mammillary region and
cerebral cortex of the rat (H.W.M. Steinbusch et al.). The Histamine H3
receptor and its ligands: from gene to clininc. Molecular identification of
the human and rat histamine H3- receptors: New pharmacological and functional
insight (T.W. Lovenberg et al.). Clonining functional characterisation and
CNS expression of H3 receptor isoforms (R. Leurs et al.). Partial agonists
for the histamine H3 receptor with high in vivo activity (W. Schunack et
al.). Structure-activity relationship of histamine H3-ligands: Organic
synthesis imidazole C-nucleoside derivatives (S. Harusawa et al.). Histamine
H1 antagonists. Role of protein kinase C-a in signalling from the histamine
H1-receptor to the c-fos promoter (S.J. Hill, A.C. Megson, E.M. Walker).
Molecular basis for the cardiovascular adverse effects of first- and
second-generation antihistamines (M. Taglialatela et al.). The skin
reactivity to histamine: The traps of the investigation (J.-P. Rihoux, A.
Campbell). Safety and efficiency of histamine H1 antagonists. Efficacy and
safety of H1-receptor antagonists in the treatment of allergic disorders: an
overview (F. Estelle, R. Simons). Histaminergic neurons and sleep-wake
regulation (J.S. Lin, G. Vanni-Mersier, R. Parmentier). Brain penetration of
ebastine evaluated in human by positron emission tomography PET (M. Tagawa et
al.). Signal transduction. Pathways of histamine H1receptor-induced Ca2+
entry in an human astrocytoma cells (M.M.-P. Wong, J.M. Young). Qualitative
structure activity relationship for inverse agonism of histamine H2 receptor
(A.E. Alewijnse et al.). Constitutive signalling of the human histamine H1
receptor (R.A. Bakker et al.). H1-Histamine receptor communicates to G14 with
a relatively higher affinity than to G11 (N. Nakahata et al.). Pathological
significance of over-production of histamine and altered transcriptional
regulation of H1- and H2- receptors during septic shock (N.Matsuda et al.).
Histamine receptors in the chick cerebral cortex: effects on cyclic AMP
formation and characterization by radioreceptor binding (J.B. Zawilska, A.
Wolan-Tambor, J.Zwak). Histaminergic effect on apoptosis of small intestinal
mucosa after ischemia-reperfusion in the rat (K. Fujimoto et al.).
Hypothalamus and histamine neurons. Changes in circadian rhythmicity and
melatonin balance in rats with portacaval anastomosis (PCA)-relation with
histamine (L. Tuomisto et al.). Histamine is a transmitter to maintain tonic
firing of mesopontine tegmental cholinergic neurons during wakefulness (Y.
Koyama, K. Tkahashi, Y. Kayama). Effects of leptin on feeding in histamine
H1-receptor knockout mice (T. Masaki et al.). Chronic histamine treatment
improves impaired energy intake and hyperinsulinia in diet-induced obese mice
(H. Yoshimatsu et al.). Neurotransmitter inputs to the tuberomammillary
neurons (K.S. Eriksson et al.). The difference of leptin-histamine signaling
in the hypothalamus of obese animal models (H. Yoshimatsu et al.). A possible
involvement of the chorda tympani in the enhancement of the hypothalamic
histamine release by leptin (T. Morimoto-Ishizuka et al.). H2 receptors and
diseases. Functional and morphological abnormality of gastric mucosa in
histamine H2 receptor (H2R)- deficientm mice (T. Watanabe et al.). New
perspectives for histamine-mediated CNS functions. A third legacy for
burimamide: Discovery and characterization of improgan and a new class of
non-opioid analgesics derived from histamine antagonist (L.B. Hough et al.).
Involvement of central histamine in amygdaloid kindled seizures in rats (C.
Kamei). The role of histamine in a hypocretin orexin-deficient sleep
disorder, narcolepsy (S. Nishino at al.). Central histamine and behavioral
respiration (I. Homma et al.). Peripheral neuronal histamine down regulates
sympathetic activity and arterial pressure (H. Campos). Changes in brain
histamine H1 reseptors in chronic hepatic encephalopathy (V. Lozeva et al.).
Activation of central histminergic system induced by histamine H3-receptor
antagonists on anxiety and learning in mice (K. Onodera et al.). Mast cells,
ECL cells and others. Role of Histamine and mast cells in metabolic
encephalopathy (P.J. Langlais). Mast cell degranulation in the rat small
intestine: role of endothelin-A receptors (M. Boros, L. Szalay, J. Kaszaki)
Altered response of (isolated) placental vessels to histamine in diabetes
complicated pregnancy (D. Szukiewicz et al.). Gastric submucosal
microdialysis: A method to monitor ECL-cell histamine mobilization from rat
stomach (M. Kitano et al.). The interaction between histamine H3receptors and
dopamine D1 receptors in the regulation of [ 3H]-a-aminobutyric acid relaese
in rat striatum (J.-A. Arias-Montano et al.). Immunohistochemical
localization of histamine N-methyltransferase in the bovine central nervous
system (M. Nishibori et al.). Histidine decarboxylase. Histidine
decarboxylase activity in hematopoietic progenitors as a marker for basophil
potentiality. Evidence for the existance of a common progenitor for
megakaryocytes and basophils (M. Dy et al.). Endogenous histamine and
allergic eosinophol infiltration into the airways (A. Korai et al.). Role of
histamine in gastric acid secrection: L-hisidine decarboxylase deficient mice
(S. Tanaka et al.). Histamine and allergic disease. Histamine as a
mediator of allergic airway disease (S. Holgate). Histamine and skin allergic
diseases (T. Koga, F. Kohda, M. Furue). Effects of a selective H1-receptor
antagonist, epinastine, on airway inflammation in asthmatics (K. Kimura et
al.). Mast cells and inflammation. Suppression of MAP kinase pathways in
mast cells by glucocorticolds; mechanisms and consequences (M.A. Beaven, D.S.
Cissel, T.R. Hundley). Antiasthmatic Indonesian Medicinal plants: Their
tracheospasmolytic activity against histamine induced contractions (S.
Wahyuono et al.). Mast cells in rhinitis (R. Pawankar et al.). Poster
Sessions. Molecular biology and application. Characterization of splicing
variants of histamine H3 receptor (K. Tanaka et al.). Molecular cloning and
characterization of a new subtype histamine receptor, H4 (T. Nakamura et
al.). Genomic structure of histamine N-methyl-transferase in mammals (M.
Takemura et al.). In situ hybridization analysis of gene expression of
histamine H1 receptor in murine dorsal root and trigeminal ganglia (M. Itoh
et al.). L-Histamine decarboxylase protein and activity in rat brain
microvascular endothelial cells (E. Sakurai et al.). Allergy, inflammation
and immunology. Participation of histamine H1 and H2 receptors in the
induction of scratching behavior of ICR mice caused by IgE-mediated passive
cutaneous anaphylaxis (N. Inagaki et al.). Immediate-type allergic reaction
and helper T cell fuction in histamine H1 receptor- and H2 receptor-deficient
mice (T. Kobayashi et al.). IL-18 production induced by histamine in human
PBMCs through H2 receptor stimulation (H. Kohka et al.). Regulatory mechanism
of eosinophil peroxidase release from guinea pig eosinophils (Y. Kirino, M.
Mio, C. Kamei). Induction of VEGF expression by histamine in the granulation
tissue in rats (A.K. Ghosh, N. Hirasawa, K. Ohuchi). Induction of histidine
decarboxylase in the neointimal smooth muscle cells of balloon-injured
porcine coronary arteries (Y.-Il. Fang et al.). Localization of histamine
N-methyltransferase in guinea pig tissues: an immunohistochemical study (A.
Tahara et al.). Signal transduction. Agonist-mediated regulation of
histamine H1 receptors and Ca2+ signaling: Ca2+/calmodulin-mediated
regulation of receptor function and distribution (S. Hishinuma). Involvement
of protein kinase C in regulation of histamine H1 receptor expression in U373
astrocytoma cells (R. Ishikawa et al.). Glucose overload attenuates histamine
H2 receptor-mediated Ca2+ mobilization due to protein kinase C production in
bovine cerebral endothelial cells (M. Oike, C. Kimura, Y. Ito). Studies of
histamine H1 receptor down-regulation using mutant receptors lacking putative
phosphorylation sites (M. Ogawa et al.). Mechanism underlying
histamine-induced desensitization of amylase secretion in rat parotid glands
(H. Ishida et al.). Regulation of histidine decarboxylase protein expression
in macrophages: Involvement of MAP kinases and inhibition by dexamethasone
(A. Murakami et al.). Mast cells. Functional maturation of mouse cultured
mast cells to a connective tissue mast cell-like phenotype in vitro (Y.
Taketomi et et.). Functional differences between the connective tissue and
mucosal mast cells on the contraction of isolated rat trachea (Z. Ikawati et
al.). Rho GTPases regulate degranulation and cytokine release from RBL-2H3
cells (I. Hide et al.). Effect of lipid peroxide on histamine release from
rat peritoneal mast cells (M. Akagi et al.). Effects of ultraviolet light UV
on histamine release from rat peritoneal mast cells (M. Mio et al.).
Placental mast cells and histamine in pregnancy complicated by intrauterine
growth retardation (IUGR): relation to the development of villous
microvessels (D. Szukiewicz et al.). Involvement of mast cells in
inflammation sites of colitis induced by dextran sulfate sodium (Y. Iba, Y.
Sugimoto, C. Kamei). Development of histamine sensor using recombinant
histamine oxidase (S. Iwaki et al.). H3 receptors and ligands. Histamine
H3 receptor mRNA expression in adult rat brain: cloning of receptor isoforms
with differential expression patterns (K.Karlstedt et al.). Histamine H3
receptor-mediated regulation of glutamatergic synaptic transmission in the
hippocampus and striatum (R.E. Brown et al.). Peripherally administered
ciproxifan elevates hypothalamic histamine levels and potently reduces food
intake in the Sprague Dawley rat (C. Bjenning et al.). Peripherally
administered histamine H3 antagonist potently reduces snacking behavior in
the obes Zucker rat (C. Bjenning, W. Liu, K. Rimvall). Auditory evoked
potentials in rats: Effects of anticonvulsants and thioperamide (S. Lensu et
al.). Histamine H3-receptor activation modulates glutamate release from rat
striatal synaptosomes (A. Molina-Hernandez, A. Nunez, J.-A. Aria-Montano).
CNS-1. Mechanism for the inhibition of amygdaloid kindled seizures induced
by histamine in rats (C. Okuma, T. Hirai, C. Kamei). The role of endogenous
histamine in learning and memory in rats (C. Kamei, Y. Sugimoto, Z. Chen)
Effects of immunosuppressive drugs on food and kaolin intakes, and
hypothalamic histamine turnover in rats (R. Oishi et al.). Glucagon-like
peptide 1 modulates histaminergic action in the central regulation of food
intake in rats (Y. Kuros et al.). Histamine-induced itch-scratch response and
cutaneous nerve firing in mice: comparison with serotonin (H. Nojima, T.
Maekawa, Y. Kuraishi). Intrathecal histamine elicites a scratching, biting
and licking behavior in mice (T. Orita et al.). The role of brain histamine
in visceral pain and emotion: Analysis through functional neuroimaging in
human barins (M. Kano et al.). CNS-2. Involvement of histamine receptors
in p-hydroxyamphetamine-induced head-twitch behavior (T. Tadano et al.). The
role of histaminergic neuron system in the methamphetamine induced behavioral
sensitization: A study using histamine related gene knockout mice (Y. Kubota
et al.). Brain histamine as protective system for the formation of neural
sensitization (C. Ito, M. Sato, T. Watanabe). The changes of histamine
concentrations in the plasma and brain in response to acute stress (Z.-B.
Yang et al.). Anti-stress effects of chicken essence in food-deprived
activity stress: Possible involvement of histaminergic neurons (Z.-B. Yang et
al.). Decreased histamine H1 receptors in the rat brain subjected to
food-deprived activity stress (M. Endou et al.). Central histamine influences
respiration in the POA/AH (M. Iwase et al.). Central histamine is a
contributory factor in temperature-induced polypnea in conscious mice (M.
Izumizaki et al.). Histamine release in the medulla oblongata influences
tracheal tone and blood pressure (M. Kanamaru, M. Iwase, I. Homma). The
effects of histamine receptor antagonists on the induction of metallothionein
mRNA after lipopolysaccharide injection in the mouse spleen (N. Sogawa et
al.). CNS-3. Evidence for the presence of histamine reuptake system in the
brain and its characterization (E. Sakurai et al.). The effects of
"sleepiness" on the brain activity during spatial cognition tasks: A human
PET study (H. Mochizuki et al.). Index of authors