Muutke küpsiste eelistusi

Molecular epidemiology: principles and practices [Pehme köide]

  • Formaat: Paperback / softback, 522 pages, kõrgus: 310 mm, ill.
  • Sari: IARC scientific publication 163
  • Ilmumisaeg: 30-Sep-2012
  • Kirjastus: International Agency for Research on Cancer
  • ISBN-10: 928322163X
  • ISBN-13: 9789283221630
Teised raamatud teemal:
  • Formaat: Paperback / softback, 522 pages, kõrgus: 310 mm, ill.
  • Sari: IARC scientific publication 163
  • Ilmumisaeg: 30-Sep-2012
  • Kirjastus: International Agency for Research on Cancer
  • ISBN-10: 928322163X
  • ISBN-13: 9789283221630
Teised raamatud teemal:
Molecular epidemiology has taken advantage of the emergence of technological advances collectively identified as "-omics" (genomics, transcriptomics, proteomic, metabonomics) and their usage in epidemiological studies has heralded a revolution in the design implementation, and interpretation of studies on disease causation. Not the least, molecular epidemiology has brought together scientists of all disciplines to interact into very large, often multi-national networks, fostering consortia that have the size and power to address diseases as a global challenge.

This book captures these fascinating developments and provides an extended, forward-looking vision of the principles, practice and impact of molecular epidemiology. Written and coordinated by world leaders in the field, the book covers, in a systematic way, the major conceptual advances, with a strong emphasis on study design and on how to incorporate biomarker studies into epidemiology practice. While providing a cornerstone for specialists, the book is also a teaching and training manual for public health, biology and medical students at the undergraduate, graduate, and post-graduate levels. With its strong insistence on interdisciplinarity and its focus on translating complex concepts into information that can be shared across the borders of scientific disciplines, the book will be a door-opener for researchers whose work is being attracted by the potent magnet of molecular epidemiology.
Foreword v
Preface vii
Unit 1 Contextual framework for molecular epidemiology
Chapter 1 Molecular epidemiology: Linking molecular scale insights to population impacts
1(8)
Chapter 2 Ethical issues in molecular epidemiologic research
9(14)
Unit 2 Biomarkers: practical aspects
Chapter 3 Biological sample collection, processing, storage and information management
23(20)
Chapter 4 Physical/chemical/immunologic analytical methods
43(10)
Chapter 5 Assessment of genetic damage in healthy and diseased tissue
53(46)
Chapter 6 Basic principles and laboratory analysis of genetic variation
99(22)
Chapter 7 Platforms for biomarker analysis using high-throughput approaches in genomics, transcriptomics, proteomics, metabolomics, and bioinformatics
121(22)
Chapter 8 Measurement error in biomarkers: sources, assessment, and impact on studies
143(20)
Unit 3 Assessing exposure to the environment
Chapter 9 Environmental and occupational toxicants
163(12)
Chapter 10 Infectious agents
175(14)
Chapter 11 Dietary intake and nutritional status
189(10)
Chapter 12 Assessment of the hormonal milieu
199(16)
Chapter 13 Evaluation of immune responses
215(26)
Unit 4 Integration of biomarkers into epidemiology study designs
Chapter 14 Population-based study designs in molecular epidemiology
241(20)
Chapter 15 Family-based designs
261(20)
Chapter 16 Analysis of epidemiologic studies of genetic effects and gene-environment interactions
281(22)
Chapter 17 Biomarkers in clinical medicine
303(20)
Chapter 18 Combining molecular and genetic data from different sources
323(14)
Unit 5 Application of biomarkers to disease
Chapter 19 Cancer
337(26)
Chapter 20 Coronary heart disease
363(24)
Chapter 21 Work-related lung diseases
387(20)
Chapter 22 Neurodegenerative diseases
407(14)
Chapter 23 Infectious diseases
421(20)
Chapter 24 Obesity
441(12)
Chapter 25 Disorders of reproduction
453(22)
Chapter 26 Studies in children
475(18)
Chapter 27 Future perspectives on molecular epidemiology
493(8)
Authors' list 501(4)
Index 505