Metastatic Diseases: Novel Approaches in Diagnosis and Therapeutic Management opens new horizons for exploring modern therapeutic entities and emerging targets for combating the deadly disease of cancer. The authors provide a review of cancer along with descriptions of its molecular level mechanisms and emphasize the role of promising new therapies, including herbal therapies that can be utilized for the treatment of metastatic diseases. The chapters look at specific approaches that have been researched and developed and that have almost reached the standardization stage. One of the approaches focuses on intracellular mechanisms, particularly proteins, and the pathway involving or being regulated by the proteins that limit the metastatic cellular growths. In particular phosphoprotein enriched astrocytes are being extensively tried. Also discussed is transerythretin protein, which has been significantly studied for its involvement in formation and transportation of proteins in metastatic diseases. Other receptors and approaches examined include CXCR4, autophagy-inhibiting drugs, phosphoprotein-enriched astrocytes, spatiotemporal genetic analysis, tyrosine kinase inhibitors, and more.
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xiii | |
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xv | |
| Preface |
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xxi | |
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1 A Review on Cancer: From Clinical Perspective to Chemotherapy |
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1 | (32) |
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2 Phosphoprotein-Enriched Astrocytes as Potential Anticancer Agents |
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33 | (14) |
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3 Autophagy-Modulating Drugs as Complements to Cancer Chemotherapy |
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47 | (18) |
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4 Transthyretin Protein in Renowned Metastatic and Other Conditions |
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65 | (12) |
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5 Role of CXCR4 Receptor Protein in Cancer Development and Therapies |
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77 | (12) |
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6 C3D Complement System in Immunotherapy-Based Cancer Treatment |
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89 | (12) |
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101 | (16) |
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8 Spherical Nucleic Acid Platform-Based Drug Delivery for Brain Cancer and Improved Blood-Brain Barrier Crossing for Alzheimer's and Other Diseases |
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117 | (22) |
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9 Intra-Vital Microscopy: A New Amelioration in Cancer Immunotherapy Monitoring |
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139 | (12) |
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10 Molecular Imaging: A New Advancement in Cancer Immunotherapy Monitoring |
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151 | (18) |
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11 Spatiotemporal Genetic Analysis (SAGA) Technique for Cancer Cell Biology Studies |
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169 | (10) |
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12 Plant-Derived Anti-Malarial Compounds and Their Derivatives as Anticancer Agents: Future Perspectives |
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179 | (18) |
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13 Epigenetic Control of the Immune System and Its Applications in Metastatic Diseases |
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197 | (10) |
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14 Immune Checkpoint Inhibitors |
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207 | (18) |
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15 Tyrosine Kinase Inhibitors in Lymphocytic Leukemia |
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225 | (14) |
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16 Cyclooxygenase-1 (COX-1) Inhibitors in the Management of Neoplastic Disorders |
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239 | (22) |
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17 Microfluidic Devices in Capturing Circulating Metastatic Cancer Cell Clusters |
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261 | (18) |
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| Index |
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279 | |
Sandeep Arora, PhD, MPharm, is Dean/Director of the Chitkara College of Pharmacy at Chitkara University, India, as well Professor of Healthcare. He is also an industrial consultant. Dr. Arora is a seasoned pharma and academic professional with over 27 years of experience in pharma operations, quality management, academics, training, research, and consultancy planning and administration. An avid researcher and prolific writer, he has written books and articles and holds several patents. He is an honorary editor of the journal Advanced Drug Review, editor of the Journal of Pharmaceutical Technology, Research, and Management, and honorary technical director and advisor to Natural Solutions, Mumbai, India.
Tapan Behl, PhD, MPharm, is Associate Professor in the Department of Pharmacology, Chitkara College of Pharmacy, India. Dr. Behl has published several books, book chapters, and more than 75 publications in journals. He is a guest speaker at conferences and represents India as a voting delegate for the IUPHAR meeting and selection of IUPHAR 2026 in Kyoto, Japan. He also serves as a reviewer for many reputed journals in his field.
Sukhbir Singh, PhD, is Associate Professor and Associate Head, Centre of Excellence, Phytopharmaceutical at the Chitkara College of Pharmacy, India. He has over 100 publications in various national and international journals as well as books and book chapters. A frequent presenter, he is engaged with consultancy projects on herbal/homeopathic formulations and is an associate editor of the Open Access Journal of Pharmaceutical Research.
Neelam Sharma, PhD, is Associate Professor at the Chitkara College of Pharmacy, Chitkara University, Punjab, and Associate Head, Centre of Excellence, Pharma Tech and Nanotechnology, Chitkara College of Pharmacy, India. She has over 90 publications in various national and international journals, three books, and 10 book chapters and is engaged in several consultancy projects on herbal/homeopathic formulations.
Saurabh Gupta, PhD, is Associate Head of the Department of Pharmacology at Chitkara College of Pharmacy, India. He is an editorial member and an expert reviewer for the journals International Immunopharmacology and Journal of Physiology and Pharmacology, among others. He has authored over 30 international and national research articles, two books, and a book chapter.
