Mesenchymal Stem Cells and Extracellular Vesicles as Next-Generation Therapeutics is a comprehensive exploration of the groundbreaking roles stem cells and extracellular vesicles (EVs) play in regenerative medicine. The book examines the fundamental biology of stem cells and EVs, their therapeutic applications across tissues - including skin, neural, cardiac, ocular, and more and the innovative interdisciplinary approaches shaping the future of healthcare. The book is divided into three distinct sections. Section 1 covers Basic and Emerging Concepts, while Section 2 examines Therapeutic Applications and Disease Focus, and Section 3 explores Cross-disciplinary Innovations and Future Directions this field will encounter in this rapidly growing branch of medicine. Written by experts in the field for researchers and academics engaged in regenerative medicine, stem cell biology, and biomedical engineering. It will also be of interest to healthcare professionals such as physicians, surgeons, and specialists interested in tissue repair and regeneration.
Section 1: Basic and emerging concepts
1. Introduction to stem cell biology
2. Introduction to extracellular vesicles biology
3. An overview on mesenchymal stem cells in regenerative medicine
4. An overview on extracellular vesicles in regenerative medicine
5. Engineering stem cells for enhanced organ retention, biodistribution and
targeted delivery
6. Engineering extracellular vesicles for enhanced organ retention,
biodistribution and targeted delivery
7. Challenges and advances in biomanufacturing of mesenchymal stem cells:
from isolation, scale-up, storage, transportation to bench side application
8. Challenges and advances in biomanufacturing of extracellular vesicles:
from isolation, scale-up, storage, transportation to bench side application
9. Ethical, quality and regulatory considerations in mesenchymal stem cell
and extracellular vesicles based therapies
Section 2: Therapeutic applications and disease focus
10. Mesenchymal stem cells and extracellular vesicles in skin regeneration
11. Mesenchymal stem cells and extracellular vesicles in neural regeneration
12. Mesenchymal stem cells and extracellular vesicles in cardiac
regeneration
13. Mesenchymal stem cells and extracellular vesicles in ocular regeneration
14. Mesenchymal stem cells and extracellular vesicles in bone regeneration
15. Mesenchymal stem cells and extracellular vesicles in cartilage
regeneration
16. Mesenchymal stem cells and extracellular vesicles in liver regeneration
17. Mesenchymal stem cells and extracellular vesicles in pancreatic
regeneration
18. Mesenchymal stem cells and extracellular vesicles in lung regeneration
19. Mesenchymal stem cells and extracellular vesicles in cancer
immunotherapy
Section 3: Cross-disciplinary innovations and future directions
20. Biomaterials in mesenchymal stem cells and extracellular vesicles
research
21. Bioreactors in mesenchymal stem cells and extracellular vesicles
research
22. Nanotechnology in mesenchymal stem cells and extracellular vesicles
research
23. Microfluidics in mesenchymal stem cells and extracellular vesicles
research
24. AI and ML in mesenchymal stem cells and extracellular vesicles research
25. Sustainability approaches in mesenchymal stem cells and extracellular
vesicles research
26. Systems biology approaches in mesenchymal stem cells and extracellular
vesicles research
27. Synthetic biology approaches in mesenchymal stem cells and extracellular
vesicles research
28. Quantum biology approaches in mesenchymal stem cells and extracellular
vesicles research
29. Mesenchymal stem cells and extracellular vesicles in space medicine:
challenges and opportunities
Dr. Naresh Kasoju is a Scientist at Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala. He obtained his Ph.D. in Biotechnology from Indian Institute of Technology and postdoctoral experience from Institute of Macromolecular Chemistry, Prague, Czech Republic and University of Oxford, Oxford, UK. His research interests include mesenchymal stem cells-based therapeutics for regenerative medicine, natural polymers-based biomaterials for biomedical applications, and 3D bioprinting based approaches for tissue engineering. He filed 06 Indian patents and 03 Indian design registrations and has published 70+ articles, with 4500+ citations. He's editor of 3 books, guest editor for 3 special issues, editorial board member for 2 journals and reviewer for 50+ journals. He's a member of National Academy of Science, India and Royal Society of Biology, UK. Recently, he received Young Scientist Award by Indian Academy of Biomedical Sciences, Lucknow for his outstanding contributions in biomaterials, stem cells and tissue engineering. Dr. Ramesh Bhonde joined Dr D Y Patil University, Pune, as Director (Research) in September 2016. Prior to that he served as Professor & Dean, at the School of Regenerative Medicine, Bangalore for the last 5 years. He retired from National Center for Cell Science Pune as Scientist F and joined Stempeutics Research Pvt. Ltd. Bangalore as Technical Director, moving to Stempeutics Research Malaysia branch in Kuala Lumpur, Malaysia. Hes worked in the field of pancreatic regeneration in diabetes for the past 25 years. His areas of interest and expertise include stem cells, regenerative biology, tissue banking and engineering, with special reference to the cultivation of fastidious cells such as hepatocytes, vascular endothelial cells, and islets of Langerhans. Hes well trained in hESC and iPS technology. Dr. Bhonde authored 7 book chapters, and is a recipient of Dr. TMA Pai Endowment Chair in Islet Engineering & Banking in October 2013.
