Researchers and clinicians alike are finding it difficult to keep up with all the advances in mapping disease genes. This synthesis offers a brief technical overview and history so readers can locate their own current level of knowledge in this rapidly changing fields, then contributors of the remaining papers describe linkage disequilibrium maps (LDMAPs) and location databases, construction of high-resolution LDMAPs for the human genome, linkage disequilibrium as a tool for detecting signatures of natural selections, the genetic basis of complex traits, LDMAPs as tools in studying complex disease genes, LDMAPs and disease-association mapping, coalescent methods for fine-scale disease-gene mapping, family-based linkage disequilibrium tests using general pedigrees, and association studies using familial cases as an efficient strategy for identifying low-penetrating disease alleles. Annotation ©2007 Book News, Inc., Portland, OR (booknews.com)
As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In Linkage Disequilibrium and Association Mapping: Analysis and Applications, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike.The volume comprises four general sections: the first presents an overview and historical basis of the subject. The second section considers the developing methodology and recent findings from studies which have characterized the genome-wide linkage disequilibrium structure in enormous detail. The following section examines all aspects of disease association mapping methodology, and the final two chapters review the early successes in mapping genes involved in two of the most important human diseases: asthma and type 2 diabetes.
As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In this book, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike. They provide cutting-edge analysis of the most up-to-date and preeminent information available.
