A highly disabling infectious disease in developing countries, leprosy, or Hansen’s disease, is caused by Mycobacterium leprae, and is still very relevant for the human community due to its transmissible nature, variable presentation and composite clinical picture. Early identification of leprosy and Buruli ulcer (also caused by a Mycobacterium, M. ulcerans) is critical to prevent spreading and patient disability and to establish appropriate therapy.
This richly illustrated, completely revised second edition of Leprosy and Buruli Ulcer describes the characteristic signs of both these diseases, and contents include abnormalities of the skin, nerves, eyes, hands, feet, testes and bone. It also presents the latest diagnostic tools to identify and quantify organ damage to enable readers to recognize and treat this composite systemic disorder, which can represent a true medical emergency if affecting eyes, nerves, and kidneys. Further, it includes additional chapters on leprosy in childhood, prophylaxis and vaccines. For both leprosy and Buruli ulcer, this handy guide helps practitioners and nursing personnel to spot the different clinical manifestations, make a prompt diagnosis and apply effective treatment of both these diseases.
Foreword.- Preface.- Part I Leprosy: General Section.-
1. History and
Phylogeography of Leprosy.- 2. Microbiology of Mycobacterium leprae.-
3.
Genetics of Leprosy.-
4. Host Response to Mycobacterium leprae.- 5.
Pathogenesis of Leprosy.-
6. Classification of Leprosy.- Part II Leprosy:
Patients Examination.-
7. Leprosy Patient History.-
8. Laboratory
Investigations in Leprosy.- Part III Skin.-
9. Physical Examination in
Leprosy: Skin.-
10. Clinical Features of Leprosy.-
11. LucioLatapí Leprosy.-
12. Histopathology of the Skin in Leprosy [ FP1] .- 13. Differential
Diagnosis of Leprosy: Skin.- Part IV Leprosy and Nerves.-
14. Peripheral
Nerves in Leprosy.-
15. The Leprosy Neuropathy.-
16. Primary Neural Leprosy.-
17. Chronic Neuropathic Pain in Leprosy.-
18. Electrodiagnostic Studies in
Leprosy.-
19. Imaging in Leprosy.-
20. Differential Diagnosis of Leprosy:
Nerves.- Part V Reactions in Leprosy.-21. Reactions in Leprosy.-
22.
Lucios Phenomenon in Leprosy.- Part VI Leprosy: Systemic Involvement.-
23.
Ocular Involvement in Leprosy.-
24. Otolaryngological Manifestations of
Leprosy.- 25. Other Organs involved in Leprosy.- Part VII Patients
Management in Leprosy.-
26. Diagnostic Work-Up of Leprosy.-
27. Drugs in
Leprosy.-
28. Treatment and Prophylaxis of Leprosy.-
29. Prognosis of
Leprosy.- 30. Neurolysis in Leprosy.-
31. Prevention of Disability and Ulcer
Care in Leprosy.-
32. Surgical and Social Rehabilitation in Leprosy.- Part
VIII Leprosy and Community.-
33. Leprosy in Pregnancy.-
34. Leprosy in
Childhood.-
35. Leprosy and HIV/AIDS Co-infection.-
36. Epidemiology of
Leprosy.-
37. Leprosy Control.- 38. The Leprosy Mailing List.- Part IX Buruli
Ulcer: General Section.-
39. History and geographic distribution of Buruli
ulcer.-
40. Microbiology of Mycobacterium ulcerans.- Part X Buruli Ulcer:
Patients Examination.-
41. Laboratory Investigations in Buruli ulcer.-
42.
Clinical Features of Buruli ulcer.-
43. Differential Diagnosis of Buruli
ulcer.- Part XI Buruli Ulcer: Patients Management.-
44. Diagnostic
Work-up of Buruli ulcer.- 45. Treatment of Buruli ulcer.-
46. Rehabilitation
in Buruli ulcer.- Part XII Buruli Ulcer and Community.-
47. Epidemiology
of Buruli ulcer.-
48. Buruli ulcer Control.- Subject Index.
Professor Enrico Nunzi graduated with honors and specialized in dermatology and syphilography, medical microbiology, dermatology and tropical medicine at the University of Genoa (Italy). He has been Director of the Institute of Dermatology at Loja Technical University Hospital (Ecuador) since 2012. Before that he was Director of the Social Dermatology Unit at S.Martino Hospital and of the Skin Immunopathology Service. Author of over 130 publications in Italian and Spanish, he has worked for the governmental health services of the Democratic Republic of Congo as the Medical Director of the health sector at Kimbau Hospital, as a Research Fellow at the Dermatology Department of the University of Amsterdam, and as Director of the Genoa University Postgrad School of Leprology and Tropical Dermatology.
Cesare Massone is an Associate Professor of Dermatology and Venereology, and Medical Director of the Dermatology Unit-Ospedali Galliera in Genova, Italy. After graduating with honors and receiving board certification, he was made an Associate Professor of Dermatology at the Medical University of Graz. His areas of research interest include dermoscopy and melanoma, cutaneous lymphomas, leprosy & tropical dermatology, psoriasis & biologicals therapies, dermatopathology, and teledermatology. Dr. Massone is the author of over 200 publications, including books (WoS HI 34). Regularly presenting at international congresses, he was awarded the Pathnet grant from the French Ministry for Research, and the AESCA Award of the Austrian Society of Dermatology in 2005.
Professor Françoise Portaels was Head of the Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine (Belgium). Her areas of expertise include microbiology and epidemiology. She is a Professor Emeritus of the Free University of Brussels (VUB), Belgium and of the Institute of Tropical Medicine Antwerp, Belgium and has a extensive experience in teaching and headinglab research. Member of various academies and societies, including the International Union Against Tuberculosis (UNION), Belgian Royal Academy of Medicine, Belgian Royal Academy of Oversees Sciences and the American Society of Tropical Medicine and Hygiene. She was awarded the Follereau-Damien and the American Society of Tropical Medicine prizes. She has authored over 400 publications and edited 5 books (WoS HI 32), and has participated in countless field activities, international courses and missions.
