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Nanocarriers for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery [Pehme köide]

Edited by (LV Prasad Eye Inst), Edited by (School of Nano Science and Technology (SNST), Indian Institute of Technology, Kharagpur), Edited by , Edited by (Distinguished USF Health Professor, Director of the Division of Translational Medicine, University of South Florida, USA), Edited by
  • Formaat: Paperback / softback, 694 pages, kõrgus x laius: 235x191 mm, kaal: 450 g
  • Sari: Micro & Nano Technologies
  • Ilmumisaeg: 10-Oct-2018
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 012814033X
  • ISBN-13: 9780128140338
Teised raamatud teemal:
  • Formaat: Paperback / softback, 694 pages, kõrgus x laius: 235x191 mm, kaal: 450 g
  • Sari: Micro & Nano Technologies
  • Ilmumisaeg: 10-Oct-2018
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 012814033X
  • ISBN-13: 9780128140338
Teised raamatud teemal:

Nano-carriers for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery presents recent discoveries in research on the pharmaceutical applications of the various types of nanosystem-based drug delivery systems. As many nanosystems have reached the market over the past decade, this book proves their benefits to patients. It explores these new carriers and the advances in drug delivery they have facilitated. Reflecting the interdisciplinary nature of the subject matter, the book includes experts from different fields, and with various backgrounds and expertise. It will appeal to researchers and students from different disciplines, such as materials science, technology and various biomedical fields.

Coverage includes industrial applications that bridge the gap between lab-based research and practical industrial use. The resulting work is a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science and technology and biomedical science.

  • Enables readers from different fields to access recent research and protocols across traditional boundaries
  • Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques
  • Includes sections on nanocarrier systems
List of Contributors
xix
Foreword xxv
Chapter 1 Efficient Nanocarriers for Drug-Delivery Systems: Types and Fabrication
1(42)
Raghvendra Kumar Mishra
Santosh K. Tiwari
Shyam Mohapatra
Sabu Thomas
1 Introduction
1(3)
2 An Overview of the Role of Nanoparticles in Drug Delivery
4(16)
2.1 Carriers and Vehicles for Drug Delivery
7(2)
2.2 Need for Nanocarriers for Drug Delivery: An Outline
9(1)
2.3 Thermoresponsive Nanoparticles
9(2)
2.4 Magnetic-Responsive Nanoparticles
11(2)
2.5 Electrical-Responsive Nanoparticles
13(1)
2.6 Light-Responsive Nanoparticles
14(1)
2.7 Mechanical-Responsive Nanoparticles
15(1)
2.8 Ultrasound-Responsive Nanoparticles
16(1)
2.9 pH-Responsive Nanoparticles
17(1)
2.10 Redox-Responsive Nanoparticles
18(1)
2.11 Various Biomolecular-Responsive Nanoparticles
18(1)
2.12 Enzyme-Responsive Nanoparticles
19(1)
3 Types of Nanocarriers: Fabrication Approaches and Applications in Drug Delivery
20(10)
3.1 Metal and Metal Oxide Nanocarriers for Drug Delivery
22(1)
3.2 Magnetic Nanoparticles
23(1)
3.3 Solid Lipid Nanoparticles
24(3)
3.4 Carbon Quantum Dots
27(1)
3.5 Carbon Nanotubes
28(2)
3.6 Graphene and Its Derivatives
30(1)
4 Conclusion
30(1)
References
30(13)
Chapter 2 Nanohybrid Filler-Based Drug-Delivery System
43(38)
Monica C. Garcia
Paula M. Uberman
1 Introduction
43(1)
2 Hybrid Nanomaterials
44(26)
2.1 Organic---Organic Hybrids
45(7)
2.2 Organic---Inorganic Hybrids
52(18)
3 Concluding Remarks and Future Perspectives
70(1)
References
71(10)
Chapter 3 Hydrogel Nanocomposite Systems: Physico-Chemical Characterization and Application for Drug-Delivery Systems
81(52)
Debora F. Argenta
Talitha C. dos Santos
Angela M. Campos
Thiago Caon
1 Introduction
81(1)
2 Hydrogels: Physicochemical Properties and General Applications
82(2)
3 Hydrogel Synthesis
84(3)
3.1 Bulk Polymerization
84(1)
3.2 Solution Polymerization
85(1)
3.3 Emulsion/Suspension Polymerization
85(1)
3.4 Polymerization by High-Energy Radiation
85(1)
3.5 Free Radical Polymerization
85(1)
3.6 Chemical Modification of Polymers
86(1)
4 Hydrogel Nanocomposites
87(16)
4.1 Inorganic Nanoparticle-Based Hydrogels
89(10)
4.2 Polymeric Nanoparticle-Based Hydrogels
99(3)
4.3 Liposomal Nanocomposite Hydrogels
102(1)
5 Physicochemical Characterization of Hydrogel Nanocomposites
103(9)
5.1 Morphology
103(1)
5.2 Porosity Measurement
104(2)
5.3 Swelling Behavior
106(1)
5.4 Fourier Transform Infrared Spectroscopy
107(1)
5.5 X-ray Diffraction
107(1)
5.6 Thermal Analysis
107(1)
5.7 Sol---Gel Transition Behavior
108(1)
5.8 Rheological Properties
109(1)
5.9 Viscosity Determination
109(1)
5.10 In Vitro Release Studies
110(1)
5.11 Stability Studies
111(1)
5.12 Biocompatibility Evaluation
111(1)
6 Application of Hydrogel Nanocomposites as Drug-Delivery Systems
112(7)
6.1 Skin Wound Healing
112(4)
6.2 Antitumor Drug-Delivery Systems
116(2)
6.3 Ocular Drug Delivery
118(1)
7 Concluding Remarks
119(1)
List of Abbreviations of the Polymers
120(1)
References
121(12)
Chapter 4 Nanopharmaceuticals as Drug-Delivery Systems: For, Against, and Current Applications
133(22)
Sema Calis
Kivilcim Ozturk Atar
Fatma B. Arslan
Hakan Eroglu
Yilmaz Capan
1 Introduction
133(1)
2 History of Nanotechnology and Nano Definitions
133(1)
3 Nanomedicines and Biological Environment
134(1)
4 Characterization of Nanomaterials
135(1)
5 Nanoparticle Types, Applications, Advantages, and Potential
136(3)
5.1 Polymeric Nanoparticles
138(1)
5.2 Liposomes
139(1)
6 Manufacturing Prospects for Nano Drugs, Nanoadditives, and Nanocarriers
139(2)
7 Regulatory Perspective on the Development of Nanomedicines
141(1)
8 Scale-Up of Nanomedicines: Preparative Methods and Their Challenges
141(2)
9 Nanotechnology Clinical Applications
143(1)
10 Nanotechnology in the Treatment of Neurodegenerative Disorders
144(5)
11 Problems With Current Nanotechnology Concepts
149(2)
11.1 Drug Loading
149(1)
11.2 Stability and Storage
149(1)
11.3 Complexity of Nanocarriers
150(1)
11.4 Toxicity Issues
150(1)
12 Conclusions
151(1)
References
151(4)
Chapter 5 Nucleic Acid-Based Nanocarriers
155(18)
Asit Kumar Chakraborty
1 Introduction
155(1)
1.1 Silver and Gold Nanoparticles
155(1)
1.2 Carbon Nanoparticles (Graphenes, Fullerenes, and Nanodiamond)
156(1)
2 Watson---Crick DNA Structure and DNA Nanotechnology
156(4)
3 DNA Nanotechnology as Drug Delivery
160(1)
3.1 Organic Drugs
160(1)
3.2 Enzymes
161(1)
3.3 Ribozymes, small interfering RNA, Antisense RNA, and Inhibitory RNA
161(1)
3.4 Vaccines
161(1)
4 Uses of DNA Nanotechnology in Various Diseases
161(4)
4.1 Special Discovery for Cancer
161(2)
4.2 Special Discovery for Multidrug-Resistant Bacteria
163(1)
4.3 Special Discovery for HIV and AIDS
163(1)
4.4 Special Discovery for Diabetes
163(1)
4.5 Special Discovery for Parkinson's Disease
164(1)
4.6 Special Discovery for Alzheimer's Disease
164(1)
4.7 Special Discovery for Hemophilia
165(1)
5 Discussion
165(1)
6 Conclusion
166(1)
Acknowledgments
167(1)
References
167(5)
Further Reading
172(1)
Chapter 6 Protein Nanocarriers for Targeted Drug Delivery for Cancer Therapy
173(32)
Mahadevappa Y. Kariduraganavar
Geetha B. Heggannavar
Sandra Amado
Geoffrey R. Mitchell
1 Introduction
173(1)
2 Types of Proteins
174(2)
2.1 Animal Proteins
174(1)
2.2 Plant Proteins
175(1)
2.3 Silk Proteins
176(1)
2.4 Elastin
176(1)
3 Preparation Methods of Protein Nanocarriers
176(8)
3.1 Coacervation/Desolvation
177(1)
3.2 Emulsion/Solvent Extraction
178(1)
3.3 Complex Coacervation
179(2)
3.4 Electrospray
181(1)
3.5 Nanoprecipitation
181(2)
3.6 Dialysis
183(1)
4 Preparation Methods for Hybrid Protein Nanocarriers
184(5)
4.1 Chemical Conjugation
184(1)
4.2 Desolvation---Chemical Crosslinking
185(2)
4.3 In Situ Coating
187(1)
4.4 Spray-Drying
187(1)
4.5 Miscellaneous
188(1)
5 Drag Loading Mechanism of Protein and Hybrid Nanocarriers
189(6)
5.1 Covalent Bonding
189(2)
5.2 Physical Entrapment
191(4)
6 Protein and Hybrid Protein Nanocarriers in Targeted Drug Delivery
195(3)
6.1 Albumin Nanocarriers: Targeted Drug Delivery for Solid Tumors
195(1)
6.2 PEGylated Gelatin Nanocarriers: Targeted Drug Delivery for Cancer Therapy
196(1)
6.3 Casein Nanocarriers: Targeted Drug Delivery for Tumor Growth
196(1)
6.4 Zein Nanocarriers: Targeted Drug Delivery for Breast Cancer
196(1)
6.5 Gliadin Nanocarriers: Targeted Drug Delivery for Cancer
197(1)
7 Future Prospects
198(1)
8 Conclusions
198(1)
Acknowledgments
199(1)
References
199(6)
Chapter 7 TiO2-Based Nanocarriers for Drug Delivery
205(44)
Amirali Abbasi
1 Introduction
205(1)
2 Computational Density Functional Theory Method: The Kohn---Sham Approach
206(3)
3 The Kohn---Sham Equations
209(1)
4 Computational Methods and Models of Nanoparticles
209(1)
5 Models of Nanoparticles
210(1)
6 Curcumin Interaction with TiO2 Anatase Nanoparticles
211(2)
7 Curcumin Adsorption on the N-Doped Nanoparticles (Position 1)
213(3)
8 Density of States and Molecular Orbitals
216(4)
9 Curcumin Adsorption on the N-Doped Nanoparticle (Position 2)
220(5)
10 Curcumin Adsorption on the Cu/N-Codoped Nanoparticles (Position 3)
225(4)
11 The Charge Exchange Between Adsorbed Curcumin and TiO2 Nanoparticles
229(1)
12 The Interaction of Immucillin-A With TiO2 Nanoparticles
230(8)
13 Adsorption of Immucillin-A on the N-Doped and Cu/N-Codoped TiO2 Nanoparticles
238(8)
References
246(3)
Chapter 8 Lipid-Based Nanoparticles for Drug-Delivery Systems
249(36)
Raj Kumar
1 Introduction
249(2)
2 Liposomes
251(2)
2.1 Niosomes
251(1)
2.2 Liposome Production Methods
252(1)
3 Self-Micro-/nanoemulsifying Drug-Delivery Systems
253(1)
4 Lipid Nanoparticles
254(6)
4.1 Solid Lipid Nanoparticles
254(1)
4.2 Nanostructured Lipid Carriers
255(1)
4.3 Methods for Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers
256(4)
5 Lipid-Based Nanoparticle Characterization Techniques
260(3)
5.1 Particle Size and ζ Potential
260(1)
5.2 Electron Microscopy Techniques
260(1)
5.3 Atomic Force Microscopy
261(1)
5.4 X-Ray Diffraction
261(1)
5.5 Thermal Analysis
262(1)
5.6 Infrared Spectroscopy
262(1)
5.7 Stability
262(1)
5.8 Solubility and Permeability
263(1)
6 Lipid-Based Nanoparticle Routes of Administration
263(3)
6.1 Parenteral Drug Delivery
263(1)
6.2 Oral Drug Delivery
264(1)
6.3 Rectal Delivery
264(1)
6.4 Nasal Delivery
265(1)
6.5 Respiratory Delivery
265(1)
6.6 Ocular Delivery
265(1)
6.7 Topical Delivery
265(1)
7 Lipid-Based Nanoparticle Applications in Drug Delivery
266(3)
7.1 Solid Lipid Nanoparticles in Cancer Therapy
266(1)
7.2 Solid Lipid Nanoparticles for Peptide and Protein Delivery
266(1)
7.3 Solid Lipid Nanoparticles for Targeting Brain Drug Delivery
266(1)
7.4 Solid Lipid Nanoparticles for Parasitic Diseases
267(1)
7.5 Solid Lipid Nanoparticles for Ultrasonic Drug and Gene Delivery
267(1)
7.6 Solid Lipid Nanoparticles Applied to Malaria Treatment
268(1)
7.7 Lung Diseases
269(1)
7.8 Cosmetic and Dermatological Preparations
269(1)
8 Conclusion and Future Perspectives
269(1)
Acknowledgments
270(1)
References
270(15)
Chapter 9 Mesoporous Silica-Based Nano Drug-Delivery System Synthesis, Characterization, and Applications
285(34)
Sougata Ghosh
1 Mesoporous Silica in General
285(1)
2 Synthesis and Characterization
286(5)
2.1 Ordered Mesoporous Silica
286(2)
2.2 Hollow/Rattle-Type Mesoporous Silica Nanoparticles
288(3)
3 Factors for Fabrication of Fine-Tuned Mesoporous Silica Nanoparticles
291(3)
3.1 pH of Reaction Mixture and Charge State
291(1)
3.2 Dispersion
291(1)
3.3 Solvents and Catalysts
292(1)
3.4 Surfactants
293(1)
3.5 Basic Chemicals and Sources of Silica
293(1)
3.6 Mesoporous Dimensions
293(1)
3.7 Surfactant Removal
294(1)
4 Biocompatibility
294(3)
4.1 Size
295(1)
4.2 Surface Properties
295(1)
4.3 Shape
296(1)
4.4 Structure
296(1)
5 Toxicity
297(3)
6 Functionalization Strategies
300(1)
7 Applications
300(13)
7.1 Cancer
302(3)
7.2 Antibacterial Activity
305(3)
7.3 Antifungal Activity
308(1)
7.4 Antiviral Activity
308(1)
7.5 Catalytic Activity
309(1)
7.6 Food Industry
309(1)
7.7 Controlled Release
310(1)
7.8 Sensors
311(2)
8 Patents
313(1)
9 Future Prospects
313(1)
References
314(5)
Chapter 10 Hydrogel Nanocomposite Systems: Characterization and Application in Drug-Delivery Systems
319(32)
Raffaele Conte
Adriana De Luise
Anna Valentino
Francesco Di Cristo
Orsolina Petillo
Francesco Riccitiello
Anna Di Salle
Anna Calarco
Gianfranco Peluso
1 Introduction
319(3)
1.1 Drug Delivery and Nanotechnologies
319(1)
1.2 Hydrogels
320(1)
1.3 Hydrogel Classification
320(1)
1.4 The Exigence of Hydrogel Nanocomposite Systems
321(1)
2 Hydrogel Nanocomposite Systems
322(6)
2.1 Materials Used for Hydrogel Nanocomposite Systems
322(4)
2.2 Synthetic Procedure
326(1)
2.3 Structure
326(2)
2.4 Shape
328(1)
3 Nanocomposite Hydrogel Properties
328(3)
3.1 Tensile Properties
328(1)
3.2 Compression
329(1)
3.3 Equilibrium Swelling
329(1)
3.4 Stimulus Sensitivity
329(1)
3.5 Transparency
330(1)
3.6 Optical Anisotropy
330(1)
3.7 Sliding Frictional Behaviors
330(1)
3.8 Water Contact Angles
331(1)
3.9 Porosity
331(1)
3.10 Cell Cultivation and Biocompatibility
331(1)
4 Hydrogel Nanocomposite Applications in Drug Delivery
331(9)
4.1 Nanocomposite Hydrogels From Carbon-Based Nanomaterials
332(2)
4.2 Nanocomposite Hydrogels From Polymeric Nanoparticles
334(1)
4.3 Nanocomposite Hydrogels From Inorganic Nanoparticles
335(1)
4.4 Nanocomposite Hydrogels From Metal and Metal Oxide Nanoparticles
336(3)
4.5 Next Generation of Nanocomposite Hydrogels
339(1)
5 Conclusions and Future Perspectives
340(1)
References
341(10)
Chapter 11 Mesoporous Silica as Carrier for Drug-Delivery Systems
351(24)
Raul-Augustin Mitran
Mihaela Deaconu
Cristian Matei
Daniela Berger
1 Introduction
351(2)
2 Synthesis of Mesoporous Silica Nanoparticle Carriers
353(3)
3 Applications of Mesoporous Silica in Antibiotic-Delivery Systems
356(10)
3.1 Mesoporous Silica---Based Tetracycline Drug-Delivery Systems
357(2)
3.2 Aminoglycoside---Mesoporous Silica Drug-Delivery Systems
359(3)
3.3 Mesoporous Silica Drug-Delivery Systems for Penicillin Antibiotics
362(4)
4 Perspectives and Outlook for Mesoporous Silica---Based Antibiotic-Delivery Systems
366(3)
References
369(6)
Chapter 12 Cell-Line-Based Studies of Nanotechnology Drug-Delivery Systems: A Brief Review
375(20)
Evelyn Garcia
Ravikumar Shinde
Stephanie Martinez
Ajeet Kaushik
Hitendra S. Chand
Madhavan Nair
Rahul D. Jayant
1 Introduction
375(2)
2 Nanotechnology-Based Drug-Delivery System
377(2)
3 Cell Sources and Cell Types
379(4)
3.1 Immortalized Cell Lines
379(2)
3.2 Primary Cells
381(1)
3.3 Human Cancer Cell Lines
382(1)
3.4 Mesenchymal Stem Cells
382(1)
3.5 Embryonic Stem Cells and Induced Pluripotent Stem Cells
382(1)
4 Cell-Culture-Based Assays
383(4)
4.1 Cell-Based Assay
384(2)
4.2 Microfluidic-Based Assay
386(1)
4.3 Other Nonconventional Methods for High-Throughput Screening in Drug Discovery
387(1)
5 Limitation and Challenges
387(1)
6 Conclusion and Perspectives
388(1)
Acknowledgments
389(1)
References
389(6)
Chapter 13 Nanoscale Drug-Delivery Systems: In Vitro and In Vivo Characterization
395(26)
Anthony Singer
Zein Barakat
Subhra Mohapatra
Shyam S. Mohapatra
1 Introduction
395(1)
2 In Vitro Characterization of Nanoparticles
396(7)
2.1 Importance of Characterization of Nanoparticles
396(1)
2.2 Overview of Physicochemical Characteristics
397(3)
2.3 Modalities for Physicochemical Characterization
400(3)
2.4 Challenges
403(1)
3 In Vivo Characterization Assays and Imaging
403(4)
3.1 Theranostics
404(1)
3.2 Contrast Agents, Molecular Markers, and Labels
404(1)
3.3 Imaging Techniques
405(2)
4 In Vivo Classification
407(2)
4.1 Nanotherapeutics
407(1)
4.2 Nanocarriers
407(2)
4.3 Nano-imaging and Contrast Agents
409(1)
5 Classification Based on Administration Route
409(3)
5.1 In Vivo Interactions During Administration
410(1)
5.2 Challenges of Systemic Circulation and Cellular Internalization
411(1)
6 In Vivo Characterization Based on Structural Properties
412(1)
7 In Vivo Characterization Based on Functionalization
413(1)
7.1 Optimized Administration by Functionalization
413(1)
8 Summary
414(1)
Acknowledgments
415(1)
References
415(6)
Chapter 14 Self-Nanoemulsifying Drug-Delivery System and Solidified Self-Nanoemulsifying Drug-Delivery System
421(30)
Li Li
Chun Hui Zhou
Zhi Ping Xu
1 Introduction
421(2)
2 Self-Nanoemulsifying Drug-Delivery Systems
423(7)
2.1 Natural Oils
423(2)
2.2 Surfactants
425(4)
2.3 Cosurfactants
429(1)
2.4 Optimization of SNEDDS Compositions
429(1)
3 Solidified Self-Nanoemulsifying Drug-Delivery System
430(3)
3.1 Adsorption to Solid Carriers
430(1)
3.2 Spray-Drying
430(1)
3.3 Melt Extrusion
431(1)
3.4 Extrusion---Spheronization Process
432(1)
3.5 Lyophilization (Freeze-Drying)
432(1)
4 Characterization of SNEDDSs and S-SNEDDSs
433(3)
4.1 Particle Size and ζ Potential
433(1)
4.2 Turbidity Measurement
433(1)
4.3 Emulsification Rate and Time Measurement
433(1)
4.4 Small-Angle X-Ray Scattering Measurement
434(1)
4.5 Morphology
434(1)
4.6 Crystallization of Drugs
435(1)
4.7 In Vitro Lipolysis
435(1)
4.8 Cloud-Point Measurement
435(1)
5 Drug-Release Studies
436(2)
6 Stability of SNEDDSs and S-SNEDDSs
438(1)
6.1 Centrifugation Test
438(1)
6.2 Freeze-Thaw Cycle Test
438(1)
6.3 Thermal Stress Test
438(1)
6.4 Dilution Stability
438(1)
7 Mechanism of SNEDDS Formation
438(2)
8 Application of SNEDDSs and S-SNEDDSs
440(3)
8.1 Oral Drug Delivery
440(2)
8.2 Diabetic Treatment
442(1)
8.3 Antimicrobial Activities
442(1)
9 Conclusions and Outlooks
443(1)
References
443(8)
Chapter 15 Carbon and Carbon Nanotube Drug Delivery and Its Characterization, Properties, and Applications
451(18)
Nuchnapa Tangboriboon
1 Introduction
451(1)
2 Goals of Using Drug Delivery
451(3)
3 Types of Drug Delivery
454(3)
3.1 Classical Drug-Delivery Systems
454(2)
3.2 Drugs via Cell Carriers
456(1)
4 Functions of Drug Delivery
457(1)
5 Properties of Drug Delivery
458(1)
6 Applications of Drug Delivery
458(1)
7 Case Study of Carbon Nanotube Drug Delivery
459(1)
8 Sources of Carbon
459(5)
8.1 Allotropes, Structures, Properties, and Characterization of Carbon
459(2)
8.2 Carbon Drug Delivery
461(3)
References
464(5)
Chapter 16 Carbon Nanotubes: Synthesis, Characterization, and Applications in Drug-Delivery Systems
469(62)
Guillaume Herlem
Fabien Picaud
Claude Girardet
Olivier Micheau
1 Introduction
469(1)
2 Carbon Nanotubes: Synthesis and Nomenclature
470(6)
2.1 General
470(1)
2.2 Synthesis
471(1)
2.3 Nomenclature
472(2)
2.4 Properties
474(2)
3 Functionalization
476(3)
3.1 Covalent Functionalization
476(1)
3.2 Noncovalent Functionalization
477(2)
4 Biomedical Applications
479(31)
4.1 Nanotherapeutic Delivery
479(18)
4.2 Biomedical Engineering
497(1)
4.3 Medical Imaging
498(4)
4.4 Biosensors
502(5)
4.5 Theranostics
507(2)
4.6 Computer Advanced Simulations
509(1)
5 Conclusion and Outlook
510(2)
References
512(19)
Chapter 17 Polymer-Based Nanomaterials for Drug-Delivery Carriers
531(26)
Hemant K.S. Yadav
Aiah A. Almokdad
Sumia I.M. shaluf
Manor S. Debe
1 Introduction
531(1)
2 Types of Polymer-Based Nanomaterials
532(5)
2.1 Polymeric Nanocarriers
532(3)
2.2 Polymeric Nanocomposites
535(2)
3 Methods of Preparation
537(4)
3.1 Direct Dissolution (Polymeric Micelles)
537(1)
3.2 Dialysis (Polymeric Micelles and Polymeric Nanoparticles)
537(2)
3.3 Solvent Evaporation (Polymeric Nanoparticles)
539(1)
3.4 Nanoprecipitation (Polymeric Nanoparticles)
540(1)
3.5 Interfacial Polymerization (Polymeric Nanoparticles)
541(1)
3.6 Exfoliation---Adsorption (Layered Silicate)
541(1)
3.7 Template Synthesis (Layered Silicate)
541(1)
4 Characteristics of Polymeric Nano Materials
541(2)
5 Applications
543(4)
5.1 Dendrimers in Drug Delivery
544(1)
5.2 Polymeric Nanoparticles in Drug Delivery
545(1)
5.3 Polymeric Micelles in Drug Delivery
546(1)
5.4 Hydrogels Based on Chitosan for Drug Delivery
546(1)
5.5 Lipid---Polymer Hybrid Nanoparticles in Drug Delivery
546(1)
6 Characterizations of Polymeric Nanomaterials
547(2)
6.1 Size and Encapsulation Efficiency
547(1)
6.2 Potential
548(1)
6.3 Surface Hydrophobicity
548(1)
6.4 Drug Release
548(1)
7 Ongoing Research
549(1)
8 Environment and Health Safety
550(2)
8.1 Toxicity of Some Nanomaterials
550(1)
8.2 Health Impacts
550(1)
8.3 Nanomaterials for Water Treatment
551(1)
8.4 Dendrimers in Environmental Applications
551(1)
9 Challenges and Limitations
552(1)
9.1 Accumulation
552(1)
9.2 Failure in Reaching the Core of the Tumor Cell
552(1)
9.3 The Toxicity of Some Nanomaterials
552(1)
10 Conclusion
552(1)
References
553(4)
Chapter 18 Polymeric Nanomaterials: Methods of Preparation and Characterization
557(98)
Miguel Moreno Raja
Pei Qi Lim
Yee Shan Wong
Gordon M. Xiong
Yiming Zhang
Subbu Venkatraman
Yingying Huang
1 Introduction
557(1)
2 Types of Polymers
558(13)
2.1 Natural Polymers
559(7)
2.2 Synthetic Polymers
566(5)
2.3 Polymers With FDA Approval for Use in Drug Products
571(1)
3 Polymer-Based Therapeutics for Drug Delivery
571(26)
3.1 Solid Polymeric Nanoparticles
571(7)
3.2 Self-Assembled Nanoparticles From Amphiphilic Block Copolymers
578(9)
3.3 Hybrid Particles
587(4)
3.4 Dendrimers
591(6)
4 Biomedical Applications
597(23)
4.1 Nanomedicine in Cancer
597(9)
4.2 Nanomedicine in Cardiovascular Disease
606(7)
4.3 Nanomedicine in Ocular Diseases
613(2)
4.4 Nanomedicine in Oral Delivery
615(5)
5 Challenges and Concluding Remarks
620(1)
References
621(34)
Index 655
Shyam Mohapatra is Distinguished USF Health Professor, Director of the Division of Translational Medicine at the University of South Florida. He also directs the USF Center for Research and Education in Nanobioengineering and is a Research Career Scientist at the James A. Haley VA Hospital in Tampa. He also serves as Associate Dean of Graduate Programs at the USF College of Pharmacy, and established a highly innovative Master of Science program in Pharmaceutical Nanotechnology. He has published over 170 papers and holds over 30 U.S. and international patents. He is a Fellow of the AAAAI, NAI, and AIMBE, and a 2014 inductee of the Florida Inventors Hall of Fame. Dr. Shivendu Ranjan has extensive expertise in Micro/Nanotechnology and is currently working as Head R&D and Technology Development at E-Spin Nanotech Pvt. Ltd. He has founded and drafted the concept for the first edition of the VIT Bio Summit” in 2012, and the same has been continued till date by the university. He has worked in CSIR-CFTRI, Mysuru, India as well as UP Drugs and Pharmaceutical Co. Ltd., India and IIFPT, Thanjavur, MoFPI, Govt of India. At IIFPT, Thanjavur, he was involved in a project funded by a leading pharmaceutical company, Dr. Reddys Laboratories and have successfully engineered micro-vehicles for model drug molecules. His research interests are multidisciplinary and include: Micro/Nanobiotechnology, Nano-toxicology, Environmental Nanotechnology, Nanomedicine, and Nanoemulsions. . He is the associate editor of Environmental Chemistry Letters a Springer journal of 3.59 impact factor and an editorial board member in Biotechnology and Biotechnological Equipment(Taylor and Francis). He is serving as executive editor of a journal in iMed Press, USA, and also serving as editorial board member and referee for reputed international peer-reviewed journals. He is the author of many books and edited six books. Dr. Nandita Dasgupta has vast working experience in Micro/Nanoscience and is currently working at LV Prasad Eye Institute, Bhubaneswar, India. She has exposure of working at university, research institutes and industries including VIT University, Vellore, Tamil Nadu, India; CSIR-Central Food Technological Research Institute, Mysore, India; and Uttar Pradesh Drugs and Pharmaceutical Co. Ltd., Lucknow, India and Indian Institute of Food Processing Technology (IIFPT), Thanjavur, Ministry of Food Processing Industries, Government of India. At IIFPT, Thanjavur, she was involved in a project funded by a leading pharmaceutical company, Dr. Reddys Laboratories and have successfully engineered micro-vehicles for model drug molecules. Her areas of interest include Micro/Nanomaterial fabrication and its applications in various fields medicine, food, environment, agriculture biomedical. She is the author os many books and edited more than 6 books. She has authored many chapters and also published many scientific articles in international peer-reviewed journals. She has received the Certificate for Outstanding Contribution” in Reviewing from Elsevier, Netherlands. She has also been nominated for advisory panel for Elsevier Inc., Netherlands. She is the associate editor of Environmental Chemistry Letters a Springer journal of 3.59 impact factor and also serving as editorial board member and referee for reputed international peer-reviewed journals. She has received several awards and recognitions from different national and international organizations. Dr. Sabu Thomas (Ph.D.) is the Director of the School of Energy Materials, School of Nanoscience and Nanotechnology of Mahatma Gandhi University, India. He received his Ph. D. in 1987 in Polymer Engineering from the Indian Institute of Technology (IIT), Kharagpur, India. He is a fellow of the Royal Society of Chemistry, London, and a member of the American Chemical Society. He has been ranked no.1 in India about the number of publications (most productive scientists). Prof. Thomass research group specialized areas of polymers which includes Polymer blends, Fiber filled polymer composites, Particulate-filled polymer composites and their morphological characterization, Ageing and degradation, Pervaporation phenomena, sorption and diffusion, Interpenetrating polymer systems, Recyclability and reuse of waste plastics and rubbers, Elastomer cross-linking, Dual porous nanocomposite scaffolds for tissue engineering, etc. Prof. Thomass research group has extensive exchange programs with different industries, research, and academic institutions all over the world and is performing world-class collaborative research in various fields. Professors Centre is equipped with various sophisticated instruments and has established state-of-the-art experimental facilities which cater to the needs of researchers within the country and abroad. His H Index- 133, Google Citations- 86424, Number of Publications- 1300, and Books-160.

Raghvendra Kumar Mishra is a Materials Scientist in the Chemical Engineering Department at IIT Delhi, India, and he has previously held research positions at Cranfield University (United Kingdom), Madrid Institute of Advanced Studies (Spain), and Mahatma Gandhi University (India). His research interests focus on nanomaterials and polymer composites, including new applications of nanomaterials, developing nanomaterials-based systems for diverse functionalities, creating biopolymer-based composites, and utilizing advanced fabrication techniques such as electrospinning and 3D printing.