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Isotopically Labeled Compounds: Recent Advances and Emerging Topics in Synthesis and Applications [Pehme köide]

Edited by (Volker Derdau, Head of the Centre of Excellence for Isotope Chemistry and Senior Distinguished Scientist, Sanofi, Germany), Edited by (Director, Chemistry, Center for Drug Discovery, USA)
  • Formaat: Paperback / softback, 250 pages, kõrgus x laius: 229x152 mm, kaal: 450 g
  • Ilmumisaeg: 24-Apr-2026
  • Kirjastus: Elsevier - Health Sciences Division
  • ISBN-10: 0443191549
  • ISBN-13: 9780443191541
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Isotopically Labeled Compounds: Recent Advances and Emerging Topics in Synthesis and Applications
  • Formaat: Paperback / softback, 250 pages, kõrgus x laius: 229x152 mm, kaal: 450 g
  • Ilmumisaeg: 24-Apr-2026
  • Kirjastus: Elsevier - Health Sciences Division
  • ISBN-10: 0443191549
  • ISBN-13: 9780443191541
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9780443191541.html
Märksõnad:
Isotopically-Labeled Compounds: Recent Advances and Emerging Topics in Synthesis and Applications delves into the transformative developments in isotopic labelling, a crucial field underpinning advancements in chemistry, biology, and medicine. The book emphasizes innovative methodologies for synthesizing compounds labelled with isotopes such as tritium, carbon-14, and various stable isotopes. It also discusses the tools and technologies refined over recent years to enhance analytical precision in their study. By combining theory with practical applications, it serves as an invaluable resource for researchers and professionals seeking deeper insights into isotopic synthesis and utilization.

Additionally, the book explores emerging topics, including novel applications in drug development, environmental tracing, and biochemical research. It integrates findings that push the boundaries of isotopic analysis, offering perspectives on future trends and challenges in the field.
1. General Introduction
2. Recent advances in tritium chemistry
3. Recent advances in carbon-14 chemistry
4. Recent advances in the chemistry of PET and SPECT isotopes
5. Recent advances in the chemistry of stable isotopes
6. Preclinical and clinical studies of pharmaceuticals supported by labelled compounds
7. Non pharmaceutical applications of labelled compounds
8. Emerging new fields in the chemistry of isotopes and their application
9. Deuterated APIs
10. Recent advances in the analysis of isotopically labelled compounds
11. Radiolabeling of large molecules
12. Summary and outlook
David Hesk is Director of Radiochemistry in the Center for Drug Discovery at RTI International. After obtaining his Ph.D. studying hydrogen isotope exchange chemistry under the direction of Professor J.R. Jones, Dr. Hesk worked for 27 years in the Radiochemistry and Labeled Compound Synthesis groups at Schering-Plough and Merck where he was responsible for the synthesis, purification, and analysis of isotopically labelled compounds in support of pharmaceutical research. There he maintained his interest in hydrogen isotope exchange labelling (HIE) and published the first example of the application of Crabtrees catalyst in HIE in 1995. Volker Derdau is the Head of the Centre of Excellence for Isotope Chemistry and Senior Distinguished Scientist at Sanofi, based in Germany. With over 25 years of experience in the pharmaceutical industry, he is an expert in the area of homogeneous catalysis, including radiochemistry and photocatalysis. He is author of over 70 articles and patents.