Enzymes Mechanisms and Dynamics: Insights from Experimental and Computational Methods is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.
- Provides cutting-edge developments in protein chemistry and structural biology
- Written by authorities in their respective fields
- Targeted to a wide audience of researchers, specialists, and students
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Publishing cutting-edge developments in protein chemistry and structural biology, this comprehensive series, continues to be an essential resource for protein chemists
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vii | |
| Preface |
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ix | |
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1 Molecular Modeling and Chemoinformatics to Advance the Development of Modulators of Epigenetic Targets: A Focus on DNA Methyltransferases |
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1 | (26) |
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2 | (2) |
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2 Progress on Chemical Information |
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4 | (5) |
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3 Chemoinformatic Studies of DNMTs |
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9 | (7) |
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4 VS: Hit Identification and Optimization |
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16 | (3) |
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5 Computer-Assisted Drug Repurposing |
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19 | (1) |
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6 Food Chemicals as Potential Modulators of DNMTs and Other Epigenetic Targets |
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20 | (1) |
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21 | (6) |
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22 | (1) |
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23 | (4) |
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2 Recent Advances in Computational Models for the Study of Protein-Peptide Interactions |
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27 | (32) |
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28 | (2) |
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30 | (9) |
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39 | (12) |
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51 | (8) |
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51 | (8) |
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3 Structural Plasticity in Globins: Role of Protein Dynamics in Defining Ligand Migration Pathways |
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59 | (22) |
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60 | (3) |
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2 Ligand Migration Pathways in the Globin Superfamily: Structure-Function Relationships |
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63 | (10) |
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3 The Coordination of the Heme Group and Its Role in Ligand Binding |
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73 | (3) |
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76 | (5) |
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77 | (1) |
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77 | (4) |
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4 Dynamic Reorganization and Enzymatic Remodeling of Type IV Collagen at Cell-Biomaterial Interface |
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81 | (24) |
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82 | (3) |
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85 | (6) |
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91 | (9) |
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100 | (5) |
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101 | (4) |
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5 Cytochromes P450: History, Classes, Catalytic Mechanism, and Industrial Application |
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105 | (22) |
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1 Background and History of Cytochromes P450 |
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106 | (4) |
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110 | (4) |
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3 P450 Family Nomenclature |
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114 | (1) |
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115 | (2) |
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117 | (2) |
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119 | (8) |
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123 | (4) |
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6 Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A |
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127 | (46) |
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T. K. Smulders-Srinivasan |
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128 | (1) |
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2 Minibrain in Drosophila |
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129 | (3) |
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3 Role of DYRK1A in Infection and Immunity |
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132 | (4) |
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4 Cardiovascular Function of DYRK1A |
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136 | (3) |
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5 Role of DYRK1A in Cancer |
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139 | (9) |
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6 Understanding the Neuronal Function of DYRK1A |
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148 | (9) |
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157 | (16) |
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158 | (15) |
| Author Index |
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173 | (622) |
| Subject Index |
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795 | |
Dr. Christo Z. Christov teaches at Northumbria University, Ellison Building, Newcastle-upon-Tyne, UK
