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Medical Physiology: Principles for Clinical Medicine 6th edition [Pehme köide]

  • Formaat: Paperback / softback, 960 pages, kõrgus x laius: 276x213 mm, 610
  • Ilmumisaeg: 28-Jul-2022
  • Kirjastus: Wolters Kluwer Health
  • ISBN-10: 1975160436
  • ISBN-13: 9781975160432
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  • Formaat: Paperback / softback, 960 pages, kõrgus x laius: 276x213 mm, 610
  • Ilmumisaeg: 28-Jul-2022
  • Kirjastus: Wolters Kluwer Health
  • ISBN-10: 1975160436
  • ISBN-13: 9781975160432
Teised raamatud teemal:
Delivering the most up-to-date information available in a rich, engaging presentation, Medical Physiology: Principles for Clinical Medicine, 6th Edition, instills a complete understanding of physiology essential to effective clinical practice. This robust text not only details how the human body reacts to internal and external changes but also provides a deep understanding of how physiologic systems coordinate to maintain optimal health, as well as the involvement of altered functions in disease processes.
 
Extensively updated throughout and fully aligned with today’s medical curriculum, the 6th Edition emphasizes the physiologic principles key to understanding human function, places them in their fundamental context in clinical medicine, and provides opportunities for student self-directed and team-based learning through case studies, clinical application exercises, and board-style review questions.
 

Delivering the most up-to-date information available in a rich, engaging presentation, Medical Physiology: Principles for Clinical Medicine, 6th Edition, instills a complete understanding of physiology essential to effective clinical practice. This robust text not only details how the human body reacts to internal and external changes but also provides a deep understanding of how physiologic systems coordinate to maintain optimal health, as well as the involvement of altered functions in disease processes.
 
Extensively updated throughout and fully aligned with today’s medical curriculum, the 6th Edition emphasizes the physiologic principles key to understanding human function, places them in their fundamental context in clinical medicine, and provides opportunities for student self-directed and team-based learning through case studies, clinical application exercises, and board-style review questions.
  • NEW! Physiology of Aging and Organ Function chapter details the impact of aging on the body as it relates to human function.
  • New and revised content throughout familiarizes you with the latest perspectives on cardiovascular physiology, neuromuscular physiology, gastrointestinal physiology, endocrine physiology, exercise physiology, and more.
  • Updated USMLE-style review questions with answers provide valuable self-assessment and board exam prep.
  • Clinical Focus essays clarify how and where physiology relates to clinical medicine and diagnosis. 
  • Integrated Medical Sciences essays alert you to important connections between physiology and other basic sciences.
  • Clinical Applications exercises offer practice applying clinical knowledge and solving problems.
  • Conceptual diagrams strengthen comprehension of difficult concepts and present both normal and abnormal clinical conditions.
  • Active Learning Objectives, Chapter Summaries, and full-color artwork and tables make learning engaging and efficient.
  • Additional online resources provide instant access to animations, additional review questions, additional clinical application exercises, advanced clinical problem-solving exercises, and suggested readings.
Preface v
Contributors ix
Reviewers x
Part I Cellular Physiology 1(36)
Chapter 1 Medical Physiology: An Overview
1(8)
Scope of Physiology
1(1)
Recent Directions for Medical Physiology
2(7)
Chapter 2 Membrane Transport and Cell Signaling
9(28)
Basis of Physiologic Regulation
9(2)
Cytosol and the Plasma Membrane
11(3)
Solute Transport Mechanisms
14(8)
Water Movement Across the Plasma Membrane
22(3)
Communication and Signaling Modes
25(1)
Molecular Basis of Cellular Signaling
26(11)
Part II Neuromuscular Physiology 37(159)
Chapter 3 Action Potential, Synaptic Transmission, and Nerve Function
37(22)
The Nervous System
37(3)
Resting Membrane Potential
40(3)
Action Potentials
43(4)
Synaptic Transmission
47(3)
Neurotransmission
50(9)
Chapter 4 Sensory Physiology
59(34)
Sensory Systems
59(5)
Somatosensory System
64(3)
Visual System
67(7)
Auditory System
74(8)
Vestibular System
82(2)
Gustatory and Olfactory Systems
84(9)
Chapter 5 Motor System
93(25)
Skeleton as Framework for Movement
93(1)
Muscle Function and Body Movement
93(1)
Nervous System Components for the Control of Movement
94(4)
Spinal Cord in the Control of Movement
98(4)
Supraspinal Influences on Motor Control
102(2)
Cerebral Cortex Role in Motor Control
104(5)
Basal Ganglia and Motor Control
109(3)
Cerebellum in the Control of Movement
112(6)
Chapter 6 Autonomic Nervous System
118(18)
Anatomy of the Autonomic Nervous System
118(1)
Neurotransmitters of the Autonomic Nervous System
119(4)
The Parasympathetic Nervous System
123(2)
Sympathetic Nervous System
125(3)
Autonomic Integration
128(8)
Chapter 7 Integrative Functions of the Central Nervous System
136(24)
Hypothalamus
136(8)
Brain Electrical Activity
144(3)
Functional Components of the Forebrain
147(6)
Higher Cognitive Skills
153(7)
Chapter 8 Skeletal and Smooth Muscle
160(36)
Skeletal Muscle
160(3)
Excitation-Contraction Coupling in Skeletal Muscle
163(7)
The Neuromuscular Motor Unit and Mechanics of Skeletal Muscle Contraction
170(3)
Loading Conditions and Muscle Mechanics
173(7)
Muscle Plasticity, Epigenetics, and Endocrine Muscle
180(1)
Smooth Muscle
180(5)
Activation-Contraction Coupling in Smooth Muscle
185(11)
Part III Blood And Immunology 196(49)
Chapter 9 Blood Composition and Function
196(22)
Blood Functions
196(1)
Whole Blood
197(1)
Soluble Components of Blood and their Tests
197(3)
Formed Elements of Blood and Common Diagnostic Tests
200(4)
Red Blood Cells
204(3)
White Blood Cells
207(3)
Platelet Formation
210(1)
Blood Cell Formation
210(1)
Blood Clotting
210(8)
Chapter 10 Immunology, Organ Interaction, and Homeostasis
218(27)
Immune System Components
218(1)
Immune System Activation
219(2)
Immune Detection System
221(1)
Immune System Defenses
221(3)
Cell-Mediated and Humoral Responses
224(7)
Acute and Chronic Inflammation
231(2)
Chronic Inflammation
233(1)
Anti-inflammatory Drugs
234(1)
Organ Transplantation and Immunology
235(2)
Immunologic Disorders
237(2)
Neuroendoimmunology
239(6)
Part IV Cardiovascular Physiology 245(144)
Chapter 11 Overview of the Cardiovascular System and Hemodynamics
245(17)
Functional Organization of the Cardiovascular System
246(1)
Hemodynamics: The Physics of Blood Containment and Movement
247(9)
Rheology
256(1)
Distribution of Pressure, Flow, Velocity, and Blood Volume
256(6)
Chapter 12 Electrical Activity of the Heart
262(26)
Electrophysiology of Cardiac Muscle
263(6)
The Pathophysiology of Abnormal Generation of Cardiac Action Potentials
269(1)
The Electrocardiogram
270(18)
Chapter 13 Mechanics of the Cardiac Pump
288(25)
Excitation-Contraction Coupling in Cardiac Muscle
289(3)
The Cardiac Cycle
292(2)
Determinants of Myocardial Performance
294(6)
Determinants of Myocardial Oxygen Demand and Clinical Evaluation of Cardiac Performance
300(3)
Cardiac Output
303(3)
Imaging Techniques for Measuring Cardiac Structures, Volumes, Blood Flow, and Cardiac Output
306(7)
Chapter 14 Interactions between the Heart and the Systemic Circulation
313(15)
Components of Arterial Pressure
313(3)
Clinical Measurement of Arterial Pressure
316(2)
The Concept of Peripheral and Central Blood Volume
318(2)
Interconnections between Vascular and Cardiac Function
320(8)
Chapter 15 Regulation of Organ Blood Flow and Capillary Transport
328(21)
Local Regulation of Organ Blood Flow
328(7)
The Microcirculation and Capillary Dynamics
335(2)
Solute Exchange between the Cardiovascular System and Tissues
337(2)
Capillary Water Transport
339(3)
The Lymphatic System
342(7)
Chapter 16 Special Vascular Physiology of Individual Organs
349(20)
The Coronary Circulation
349(2)
The Cerebral Circulation
351(3)
The Circulation of the Small Intestine
354(2)
The Hepatic Circulation
356(1)
Skeletal Muscle Circulation
357(2)
The Cutaneous Circulation
359(1)
Fetal and Placental Circulations
360(9)
Chapter 17 Neurohumoral Control Mechanisms in Cardiovascular Function
369(20)
Autonomic Neural Control of the Cardiovascular System
369(8)
Hormonal Control of the Cardiovascular System
377(4)
Circulatory Shock
381(8)
Part V Respiratory Physiology 389(81)
Chapter 18 Ventilation and the Mechanics of Breathing
389(32)
Lung Structural and Functional Relationships
390(1)
Pulmonary Pressures and Airflow during Breathing
391(5)
Spirometry and Lung Volumes
396(3)
Minute Ventilation versus Alveolar Ventilation
399(5)
Elastic Properties of Lung and Chest Wall
404(7)
Airway Resistance and the Work of Breathing
411(10)
Chapter 19 Gas Transfer and Transport
421(15)
Gas Diffusion and Uptake
421(3)
Diffusing Capacity
424(1)
Gas Transport by the Blood
424(4)
Respiratory Causes of Hypoxemia
428(8)
Chapter 20 Pulmonary Circulation and Matching Ventilation/Perfusion
436(15)
Functional Organization
436(1)
Pulmonary Hemodynamic
437(4)
Fluid Exchange in the Pulmonary Capillaries
441(2)
Blood Flow Distribution in the Lungs
443(1)
Shunts and Venous Admixture
444(7)
Chapter 21 Control of Breathing
451(19)
Involuntary and Voluntary Control of Breathing
451(3)
Pulmonary Neural Reflexes Modify Breathing
454(2)
Physiologic Responses to Altered Oxygen and Carbon Dioxide
456(1)
Ventilatory Responses to Altered Environments
457(2)
Control of Breathing During Sleep
459(2)
Control of Breathing in Unusual Environments
461(9)
Part VI Renal Physiology And Body Fluids 470(86)
Chapter 22 Kidney Function
470(35)
Overview of Renal Function
470(1)
The Nephron: The Functional Unit of the Kidney
471(3)
Renal Blood Flow
474(2)
Glomerular Filtration
476(4)
Renal Clearance and Kidney Function
480(4)
Basic Principles of Renal Tubular Transport
484(6)
Tubule Secretion
490(3)
Urinary Concentration Mechanisms and Water Conservation by the Kidney
493(5)
Micturition
498(7)
Chapter 23 Regulation of Fluid and Electrolyte Balance
505(28)
Fluid Compartments of the Body
505(6)
Water Balance
511(3)
Fluid-Electrolyte Disturbances and Renal Function
514(1)
Sodium Balance
515(7)
Potassium Balance
522(3)
Renal Handling of Calcium
525(1)
Renal Handling of Magnesium
526(1)
Renal Handling of Phosphate
526(7)
Chapter 24 Acid-Base Homeostasis
533(23)
Basic Principles of Acid-Base Chemistry
533(2)
Metabolic Production of Acids in the Body
535(1)
The Body's Integrated Buffering Systems
536(8)
Regulation of Intracellular pH
544(1)
Physiologic Disturbances of Acid-Base Balance
545(11)
Part VII Gastrointestinal Physiology 556(83)
Chapter 25 Gastrointestinal Motility
556(28)
Organization of the Digestive System
557(2)
Gastrointestinal Motility
559(2)
Swallowing and Esophageal Motility
561(1)
Esophageal Motility
562(1)
Gastric Motility
563(3)
Small Intestinal Motility
566(1)
Large Intestinal Motility
567(3)
Intestinal Smooth Muscle
570(1)
Gut Motility and Digestive Function
571(3)
Enteric Motor Neurons
574(10)
Chapter 26 Gastrointestinal Secretory Functions
584(21)
Gastrointestinal Secretion
584(1)
Salivary Secretion
584(3)
Gastric Secretion
587(6)
Pancreatic Secretion
593(4)
Biliary Secretion
597(2)
Intestinal Secretion
599(6)
Chapter 27 Gastrointestinal Digestion and Absorption of Nutrients
605(34)
The Gastrointestinal System
605(1)
Gastric Digestion and Absorption
606(1)
The Small Intestine
607(1)
Digestion and Absorption: Carbohydrates
608(1)
Digestion and Absorption: Lipids
609(4)
Digestion and Absorption: Proteins
613(2)
Absorption: Vitamins
615(2)
Absorption: Electrolytes and Minerals
617(3)
Absorption: Water
620(1)
Liver Function
621(3)
Liver: Carbohydrate Metabolism
624(2)
Liver: Lipid Metabolism
626(2)
Liver: Protein Metabolism
628(1)
Liver: Nutrient Storage
629(2)
Liver: Drug Metabolism
631(2)
Liver: Endocrine Function
633(1)
Liver: Immune Function
633(6)
Part VIII Temperature Regulation And Exercise Physiology 639(44)
Chapter 28 Regulation of Body Temperature
639(27)
Body Temperature and Heat Transfer
639(3)
Thermoregulation: Heat Production and Heat Loss
642(1)
Metabolic Rate and Heat Production at Rest
643(3)
Heat Dissipation
646(4)
Thermoregulatory Control
650(3)
Thermoregulatory Responses During Exercise
653(2)
Heat Acclimatization
655(2)
Physiological Responses to Cold
657(1)
Clinical Aspects of Thermoregulation
658(8)
Chapter 29 Exercise Physiology
666(17)
Oxygen Uptake and Exercise
666(1)
Cardiovascular Responses to Exercise
667(4)
Respiratory Responses to Exercise
671(2)
Exercise-Induced Changes in Skeletal Muscle Dynamics and Bone Metabolism
673(4)
Obesity, Aging, and Immune Responses to Exercise
677(6)
Part IX Endocrine Physiology 683(90)
Chapter 30 Endocrine Control Mechanisms
683(13)
General Endocrine Concepts
683(3)
Chemical Nature of Hormones
686(3)
Measurement of Circulating Hormones
689(2)
Mechanisms of Hormone Action
691(5)
Chapter 31 Hypothalamus and the Pituitary Gland
696(17)
Structure of the Hypothalamic-Pituitary Axis
696(2)
Posterior Pituitary Hormones
698(1)
Anterior Pituitary Hormones
699(5)
Hypothalamic-Pituitary Regulation of Growth
704(9)
Chapter 32 Thyroid Gland
713(14)
Thyroid Hormone Synthesis, Secretion, and Metabolism
713(5)
Thyroid Hormone Effects on the Body
718(2)
Abnormalities of Thyroid Function in Adults
720(7)
Chapter 33 Adrenal Gland
727(15)
Adrenal Steroid Hormone Synthesis, Secretion, and Metabolism
727(7)
Glucocorticoid Effects on the Body
734(3)
Adrenal Catecholamines
737(5)
Chapter 34 Endocrine Pancreas
742(17)
Islets of Langerhans
742(1)
Mechanisms of Islet Hormone Synthesis and Secretion
743(5)
Insulin and Glucagon Action
748(3)
Diabetes Mellitus
751(8)
Chapter 35 Endocrine Regulations of Calcium, Phosphate, and Bone Homeostasis
759(14)
Overview of Calcium and Phosphate in the Body
759(2)
Calcium and Phosphate Metabolism
761(2)
Plasma Calcium and Phosphate Regulation
763(3)
Bone Dysfunction
766(7)
Part X Reproductive Physiology 773(56)
Chapter 36 Male Reproductive System
773(18)
The Endocrine Glands of the Male Reproductive System
773(1)
Testicular Function and Regulation
773(6)
Spermatogenesis
779(2)
Endocrine Function of the Testis
781(2)
Androgen Action and Male Development
783(3)
Male Reproductive Disorders
786(5)
Chapter 37 Female Reproductive System
791(19)
Female Reproductive Organs
791(1)
Puberty
792(2)
Hormonal Regulation of the Female Reproductive System
794(2)
Ovarian Steroid Synthesis
796(2)
Ovarian Cycle
798(3)
Menstrual Cycle
801(4)
Female Reproductive System Disorders
805(5)
Chapter 38 Fertilization, Pregnancy, and Fetal Development
810(19)
Fertilization, Implantation, and Placenta Development
810(6)
Maternal Adaptation during and Following Pregnancy
816(4)
Fetal Development and Growth
820(4)
Contraception
824(5)
Part XI Aging 829(16)
Chapter 39 Physiology of Aging and Organ Function
829(16)
Aging Defined
829(1)
Science of Aging
830(3)
Physiological Changes and Aging
833(1)
Aging and Respiratory Changes
834(1)
Aging and Musculoskeletal Changes
835(1)
Aging and Gastrointestinal Changes
836(1)
Aging and the Endocrine System
837(1)
Aging and the Sensory System
838(1)
Aging and the Urinary System
839(6)
Appendix A: Common Abbreviations in Physiology 845(3)
Appendix B: Normal Blood, Plasma, or Serum Values 848(3)
Glossary 851
Index 91