This book sheds light on how the abundance of epigenetic regulations, RNA group interactions, the role of viruses and related infectious agents in cellular host organisms drive evolutionary processes. Rather than presenting a final Integrative Theory of Evolution, this book assembles aspects and insights from leading experts that must be incorporated into such a theory in order to better integrate current empirical knowledge than is achieved by models that still insist on the crucial role of replication errors as the main reason for genetic variability.
Since nearly a century the key narrative in evolutionary biology is founded on two principles: evolutionary relevant genetic variations are the result of error replication events (mutation) and natural selection. With the comeback of virology the role of viruses in the evolution of life lead to change our view on (a) how evolutionary relevant variations occur, (b) viruses as exclusively disease causing genetic parasites, (c) the definition of life itself. Empirical data of the last decades demonstrate that most viruses do not harm the host but settle host in a persistent way, remaining as exapted RNA networks known as mobile genetic elements and a variety of non-coding RNAs being essential in host gene regulations such as transcription, translation, immunity, repair and epigenetic (re)programming. Epigenetic programming determines each cell of every organism across all domains of life through epigenetic markings. If learned behaviors can be epigenetically inherited and lead to organisms that are better adapted, the error-replication (mutation) narrative is insufficiently complex to integrate this.
Chapter
1. A Brief Look at the Biological Theory of Evolution: What
Determines How Life Changes Itself?
Chapter
2. DNA Methylation and
Evolution.
Chapter
3. Developmental Dynamics: Shaping the Pathways of
Evolution.
Chapter
4. Modular Complementarity as an Evolutionary Organizer:
Beyond Base Pairing.
Chapter
5. Transposons, Stress and the Evolution of
Adaptability.
Chapter
6. Transgenerational programming of brain development
and behaviour in response to early life adversity.
Chapter
7. Maternal
transmission of atopic disease susceptibility.
Chapter
8. Small RNA
inheritance in Caenorhabditis elegans: phenomenology, constraints, and
evolutionary logic.
Chapter
9. Transposable elements in Evolution: our
'frenemy' within.
Chapter
10. Defense and Immune Systems Evolving from
Coopted Selfish Genetic Elements From the Origin of Life to the Present.-
Chapter
11. Non-Mendelian inheritance and evolution in ciliates with a focus
on transposons.
Chapter
12. Structural Neutrality and Accommodation Shape
RNA Evolution.
Chapter
13. RNA dynamics in the evolution of RNA function.-
Chapter
14. 'Location, Location, Location' Cis-acting antisense transcripts
in evolution and disease.
Chapter
15. System-Evolutionary View of RNA
Presence in Living Cells .
Chapter
16. Archaeology as a toolkit for mRNA:
history and meaning in use.
Chapter
17. The proteomic and coevolutionary
roots of the genetic code.
Chapter
18. Inteins emerging regulatory roles
and their exaptation for hedgehog signaling.
Chapter
19. Opinion: of RNA,
virus and groups.
Chapter
20. The Viral Turn in Biology.
Chapter
21. Viral
quasispecies as models of biological complexity. New findings with
SARS-CoV-2.
Chapter
22. Wholobionts and Viruses.
Chapter
23. A hypercycle
for ribozymes or viroids as origin of life.
Chapter
24. Minimal RNA
replicons in the origin and evolution of life.
Chapter
25. The Many Shades
of Compartmentalization in Prebiotic Evolution.
Chapter
26. The challenge of
scale in molecular adaptation: Local searches in astronomical genotype
networks.
Chapter
27. Nongenetic mechanisms of animal evolution.
Chapter
28. Biological Senomic Thermodynamics in Evolution of Life on Earth.
Guenther Witzany developed a new philosophy of biology. His theory of biocommunication and Natural Genome Editing is the first theory that integrates all domains of life empirically in a non-reductionistic and non-mechanistic way, proving in all domains that every coordination within and between cells, tissues, organs and organisms depends on successful communication processes. Additionally Natural Genome Editing demonstrates that the genetic code is a natural language-like text that is edited by competent agents that infect, compete and cooperate within host genomes. These agents are viruses and related parasites which remain persistently as mobile genetic elements and RNA-networks that serve as essential tools in all regulatory processes of cells. 1983 Doctor of Philosophy at the Ludwig Maximilians University in Munich (Germany). First concept of a Theory of Communicative Nature in 1986 which he further developed into the Theory of Biocommunication and Natural Genome Editing in 2006. Adaptation to all domains of Life in a series of books he edited between 2010 und 2026 (bacteria, archaea, viruses, phages, ciliates, plants, fungi, animals, epigenetics, evolutionary theory). Organizer of various meetings between 2008 and 2022 on natural genome editing, viruses, RNA networks, evolution and epigenetics with leading experts in their fields. The Proceedings he edited where all published at the Annals of the New York Academy of Sciences.
