Microglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves into the physiological roles of microglia, the effects of aging on their structure and activity, and their significance in age-related neurodegenerative diseases. With insights from basic, translational, and clinical studies, it provides a thorough understanding of microglial health and its impact on aging. The book discusses how lifestyle choices can enhance microglial functions and prevent neurodegenerative diseases. It covers both pharmacological and non-pharmacological approaches, such as the ketogenic diet, cannabinoids, psychedelics, and non-invasive vagal nerve stimulation.
This text is invaluable for researchers and clinicians focused on improving the quality of life for an aging population.
Section
1. Introduction to microglial aging and its involvement in
neurodegenerative diseases
1. The microglial aging process at cellular and molecular levels across its
different layers of complexity
2. Involvement of microglial aging in neurodegenerative diseases: a focus on
Alzheimers disease
3. Involvement of microglial aging in neurodegenerative diseases: a focus on
Parkinsons disease
4. Involvement of microglial aging in neurodegenerative diseases: a focus on
multiple sclerosis
5. Involvement of microglial aging in neurodegenerative diseases: a focus on
amyotrophic lateral sclerosis
6. Involvement of microglial aging in neurodegenerative diseases: a focus on
vascular cognitive impairment and dementia
Section
2. Outcomes of the lifestyle on microglial aging and
neurodegenerative diseases along the aging trajectory
7. Diet and the gut-brain axis
8. Sleep disturbances
9. Psychological stress
10. Bacterial and viral infections
11. Physical activity
12. Substance use
Section
3. Emerging treatment strategies to rejuvenate microglia in aging and
neurodegenerative diseases
13. Ketogenic diets and supplements
14. Senolytic drugs
15. Cannabinoids
16. Psychedelics
17. Plasmalogens
18. Multi-modal lifestyle interventions
Dr. Marie-Ève Tremblay is a Full Professor at the School of Medical Sciences, University of Victoria, British Columbia, Canada. She was awarded a Tier II Canada Research Chair in Neurobiology of Aging and Cognition until 2025. Dr. Tremblay is an internationally recognized leader in microglial research. Her career goal is to become a world leader in the development of innovative therapies normalizing microglial functions upon exposure to various environmental risk factors for disease throughout life. She has been invited to present her work over 143 times, at seminars, lectures at symposia, specialized courses, and other meetings. She has 182 publications cited 11,854 times, corresponding to an h-index of 50 and i10-index of 116 (Google Scholar). She was also named a Clarivate Highly Cited Researcher, being among the top 1% across fields in 2021 and 2022 and is ranked 4th world microglial expert by ExpertScape.
