This fourth edition, is the perfect text for science undergraduates and medical students looking for a concise introduction to the subject, or a study guide to use before examinations. Thoroughly updated in all areas, especially in mucosal immunity, regulation of the immune response and cancer immunotherapy.
Instant Notes in Immunology, Fourth Edition, is the perfect text for science undergraduates and medical students looking for a concise introduction to the subject or a study guide to use before examinations. This edition has been thoroughly updated in all areas, especially in mucosal immunity, regulation of the immune response and cancer immunotherapy. Each topic begins with a summary of essential facts, which serves as an ideal revision checklist, followed by a description of the subject that focuses on core information along with clear, simple diagrams that are easy for students to understand and recall in essays and exams.
Key Features:
Beautifully illustrated to elucidate key concepts and mechanismsTopics listed under basic and clinical immunologyNew to this edition, the page design and many of the key diagrams and photos are now in full colorEach subsection begins with a concise list of key conceptsA free-to-access companion website hosts a wealth of resources, including interactive questions, as well as additional content to supplement that provided in the book
Preface. SECTION A OVERVIEW OF THE IMMUNE SYSTEM. A1 The Need. A2
External Defenses. A3 Immune Defense. A4 Antigens. A5
HematopoiesisDevelopment of Blood Cells. SECTION B CELLS AND MOLECULES OF
THE INNATE IMMUNE SYSTEM. B1 Cells of the Innate Immune System. B2 Molecules
of the Innate Immune System. B3 Recognition of Microbes by the Innate Immune
System. B4 Innate Immunity and Inflammation. SECTION C THE ADAPTIVE IMMUNE
SYSTEM. C1 Lymphocytes. C2 Lymphoid Organs and Tissues. C3 Mucosa-Associated
Lymphoid Tissues. C4 Lymphocyte Traffic and Recirculation. C5 Adaptive
Immunity in the Neonate and Early Life. SECTION D ANTIBODIES. D1 Antibody
Structure. D2 Antibody Classes. D3 Generation of Diversity. D4 Allotypes and
Idiotypes. D5 AntigenAntibody Complexes (Immune Complexes). D6 Immunoassay.
D7 Antibody Functions. SECTION E THE T-CELL RESPONSESCELL-MEDIATED IMMUNITY.
E1 The Role of T Cells in Immune Responses. E2 T-Cell Recognition of Antigen.
E3 Shaping the T-Cell Repertoire. E4 T-Cell Activation. E5 Clonal Expansion
and Development of Memory and Effector Function. SECTION F THE ANTIBODY
RESPONSE. F1 The B-Cell Receptor Complex and Co-Receptors. F2 B-Cell
Activation and Signaling. F3 The Cellular Basis of the Antibody Response. F4
Antibody Responses in Different Tissues. SECTION G REGULATION OF THE IMMUNE
RESPONSE. G1 Overview. G2 Regulation of Innate and Adaptive Immune Systems.
G3 Tolerance to Self-Antigens. G4 Neuroendocrine Regulation of Immune
Responses. G5 Regulation of the Immune Response: Environmental Mechanisms.
SECTION H IMMUNITY TO INFECTION. H1 The Microbial Cosmos. H2 Immunity to
Different Organisms. H3 Pathogen Defense Strategies. H4 Pathophysiology of
Infectious Diseases. SECTION I VACCINATION. I1 Principles of Vaccination. I2
Immunization. I3 Antigen Preparations. I4 Vaccines to Pathogens and Tumors.
SECTION J IMMUNODEFICIENCYWHEN THE IMMUNE SYSTEM FAILS. J1 Deficiencies in
the Immune System. J2 Primary Immunodeficiency. J3 Secondary (Acquired)
Immunodeficiency. J4 Diagnosis and Treatment of Immunodeficiency. SECTION K
HYPERSENSITIVITYWHEN THE IMMUNE SYSTEM MISBEHAVES. K1 Definition and
Classification. K2 IgE-Mediated (Type I) Hypersensitivity: Allergy. K3 IgG-
and IgM-Mediated (Type II) Hypersensitivity. K4 Immune-Complex-Mediated (Type
III) Hypersensitivity. K5 Delayed (Type IV) Hypersensitivity. SECTION L
AUTOIMMUNITY AND AUTOIMMUNE DISEASES. L1 The Spectrum and Prevalence of
Autoimmunity. L2 Factors Contributing to the Development of Autoimmune
Disease. L3 Autoimmune Diseases: Potential Mechanisms for the Breakdown of
Self-Tolerance. L4 Disease PathogenesisEffector Mechanisms. L5 Diagnosis and
Treatment of Autoimmune Disease. SECTION M TRANSPLANT REJECTION. M1 The
Transplantation Problem. M2 Transplantation Antigens. M3 Rejection
Mechanisms. M4 Prevention of Graft Rejection. SECTION N TUMOR IMMUNOLOGY. N1
Origin and Host Defense against Tumors. N2 Tumor Antigens. N3 Immune
Responses to Tumors. N4 Immunodiagnosis. N5 Cytokine and Cellular
Immunotherapy of Tumors. N6 Immunotherapy of Tumors with Antibodies. N7 Tumor
Vaccines. SECTION O GENDER AND THE IMMUNE SYSTEM. O1 Overview. O2 Immune
Cells and Molecules Associated with the Reproductive Tracts. O3 Functional
Effects of Sex Hormones on the Immune System. SECTION P AGING AND THE IMMUNE
SYSTEM (IMMUNOSENE SCENCE). P1 Overview. P2 Changes in Lymphoid Tissues and
Lymphocytes with Age. P3 The Effects of Aging on the Innate and Adaptive
Immune Systems. P4 Other Factors Contributing to Immunosenescence in the
Aged. SECTION Q IMMUNOTHERAPY. Q1 Cytokine-, Antibody-, and Cell-Mediated
Immunotherapy. Q2 Cytokine-Mediated Immunotherapy. Q3 Antibody-Mediated
Immunotherapy of Non-Cancer Diseases. Q4 Cellular Immunotherapy of Non-Cancer
Diseases. Further Reading. Abbreviations. Glossary. Index.
Peter M Lydyard is an emeritus professor of immunology at University College London, UK, and an associate professor at the University of Georgia, Tbilisi, Georgia.
Nina Porakishvili is an emeritus fellow at the University of Westminster, London, UK, and Professor and Head of the Institute of Immunology and Molecular Medicine, University of Georgia, Tbilisi, Georgia.
Michael F Cole is an emeritus professor of microbiology and immunology, School of Medicine, Georgetown University, Washington, DC, USA.
PML and NPs research interests are the immunobiology and immunotherapy of chronic lymphocytic leukemia and cancer vaccines. MFCs research interest is the interplay between the commensal microbiota and the mucosal immune system of humans, with a focus on the oral cavity.
