This book offers a comprehensive overview of fundamental principles and the latest applications in cell biology and regenerative medicine, beginning with the foundational concepts of cell theory. It discusses the various types of cells and their defining characteristics, and dynamic processes of cell division, differentiation, dedifferentiation, proliferation, and apoptosis. The text also introduces the basics of embryo development and delve into the applications of induced pluripotent stem cells, cancer stem cells, tissue-specific niches, and the innovative techniques for editing stem cells. Additionally, the book explores the stem cell niche and its surrounding microenvironment, along with the complex interactions between stem cells and the immune system. It underscores the therapeutic potential of stem cells in treating neurodegenerative diseases, facilitating cardiovascular regeneration, enhancing skin regeneration and wound healing, and improving orthopedic applications. Furthermore, the book examines the use of stem cells in ocular therapies, dental, and craniofacial regeneration. It provides an overview of the regulatory frameworks governing stem cell research, outlines the principles of tissue engineering, and discusses the development of organ-on-a-chip models. This book is an essential resource for students, researchers, and professionals in cell biology and regenerative medicine.
Key Features:
· Provides extensive overview of fundamental cell biology principles, the latest advancements in regenerative medicine.
· Presents therapeutic potential of various types of stem cells, including embryonic stem cells, induced pluripotent stem cells, and cancer stem cells.
· Addresses the regulatory landscapes and the ethical issues related to use of stem cell therapy.
· Discusses cutting-edge techniques for editing stem cells, principles of tissue engineering, and the development of organ-on-a-chip models.
· Delves into the dynamic cellular processes such as division, differentiation, dedifferentiation, proliferation, and apoptosis.
SECTION 1: BASIC BIOLOGY OF STEM CELLS
Chapter 1: Stem Cells, Their Applications, and Future Prospects.
Chapter 2:
The Cell Theory and Concepts, Their Types and Cell Characteristics.
Chapter
3: Cellular Processes: Cell Division, Differentiation, Dedifferentiation,
Proliferation, and Apoptosis.
Chapter 4: Blueprint of Life: Patterns and
Molecular Mechanisms in Embryogenesis Across Model Organisms.
SECTION 2: STEM CELL TYPES AND THEIR TECHNICAL ASPECTS
Chapter 5: Discovery of Stem Cells and Their Types.
Chapter 6:
Instrumentation and Techniques in Stem Cells Cultures.
Chapter 7: Milestones
in Animal Cell Culture.
Chapter 8: Adult Stem Cells and Applications.
Chapter
9: Embryonic Stem Cells, Ethics, Concerns and Applications.
Chapter 10:
Mechanism of Pluripotency.
Chapter 11: Induced Pluripotent Stem Cells: From
Discovery to Application.
Chapter 12: Editing in the Stem Cells.
SECTION 3: STEM CELLS IN BIOMATERIAL AND TISSUE ENGINEERING
Chapter 13: Concepts of Tissue Engineering.
Chapter 14: Scaffolds in Tissue
Engineering.
Chapter 15: Emerging Trends in Tissue Engineering: Biomaterials,
Scaffolds, and Regenerative Strategies.
Chapter 16: Tissue Engineering:
Bridging Regenerative Medicine and Cancer Therapy.
Chapter 17: Tissue
Constructs in Functional Tissue Engineering.
SECTION 4: STEM CELL IN BIOMANUFACTURING AND PRECISION MEDICINE
Chapter 18: Organoids in Medicine.
Chapter 19: Organ-on-a-Chip and
Metabolomics: Converging Technologies for Translational Research.
Chapter 20:
Stem Cells and Bioprinting.
Chapter 21: Advances in Bioprinting for Precision
Medicine.
SECTION 5: APPLICATIONS IN REGENERATIVE MEDICINE AND CANCER
Chapter 22: Current Trends and Futuristic Scope of Stem Cells.
Chapter 23:
Rewriting Life: Implication of Stem Cells and Their Medicine Promise.
Chapter
24: Stem Cells in Regenerative and Molecular Medicine.
Chapter 25: Industrial
Approaches to Regenerative Medicine.
Chapter 26: Understanding Cancer Stem
Cells: From Tumor Initiation to Therapeutic Targeting.
Chapter 27: The
Biology of Adult Stem Cells and Their Significance in Cancer: Overview.
Chapter 28: Scaffolds in Cancer Research: Bridging Tumor Microenvironment
Replication and Therapeutic Advancements.
SECTION 6: REGULATORY MECHANISMS AND POLICY
Chapter 29: Regulatory Aspects in Stem Cell Research.
R. C. Sobti is an Emeritus Professor and Indian National Science Academy (INSA) senior scientist at Punjab University. He is a former of Vice-Chancellor Panjab University, Chandigarh & Babasaheb Bhimrao Ambedkar University (Central University), Lucknow. He started his career as a cytogeneticist and subsequently used modern technologies of molecular biology, like genomics for understanding the susceptibility and disease process of cancer, COPD, AIDS metabolic syndrome, and kidney diseases. He has also used stem cells and nanoparticles to understand the process of tissue organ development through a designed de-cellularization protocol. He has published more than 300 papers in the journals of international repute and has also published more than 40 books.He is a Fellow of the Third World Academy of Sciences, National Academy of Sciences India, Indian National Science Academy, National Academy of Medical Sciences, National Academy of Agricultural Sciences, Canadian Academy of Cardiovascular Diseases, and few others. He was the General President of the Indian Science Congress for the 102nd session held at the University of Jammu in 2013. Dr. Sobti is the recipient of many prestigious awards like the INSA Young Scientist Medal, UGC Career Award, Punjab Rattan Award, JC Bose Oration, and Sriram Oration Awards, and of Lifetime Achievement Awards of the Punjab Academy of Sciences, Zoological Society of India, and the Environment Academy of India.
Aastha Sobti, BDS, MClinDent, PhD is a Postdoctoral Research Fellow at the University of Pittsburgh and UPMC Hillman Cancer Center, specializing in computational approaches to head and neck cancer biology. She earned her PhD in Onco-Immunology with honors from Lund University, Sweden (2023) under the Marie Skodowska-Curie COFUND program, and holds an MClinDent with distinction from University College London (2015). Dr. Sobti's research integrates artificial intelligence, genomics, and experimental biology for precision medicine applications in cancer. She has published over 10 papers in leading journals and received prestigious awards, including the SITC Young Investigator Award (2024), VINNOVA Grant (2022), and Academic Certificate of Excellence from the British Association of Oral Surgeons. With international research experience across four countries and proven success in clinical translation, she brings unique expertise bridging computational innovation with clinical application in oncology.
