Lyme disease remains a subject of considerable public and clinical interest, and misunderstandings about Lyme borreliosis continue to cause widespread concern about potential long-term disability. Although the infection occurs primarily in highly endemic areas of Europe and North America, these areas are expanding, as global warming leads to a steady expansion of the tick vectors' habitats. In the period since the 2nd edition was published our understanding of the biology, clinical manifestations, diagnosis and treatment of this infection have continued to evolve. Many of these important advances have been clarified in a new US joint clinical guideline by the Infectious Diseases Society of America, American Academy of Neurology and American College of Rheumatology. The new edition of the book also: · - Updates knowledge of the reservoir hosts, competent vectors and the necessary vector-human interactions required to make infection possible. · - Explains new approaches that improve accurate laboratory diagnosis. · - Elaborates on the clinical manifestations that may or may not be indicative of infection. · - Updates treatment recommendations. · - Considers multiple dimensions of symptoms occurring in patients who have had Lyme disease. This volume is intended for all medical practitioners who will need to consider this infection in the differential diagnosis of the patients they treat. Alongside an overview of the disease and its pathology, focused chapters explain the cutaneous, rheumatologic and neurologic manifestations. The book further emphasizes how to differentiate between neurobehavioral symptoms commonly misattributed to Lyme neuroborreliosis and disorders actually associated with nervous system infection - a differentiation informed by considerable new data in recent years.
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Suitable for health care professionals and researchers involved in the diagnosis and treatment of Lyme disease. Targeted at practitioners, trainees and medical students.
PART I: BIOLOGICAL SUBSTRATE 1: Biology of the Lyme Disease Agents: A
Selective Survey of Clinical and Epidemiologic Relevance 2: Ticks: The
Vectors of Lyme Disease 3: Global Epidemiology of Borrelia burgdorferi
Infections 4: Borrelia: Interactions with the Host Immune System PART II:
CLINICAL ASPECTS 5: Diagnostic Testing for Lyme Disease 6: Erythema Migrans
7: The Musculoskeletal Manifestations of Lyme Disease 8: Lyme Carditis 9:
Lyme Disease in Children 10: Lyme Borreliosis: The European Perspective 11:
Lyme Neuroborreliosis: The European Perspective 12: Lyme Neuroborreliosis:
The North American Perspective 13: Lyme Neuroborreliosis: Imaging findings
14: Antibiotic Therapy for Infection Caused by Borrelia burgdorferi Sensu
Lato PART III: SYMPTOMS AFTER LYME DISEASE 15: Lyme Neuroborreliosis
Cognitive function and medically unexplained symptoms. What do we know? 16:
Chronic Lyme Disease 17: Lyme Disease: The Great Controversy
Educated at MIT and Harvard and received his clinical training at the University of Chicago and Massachusetts General Hospital. Currently Professor of Neurology and Medicine at New York's Mount Sinai School of Medicine, he began his career on the neurology faculty of SUNY Stony Brook, just as Lyme disease was being characterized. The multidisciplinary collaborative group there was able to substantially improve the knowledge base regarding this infection. An author or contributor to approximately 150 articles and chapters, Dr. Halperin lectures widely. He serves on the Guideline Development Subcommittee of the American Academy of Neurology, has been a long-standing examiner for the Neurology Board examination, and has been heavily involved in patient outcome improvement at Atlantic Health, the multihospital system in New Jersey where he now leads Neurosciences. Under his leadership, Overlook Hospital's Neuroscience program has rapidly become recognized as the state's best and busiest.
