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Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function 2015 ed. [Kõva köide]

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  • Formaat: Hardback, 447 pages, kõrgus x laius: 254x178 mm, 65 Illustrations, color; 59 Illustrations, black and white, 1 Hardback
  • Sari: Methods in Molecular Biology 1265
  • Ilmumisaeg: 30-Jan-2015
  • Kirjastus: Humana Press Inc.
  • ISBN-10: 1493922874
  • ISBN-13: 9781493922871
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  • Formaat: Hardback, 447 pages, kõrgus x laius: 254x178 mm, 65 Illustrations, color; 59 Illustrations, black and white, 1 Hardback
  • Sari: Methods in Molecular Biology 1265
  • Ilmumisaeg: 30-Jan-2015
  • Kirjastus: Humana Press Inc.
  • ISBN-10: 1493922874
  • ISBN-13: 9781493922871

This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions.Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function describes techniques developed for manipulating and assessing mitochondrial function under general pathological conditions and specific disease states. Written in the highly successfulMethods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.

Preface v
Contributors xix
1 DQAsomes as the Prototype of Mitochondria-Targeted Pharmaceutical Nanocarriers: Preparation, Characterization, and Use
1(12)
Volkmar Weissig
2 Predicting Mitochondrial Targeting by Small Molecule Xenobiotics Within Living Cells Using QSAR Models
13(12)
Richard W. Horobin
3 Targeting Mitochondria with Small Molecules: The Preparation of MitoB and MitoP as Exomarkers of Mitochondrial Hydrogen Peroxide
25(26)
Andrew G. Cairns
Stephen J. McQuaker
Michael P. Murphy
Richard C. Hartley
4 Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes
51(8)
Parul Benein
Mohammed A. Almuteri
Ahmed S. Mehanna
Gerard G.M. D'Souza
5 Synthesis and Evaluation of 18F-Labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging
59(14)
Dong-Yeon Kim
Jung-Joon Min
6 Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria
73(12)
Jose Teixeira
Pedro Soares
Sofia Benfeito
Michael P. Murphy
Paulo J. Oliveira
Fernanda Borges
7 Mitochondriotropic Nanoemulsified Genistein-Loaded Vehicles for Cancer Therapy
85(18)
Jimmy Pham
Oliver Grundmann
Tamer Elbayoumi
8 Formulation and Optimization of Mitochondria-Targeted Polymeric Nanoparticles
103(10)
Sean Marrache
Rakesh K. Pathak
Shanta Dhar
9 Ex Vivo Generation of Functional Immune Cells by Mitochondria-Targeted Photosensitization of Cancer Cells
113(10)
Sean Marrache
Smanla Tundup
Donald A. Harn
Shanta Dhar
10 Targeting the Mitochondrial Genome via a Dual Function MITO-Porter: Evaluation of mtDNA Levels and Mitochondrial Function
123(12)
Yuma Yamada
Hideyoshi Harashima
11 Mitochondrial, Acidic, and Cytosolic pHs Determination by 31P NMR Spectroscopy: Design of New Sensitive Targeted pH Probes
135(14)
Marcel Culcasi
Sophie Thetiot-Laurent
Ariane Atteia
Sylvia Pietri
12 Methodology for Use of Mitochondria-Targeted Cations in the Field of Oxidative Stress-Related Research
149(12)
Mikhail Y. Vyssokikh
Yury N. Antonenko
Konstantin G. Lyamzaev
Tatyana I. Rokitskaya
Vladimir P. Skulachev
13 Synthesis and Testing of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin
161(20)
Lucia Biasutto
Andrea Mattarei
Cristina Paradisi
14 Evaluation of Respiration of Mitochondria in Cancer Cells Exposed to Mitochondria-Targeted Agents
181(14)
Katarina Kluckova
Lan-Feng Dong
Martina Bajzikova
Jakub Rohlena
Jiri Neuzil
15 The Effect of Mitochondrially Targeted Anticancer Agents on Mitochondrial (Super)Complexes
195(14)
Magdalena Vondrusova
Ayanachew Bezawork-Geleta
Karishma Sachaphibulkij
Jaroslav Truksa
Jiri Neuzil
16 Mitochondrial Targeting of Recombinant RNA
209(18)
Ilya Dovydenko
Anne-Marie Heckel
Yann Tonin
Ali Gowher
Alya Venyaminova
Ivan Tarassov
Nina Entelis
17 Mitochondrial Targeting of Catalytic RNAs
227(28)
Daria Mileshina
Adnan Khan Niazi
Eliza Wyszko
Maciej Szymanski
Romain Val
Clarisse Valentin
Jan Barciszewski
Andre Dietrich
18 Allotopic Expression of ATP6 in the Mouse as a Transgenic Model of Mitochondrial Disease
255(16)
David A. Dunn
Carl A. Pinkert
19 Analysis of Pollutant-Induced Changes in Mitochondrial DNA Methylation
271(14)
Hyang-Min Byun
Timothy M. Barrow
20 ETS and DEAS Studies of the Reduction of Xenobiotics in Mitochondrial Intermembrane Space
285(22)
Stanislav A. Pshenichnyuk
Alberto Modelli
21 Analysis of Mitochondrial Morphology and Function Under Conditions of Mitofusin 2 Deficiency
307(14)
Juan Pablo Munoz
Antonio Zorzano
22 Yeast as a Tool to Study Mitochondrial Retrograde Pathway En Route to Cell Stress Response
321(12)
Masa Zdralevic
Nicoletta Guaragnella
Sergio Giannattasio
23 Cell Energy Budget Platform for Assessment of Cell Metabolism
333(16)
Dmitri B. Papkovsky
Alexander V. Zhdanov
24 Induced Pluripotent Stem Cells (iPSCs) for Modeling Mitochondrial DNA Disorders
349(8)
Alessandro Prigione
25 Cytoplasmic Transfer Methods for Studying the Segregation of Mitochondrial DNA in Mice
357(10)
Thomas Kolbe
Ralf Steinborn
Joerg P. Burgstaller
26 In Vivo Visualization and Quantification of Mitochondrial Morphology in C. elegans
367(12)
Reuben L. Smith
Winnok H. De Vos
Richard de Boer
Erik M.M. Manders
Hans van der Spek
27 Mitochondrial DNA as a Biosensor of UV Exposure in Human Skin
379(10)
Amy Bowman
Mark A. Birch-Machin
28 Assessment of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation
389(8)
Matthias Hecker
Natascha Sommer
Konstantin Mayer
29 Atomic Force Microscopy-Based Shape Analysis of Heart Mitochondria
397(10)
Gi-Ja Lee
Hun-Kuk Park
30 Enzymatic Assays for Probing Mitochondrial Apoptosis
407(8)
Zhenyu Wang
Claire Nicolas
Rodolphe Fischmeister
Catherine Brenner
31 A Cybrid Cell Model for the Assessment of the Link Between Mitochondrial Deficits and Sporadic Parkinson's Disease
415(10)
Daniela M. Arduino
A. Raquel Esteves
Russell H. Swerdlow
Sandra M. Cardoso
32 Analysis of Mitochondrial Network by Imaging: Proof of Technique in Schizophrenia
425
Dorit Ben-Shachar
Edith Suss-Toby
Odile Robicsek
Erratum 1(440)
Index 441