This book presents an authoritative, extensive exploration of the models of degenerative diseases, providing coverage of the preclinical models that are essential for investigation of principles of the diseases, mechanisms of development of functional deficits, and development of therapeutic approaches, including safety analysis. The book is divided into four major sections. The introductory section provides a definition of neurodegenerative diseases as objects of modeling, their classification, and an overview of their features and pathogenetic mechanisms, types of models and their importance, and translational applications and limitations. Section 2 discusses approaches to study the models from the behavioral, motor, cognitive, electrophysiological, biochemical, and structural standpoints. Chapters in Section 3 are organized according to individual neurodegenerative diseases, highlighting specific features of the models and providing examples of disorders-oriented models. The final section focuses on using preclinical models to develop and test new therapies for neurodegenerative diseases. The book will appeal to neuroscientists, laboratory scientists, neurologists, biologists, and PhD students dealing with basic research of neurodegenerative diseases as well as other phases of translation research, including the development and testing of treatment methods.
Introduction.- Mechanisms of neurodegeneration and their modelling.-
Animal models.- In vitro models.- Computational models.- Genetically modified
organisms.- Applications and limitations of the models: an overview.-
Examination of behavior cognition and motor function in animal model.-
Electrophysiological approaches to examine animal models of neurodegenerative
diseases.- Histological approaches to investigate animal models of
neurodegenerative diseases.- Biochemical and molecular biology approaches to
investigate models of neurodegenerative diseases.- Models of the Alzheimers
disease and other amyloidopathies.- Models of tauopathies.- Models of
synucleinopathies.- Models of the Huntington disease and other
polyglutaminopathies.- Models of degenerative ataxias.- Models of the motor
neuron disorders.- Spinal cord disorders.- Models of polyneuropathies.-
Sensory system degenerations.- Models of mitochondrial.- neurodegenerative
diseases.- Models of storage diseases.- Models of other neuropathologies with
contribution of neurodegeneration.- lTesting pharmacotherapy in preclinical
models, principles of translational approach.- Experimental therapeutic
approaches molecular and genetic.- Experimental therapeutic approaches
neurostimulation.- Investigation of neurotransplantation and regenerative
therapy in preclinical models.
Jan Cendelin, MD, is Associate Professor, Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, Plzen, Czech Republic
Jan Tuma, PhD, is Assistant Professor, Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, Plzen, Czech Republic
Mario Manto, MD, is Professor of Neuroanatomy, University of Mons, and Head of the Department of Neurology at the CHU-Charleroi, Belgium. He is Series Editor for the Springer series, Contemporary Clinical Neuroscience
