This book covers the latest findings of a wide variety of viral, prokaryotic and eukaryotic macromolecular protein complexes and builds upon the solid macromolecular foundations established by previous volumes of the Subcellular Biochemistry series. Thus, an almost encyclopaedic coverage of the broad field of protein complex structure and function has been established.
The 17 interesting chapters included in this book have been organised into four sections: Soluble Protein Complexes, Membrane Protein Complexes, Fibrous Protein Complexes and Viral Protein Complexes. Significant topics present here are: Fatty Acid Synthase, the Fork Protection Complex, Ribonucleotide Reductase, the Kinetochore, G proteins, the FtsEX Complex, the Kainate Receptor, the Photosystem I-antenna, the Mycobacterial Arabinofuranosyltransferases, the the Bacterial Flagellum, the Actomyosin Complex, Motile Cilia, SLS Collagen Polymorphic Structures, and the Reovirus Capsid and Polymerase. Up-dates/expansion of chapter topics present in earlier volumes are now included in chapters here, e.g., those on Ferritin-like proteins and the Multi-tRNA Synthetase.
The book is richly illustrated throughout, the result of an impressive integration of structural data from X-ray crystallography and cryo-electron microscopy. The functional aspects of protein-protein interactions are also given a high priority.
Part 1: Soluble Protein Complexes.
Chapter 1: Fatty Acid Synthase:
Structure, Function, and Regulation.
Chapter 2: ATP-binding cassette
transporters: Snap-on complexes?.
Chapter 3: The Fork Protection Complex:
A regulatory hub at the head of the replisome.
Chapter 4: Ferritin-like
Proteins: A Conserved Core for a Myriad of Enzyme Complexes.
Chapter 5:
Still no rest for the reductases: Ribonucleotide reductase (RNR) Structure
and Function an update.
Chapter 6: Structure and Dynamics of the Human
Multi-tRNA Synthetase Complex.
Chapter 7: On the regulation of mitosis by
the kinetochore, a macromolecular complex and organising hub of eukaryotic
organisms.- Part 2: Membrane Protein Complexes.
Chapter 8: The
conformational dynamics of heterotrimeric G proteins during GPCR-mediated
activation.
Chapter 9: Regulation of Lytic Machineries by the FtsEX
Complex in the Bacterial Divisome.
Chapter 10 : Structure, Function, and
Regulation of the Kainate Receptor.
Chapter 11: Structure, function and
variations of the photosystem I-antenna supercomplex from different
photosynthetic organisms.
Chapter 12: Structure and Function of
Mycobacterial Arabinofuranosyltransferases.- Part 3: Fibrous Protein
Complexes.
Chapter 13: Structure and assembly of the bacterial flagellum.-
Chapter 14: Actomyosin Complex.
Chapter 15: Structure of motile cilia.-
Chapter 16: Segment-Long-Spacing (SLS) and the Polymorphic Structures of
Fibrillar Collagen.- Part 4: Virus Protein Complexes.
Chapter 17: Viral
Capsid and Polymerase in Reoviridae.
J. Robin Harris is a retired structural biologist and electron microscopist. He is an Honorary Professor of the University of Mainz, Germany, where he worked with the group of Professor Juergen Markl, in the Institute of Zoology. Since taking retirement, Robin continued part-time research for a number of years at the University of Newcastle, UK, and acted as an Editor of the Elsevier journal Micron and as Series Editor of the long-standing Springer book series Subcellular Biochemistry.Jon Marles-Wright obtained his PhD in structural biology from the University of Oxford, where he focused on understanding how human immune receptors interact with their targets. For his post-doctoral training he moved to the University of Newcastle, where his research focus moved to bacterial cell biology. In 2012 Jon was appointed to a two-year career development fellowship at the University of Newcastle where he developed his interest in the structural basis of metabolic compartmentalization within bacteria. This was followed by nearly four years at The University of Edinburgh as a Chancellors Fellow in the Institute of Structural and Molecular Biology and Centre for Systems and Synthetic Biology. Jon is currently a Senior Lecturer in Microbial Biotechnology in the School of Biology at Newcastle University.
