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Nanocarriers for Organ-Specific and Localized Drug Delivery [Pehme köide]

(Professor, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University, Karachi, Pakistan), (International Center for Chemical and), (Associate Professor, University of Karachi, Pakistan)
  • Formaat: Paperback / softback, 270 pages, kõrgus x laius: 235x191 mm, kaal: 450 g
  • Sari: Micro & Nano Technologies
  • Ilmumisaeg: 08-Apr-2022
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128210931
  • ISBN-13: 9780128210932
Teised raamatud teemal:
  • Formaat: Paperback / softback, 270 pages, kõrgus x laius: 235x191 mm, kaal: 450 g
  • Sari: Micro & Nano Technologies
  • Ilmumisaeg: 08-Apr-2022
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128210931
  • ISBN-13: 9780128210932
Teised raamatud teemal:
Organ-specific drug delivery is aimed at achieving increased concentration of therapeutic molecules at target sites with minimum side effects on other healthy tissues. Similarly, drug-specific delivery to some vital organs, such as the brain, lungs, heart and kidneys remains a challenging task for the formulation scientists. Oral delivery of most of the commercially available life-saving drugs has also been impeded by various physio-chemical and biological barriers. These advancements in nanotechnology have led to the development of various pharmaceutical nanocarriers.

Nanocarriers for Organ-Specific and Localized Drug Delivery summarizes targeted drug delivery systems and approaches to the major organs of the body. The book shows how drugs can be specifically targeted to the pathological area within an organ in a viable way. Employing pharmaceutical nanocarriers for drug delivery targeted to specific organs of the body requires a comprehensive knowledge of the disease site’s pathophysiology as well as physical, chemical and pharmaceutical techniques for modification or functionalization of the nanocarriers.

Combining theoretical principles and practical applications of various nanocarriers for organ-specific drug delivery, this is an important reference source for all those seeking to increase their understanding of how pharmaceutical nanocarriers are being used to create more efficient drug delivery systems.
  • Outlines the underlying principles for the design of advanced pharmaceutical nanocarriers for organ specific drug delivery
  • Includes guidance on how to exploit the pathophysiology and microenvironment of the diseased sites for targeted drug delivery
  • Assesses the major challenges for creating pharmaceutical nanocarriers on a mass scale
Chapter 1 Nanocarriers in drug delivery: Classification, properties, and targeted drug delivery applications
1(24)
Introduction
1(1)
Classification of nanocarriers
2(1)
Organic and polymer-based nanocarriers
3(6)
Inorganic nanocarriers
9(3)
Absorption mechanisms of nanocarriers-based drugs
12(1)
Paracellular route
13(1)
Transcellular route
14(1)
Release mechanisms of nutraceuticals from nanocarrier
15(1)
Conclusion
16(1)
References
17(8)
Chapter 2 Nanocarriers systems for brain targeted drug delivery and diagnosis
25(20)
Introduction
25(1)
The blood-brain barrier (BBB)
26(2)
Barriers to brain drug delivery
28(1)
Nanocarriers for brain drug delivery
29(2)
Viral vectors
31(1)
Liposomes
31(1)
Solid lipid nanoparticles
32(1)
Polymeric nanoparticles
33(1)
Polymeric micelles
34(1)
Dendrimers
35(1)
Micelles
36(1)
Carbon nanotubes
37(1)
Carbon nano-onions
37(1)
Carbon dots
38(1)
Conclusions and outlook
39(1)
References
40(5)
Chapter 3 Designing of nanocarriers for liver targeted drug delivery and diagnosis
45(32)
Introduction
45(1)
Physiochemical and biological characteristics of HCC
46(1)
Morphology and HCC structure
46(6)
Nanocarriers (NCs)
52(1)
Organic nanocarriers
53(8)
Inorganic nanocarriers
61(4)
Conclusion
65(1)
References
66(11)
Chapter 4 Nanocarriers-based improved drug delivery for treatment and management of cardiovascular diseases
77(26)
Introduction
77(1)
Nanostructure mediated drug delivery for cardiovascular diseases
78(1)
Nanocarriers in cardiac arrhythmias
78(4)
Nanocarriers in thrombosis
82(2)
Nanocarriers in atherosclerosis
84(4)
Nanocarriers in aortic aneurysm and other aortic diseases
88(2)
Nanocarriers in ischemic heart disease and myocardial infarction
90(2)
Conclusion
92(3)
References
95(8)
Chapter 5 Improved pulmonary drug delivery through nanocarriers
103(32)
Introduction
103(1)
Pulmonary delivery of drugs and lung physiology
104(2)
Types and classification of nanocarriers used in drug delivery
106(1)
Organic-based drugs carriers
107(4)
Inorganic nanocarriers
111(1)
Organic/inorganic hybrid nanocarriers
112(1)
General characteristics of nanocarriers
112(1)
Drug loading and site-specific targeting
113(1)
Nanocarrier's mechanism and criteria for successful deposition within the respiratory tract upon inspiration
114(1)
Nanocarriers' mechanism of action and deposition in the respiratory tract upon inspiration
115(1)
Nanocarriers interaction with lungs' epithelia and macrophages
115(2)
Nanocarriers' interaction with lung surfactant
117(1)
Nanocarriers' retention and clearance mechanisms in lungs
118(1)
Toxicological aspects of inhaled nanocarriers
119(1)
Pulmonary drug delivery applications of nanocarriers
120(1)
Polymeric nanoparticles (PNs) in pulmonary drug delivery
120(1)
Liposomes in pulmonary drug delivery
121(1)
Solid lipid nanoparticles in pulmonary delivery
122(1)
Dendrimer-based nanocarriers in pulmonary delivery
123(1)
Carbon nanotubes (CNTs) for pulmonary drug delivery
124(1)
Conclusion
124(1)
References
125(8)
Further reading
133(2)
Chapter 6 Transdermal drug delivery nanocarriers for improved treatment of skin diseases
135(32)
Introduction
135(1)
Skin anatomy
136(1)
Epidermis
136(1)
Dermis
137(1)
Subcutaneous tissues
138(1)
Human skin function
138(1)
Pathways of skin penetration
139(1)
Transepidermal pathway
139(1)
Transappendageal pathway
140(1)
Transdermal drug delivery (TDD)
140(1)
Strategies to overcome skin barriers
141(1)
Passive penetration enhancement techniques
142(5)
Nanoparticles
147(1)
Polymeric nanoparticle
148(2)
Dendrimers
150(1)
Active permeation enhancement techniques
151(4)
Application of TDDS for the treatment of skin diseases
155(1)
Melanoma
155(2)
Acne
157(1)
Psoriasis
157(1)
Wound healing
157(1)
Conclusion
158(1)
References
159(8)
Chapter 7 Targeted nano drug delivery systems for renal disorders
167(10)
Introduction
167(1)
Targeted nanocarriers for renal tubulointerstitial diseases
168(1)
Targeted nanocarriers for glomerular diseases
169(2)
Targeted nanocarriers for renal cell carcinoma
171(1)
Conclusion
172(1)
References
172(3)
Further reading
175(2)
Chapter 8 Designing of nanocarriers for enhancing drugs absorption through gastrointestinal tract
177(32)
Introduction
177(2)
Biological barriers to oral drug delivery
179(2)
Absorption mechanisms of nanocarriers in intestine
181(1)
Transcellular transport
182(2)
Paracellular transport
184(1)
Design considerations for nanocarriers to a specific section of the GI tract
184(1)
Stomach targeting
185(1)
Small intestine targeting
185(1)
Intestinal lymphatic targeting
186(1)
Colon targeting
187(1)
Nanocarriers for enhancing intestinal drug absorption
188(1)
Polymeric nanoparticles
189(3)
Lipid or oil based drug carriers
192(3)
Strategies for intestinal transport improvement of drug nanocarriers
195(1)
Mucoadhesive nanoparticles
195(1)
Permeation enhancer nanoparticles
196(1)
Coated nanoparticles
196(1)
Mucolytic nanoparticles
197(1)
Targeted nanoparticles
197(1)
Conclusions and future perspectives
198(1)
References
199(10)
Chapter 9 Nanomaterials as promising therapeutic platform for bone tissues engineering
209(16)
Introduction
209(3)
Nanoparticle-based delivery in bone tissues engineering
212(1)
Desired features of nanomaterials for bone tissues engineering
213(1)
Natural polymers based nanomaterials for bone tissues engineering
214(1)
Natural polymers in bone development
214(2)
Synthetic biodegradable polymers based nanomaterials for tissue bone regeneration
216(1)
Inorganic nanoparticles for bone tissues engineering
216(3)
Conclusion
219(1)
References
219(6)
Chapter 10 Overcoming ocular barriers through nanocarrier-based drug delivery systems
225(20)
Introduction
225(2)
Nanocarrier based ocular drug delivery system
227(1)
Anterior ocular drug delivery
227(5)
Posterior ocular drug delivery
232(8)
Conclusion
240(1)
References
241(4)
Chapter 11 Organ-specific toxicities of nanocarriers
245(10)
Introduction
245(1)
Nanotoxicology
246(1)
Organ-/tissue-specific nanotoxicity
247(1)
Toxicity in the pulmonary system
247(1)
Toxicity in cardiovascular systems
248(1)
Toxicity in hepatocellular system
249(1)
Toxicity in the renal system
249(1)
Conclusion
250(1)
References
251(4)
Index 255
Muhammad Raza Shah is a full professor at the International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research. He is a recipient of several awards, including the Tamgha-i-Imtiaz Award from the President of Pakistan, the Salam Prize, the Professor Atta ur Rahman Gold Medal, and the Dr M Raziuddin Siddiqi Prize, by the Pakistan Academy of Sciences, for scientists under 40 years of age, in the field of chemistry. Professor Shah has authored six books and edited four books, in addition to contributing over 350 peer-reviewed journal papers. One of his authored books was declared as best book of 2017 by the Government of Pakistans Higher Education Commission. Dr. Muhammad Imran Malik is an Associate Professor at the HEJ Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Pakistan. He received his doctorate in polymer chemistry at Karl-Franzens-Universitäte, Graz, Austria, in 2009, and subsequently worked as a post-doctoral research scientist, at the University of Stellenbosch, South Africa, and at POSTECH, in South Korea, with his research focusing on analytical polymer science. In 2012, he joined the International Center of Chemical and Biological Sciences at the University of Karachi as an Assistant Professor. Dr. Maliks main research interests are the synthesis of novel polymeric architectures and the development of comprehensive analytical methods for polymers, as well as polymer-stabilized nanoparticles and their applications, such as sensors, drug delivery, molecularly imprinted polymers, and organic solar cells. Shafi Ullah is a graduate student and based at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan.