Muutke küpsiste eelistusi

Immunology and Evolution of Infectious Disease [Pehme köide]

3.86/5 (28 hinnangut Goodreads-ist)
  • Formaat: Paperback / softback, 360 pages, kõrgus x laius: 235x152 mm, kaal: 482 g, 40 line illus.
  • Ilmumisaeg: 21-Jul-2002
  • Kirjastus: Princeton University Press
  • ISBN-10: 0691095957
  • ISBN-13: 9780691095950
Teised raamatud teemal:
Immunology and Evolution of Infectious DiseaseSuurem pilt
  • Formaat: Paperback / softback, 360 pages, kõrgus x laius: 235x152 mm, kaal: 482 g, 40 line illus.
  • Ilmumisaeg: 21-Jul-2002
  • Kirjastus: Princeton University Press
  • ISBN-10: 0691095957
  • ISBN-13: 9780691095950
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9780691095950.html
Märksõnad:
From HIV to influenza, the battle between infectious agents and the immune system is at the heart of disease. Knowledge of how and why parasites vary to escape recognition by the immune system is central to vaccine design, the control of epidemics, and our fundamental understanding of parasite ecology and evolution. As the first comprehensive synthesis of parasite variation at the molecular, population, and evolutionary levels, this book is essential reading for students and researchers throughout biology and biomedicine. The author uses an evolutionary perspective to meld the terms and findings of molecular biology, immunology, pathogen biology, and population dynamics. This multidisciplinary approach offers newcomers a readable introduction while giving specialists an invaluable guide to allied subjects. Every aspect of the immune response is presented in the functional context of parasite recognition and defense--an emphasis that gives structure to a tremendous amount of data and brings into sharp focus the great complexity of immunology. The problems that end each chapter set the challenge for future research, and the text includes extensive discussion of HIV, influenza, foot-and-mouth disease, and many other pathogens. This is the only book that treats in an integrated way all factors affecting variation in infectious disease. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For molecular biologists, immunologists, and evolutionary biologists, this book provides new insight into infectious agents, immunity, and the evolution of infectious disease.

Arvustused

"[ This] is a rich source of ideas for scientists working in immunology and molecular biology as well as evolution... Newcomers are offered a comprehensive introduction to basic questions of immunology, as well as a synthesis that cuts across large areas of biology. Specialists will find detailed discussions of specific infectious agents from a highly original, evolutionary perspective, and inspiration for future research."--Franziska Michor and Martin A. Nowak, Nature "Frank's book, short and clearly written, can be read through with ease, and it will serve as an excellent introduction to infectious disease dynamics for final-year undergraduates and research students, and for those who attempt to bridge the gulf between mathematics and biology. It will be particularly useful as a stimulus for new research... [ F]or an integrated and digestible account of the role of antigenic variation in the immunology and evolution of microparasites, this book has few rivals, and is highly recommended."--Charles R. M. Bangham, Trends in Ecology and Evolution "This is the first volume to comprehensively survey the integration of evolution, epidemiology, ecology, genetics, and immunology of pathogen and host population. As such, it is a valuable resource for both students and researchers."--Allison P. Galvani, Quarterly Review of Biology "This book is definitely worth reading. Frank provides a thought-provoking and timely agenda of research questions in evolutionary immunology and parasitology that will undoubtedly stay relevant for many years to come."--Paul Schmid-Hempel, Science "This book should be read by anyone interested in the evolution of infectious disease, as well as by those interested in molecular evolution or in experimental evolution... It will appeal broadly."--J.J. Bull and Dieter Ebert, Evolution "A valuable resource for both students and researchers... This stimulating book makes an important contribution by bridging the gap between immunology and epidemiology."--Alison P. Galvani, Quarterly Review of Biology

Muu info

Steven Frank provides us with a profound insight into the Darwinian evolutionary dynamics between parasite and host, told from an immunological slant. It is essential reading to understand why infections cause disease. -- Robin A. Weiss, Fellow of the Royal Society, Wohl Virion Centre, University College London This book is a real gem. Very readable, it is a teaching and research text that will be widely adopted at both the undergraduate and graduate levels. It will also provide a wonderful source of ideas for researchers working on infectious diseases, population ecology, and evolutionary biology. -- Roy Anderson, Fellow of the Royal Society, Imperial College, London This is an extremely stimulating and hugely ambitious book. It distils key essentials from the ever increasing avalanche of largely undigested molecular and immunological data to answer important questions about the natural history of antigenic variation in an evolutionary context. Frank gives us the missing part of the field: what it all means. His synthesis cuts across large areas of modern biology and is just the sort of thing the field needs. -- Andrew Read, University of Edinburgh
Acknowledgments xi
Introduction
3(10)
PART I: BACKGROUND
Vertebrate Immunity
13(9)
Nonspecific Immunity
14(1)
Specific Immunity: Antigens and Epitopes
15(1)
B Cells and Antibodies
16(3)
T Cells and MHC
19(1)
Summary
20(2)
Benefits of Antigenic Variation
22(11)
Extend Length of Infection
23(1)
Infect Hosts with Prior Exposure
24(2)
Infect Hosts with Genetically Variable Resistance
26(1)
Vary Attachment Characters
26(2)
Antigenic Interference
28(1)
Problems for Future Research
29(4)
PART II: MOLECULAR PROCESSES
Specificity and Cross-Reactivity
33(24)
Antigens and Antibody Epitopes
35(1)
Antibody Paratopes
36(2)
Antibody Affinity Maturation
38(1)
Natural Antibodies---Low-Affinity Binding to Diverse Antigens
39(1)
Affinity versus Specificity
40(2)
Cross-Reaction of Polyclonal Antibodies to Divergent Antigens
42(2)
T Cell Epitopes
44(8)
Every Host Differs
52(2)
Problems for Future Research
54(3)
Generative Mechanisms
57(16)
Mutation and Hypermutation
58(3)
Stochastic Switching between Archival Copies
61(5)
New Variants by Intragenomic Recombination
66(1)
Mixing between Genomes
67(1)
Problems for Future Research
68(5)
PART III: INDIVIDUAL INTERACTIONS
Immunodominance within Hosts
73(20)
Antibody Immunodominance
74(5)
CTL Immunodominance
79(8)
Sequence of Exposure to Antigens: Original Antigenic Sin
87(2)
Problems for Future Research
89(4)
Parasite Escape within Hosts
93(18)
Natural Selection of Antigenic Variants
94(3)
Pathogen Manipulation of Host Immune Dynamics
97(1)
Sequence of Variants in Active Switching from Archives
98(4)
Ecological Coexistence of Variants within a Host
102(4)
Problems for Future Research
106(5)
PART IV: POPULATION CONSEQUENCES
Genetic Variability of Hosts
111(13)
Polymorphisms in Specificity
112(3)
Polymorphisms in Immune Regulation
115(6)
Problems for Future Research
121(3)
Immunological Variability of Hosts
124(24)
Immunological Memory
125(4)
Kinds of Parasites
129(3)
Immunodominance of Memory
132(3)
Cross-Reactivity and Interference
135(1)
Distribution of Immune Profiles among Hosts
136(8)
Problems for Future Research
144(4)
Genetic Structure of Parasite Populations
148(27)
Kinds of Genetic Structure
149(2)
Pattern and Process
151(2)
Genome-wide Linkage Disequilibrium
153(11)
Antigenic Linkage Disequilibrium
164(2)
Population Structure: Hosts as Islands
166(2)
Problems for Future Research
168(7)
PART V: STUDYING EVOLUTION
Classifications by Antigenicity and Phylogeny
175(13)
Immunological Measures of Antigenicity
176(2)
Phylogeny
178(1)
Hypothetical Relations between Immunology and Phylogeny
179(2)
Immunology Matches Phylogeny over Long Genetic Distances
181(1)
Immunology-Phylogeny Mismatch with Radiations into New Hosts
181(2)
Short-Term Phylogenetic Diversification Driven by Immunological Selection
183(1)
Discordant Patterns of Phylogeny and Antigenicity Created by Within-Host Immune Pressure
183(3)
Problems for Future Research
186(2)
Experimental Evolution: Foot-and-Mouth Disease Virus
188(17)
Overview of Antigenicity and Structure
189(3)
Antibody Escape Mutants
192(4)
Cell Binding and Tropism
196(4)
Fitness Consequences of Substitutions
200(2)
Problems for Future Research
202(3)
Experimental Evolution: Influenza
205(25)
Overview of Antigenicity and Structure
206(8)
Antibody Escape Mutants
214(2)
Cell Binding and Tropism
216(2)
Fitness Consequences of Substitutions
218(6)
Experimental Evolution of Other Pathogens
224(3)
Problems for Future Research
227(3)
Experimental Evolution: CTL Escape
230(16)
Cleavage and Transport of Peptides
231(1)
MHC Binding
232(5)
TCR Binding
237(2)
Functional Consequences of Escape
239(1)
Kinetics of Escape
240(3)
Problems for Future Research
243(3)
Measuring Selection with Population Samples
246(19)
Kinds of Natural Selection
247(2)
Positive Selection to Avoid Host Recognition
249(2)
Phylogenetic Analysis of Nucleotide Substitutions
251(4)
Predicting Evolution
255(5)
Problems for Future Research
260(5)
Recap of Some Interesting Problems
265(4)
Population-Level Explanation for Low Molecular Variability
265(1)
Molecular-Level Explanation for Population Dynamics
266(1)
Binding Kinetics and the Dynamics of Immunodominance
266(1)
Diversity and Regulation of Archival Repertoires
267(1)
Final Note
268(1)
References 269(44)
Author Index 313(24)
Subject Index 337


Steven A. Frank is Professor of Evolutionary Biology at the University of California, Irvine, and the author of "Foundations of Social Evolution" (Princeton).