Muutke küpsiste eelistusi

Immunosensors [Kõva köide]

Edited by (Osaka University, Japan), Edited by (Alfaisal University, Saudi Arabia), Edited by (Universiti Brunei Darussalam, Brunei Darussalam)
  • Formaat: Hardback, 385 pages, kõrgus x laius: 234x156 mm, kaal: 751 g, No
  • Sari: Detection Science Series Volume 14
  • Ilmumisaeg: 28-Aug-2019
  • Kirjastus: Royal Society of Chemistry
  • ISBN-10: 1788014375
  • ISBN-13: 9781788014373
Teised raamatud teemal:
ImmunosensorsSuurem pilt
  • Formaat: Hardback, 385 pages, kõrgus x laius: 234x156 mm, kaal: 751 g, No
  • Sari: Detection Science Series Volume 14
  • Ilmumisaeg: 28-Aug-2019
  • Kirjastus: Royal Society of Chemistry
  • ISBN-10: 1788014375
  • ISBN-13: 9781788014373
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9781788014373.html
Märksõnad:

Immunosensors are widely used and are particularly important for fast diagnosis of diseases in remote environments as well as point-of-care devices. In this book, expert scientists are covering a selection of high quality representative examples from the past five years explaining how this area has developed. It is a compilation of recent advances in several areas of immunosensors for multiple target analysis using laboratory based or point-of-care set-up, for example graphene-, ISFET- and nanostructure-based immunosensors, electrochemical magneto immunosensors and nanoimprinted immunosensors.

Filling a gap in the literature, it showcases the multidisciplinary, innovative developments in this highly important area and provides pointers towards commercialisation. Delivering a single, comprehensive work, it appeals to graduate students and professional researchers across academia and industry.

Immunosensors are widely used and are particularly important for diagnosis of diseases in remote environments as well as point-of-care devices. This book is a compilation of recent advances in several areas of immunosensors for multiple target analysis using laboratory based or point-of-care set-up. A selection of high quality representative examples from the past five years will be covered by expert scientists. Filling a gap in the literature, it showcases the multidisciplinary, innovative developments in this highly important area and provides pointers towards commercialisation. Providing a single, comprehensive work, it appeals to graduate students, professional researchers across academia and industry.

Expert scientists are covering a selection of high quality representative examples from the last five years explaining how immunosensors for multiple target analysis using laboratory based or point-of-care set-up have developed.
Chapter 1 Introduction to Immunosensors 1(20)
Syazana Abdullah Lim
Minhaz Uddin Ahmed
1.1 Introduction
1(1)
1.2 Basic Principles of an Immunosensor
2(3)
1.2.1 Antibodies and Their Application to Immunosensors
3(1)
1.2.2 Immunosensor Format
4(1)
1.3 Architectures of Transducers and Their Potential Applications
5(11)
1.3.1 Electrochemical Immunosensor
7(2)
1.3.2 Optical Immunosensors
9(3)
1.3.3 Piezoelectric Immunosensor
12(3)
1.3.4 Thermometric Immunosensor
15(1)
1.4 Conclusions and Future Outlooks
16(1)
Acknowledgements
16(1)
References
17(4)
Chapter 2 Structure, Function, Orientation, Characterization and Immobilization of Antibodies for Immunosensor Development 21(21)
Sunil Bhand
Aruna Chandra Singh
2.1 Introduction
21(1)
2.2 Fundamentals, Structural Feasibility and Functions of Antibodies
22(1)
2.3 Immunosensor Development Using Antibodies
23(4)
2.3.1 Monoclonal Antibodies
24(1)
2.3.2 Polyclonal Antibodies
25(1)
2.3.3 Chopped/Half-antibodies
25(1)
2.3.4 Synthetic Antibodies (Aptamers/ Imprinted Polymers)
26(1)
2.4 Strategies Towards Immobilization of Antibodies
27(3)
2.5 Characterization Techniques
30(2)
2.6 Label-free and Labeled Immunosensing Techniques
32(3)
2.6.1 Optical Immunosensor
32(1)
2.6.2 Piezoelectric Immunosensor
33(1)
2.6.3 Impedimetric Immunosensor
33(1)
2.6.4 Thermal Immunosensor
34(1)
2.7 Recent Developments and Applications
35(1)
2.8 Conclusion
36(1)
Acknowledgements
36(1)
References
37(5)
Chapter 3 Immunosensing With Electro-active Photonic Devices 42(16)
J.H. Ghithan
A.H. Qatamin
M. Moreno
B.M. Nunn
R.S. Keynton
M.G. O'Toole
S.B. Mendes
3.1 Introduction
42(2)
3.2 Immunosensing with Single-mode, Electro-active, Integrated Optical Waveguides
44(3)
3.2.1 Methodology
44(1)
3.2.2 Sample Preparation
45(1)
3.2.3 Experimental Set-up
46(1)
3.3 Immunosensing with Electrochemical Surface Plasmon Resonance
47(2)
3.3.1 Methodology
47(1)
3.3.2 Sample Preparation and Functionalization Protocol of the EC-SPR Surface with an Immunoassay Targeting an Influenza Virus Antigen
48(1)
3.3.3 Experimental Set-up
48(1)
3.4 Results and Discussions
49(5)
3.4.1 SM-IOW-IOW Results
49(2)
3.4.2 EC-SPR Results
51(3)
3.4.3 Comparative Analysis
54(1)
3.5 Conclusions
54(1)
Acknowledgements
55(1)
References
55(3)
Chapter 4 Nanostructure-based Sensitive Electrochemical Immunosensors 58(28)
Hoang Vinh Tran
Tran Dai Lam
4.1 Electrochemical Immunosensors: Structure and Principles of Construction
58(9)
4.1.1 Construction of an Electrochemical Immunosensor
58(2)
4.1.2 Electrochemical Immunosensor Detection Mode
60(7)
4.1.3 Different Strategies for Immobilization of Capture Probes
67(1)
4.2 Nanostructure-based Materials for Improving the Sensitivity of Electrochemical Immunosensors
67(13)
4.2.1 Principles for Collections of Nanostructured-based Materials for Electrochemical Immunosensors
69(1)
4.2.2 Highly Electroactive Surface-based Nanomaterials
69(6)
4.2.3 Bio-conjugated Nanomaterials for Amplifying an Electrochemical Signal
75(4)
4.2.4 Magnetoimmunosensors
79(1)
4.3 Conclusion
80(1)
Acknowledgements
81(1)
References
81(5)
Chapter 5 Rapid and Repeated Measurement of Mite Allergens Using a Surface Acoustic Wave (SAW) Immunosensor 86(15)
K. Toma
T. Arakawa
K. Mitsubayashi
5.1 Introduction
86(2)
5.2 Sensors for Mite Allergen Detection
88(3)
5.2.1 Established Methods for Mite Allergen Tests
88(2)
5.2.2 Emerging Mite Allergen Biosensors with Improved Characteristics
90(1)
5.3 Airborne Mite Allergen Monitoring Systems
91(6)
5.3.1 Bioaerosol Sampling System
91(3)
5.3.2 Surface Acoustic Wave (SAW) Immunosensors for Rapid and Repeated Measurement of Mite Allergens
94(3)
5.4 Summary
97(1)
Acknowledgement
98(1)
References
98(3)
Chapter 6 Electrochemical Magneto-Immunosensors as Fast and Efficient Tools for Point-of-care Diagnostics 101(34)
Gisela Ruiz-Vega
Adaris Lopez-Marzo
Erica de-la-Serna
Ana Sanchez-Cano
Eva Baldrich
6.1 Introduction
101(2)
6.2 Introduction to POCT
103(2)
6.2.1 Requirements for POCT
103(1)
6.2.2 Limitations of Current Diagnostic Methods for Their Application to POCT
104(1)
6.3 Magnetic Particles (MP) as a Versatile Tool in Analytical Chemistry and Immunoassay Development
105(4)
6.3.1 Magnetic Particles: Types, Properties, Advantages and Drawbacks
105(2)
6.3.2 Strategies for MP Immunofunctionalisation
107(1)
6.3.3 Clues for the Optimisation of a Magneto- immunoassay
108(1)
6.4 MP in the Development of Electrochemical Magneto-immunosensors
109(8)
6.4.1 The Advent of Disposable Low-cost Electrodes in the Production of Electrochemical Biosensors
113(1)
6.4.2 Confinement of the MP onto the WE
114(1)
6.4.3 Electrochemical Detection of the Magneto-immunoassay
114(3)
6.5 Simplification, Automation, and Integration of Electrochemical Magneto-Immunosensors in LOC Microfluidic Platforms for POC Diagnostics
117(6)
6.5.1 Simplification of Sample Pre-treatment, Reagent Preparation and Assay Performance
117(3)
6.5.2 Automation and Multiplexing of the Electrochemical Detection
120(1)
6.5.3 Use of Paper Microfluidics and Paper Electrodes
121(2)
6.6 Implementation of Portable Measurement Equipment
123(5)
6.6.1 Exploiting Standard Portable Electrochemical Measurement Equipment: Glucose Meters, pH Meters and Smartphones
123(2)
6.6.2 Integration of Portable Measurement Equipment in POC Platforms
125(3)
6.7 Conclusions and Future Outlook
128(1)
Abbreviations
129(1)
Acknowledgements
129(1)
References
129(6)
Chapter 7 Immunosensors for Food Allergens: An Overview 135(21)
G. Selvolini
O. Hosu
G. Marrazza
7.1 Introduction
135(2)
7.2 Immunosensors for Food Analysis: Definitions, Principles and Classification
137(1)
7.3 Allergen Immunoassays
138(12)
7.3.1 Milk Allergens
138(4)
7.3.2 Cereal Allergens
142(1)
7.3.3 Peanut Allergens
143(2)
7.3.4 Egg Allergens
145(3)
7.3.5 Fish Allergens and Related Compounds
148(2)
7.4 Conclusions
150(1)
Acknowledgements
151(1)
References
151(5)
Chapter 8 Graphene Based Immunosensors 156(30)
Yong Zhang
8.1 Introduction
156(2)
8.2 Properties of Graphene with Different Morphologies
158(9)
8.2.1 Graphene Quantum Dots (QDs)
160(2)
8.2.2 2D Graphene Sheets
162(1)
8.2.3 3D Graphene Matrix
163(3)
8.2.4 Graphene-based Nanocomposites
166(1)
8.3 Graphene Based Immunosensors
167(14)
8.3.1 Graphene Based Electrochemical Immunosensors
168(3)
8.3.2 Graphene Based Photoelectrochemical Immunosensors
171(3)
8.3.3 Graphene Based Electrochemiluminescence Immunosensors
174(3)
8.3.4 Graphene Based SPR Immunosensors
177(3)
8.3.5 Other Types of Immunosensors That Are Graphene Based
180(1)
8.4 Challenge and Perspective
181(1)
Acknowledgements
182(1)
References
182(4)
Chapter 9 Gold-nanoparticles Interface-based Electrochemical Immunosensors for Tumor Biomarkers 186(33)
Mohamed Ibrahim Halawa
Baohua Lou
Guobao Xu
9.1 Introduction
186(1)
9.2 Tumor Biomarkers
187(1)
9.3 Immunosensors
188(4)
9.3.1 Electrochemical Immunosensors
189(2)
9.3.2 Immunosensor Recognition Element
191(1)
9.4 Gold Nanoparticles
192(8)
9.4.1 Synthetic Approaches of AuNPs Employed in Electrochemical Immunosensors
192(2)
9.4.2 Functions and Applications of Gold Nanostructures in Electrochemical Immunosensors
194(6)
9.5 Electrochemical Analysis of Tumor Biomarkers
200(10)
9.5.1 Prostate-specific Antigen (PSA)
200(3)
9.5.2 Carcinoembryonic Antigen (CEA)
203(1)
9.5.3 α-Fetoprotein (AFP)
204(2)
9.5.4 Cancer Antigen 125 (CA125)
206(1)
9.5.5 Squamous Cell Carcinoma Antigen (SCCA)
206(1)
9.5.6 Human Chorionic Gonadotropin (hCG)
207(1)
9.5.7 Epidermal Growth Factor Receptor (EGFR)
208(1)
9.5.8 Tumor Suppressor Protein (p53)
208(1)
9.5.9 Interleukin 6 (IL-6)
209(1)
9.5.10 Protein Kinase
209(1)
9.6 Conclusion and Outlook
210(3)
Acknowledgements
213(1)
References
213(6)
Chapter 10 Nanocomposite-based Electrochemiluminescence Immunosensors 219(19)
Mohammad Rizwan
Juthi Adhikari
Noor Faizah Mohd-Naim
Minhaz Uddin Ahmed
10.1 Introduction
219(1)
10.1.1 Biosensors
219(1)
10.1.2 Components and Constructions of Biosensors
220(1)
10.1.3 Immunosensors
220(1)
10.2 Electrochemiluminescence
220(2)
10.2.1 Electrochemiluminescence: Advantages and Applications
220(1)
10.2.2 ECL Detection Mechanism
221(1)
10.3 Nanocomposites
222(2)
10.4 Nanocomposite-based Electrochemiluminescence Immunosensors
224(3)
10.4.1 Nanocomposites in Signal Amplification
224(1)
10.4.2 Nanocomposites as Catalysts
224(2)
10.4.3 Nanocomposites in Increasing Surface Area
226(1)
10.4.4 Nanocomposites in Improving Biocompatibility
226(1)
10.5 Incorporation of Nanocomposites as Electrode Materials
227(3)
10.5.1 Metallic Nanocomposites
227(2)
10.5.2 Carbon Nanocomposites
229(1)
10.5.3 Magnetic Nanocomposites
230(1)
10.5.4 Quantum Dots Nanocomposites
230(1)
10.6 Utilization of Nanocomposites as Labeling Materials
230(3)
10.6.1 Metallic Nanocomposites
230(2)
10.6.2 Carbon Nanocomposites
232(1)
10.6.3 Magnetic Nanocomposites
233(1)
10.6.4 Quantum Dots Nanocomposites
233(1)
10.7 Typical Set-up of ECL Instruments and Devices
233(1)
10.8 Conclusion and Future Prospects
234(1)
Acknowledgements
235(1)
References
235(3)
Chapter 11 Advance Engineered Nanomaterials in Point-of-care Immunosensing for Biomedical Diagnostics 238(29)
Ashutosh Kumar
Budhhadev Purohit
Kuldeep Mahato
Pranjal Chandra
11.1 Introduction
238(2)
11.2 Transduction Mechanisms
240(5)
11.2.1 Electrochemical Transducers
240(3)
11.2.2 Optical Transducers
243(1)
11.2.3 Mechanical Transducers
244(1)
11.3 Antibodies: The Bio-receptor in Immunosensors
245(2)
11.4 Surface Functionalisation Methods
247(1)
11.5 Nanomaterials for Immunosensing
247(6)
11.5.1 Metal Nanoparticles
248(1)
11.5.2 Metal Oxide Nanoparticles
249(4)
11.6 Carbon-based Nanomaterials
253(6)
11.6.1 Carbon Nanotubes: One-dimensional Carbon Nanomaterials
253(2)
11.6.2 Graphene: Two-dimensional Carbon Nanomaterials
255(4)
11.7 Microfluidic Technology in POC Diagnosis
259(1)
11.8 Conclusions and Future Prospects
259(1)
11.9 Conflict of Interest
260(1)
Acknowledgements
260(1)
References
260(7)
Chapter 12 Immunosensors Using Screen-printed Electrodes 267(36)
N. Cheeveewattanagul
S. Buppasirakul
W. Surareungchai
12.1 Recent Advances in the Fabrication of Screen Printing Technology
267(4)
12.2 Strategies for the Immobilisation of an Antibody Over Screen-printed Electrodes
271(5)
12.2.1 Antibody Structure, Functions and Immunoreaction
272(1)
12.2.2 Immobilisation Techniques Over Screen-printed Electrodes
273(3)
12.3 Current Screen-printed Electrode-based Immunosensors and Applications
276(17)
12.3.1 Immunosensors
276(4)
12.3.2 Immunoreaction Performance
280(4)
12.3.3 Current Applications of Immunosensors
284(9)
12.4 Conclusions and Future Remarks
293(1)
Acknowledgement
293(1)
References
293(10)
Chapter 13 Antibodies Versus Aptamers: A Comparative View 303(29)
Omar A. Alsager
Shimaa Eissa
Mohammed Zourob
13.1 Introduction
303(2)
13.2 Antibodies
305(8)
13.2.1 Background
305(1)
13.2.2 In Vivo Selection of Antibodies
306(1)
13.2.3 Application of Antibodies
307(6)
13.3 Challenges of Antibodies and Their Immunosensor Applications
313(1)
13.3.1 Issues with Antibody Structure and Production
313(1)
13.3.2 Issues with Limited Detection Mechanisms
313(1)
13.4 Aptamers
314(11)
13.4.1 Background: Conventional In Vitro SELEX Selection
314(2)
13.4.2 Alternative Selection Strategies
316(1)
13.4.3 Aptamer Structures and Modes of Binding
317(2)
13.4.4 Aptamers in Biosensors: Beyond Sandwich and Competitive Assays
319(6)
13.5 Conclusions and Overall Prospects
325(1)
Acknowledgement
325(1)
References
325(7)
Chapter 14 Nanoimprinted Immunosensors 332(27)
Shu Jiang
Masato Saito
14.1 Introduction
332(1)
14.2 Plasmonic Biosensing
333(8)
14.2.1 Surface Plasmon Resonance (SPR) and Localised Surface Plasmon Resonance (LSPR)
333(5)
14.2.2 Surface Enhanced Raman Scattering (SERS) and Its Sensing Strategy
338(3)
14.3 A Review on Recent Studies in Nanostructures Fabricated via NIL Technology for LSPR/SERS Biosensing
341(1)
14.4 Development of an Au-Capped Nanopillar Structure via Thermal NIL and Its Application in Immunosensing
341(7)
14.5 Development of a Pressure-free Room- temperature NIL Method and Its Application in Immunosensing
348(1)
14.6 Development of a LSPR Imaging Platform for Simultaneous Detection Using Nanoimprinted Multiplex Assay Chips
349(7)
14.7 Conclusion
356(1)
References
356(3)
Subject Index 359