"This book examines a unique assembly of coordinated mitochondrial functions that are important in regulating cell function and are of relevance in a myriad of pathophysiological situations, such as age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. The text covers themes essential for the maintenance of mitochondrial activity, including electron transport and energy production, mitochondrial biogenesis and dynamics, mitochondrial signaling, and apoptosis andautophagy. The book features chapters that are reviews of the important topics covered and are written by an impressive cadre of internationally recognized scientist"--Provided by publisher.
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
- Electron transport and energy production
- Mitochondrial biogenesis and dynamics
- Mitochondrial signaling
- Apoptosis and autophagy
- Pharmacology signaling
- Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
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xi | |
| Preface |
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xiii | |
| Editors |
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| Contributors |
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xvii | |
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SECTION I Mitochondria---Reactive Oxygen Species (ROS)---Cell Death |
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Chapter 1 Healthy Free Radical Pessimism: A Glance from an Oxidative Lipidomics Corner |
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Chapter 2 Mitochondrial Involvement in the Execution of Cell Death |
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Chapter 3 Role of Protein Kinase C in Mitochondrial Functions in Cardiac Ischemia-Reperfusion Injury |
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Julio Cesar Batista Ferreira |
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Chapter 4 Mitocans, Mitochondria-Targeting Anticancer Drugs: Focus on Mitochondrial Complexes |
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Chapter 5 Therapeutic Potential of Lipoamide and Enhanced Mitochondrial Biogenesis for Treatment of Insulin Resistance |
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Chapter 6 Mitochondria-Targeted Antioxidants |
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SECTION II Mitochondria---Metabolism---Nitric Oxide |
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Chapter 7 Lactate Shuttling and the Mitochondrial Lactate Oxidation Complex |
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131 | (26) |
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Chapter 8 Nitric Oxide in the Regulation of Mitochondrial Biogenesis |
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157 | (12) |
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Chapter 9 Effect of Sildenafil on Heart Nitric Oxide Metabolism and Mitochondrial Function |
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Chapter 10 Kinases and Mitochondrial Cycling: The Last Encounter |
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SECTION III Acetylation---Deacetylation---Aging |
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Chapter 11 Nuclear Chromatin Factors Defining Mitochondrial Bioenergetics: Implications in Age-Associated Diseases |
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Chapter 12 Mitochondrial Protein Acetylation and Sirtuin-Mediated Deacetylation |
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Chapter 13 Mitochondrial Regulation by Protein Acetylation |
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Chapter 14 Calorie Restriction, Mitochondria, and Longevity in Saccharomyces cerevisiae |
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Chapter 15 Autophagy and Aging: Keeping Organelles and the Proteome Healthy |
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SECTION IV Neurodegeneration |
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Chapter 16 Mitochondrial Dynamics and Its Implications in Metabolic Dysregulation and Neurodegeneration |
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Maria Isabel Hernandez-Alvarez |
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Chapter 17 Mitochondrial Abnormalities and Oxidative Stress in Alzheimer's Disease: Can Mitochondrial Reactive Oxygen Species Signaling Promote Neuronal Survival? |
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Chapter 18 Role of Mitochondria in Parkinson's Disease and Huntington's Disease |
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415 | (18) |
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Chapter 19 α-Ketoglutarate Dehydrogenase Complex in Neurodegeneration |
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433 | (22) |
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Chapter 20 R-α-Lipoic Acid as a Potent Agent of Mitochondrial Protection in Alzheimer's Disease |
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455 | (14) |
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Chapter 21 Mitochondrial Antioxidants in Neuroprotection |
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469 | (24) |
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Sten Orrenius, M.D., Ph.D., holds honorary memberships in the American Society for Pharmacology and Experimental Therapeutics, the American Society for Biochemistry and Molecular Biology, the Society of Toxicology (USA), as well as the Italian and Swedish Societies of Toxicology. He is also a Member of the Royal Swedish Academy of Sciences and a Foreign Associate Member of the Institute of Medicine of the National Academy of Sciences, USA. Dr Orrenius has received honorary doctorates from the Universities of Stockholm, Turin, Konstanz, Buenos Aires, Paris V and Milan. He earned the Merit Award by EUROTOX, the Association of European Toxicologists and Societies of Toxicology, in 1997 and was the recipient of the 2006 Distinguished Lifetime Toxicology Scholar Award by the Society of Toxicology (USA). In 2003, Dr. Orrenius received the first ECDO Career Award for Excellence in Cell Death Research by the European Cell Death Organization.
Enrique Cadenas,
M.D., Ph.D., is professor of Pharmacology and Pharmaceutical Sciences at the University of Southern California School of Pharmacy and of Biochemistry and Molecular Biology at the University of Southern California Keck School of Medicine and doctor honoris causa (Medicine) at the University of Linköping, Sweden. His research interests include energy and redox metabolism in brain aging and neurodegenerative diseases, redox signaling, and nitric oxide biology.
Lester Packer,
Ph.D.,has received numerous distinctions and recently, was awarded the Chevalier de lOrdre National du Merite (Knight of the French National Order of Merit). He was President of the Society for Free Radical Research International (SFRRI) and founder and honorary President of the Oxygen Club of California (OCC). Dr. Packer has edited more than 100 books and over 800 articles. His work established the foundations for the Antioxidant Network concept that addresses the significance of the cells redox status in biology and medicine; the Antioxidant Network is more than a scientific concept, for it embraces a world-wide network of research programs that Lester Packer helped develop by supporting and co-organizing conferences on free radical research in Asia, Europe, and America.
