This book represents a concise and easily referred guide to be used when the need arises, so that trainees in radiology facing a Nuclear Medicine matter can cope with the same and understand how to report correctly, for instance, their first bone scan or first renogram and give them briefly the underlying physiology.
The sections of the volume are based on radiopharmaceuticals which enables the reader to understand the physiology underpinning the handling of the radiopharmaceuticals and why, therefore, they are applied to the imaging tests for which they are used. This setting will surely help radiological trainees to quickly acquire a grasp of the essentials of nuclear medicine and enable them to maximise the value of the period they spend training in nuclear medicine as part of their training.
Main goal of the book is to let understand the molecular structure and basic physiology of a radiopharmaceutical; leading to an understanding of why and how the radiopharmaceutical works in its application to different organ systems; leading to basic reporting skills and an understanding of the mistakes being made in the report; understanding the radiopharmaceutical kinetics and how they are used to quantify physiological variables in disease.
The book represents a very useful tool to trainees intending to specialise in nuclear medicine whether as nuclear medicine physicians or radionuclide radiologists.
Part I. Tracer Kinetics.-
1. Mathematical Equations.-
2. Physiological
Equations.-
3. Clearance, Blood Flow And Extraction Fraction [ Or Efficiency
(%)].-
4. Distribution Volume And Mean Transit Time.-
5. Blood Capillary
Function.- Part II. Basic Medical Statistics.-
6. Parametric Statistics.-
7.
Non-Parametric Statistics.-
8. Interpretation of Statistical Significance.-
Part III. Basic Sciences of Nuclear Medicine.-
9. Basic Sciences of NM.- Part
IV. Tc-99m Compounds.-
10. FREE Tc-99m (Pertechnetate; Tc-99mO4; 161 Da;
Half-Life 6 H).-
11. Tc-99m-Diethyltriaminepentaacetic Acid (DTPA; MW 650
Da).-
12. Tc-99m-Mercaptoacetyltriglycine (MAG3) (MW 417 Da).-
13.
Tc-99m-Dimercaptosuccinic Acid (DMSA) (MW 182 Da).-
14. Tc-99m-Iminodiacetic
Acid (HIDA) (MW 177 Da).-
15. Tc-99m-Labelled Diphosphonates (MW ~300 Da).-
16. Tc-99m-Sestamibi (MW 778 Da) And Tc-99m-Tetrafosmin (MW 895 Da).-
17.
Tc-99m-Hexamethylpropylamine Oxime (HMPAO) (MW 385 Da).-
18. Tc-99m-Labelled
Aerosols.-
19. Tc-99m-Labelled Liquid and Semisolid Meals.-
20.
Tc-99m-Labelled Red Blood Cells.-
21. Tc-99m-Labelled Proteins.-
22.
Tc-99m-Labelled Nanocolloids.- Part V. Miscellaneous Radiopharmaceuticals.-
23. Noble Gases.-
24. Iodine-123 (Half-Life 13.2 H; Decays by Electron
Capture To Te-123) and Iodine-131 (8.1 D, Beta Minus Emission, Xe-131).-
25.
Selenium-75 (Half-Life 120 D; Decays by Electron Capture to As-75; 136, 265
and 401 Kev).-
26. Indium-111 (Half-Life 2.8 D; Decays by Electron Capture to
Cd-111; 172 Kev and 245 Kev).-
27. Radionuclides of Historical Interest.-
Part VI. Positron Emission Tomography (PET).-
28. Compounds Of Fluorine-18.-
29. Compounds Of Gallium 68 (Half-Life 68 Minutes).-
30. Rubidium-82
(Half-Life 78 Sec).
Adrien Michael Peters has been a consultant nuclear medicine physician since 1984. He previously held chairs in Diagnostic Radiology at Royal Postgraduate Medical School (and then Imperial College), in Nuclear Medicine at University of Cambridge (Foundation Chair) and in Applied Physiology at Brighton Sussex Medical School. He is currently a nuclear medicine consultant at Kings College Hospital and holds an honorary chair in Nuclear Medicine at Kings College, London. He was awarded the higher doctorate of DSc by the University of Liverpool in 2009, was Nimmo Visiting Professor at the Royal Adelaide Hospital in 2001, and is a Fellow of the Academy of Medical Sciences.
Dr Manuela Vadrucci graduated and completed her specialist training in Nuclear Medicine in Milan, Italy in 2016. Then, she worked as a research fellow at the European Institute of Oncology IEO in Milan, focusing on molecular imaging in breast and neuroendocrine tumours, before relocating to the UK in 2017. After a few years working as a Locum and then substantive consultant in Kings College Hospital, London, in 2020 she joined St Bartholomews Hospital in the same city. Her current position as a Nuclear Medicine Consultant in one of the largest teaching hospitals in England enables her to broaden her knowledge on molecular imaging techniques in common and less common oncological and inflammatory diseases, as well as to contribute regularly to the teaching of pre- and post-graduate medical trainees and radiology resident doctors. She has also shared her experience through several publications, often in collaboration with the co-author of this book.
