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Liquid Chromatography: Applications [Kõva köide]

Edited by (Committee of the Ph.D. School in Nanoscience and Advanced Technologies, University of Verona, Verona, Italy), Edited by , Edited by (Distinguished Professor, School of Natural Sciences, University of Tasmania, Hobart, Australia), Edited by (Department of Chemistry, )
  • Formaat: Hardback, 688 pages, kõrgus x laius: 229x152 mm, kaal: 1010 g, Illustrated; Illustrations, unspecified
  • Sari: Handbooks in Separation Science
  • Ilmumisaeg: 02-Mar-2013
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 0124158064
  • ISBN-13: 9780124158061
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  • Formaat: Hardback, 688 pages, kõrgus x laius: 229x152 mm, kaal: 1010 g, Illustrated; Illustrations, unspecified
  • Sari: Handbooks in Separation Science
  • Ilmumisaeg: 02-Mar-2013
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 0124158064
  • ISBN-13: 9780124158061
Teised raamatud teemal:
"Affinity chromatography is a type of liquid chromatography that uses a biologically related agent as a stationary phase to purify or analyze specific sample components. This chapter examines the basic components and principles of affinity chromatographyand various applications of this method. The general types of ligands, immobilization schemes, support materials, and elution conditions that can be employed in affinity chromatography are first examined. Various methods in this field are then considered, including bioaffinity chromatography, immunoaffinity chromatography, dye-ligand and biomimetic affinity chromatography, immobilized metal-ion affinity chromatography, and analytical affinity chromatography. The types of ligands utilized in each of thesemethods are described, along with common applications of these techniques. Several related developments are also discussed, such as the use of affinity chromatography with mass spectrometry, miniaturized systems, molecularly imprinted polymers, and aptamers"--Provided by publisher.

A single source of authoritative information on all aspects of the practice of modern liquid chromatography suitable for advanced students and professionals working in a laboratory or managerial capacity

  • Chapters written by authoritative and visionary experts in the field provide an overview and focused treatment of a single topic
  • Each chapter emphasizes the integration of chromatographic methods and sample preparation, automation, and explains how liquid chromatography is used in different industrial sectors
  • Focuses on expanding and illustrating the main features of the fundamental section, while demonstrating where and how the best practices of liquid chromatography are utilized
  • Comprehensive coverage of modern liquid chromatography from theory, to methods, to selected applications
  • Thorough selected references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision making

Arvustused

"...provides invaluable information for laboratory scientists who are looking for information on how to separate different types of molecules for preparative, semi-preparative or analytical scale separations." -Analytical and Bioanalytical Chemistry, Oct,24-2014

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A single source of authoritative information on all aspects of the practice of modern liquid chromatography suitable for advanced students and professionals working in a laboratory or managerial capacity
Contributors xi
1 Affinity Chromatography
1(24)
D.S. Hage
J.A. Anguizola
R. Li
R. Matsuda
E. Papastavros
E. Pfaunmiller
M. Sobansky
X. Zheng
1.1 Introduction
1(2)
1.2 Basic Components of Affinity Chromatography
3(2)
1.3 Bioaffinity Chromatography
5(1)
1.4 Immunoaffinity Chromatography
6(3)
1.5 Dye-Ligand and Biomimetic Affinity Chromatography
9(2)
1.6 Immobilized Metal-Ion Affinity Chromatography
11(1)
1.7 Analytical Affinity Chromatography
11(3)
1.8 Miscellaneous Methods and Newer Developments
14(11)
Acknowledgment
17(1)
References
17(8)
2 Derivatization in Liquid Chromatography
25(32)
C.F. Poole
2.1 Introduction
25(2)
2.2 Reagent Selection
27(22)
2.3 Postcolumn Reaction Detectors
49(3)
2.4 Conclusions
52(5)
References
52(5)
3 Validation of Liquid Chromatographic Methods
57(18)
K.L. Barnett
B. Harrington
T.W. Graul
3.1 Traditional Method Validation
58(6)
3.2 Quality by Design and Analytical Methods
64(7)
3.3 Conclusion
71(4)
References
72(3)
4 Liquid Chromatographic Separation of Enantiomers
75(18)
B. Chankvetadze
4.1 Introduction
75(2)
4.2 A Short History of Chiral Separations By Liquid Chromatography
77(1)
4.3 Materials for the Liquid Chromatographic Separation of Enantiomers
78(4)
4.4 Modes of Liquid Chromatographic Separation of Enantiomers
82(4)
4.5 Separation of Enantiomers By Supercritical Fluid Chromatography
86(1)
4.6 Summary and Future Trends
87(6)
References
88(5)
5 Liquid Interaction Chromatography of Polymers
93(38)
W. Radke
J. Falkenhagen
5.1 Introduction
94(1)
5.2 Theoretical Aspects of Isocratic Liquid Chromatography of Polymers
94(4)
5.3 Applications of Liquid Chromatography of Polymers
98(9)
5.4 Hyphenated Techniques
107(14)
5.5 Summary
121(10)
References
122(9)
6 Amino Acid and Bioamine Separations
131(18)
Y. Miyoshi
T. Oyama
R. Koga
K. Hamase
6.1 Introduction
132(1)
6.2 Direct Separation of Amino Acids and Amines
132(3)
6.3 Indirect Separation of Amino Acids and Amines
135(6)
6.4 Enantioselective Liquid Chromatographic Analysis of Amino Acids
141(3)
6.5 Conclusions
144(5)
References
145(4)
7 Protein and Peptide Separations
149(36)
J. Giacometti
D. Josic
7.1 Introduction
149(2)
7.2 Methods of Protein Liquid Chromatography
151(28)
7.3 Conclusions
179(6)
Acknowledgments
180(1)
References
180(5)
8 Glycans and Monosaccharides
185(18)
L. Royle
8.1 Introduction
185(1)
8.2 Types of Glycans
186(2)
8.3 Analysis and Characterization of Glycans
188(8)
8.4 Monosaccharide Composition Analysis
196(5)
8.5 Conclusions
201(2)
References
201(2)
9 Separation of Lipids
203(46)
P. Donato
P. Dugo
L. Mondello
9.1 Introduction and Contents
204(1)
9.2 Definitions and Classification
205(1)
9.3 Structures and Occurrence
206(12)
9.4 Sample Extraction and Handling
218(6)
9.5 Lipid Analysis by Liquid Chromatography
224(19)
9.6 Conclusions and Future Perspectives
243(6)
References
244(5)
10 Forensic Toxicology
249(46)
C. Kostakis
P. Harpas
P. Stockham
10.1 General Drug Screening
251(4)
10.2 Liquid Chromatography-Mass Spectrometry in Forensic Toxicology
255(13)
10.3 Testing for Driving Under the Influence of Drugs Using Oral Fluid
268(6)
10.4 Toxicological Analysis of Hair in the Investigation of Drug Facilitated Crimes
274(3)
10.5 Targeted Poisons
277(5)
10.6 Conclusions
282(13)
References
283(12)
11 Compositional Analysis of Foods
295(24)
M. Herrero
M. Castro-Puyana
E. Ibanez
A. Cifuentes
11.1 Introduction
296(2)
11.2 Carbohydrates
298(3)
11.3 Vitamins
301(5)
11.4 Amino Acids, Peptides, and Proteins
306(1)
11.5 Lipids
307(2)
11.6 Minor Components of Food
309(2)
11.7 Food Additives
311(3)
11.8 Conclusions and Future Trends
314(5)
Acknowledgment
315(1)
References
315(4)
12 Multiresidue Methods for Pesticides and Related Contaminants in Food
319(18)
F. Hernandez
M. Ibanez
12.1 Introduction
319(3)
12.2 Sample Treatment
322(2)
12.3 Matrix Effects In LC-MS Analysis
324(1)
12.4 Method Validation
325(3)
12.5 Analysis of Samples
328(2)
12.6 Individual Methods for Specific Compounds
330(1)
12.7 LC-TOF MS in the Field of Pesticide Residue Analysis
331(6)
References
333(4)
13 Environmental Analysis: Persistent Organic Pollutants
337(52)
L.C. Sander
M.M. Schantz
S.A. Wise
13.1 Polycyclic Aromatic Hydrocarbons
341(5)
13.2 Chlorinated Aromatic Compounds
346(1)
13.3 Pesticides
347(5)
13.4 Brominated Flame Retardants
352(8)
13.5 Perfluoroalkyl Compounds
360(12)
13.6 Reference Materials
372(1)
13.7 Concluding Remarks
373(2)
13.8 Disclaimer
375(14)
References
375(14)
14 Environmental Analysis: Emerging Pollutants
389(22)
M. Petrovic
M. Farre
E. Eljarrat
M.S. Diaz-Cruz
D. Barcelo
14.1 Introduction
390(1)
14.2 General Trends
391(2)
14.3 Target Analysis of Specific Contaminant Groups Using LC-MS
393(10)
14.4 Conclusions
403(8)
References
404(7)
15 Analysis of Natural Toxins
411(20)
P. Otero
P. Rodriguez
A.M. Botana
A. Alfonso
L.M. Botana
15.1 Introduction
411(4)
15.2 Tetrodotoxin
415(3)
15.3 Lipophilic Marine Toxins
418(7)
15.4 Saxitoxin and Analogs
425(6)
References
426(5)
16 Liquid Chromatography in the Pharmaceutical Industry
431(24)
R. Szucs
C. Brunelli
F. Lestremau
M. Hanna-Brown
16.1 The Role of Separation Science in Pharmaceutical Drug Development
432(1)
16.2 Increasing Chromatographic Resolution
433(11)
16.3 Chromatographic Method Development: RPLC
444(11)
Acknowledgments
452(1)
References
453(2)
17 Determination of Veterinary Drug Residues in Foods by Liquid Chromatography-Mass Spectrometry: Basic and Cutting-Edge Applications
455(22)
M.D. Marazuela
S. Bogialli
17.1 Introduction
456(3)
17.2 Options in Veterinary Residue Analysis using LC-MS
459(12)
17.3 Conclusions
471(6)
References
472(5)
18 Analysis of Vitamins by Liquid Chromatography
477(42)
A. Gentili
F. Caretti
18.1 Introduction
478(1)
18.2 Liquid Chromatographic Determination of Water-Soluble Vitamins
479(10)
18.3 Liquid Chromatographic Determination of Fat-Soluble Vitamins
489(8)
18.4 Multivitamin Methods
497(22)
References
510(9)
19 Applications of Liquid Chromatography in the Quality Control of Traditional Chinese Medicines, an Overview
519(22)
Y. Shen
T.A. Van Beek
H. Zuilhof
B. Chen
19.1 Introduction
520(1)
19.2 Liquid Chromatographic Analysis of Traditional Chinese Medicines
520(15)
19.3 Conclusions
535(6)
Acknowledgments
536(1)
References
537(4)
20 Analysis of Neurotransmitters and Their Metabolites by Liquid Chromatography
541(70)
K.E. Bosse
J.A. Birbeck
B.D. Newman
T.A. Mathews
20.1 Introduction
542(14)
20.2 Biogenic Amines
556(12)
20.3 Acetylcholine
568(5)
20.4 Amino Acids
573(6)
20.5 Purines: Adenosine Triphosphate and Adenosine
579(3)
20.6 Endocannabinoids
582(3)
20.7 Neuropeptides
585(5)
20.8 Multianalyte Monitoring of Neurotransmitters from Diverse Classes
590(2)
20.9 Clinical Applications of Microdialysis Sampling and Liquid Chromatographic-Based Analysis
592(4)
20.10 Conclusions
596(15)
References
596(15)
21 Clinical Chemistry, Including Therapeutic Drug Monitoring and Biomarkers for Diagnosis
611(22)
G. Baird
21.1 Introduction
612(1)
21.2 Preanalytical Specimen Handling in Clinical Liquid Chromatography
613(1)
21.3 Separation Technologies in Clinical Liquid Chromatography
613(4)
21.4 Detection Technologies in Clinical Liquid Chromatography
617(3)
21.5 Applications
620(8)
21.6 Conclusion
628(5)
References
628(5)
22 Speciation and Element-Specific Detection
633(18)
B. Michalke
V. Nischwitz
22.1 Introduction
634(1)
22.2 Sampling
635(1)
22.3 Sample Storage and Processing
636(1)
22.4 Speciation Approaches: Direct Methods or Hyphenated Techniques
637(4)
22.5 Interfacing: Nebulizers, Use of Internal Standard and Postcolumn Dilution
641(2)
22.6 Element-Selective Detection
643(3)
22.7 Quantification and Quality Control
646(5)
References
648(3)
Index 651
Salvatore Fanali is Director of Research at the Institute of Chemical Methodologies, Italian National Research Council (C.N.R.) in Monterotondo (Rome), Italy, and head of the Capillary Electromigration and Chromatographic Methods Unit at the same Institute. His research activity is mainly focused on separation science including the development of modern miniaturized techniques (electrodriven and liquid chromatography). He also studies hyphenation with mass spectrometry and development of new stationary phases. Separation methods developed are currently applied to food, pharmaceuticals, chiral environment, and biomedical analysis. He is Editor of the Journal of Chromatography A and a member of the advisory editorial board of seven international scientific journals. Fanali is the author of about 300 publications including some book chapters. He received several awards including the Liberti Medal” in Separation Science from the Italian Chemical Society. Paul Haddad is currently a Distinguished Professor of Chemistry and Australian Research Council Federation Fellow at the University of Tasmania, as well as Director of the Pfizer Analytical Research Centre. He has more than 500 publications in this field and has presented in excess of 450 papers at local and international scientific meetings. He is an editor of Journal of Chromatography A, a contributing editor for Trends in Analytical Chemistry, and was an editor of Analytica Chimica Acta for 6 years. He is currently a member of the editorial boards of 10 other journals of analytical chemistry or separation science.

He is the recipient of several national and international awards, including the ACS Award in Chromatography, the Marcel Golay Award, the AJP Martin Gold Medal awarded by the Chromatographic Society, the Royal Society of Chemistry Analytical Separation Methods Award, the RACI HG Smith and Analytical Division medals, and more. Professor Colin Poole is internationally known in the field of thin-layer chromatography and is an editor of the Journal of Chromatography and former editor of the Journal of Planar Chromatography Modern TLC. He has authored several books on chromatography, recent examples being The Essence of Chromatography published by Elsevier (2003), and Gas Chromatography published by Elsevier (2012). He is the author of approximately 400 research articles, many of which deal with thin-layer chromatography, and is co-chair of the biennial International Symposium on High-Performance Thin-Layer Chromatography”. David Lloyd obtained his PhD from the Department of Chemistry, University of York, UK, working with Prof. David Goodall on the development of laser-based polarimetry as a chiral detection method. He then completed postdoctoral research on bioanalytical capillary electrophoresis (CE) with Prof. Irving Wainer at St. Jude Childrens Research Hospital in Memphis, TN. He has since worked both in academia (McGill University, Departments of Oncology and Experimental Medicine) and the pharmaceutical industry (DuPont Pharmaceuticals and Bristol-Myers Squibb). Whilst at McGill, Dr. Lloyds analytical research focused on microscale bioanalysis by CE and on chiral CE. Since moving to the pharmaceutical industry, his responsibilities have been in analytical R&D for projects ranging from the late discovery stage through worldwide registrational filings, with a primary focus on separations science. From 1995 2002, Dr. Lloyd was Contributing Editor of TrAC - Trends in Analytical Chemistry; and from 1999 - 2011, he was Editor of the Journal of Chromatography B.