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Microfluidic Devices for Biomedical Applications 2nd edition [Kõva köide]

Edited by (Department of Chemistry and Biochemistry, Biomedical Engineering, Environmental Science and Engineering, Border Biomedical Research Center, University of Texas at El Paso), Edited by (Department of R&D at ABS Global Inc., USA)
  • Formaat: Hardback, 722 pages, kõrgus x laius: 229x152 mm, kaal: 1440 g, 280 illustrations (30 in full color); Illustrations, unspecified
  • Sari: Woodhead Publishing Series in Biomaterials
  • Ilmumisaeg: 12-Aug-2021
  • Kirjastus: Woodhead Publishing
  • ISBN-10: 0128199717
  • ISBN-13: 9780128199718
Teised raamatud teemal:
  • Formaat: Hardback, 722 pages, kõrgus x laius: 229x152 mm, kaal: 1440 g, 280 illustrations (30 in full color); Illustrations, unspecified
  • Sari: Woodhead Publishing Series in Biomaterials
  • Ilmumisaeg: 12-Aug-2021
  • Kirjastus: Woodhead Publishing
  • ISBN-10: 0128199717
  • ISBN-13: 9780128199718
Teised raamatud teemal:

Microfluidic Devices for Biomedical Applications, Second Edition provides updated coverage on the fundamentals of microfluidics, while also exploring a wide range of medical applications. Chapters review materials and methods, microfluidic actuation mechanisms, recent research on droplet microfluidics, applications in drug discovery and controlled-delivery, including micro needles, consider applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds, and cover the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis.

This book is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.

  • Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores a wide range of medical applications
  • Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies
  • Details applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and its role in developing tissue scaffolds, and stem cell engineering
Contributors xi
Editor Biographies xv
Preface to the first edition xvii
Preface to the second edition xxi
1 Materials and methods for microfabrication of microfluidic devices
1(78)
Sreekcmt Damodara
Shadi Shahriari
Wen-I Wu
Pouya Rezai
Huan-Hsuan Hsu
Ravi Selvaganapathy
1.1 Introduction
1(1)
1.2 Microfabrication methods
2(6)
1.3 Materials
8(38)
1.4 Conclusion and future trends
46(2)
1.5 Acronyms
48(31)
References
49(30)
2 Surface coatings for microfluidic biomedical devices
79(46)
M. Sonker
B.G. Abdullah
A. Ros
2.1 Introduction
79(2)
2.2 Covalent immobilization strategies: polymer devices
81(11)
2.3 Covalent immobilization strategies: glass devices
92(4)
2.4 Adsorption strategies
96(6)
2.5 Other strategies utilizing surface treatments
102(2)
2.6 Examples of applications
104(4)
2.7 Conclusions and future trends
108(2)
2.8 Sources of further information and advice
110(15)
References
111(14)
3 Actuation mechanisms for microfluidic biomedical devices
125(38)
A. Rezk
J. Friend
L. Yea
Yu Zhou
3.1 Introduction
125(1)
3.2 Electrokinetics
126(17)
3.3 Acoustics
143(9)
3.4 Limitations and future trends
152(11)
References
153(10)
4 Droplet microfluidics for biomedical devices
163(42)
Marie Hebert
Carolyn L. Ren
4.1 Introduction---droplets in the wider context of microfluidics
163(2)
4.2 Fundamental principles of droplet microfluidics
165(6)
4.3 Droplet microfluidic approaches
171(4)
4.4 Biomedical applications
175(13)
4.5 Conclusion---perspective on the future of biomedical applications using droplet microfluidics
188(17)
References
190(15)
5 Controlled drug delivery using microdevices
205(20)
Ning Gao
XiuJun (James) Li
5.1 Introduction
205(2)
5.2 Microreservoir-based drug delivery systems
207(5)
5.3 Micro/nanofluidics-based drug delivery systems
212(8)
5.4 Future trends and challenges
220(5)
References
221(4)
6 Microneedles for drug delivery and monitoring
225(36)
Emma McAlister
Melissa Kirkby
Ryan F. Donnelly
6.1 Introduction
225(1)
6.2 Microneedle design parameters and structure
226(4)
6.3 Drug delivery strategies using microneedle arrays
230(7)
6.4 Other microneedle array applications
237(2)
6.5 Microneedle-mediated patient monitoring and diagnosis
239(8)
6.6 Clinical translation and commercialisation of microneedle products
247(3)
6.7 Conclusion
250(11)
References
250(11)
7 Microfluidic systems for drug discovery, pharmaceutical analysis, and diagnostic applications
261(68)
Dawei Ding
Sol Park
Jaspreet Singh Kochhar
Sui Yung Chan
Pei Shi Ong
Won Gu Lee
Lifeng Kang
7.1 Introduction
261(2)
7.2 Microfluidics for drug discovery
263(26)
7.3 Microfluidics for pharmaceutical analysis and diagnostic applications
289(21)
7.4 Examples of commercial microfluidic devices
310(1)
7.5 Future trends
311(18)
References
312(17)
8 Microfluidic devices for cell manipulation
329(62)
H.O. Fatoyinbo
XiuJun (James) Li
8.1 Introduction
329(1)
8.2 Microenvironment on cell integrity
330(2)
8.3 Microscale fluid dynamics
332(6)
8.4 Manipulation technologies
338(30)
8.5 Manipulation of cancer cells in microfluidic systems
368(6)
8.6 Conclusion and future trends
374(1)
8.7 Sources of further information and advice
374(17)
References
375(16)
9 Microfluidic devices for immobilization and micromanipulation of single cells and small organisms
391(22)
Peng Pan
Pengfei Song
Xianke Dong
Weize Zhang
Yu Sun
Xinyu Liu
9.1 Introduction
391(2)
9.2 Glass microfluidic device for rapid single cell immobilization and microinjection
393(4)
9.3 Microfluidic device for automated, high-speed microinjection of C. elegans
397(4)
9.4 Microfabricated device for immobilization and mechanical stimulation of Drosophila larvae
401(5)
9.5 Conclusions and outlook
406(7)
References
407(6)
10 Microfluidic devices for developing tissue scaffolds
413(24)
L.T. Chau
J.E. Frith
R.J. Mills
D.J. Menzies
D.M. Titmarsh
J.J. Cooper-White
Yu Zhou
10.1 Introduction
413(1)
10.2 Key issues and technical challenges for successful tissue engineering
414(5)
10.3 Microfluidic device platforms
419(9)
10.4 Conclusion and future trends
428(9)
References
429(8)
11 Microfluidic devices for stem cell analysis
437(52)
D.-K. Kang
J. Lu
W. Zhang
E. Chang
M.A. Eckert
M.M. Mi
W. Zhao
XiuJun (James) Li
11.1 Introduction
437(3)
11.2 Technologies used in stem cell analysis
440(10)
11.3 Examples of microfluidic platform for stem cell analysis: stem cell culture platform---mimicking in vivo culture conditions in vitro
450(8)
11.4 Examples of microfluidic platform for stem cell analysis: single stem cell analysis
458(3)
11.5 Microdevices for label-free and noninvasive monitoring of stem cell differentiation
461(6)
11.6 Microfluidics stem cell separation technology
467(8)
11.7 Conclusion and future trends
475(3)
11.8 Sources of further information and advice
478(11)
References
478(11)
12 Development of the immunoassay of antibodies and cytokines on nanobioarray chips
489(22)
Samar Haroun
Jonathan Lee
Paul C.H. Li
12.1 Introduction to immunoassays
489(2)
12.2 Technologies
491(3)
12.3 Immobilization chemistry
494(3)
12.4 Detection methods
497(2)
12.5 Applications
499(8)
12.6 Conclusion and future trends
507(4)
References
507(4)
13 Integrated microfluidic systems for genetic analysis
511(40)
Siwat Jakaratanopas
Bin Zhuang
Wupeng Gan
Peng Liu
13.1 Introduction
511(2)
13.2 Integrated microfluidic systems
513(1)
13.3 Development of integrated microdevices
513(5)
13.4 Applications of fully integrated systems in genetic analysis
518(17)
13.5 Future of integrated microfluidic systems
535(16)
References
536(15)
14 Paper-based microfluidic devices for low-cost assays
551(36)
Merwan Benhabib
XiuJun (James) Li
14.1 Introduction
551(1)
14.2 Fabrication techniques for paper-based microfluidic devices
552(11)
14.3 Detection and read-out technologies
563(10)
14.4 Application of paper-based microfluidic devices
573(6)
14.5 Current limitations and future perspectives in paper-based microfluidics
579(8)
References
581(6)
15 Microfluidic devices for viral detection
587(30)
Wenfu Zheng
Jiashu Sun
Xingyu Jiang
15.1 Introduction
587(1)
15.2 Microfluidic technologies used for viral detection
588(15)
15.3 Examples of applications
603(6)
15.4 Conclusion and future trends
609(8)
Acknowledgments
610(1)
References
610(7)
16 Microfluidic applications on pancreatic islets and B-cells study for human islet transplant
617(42)
Yuan Xing
Pu Zhang
Yi He
Xiaoyu Yu
Sharon Lu
Farid Ghamsari
Sarah Innis
Joshua E. Mendoza-Elias
Melur K. Ramasubramanian
Yong Wang
Jose Oberholzer
16.1 Introduction
617(6)
16.2 Microfluidic technologies: the emergence of microfluidics applied to islet transplantation
623(9)
16.3 Design and validation of microfluidic devices for islet study and transplantation
632(7)
16.4 Protocol: materials
639(4)
16.5 Protocol: procedures
643(8)
16.6 Conclusion and future trends
651(8)
Acknowledgments
652(1)
References
652(7)
17 3D printed microfluidic devices and applications
659(22)
Sui Ching Phung
Qingfu Zhu
Kimberly Plevniak
Mei He
17.1 Introduction
659(4)
17.2 Direct 3D printing of microfluidic devices and applications
663(8)
17.3 3D-printing of molds for fabricating PDMS microfluidic devices and applications
671(6)
17.4 Conclusions and future trends
677(4)
References
678(3)
Index 681
XiuJun (James) Li, Ph.D., is an Associate Professor with early tenure in the Department of Chemistry and Biochemistry, Biomedical Engineering, and Border Biomedical Research Center at the University of Texas at El Paso (UTEP), USA. After he obtained his Ph.D. degree in microfluidic lab-on-a-chip bioanalysis from Simon Fraser University (SFU) in Canada in 2008, he pursued his postdoctoral research with Prof. Richard Mathies at University of California Berkeley and Prof. George Whitesides at Harvard University, while holding a Postdoctoral Fellowship from Natural Sciences and Engineering Research Council (NSERC) of Canada. He has gained extensive experience in bioanalysis using microfluidic systems, such as single-cell analysis, genetic analysis, low-cost diagnosis, pathogen detection, 3D cell culture, and so on. Dr. Lis current research interest is centered on the development of innovative microfluidic lab-on-a-chip and nanotechnology for bioanalysis, biomaterial, biomedical engineering, and environmental applications, including but not limited to low-cost diagnosis, nano-biosensing, tissue engineering, and single-cell analysis. He has coauthored about 100 publications in high-impact journals (such as Adv. Drug Deliv. Rev, Appl. Catal. B-Environ, Anal. Chem., Lab Chip, Biosens. Bioelectron.) and 22 patents, including two books from Elsevier on microfluidic devices for biomedical applications. He is an Advisory Board member of Lab on a Chip and Analyst, the Founder of microBioChip Diagnostics LLC, and an editor of 6 journals including Scientific Reports from the Nature publishing group, Micromachines, etc. He is the recipient of the Bioanalysis New Investigator Award” in 2014, UT STARS Award in 2012, NSERC Postdoctoral Fellow Award in 2009, and so on. For more information, please visit http://li.utep.edu. Yu Zhou, PhD, is a Research Scientist in the Department of Research and Development at ABS Global Inc., USA. Dr Zhou received his Ph.D. degree in mechanical engineering from University of Illinois at Chicago in 2010. After graduation, he joined ABS Global, the world-leading genetics provider company as a key researcher and has been working on the development of a high-throughput microfluidic cytometry for biological cell detection and manipulation. He obtained extensive experience in design and fabrication of silicon-based microsystems and disposal plastic microfluidic chips, precision fluid delivery, and microfluidics-based single cell separation and analysis. He is a member of ASME and serves on the advisory editorial board for several technical journals including Microsystem Technologies, and Journal of Mechanical Engineering Research (Canada) since 2011.