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Metal Toxicology Handbook [Kõva köide]

Edited by (Dept of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX), Edited by
  • Formaat: Hardback, 510 pages, kõrgus x laius: 254x178 mm, kaal: 1061 g, 34 Tables, black and white; 44 Illustrations, black and white
  • Ilmumisaeg: 20-Nov-2020
  • Kirjastus: CRC Press
  • ISBN-10: 1138345245
  • ISBN-13: 9781138345249
  • Formaat: Hardback, 510 pages, kõrgus x laius: 254x178 mm, kaal: 1061 g, 34 Tables, black and white; 44 Illustrations, black and white
  • Ilmumisaeg: 20-Nov-2020
  • Kirjastus: CRC Press
  • ISBN-10: 1138345245
  • ISBN-13: 9781138345249
"The Metal Toxicology Handbook further explains and discusses the varying attributes of metals, discussing toxicity, safety and proper human utilization of metals. Beginning with a broad overview of metals, metalloids, redox biology and neurodegenerationand going further into the roles, benefits, and toxicity of metals with each section, this text contains 28 chapters from eminent researchers and scientists in their field and is a must have anyone researching the potential toxicity in metals"--

Heavy metals and metalloids, singly or in combination, induce toxic manifestations either through acute or chronic pathology. In particular, long-term chronic exposure to diverse heavy metals and metalloids to humans and animals can lead to numerous physical, muscular, neurological, nephrological, and diverse degenerative diseases and dysfunctions, including multiple sclerosis, muscular dystrophy, Parkinson’s and Alzheimer’s diseases, cardiovascular disorders, and several others.

Recognized heavy metals such as lead, mercury, arsenic, cadmium, thallium, and hexavalent chromium are known for enormous toxicity. The immediate vital signs of acute heavy metal exposure include nausea, vomiting, diarrhea, and acute abdominal pain. Mercury has been identified as the most toxic heavy metal, and mercury poisoning is known as acrodynia or pink disease. Similarly, lead, another toxic heavy metal, was at one time an integral part of painting.

Metal Toxicology Handbook

further explains and discusses the varying attributes of metals, discussing toxicity, safety, and proper human utilization of metals. Beginning with a broad overview of metals, metalloids, redox biology, and neurodegeneration and going further into the roles, benefits, and toxicity of metals with each section, the text contains 28 chapters from eminent researchers and scientists in their respective fields and is a must-have for anyone researching the potential toxicity in metals.

Key Features

  • Discusses the pathology of metal toxicity
  • Highlights the benefits of metals
  • Explains the mechanism and salient features of restoring metabolic homeostasis
    • Highlights dose-dependent beneficial and adverse effects of vanadium safety and toxicity
  • The initial introductory section provides a broad overview of metals, metalloids, redox biology, and neurodegeneration. The second section discusses the pathology of metal toxicity in two chapters, while the third section highlights the mechanism and salient features of restoring metabolic homeostasis in two chapters. The fourth section demonstrates the aspect of radionuclides toxicity. In a change of pace, the fifth section discusses the benefits of metals in four chapters. The sixth section, titled "Toxic Manifestations by Diverse Heavy Metals and Metalloids," provides fourteen chapters that discuss the toxicological mechanism and manifestation of individual metals.

    The editors have crafted a commentary titled "A Treatise on Metal Toxicity" and summarized a vivid scenario of metal toxicity and its consequences.

    Preface xi
    Editors xiii
    Contributors xv
    Part I Introduction: Metals, Metalloids, Redox Biology, and Neurodegeneration
    Chapter 1 Role of Metals and Metalloids in Redox Biology
    3(10)
    Amit Madeshiya
    Pradipta Banerjee
    Suman Santra
    Nandini Ghosh
    Sayantani Karmakar
    Debasis Bagchi
    Sashwati Roy
    Amitava Das
    Chapter 2 Role of Metals in Neurodegeneration
    13(12)
    Abhai Kumar
    Smita Singh
    Rameshwar Nath Chaurasia
    Part II Pathology of Metal Toxicity
    Chapter 3 Pathological Manifestations and Mechanisms of Metal Toxicity
    25(28)
    Odete Mendes
    Chidozie Amuzie
    Chapter 4 An Overview of Heavy Metal Research in Traditional Chinese Medicine
    53(14)
    Yu Xu
    Ning Wang
    Yibin Feng
    Part III Mechanisms of Restoring Metabolic Homeostasis
    Chapter 5 Development and Utilization of a Novel Prodosomed-Electrolyte and Phytochemical Formulation Technology to Restore Metabolic Homeostasis
    67(14)
    Bernard W. Downs
    Manashi Bagchi
    Bruce S. Morrison
    Jeffrey Galvin
    Steve Kushner
    Debasis Bagchi
    Chapter 6 Gut Microbiome and Heavy Metals
    81(20)
    Ashfaque Hossain
    Muhammad Manjurul Karim
    Tania Akter Jhuma
    Godfred A. Menezes
    Part IV Radionuclides Toxicity
    Chapter 7 A Review on Radionuclide Toxicity
    101(12)
    Fco Javier Guillen Gerada
    Jose Angel Corbacho Merino
    Part V Benefits of Metals
    Chapter 8 Contribution of Bioavailable Silicon in Human Health
    113(34)
    Keith Robert Martin
    Chapter 9 Benefits of Trivalent Chromium in Human Nutrition?
    147(14)
    John B. Vincent
    Chapter 10 Trivalent Chromium: A Vital Insulin Sensitizer
    161(14)
    Harry G. Preuss
    Debasis Bagchi
    Chapter 11 Differential Impact of Organic Vanadium Compounds on Human Health: Deficiency States, Toxic Effects, and Potential Therapeutic Use
    175(8)
    Satinath Mukhopadhayay
    Bidisha Mukherjee
    Chapter 12 Vanadium--Speciation Chemistry Can Be Important When Assessing Health Effects on Living Systems
    183(16)
    Debbie C. Crans
    Kahoana Postal
    Judith A. MacGregor
    Part VI Toxic Manifestations by Diverse Heavy Metals and Metalloids
    Chapter 13 Clinical Toxicology of Copper: Source, Toxidrome, Mechanism of Toxicity and Management
    199(20)
    Sonal Sekhar Miraj
    Mahadev Rao
    Chapter 14 Cadmium Exposure and Toxicity
    219(54)
    Soisungwan Satarug
    Kenneth R. Phelps
    Chapter 15 Cobalt Toxicity and Human Health
    273(14)
    Md. Hafiz Uddin
    Marufa Rumman
    Chapter 16 Cobalt Toxicity
    287(16)
    Muhammad Umar
    Ayyaz Sultan
    Noman Jahangir
    Zobia Saeed
    Chapter 17 Iron-Siderophore and Tumorigenesis: Molecular Insight and Therapeutic Targets
    303(8)
    Sayantan Maitra
    Dibyendu Dutta
    Chapter 18 Clinical Toxicology of Iron: Source, Toxidrome, Mechanism of Toxicity, and Management
    311(12)
    Shilia Jacob Kurian
    Sonal Sekhar Miraj
    Ahmed Alshrief
    Sreedharan Nair
    Mahadev Rao
    Chapter 19 Vanadium Toxicity Revisited: Striking the Right Balance between Potential New Generation Therapeutics and Adverse Side Effects
    323(22)
    Rituparna Ghosh
    Ahana Das
    Arnab Bandyopadhyay
    Rajib Majumder
    Samudra Prasad Banik
    Chapter 20 The Ubiquitous Lead--Biological Effects, Toxicity, and Management
    345(8)
    Sreejayan Nair
    Debasis Bagchi
    Chapter 21 Lead Toxicity: An Overview of Its Pathophysiology and Intervention Strategies
    353(20)
    Rokeya Pervin
    Md. Akil Hossain
    Dipti Debnath
    Mohiuddin Ahmed Bhuiyan
    Chapter 22 Arsenic Toxicity: Source, Mechanism, Global Health Complication, and Possible Way to Defeat
    373(20)
    Dipti Debnath
    Biddut Deb Nath
    Rokeya Pervin
    Md. Akil Hossain
    Chapter 23 Clinical Toxicology of Mercury: Source, Toxidrome, Mechanism of Toxicity, and Management
    393(12)
    Sonal Sekhar Miraj
    Pooja Gopal Poojari
    Girish Thunga P.
    Mahadev Rao
    Chapter 24 An Overview of Tungsten Toxicity
    405(12)
    Ola Wasel
    Jennifer L. Freeman
    Chapter 25 Boron Toxicity: An Insight on Its Influence on Wheat Growth
    417(16)
    Anamika Pandey
    Mohd. Kamran Khan
    Mehmet Hamurcu
    Fatma Gokmen Yilmaz
    Sait Gezgin
    Chapter 26 Diversity of Mechanisms for Boron Toxicity in Mammals
    433(22)
    Diana Rodriguez-Vera
    Antonio Abad-Garria
    Monica Barron-Gonzalez
    Julia J. Segura-Uribe
    Eunice D. Farfan-Garcia
    Marvin A. Soriano-Ursua
    Chapter 27 Lithium: Is It Good or Bad for Plant Growth?
    455(10)
    Mohsin Tanveer
    Lei Wang
    Chapter 28 An Overview of Nickel Toxicity in Plants
    465(10)
    Mohsin Tanveer
    Commentary: A Treatise on Metal Toxicology 475(4)
    Index 479
    Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his PhD in medicinal chemistry in 1982. He is the Director of Scientific Affairs, VNI, Inc., Lederach, Pennsylvania; an Adjunct Faculty at Texas Southern University, Houston, Texas and a past Faculty in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, Texas. He served as the Chief Scientific Officer at Cepham, Inc., Belmont, New Jersey, from June 2013 through December 2018. He was the Senior Vice President of Research and Development of InterHealth Nutraceuticals, Inc., Benicia, California, from 1998 until February 2011, and then as the Director of Innovation and Clinical Affairs of Iovate Health Sciences, Oakville, Ontario, Canada, until June 2013. Dr Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, Florida, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, Illinois. He is serving as a Distinguished Advisor at the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. He is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, Maryland. He has published 372 papers in peer-reviewed journals, has written 41 books, and has 20 patents. He is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright-Patterson Air Force Base, Ohio. He is the Associate Editor of the Journal of Functional Foods, Journal of the American College of Nutrition, and Archives of Medical and Biomedical Research, and he also serves as an Editorial Board Member of numerous peer-reviewed journals, including Antioxidants and Redox Signaling, Cancer Letters, Food and Nutrition Research, Toxicology Mechanisms and Methods, The Original Internist, and other peer-reviewed journals.









    Manashi Bagchi, PhD, FACN, received her PhD in chemistry in 1984. She is currently the Chief Scientific Officer of Dr. Herbs LLC, Concord, California. She is also a Consultant for VNI, Lederach, Pennsylvania. She served as an Associate Professor at the Creighton University School of Pharmacy and Allied Health Profession, Omaha, Nebraska, from September 1990 until August 1999. Later, she served as the Director of Research at InterHealth Nutraceuticals, Benicia, California, from September 1999 to July 2009. She is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, Maryland. Her research interests include free radicals, human diseases, toxicology, carcinogenesis, anti-aging and anti-inflammatory pathophysiology, mechanistic aspects of cytoprotection by antioxidants and chemoprotectants, regulatory pathways in obesity and gene expression, diabetes, arthritis, and efficacy and safety of natural botanical products and dietary supplements. She is a Member of the Society of Toxicology (Reston, Virginia), the New York Academy of Sciences (New York, New York), and the Institutes of Food Technologists (Chicago, Illinois). She is a Fellow and currently Board Member of the American College of Nutrition (Clearwater, Florida). She has published 225 papers in peer-reviewed journals and 2 books, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods and Bio-Nanotechnology: A Revolution in Food, Biomedical and Health Sciences, from Wiley-Blackwell. She has delivered invited lectures at various national and international scientific conferences and organized workshops and group discussion sessions. She serves as an Editorial Board Member of the Journal of the American College of Nutrition, and is a reviewer of many peer-reviewed journals. She received funding from various institutions and agencies, including the U.S. Air Force Office of Scientific Research, the National Institute of Aging, the Nebraska State Department of Health, and the Cancer Society of Nebraska.









    Both Dr. D. Bagchi and Dr. M. Bagchi have extensively researched diverse heavy metals and metalloids, including cadmium, chromium(III), chromium(VI), arsenic, nickel, platinum, zinc, vanadium, manganese, magnesium, bismuth, cobalt, calcium, potassium, iron, and silver since 1993 to demonstrate the diverse molecular mechanisms of toxicity as well as to explore the beneficial effects of selected metals on human health. They have published approximately 75 peer-reviewed publications and book chapters as author or co-author. Their research studies have been supported by the Biomedical Research Support Grant (BRSG), the U.S. Air Force Office of Scientific Research (AFOSR), the National Institutes of Health (NIH), the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), the Nebraska State Department of Health, and the Procter and Gamble Company (P&G).