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Insider's Guide to Clinical Trials [Pehme köide]

(Professor of Epidemiology and Biostatistics, Bloomberg School of Public Health, Johns Hopkins Univey, Baltimore, Maryland)
  • Formaat: Paperback / softback, 296 pages, kõrgus x laius x paksus: 137x208x18 mm, kaal: 340 g, 2 illustrations
  • Ilmumisaeg: 09-Jun-2011
  • Kirjastus: Oxford University Press Inc
  • ISBN-10: 0199742960
  • ISBN-13: 9780199742967
Teised raamatud teemal:
  • Formaat: Paperback / softback, 296 pages, kõrgus x laius x paksus: 137x208x18 mm, kaal: 340 g, 2 illustrations
  • Ilmumisaeg: 09-Jun-2011
  • Kirjastus: Oxford University Press Inc
  • ISBN-10: 0199742960
  • ISBN-13: 9780199742967
Teised raamatud teemal:
Clinical trials receive a lot of media attention; we hear or read about them almost daily in reports heralding new and promising treatments or reports raising questions about the safety or efficacy of an established treatment. The randomized trial is the foundation of evidence-based medicine and the cornerstone for comparative effectiveness research.

This book is designed for budding students of clinical trials, novice researchers, and for the serious lay reader wanting to know more about the inner workings of trials, how they are reported, who and what gets studied, what to make of results, and how to shop for trials as a patient. Written with wit and charm, this guide will interest readers in way that formal, didactic texts cannot.

Arvustused

"An Insider's Guide to Clinical Trials provides a solid overview of the entire clinical trial process. More importantly, it provides valuable behind the scenes information and insights into performing clinical trials that you won't get from the usual textbook." -- Kevin McCague, Novartis Pharmaceuticals "An Insider's Guide to Clinical Trials is a quick introduction to clinical trials from the perspective of an academic researcher who has distilled his thoughts over a long, distinguished career. The book is written is an easy going, to-the-point style. " -- Norman M. Goldfarb, Journal of Clinical Research Best Practices

Preface xi
1 Introduction
1(10)
2 The Language of Clinical Trials
11(12)
3 The Recipe for Trials
23(8)
4 The Stages of Trials
31(6)
5 The Anatomy of Trials
37(12)
6 Authorship and Credits
49(8)
7 The Nature of Trials
57(12)
8 The Ethics of Trials
69(8)
9 Regulation of Trials
77(8)
10 Research Misconduct
85(6)
11 Myths Regarding Trials
91(14)
12 Tricks of the Trade from a Cynic
105(6)
13 Reading Between the Lines, or How to Read a Journal Article
111(8)
14 Critics and Criticisms
119(6)
15 What to Make of Results
125(12)
16 Biostatistics 101
137(14)
17 Subgroup Analysis vs. Data Dredging
151(8)
18 Meta-analyses and Systematic Reviews
159(6)
19 Re-Search
165(8)
20 Shopping for a Trial?
173(4)
21 Readings
177(14)
22 Clinical Trials and Our Health
191(6)
23 Final Exam
197(16)
24 Last Words
213(8)
Appendix A The Mother Test for Designers of Trials 221(10)
Appendix B Rating Index for Clinical Trials 231(8)
Appendix C A Patient's Guide For Deciding Whether to Enroll in a Randomized Trial 239(4)
Appendix D Abbreviations 243(4)
References 247(14)
Author Index 261(6)
Subject Index 267
Curtis L. Meinert, PhD, is a Professor in the Departments of Epidemiology and Biostatistics at the Johns Hopkins Bloomberg School of Public Health. He was founder of the Center for Clinical Trials and served as its director through September 2005. He was a founding member of the Society for Clinical Trials and was Editor of Controlled Clinical Trials from its inception in 1980 through 1993.