This timely volume presents recent studies on the biological importance of chemically or environmentally induced mouse liver tumors to human cancer risk assessment. With contributions by leading investigators from universities, regulatory agencies, industrial, and public research groups, the text includes extensive discussions of cellular, biochemical, and molecular events leading to initiation, promotion, and neoplastic progression. Specific topics include overviews of the mouse liver as an experimental system; the use of mouse liver tumor data in risk assessment; correlations between tumors in different sites and species; various tumor models, including transplacental and perinatal; morphological changes and histological markers; DNA and chromosome alterations, including oncogene activation; and cell proliferation and cell death. In addition,Mouse Liver Carcinogenesis indicates the most promising paths for future discovery.
