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Nanomaterials in Advanced Medicine [Kõva köide]

  • Formaat: Hardback, 224 pages, kõrgus x laius x paksus: 249x173x13 mm, kaal: 590 g
  • Ilmumisaeg: 17-Apr-2019
  • Kirjastus: Blackwell Verlag GmbH
  • ISBN-10: 3527345493
  • ISBN-13: 9783527345496
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Nanomaterials in Advanced MedicineSuurem pilt
  • Formaat: Hardback, 224 pages, kõrgus x laius x paksus: 249x173x13 mm, kaal: 590 g
  • Ilmumisaeg: 17-Apr-2019
  • Kirjastus: Blackwell Verlag GmbH
  • ISBN-10: 3527345493
  • ISBN-13: 9783527345496
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9783527345496.html
A comprehensive and multidisciplinary review of the fundamental concepts and medical applications of nanomaterials development technology

Nanomedicine offers a range of multi-interdisciplinary approaches and brings together the field of chemistry, pharmaceutical science, biology, and clinical medicines by focusing on design and preparation of biodegradable or non-biodegradable biomaterials for their biological, medical, and pharmaceutical applications. Nanomaterials in Advanced Medicine reviews the concepts and applications of the combination of the technology of biology and engineering that are emerging as an integral aspect of today s advanced medicine. Nanomedicine provides the technology for imaging, cancer treatment, medical tools, bone treatment, drug delivery, diagnostic tests, drug development, angiogenesis and aims to exploit the improved and often novel physical, chemical, and biological properties of materials at the nanometer scale.

Designed to provide a broad survey of the field, Nanomaterials in Advanced Medicine is divided into three main sections: Nanophysics, Nanochemistry, and Nanomedicine. Each chapter describes in detail the most current and valuable methods available and contains numerous references to the primary literature. This important book:

-Offers a field guide for biologists and physicians who want to explore the fascinating world of nanotechnology
-Contains a comprehensive review of the topic from a noted expert in the field
-Includes an introduction to nanotechnology and explores the synthesis, structure and properties of various types of nanobiomaterials
-Bridges the gap between various aspects of nanomaterials? development technology and their applications

Written for pharmaceutical chemists, biotechnologists, life scientists, materials scientists, polymer chemists, and biochemists, Nanomaterials in Advanced Medicine provides a must-have guide to the fundamental concepts and current applications of nanomaterials in the medical field.
Preface ix
1 Introduction to Nanotechnology
1(10)
1.1 Introduction
1(1)
1.2 Importance of Size in Nanotechnology
2(1)
1.3 Approaches in Nanotechnology
2(2)
1.3.1 Top-Down Approach
2(1)
1.3.2 Bottom-Up Approach
3(1)
1.4 Impact of Nanotechnology
4(2)
1.4.1 Sensors for the Automotive Industry
4(1)
1.4.2 Health and Medicine
5(1)
1.4.3 Energy and Environment
5(1)
1.4.4 National Security
5(1)
1.5 Nanotechnology Applications
6(1)
1.5.1 Information Technology
6(1)
1.5.2 Energy
6(1)
1.5.3 Medicine
6(1)
1.5.4 Consumer Goods
6(1)
1.6 Summary and Challenges
6(5)
References
8(3)
2 Biomaterials in Medicine
11(36)
2.1 Introduction
11(9)
2.2 Biodegradable Polymers
20(5)
2.3 Natural Biomaterials
25(14)
2.3.1 Gelatin
26(1)
2.3.2 Pectin
27(1)
2.3.3 Chitosan
28(1)
2.3.4 Cyclodextrins (CDs)
29(1)
2.3.5 Dextran, Dextran--Spermine (D-SPM)
30(2)
2.3.6 Miscellaneous Polysaccharide Polymers
32(1)
2.3.6.1 Pullulan
32(1)
2.3.6.2 Schizophyllan
33(1)
2.3.6.3 Alginic Acid
33(1)
2.3.6.4 Hydroxypropyl Cellulose
33(1)
2.3.6.5 Glycosaminoglycans
33(2)
2.3.7 Modified Polysaccharides as Gene Delivering Agents
35(3)
2.3.8 Cationic Lipid
38(1)
2.4 Biodegradable Nanoparticles
39(8)
References
40(7)
3 Classification of Nanomaterials
47(16)
3.1 Introduction
47(1)
3.2 Classification of Nanomaterials
48(6)
3.2.1 Nanoparticles
48(1)
3.2.2 Nanofibers, Nanowires, and Nanorods
49(3)
3.2.3 Self-assembly of Proteins and Peptides
52(2)
3.3 Nanocarriers
54(5)
3.3.1 Nanocarriers in Gene Therapy Technology
54(1)
3.3.2 Nanocarriers in siRNA Technology
55(2)
3.3.3 Colloidal Carrier System
57(2)
3.3.4 Nanoparticulate System
59(1)
3.4 Nanoscaffolding Materials
59(4)
References
60(3)
4 Nanomaterials in Gene Therapy Technology
63(46)
4.1 Introduction
63(1)
4.2 Approaches to Gene Therapy
64(14)
4.2.1 Viral Vectors for Gene Delivery
64(1)
4.2.2 Nonviral Vectors for Gene Delivery
65(1)
4.2.2.1 Cationic Polymers
65(7)
4.2.2.2 Cationic Lipid
72(1)
4.2.2.3 Conventional Phosphate Method
72(1)
4.2.2.4 Cell-Receptor-Mediated Uptake
72(6)
4.3 Physical Methods for Gene Delivery
78(2)
4.4 Combination of Physical and Nonviral Methods to Enhance DNA Nanoparticle Uptake by the Cells
80(11)
4.5 Summary
91(18)
References
92(17)
5 Nanomaterials in Gene-Silencing Technology
109(8)
5.1 Introduction
109(1)
5.2 Gene Silencing
110(1)
5.2.1 siRNAs
110(1)
5.2.2 shRNAs
110(1)
5.2.3 miRNAs
111(1)
5.3 Approaches to siRNA Delivery Systems
111(2)
5.4 siRNA Technology in Cancer Therapy
113(1)
5.5 Future Prospects
114(3)
References
114(3)
6 Imaging Technology
117(16)
6.1 Introduction
117(2)
6.2 Polymeric Nanoparticles in MRI Technology and Disease Therapy
119(2)
6.3 Surface-Coating Polymer in Nanoparticles
121(1)
6.4 Drug Delivery with Polymeric Nanoparticles
122(1)
6.5 Stimuli-Sensitive Drug Delivery
123(1)
6.6 Multifunction of Targeted Drug Delivery
124(1)
6.7 Gene Transfer via Polymeric Nanoparticles in Drug Delivery
124(1)
6.8 Magnetic Hyperthermia
125(1)
6.9 Future Prospects
126(7)
References
126(7)
7 Nanotechnology in Natural Hydrogel
133(18)
7.1 Introduction
133(1)
7.2 Mechanical Properties of Hydrogels and Interpenetrating Networks
134(4)
7.3 Engineering Hydrogels with Controlled Mechanical, Chemical, and Biological Properties
138(1)
7.4 Developing Methods of Fabricating Composite Biodegradable Hydrogels Using IPNs
139(3)
7.5 Engineering Approaches to Deliver Growth Factors from Hydrogels
142(1)
7.6 Drug Delivery Systems Using Polymeric Hydrogel
143(3)
7.7 RNA-Responsive Hydrogels
146(1)
7.8 DNA-Responsive Hydrogels
146(1)
7.9 Aptamer-Responsive Hydrogels
147(4)
References
148(3)
8 Nanotechnology in Tissue Engineering
151(36)
8.1 Introduction
151(2)
8.2 3D In vitro Systems
153(7)
8.2.1 Porous Scaffolds
153(3)
8.2.2 Hydrogels
156(2)
8.2.3 Self-assembly of Proteins
158(2)
8.3 Cellular Microenvironment
160(2)
8.3.1 Extracellular Matrix
160(1)
8.3.2 Cellular Microenvironment (Niche)
160(1)
8.3.3 Nerve Tissue
161(1)
8.4 3D Technology on Frontier of Neuroscience
162(5)
8.4.1 Tissue Engineering
162(2)
8.4.2 Development of 3D In vitro Cell Culture Technology
164(1)
8.4.3 Nerve Regeneration in 3D Models
164(2)
8.4.4 Nanotechnology in Neuroscience
166(1)
8.5 Regenerative Medicine Therapy
167(12)
8.5.1 Specific Mediated Nanomaterials
167(1)
8.5.1.1 Three-Dimensional Peptide Matrices
168(1)
8.5.1.2 In vitro Biological Approaches of Self-Assembled Systems
169(1)
8.5.1.3 Antimicrobial Activities
169(1)
8.5.1.4 Cell Culture Scaffold for Tissue Engineering
170(1)
8.5.1.5 Drug and Gene Delivery
171(3)
8.5.2 Biomineralization Materials
174(1)
8.5.3 Self-Assembled Systems in Regenerative Medicine Therapy
174(1)
8.5.4 Enhancement of Angiogenesis in Self-Assembled Systems
175(3)
8.5.5 Enhancement of Bone Regeneration in Self-Assembled Systems
178(1)
8.5.6 Other Forms of Self-Assembled Systems in Regenerative Medicine
178(1)
8.6 Future Prospects
179(8)
References
180(7)
9 Safety Issue of Nanomaterials
187(16)
9.1 Introduction
187(1)
9.2 Biocompatibility and Toxicity of Nanomaterials
188(3)
9.2.1 In vitro Biological Approaches of Nanomaterials
188(2)
9.2.2 Cell Cytotoxicity Assay
190(1)
9.2.3 Chemical Reference Standard
190(1)
9.3 Safety Issue of Nanomaterials
191(3)
9.3.1 Quality Assurance Statement
191(1)
9.3.2 Environmental, Health, and Safety Issues of Nanomaterials
192(1)
9.3.3 Biohazard of Nanomaterials
193(1)
9.4 Limitations of Nanomaterials Technology in Nature and Medicine
194(1)
9.5 Future Prospects
195(8)
References
196(7)
Index 203
Dr. Hossein Hosseinkhani is an expert in nanotechnology, biomaterials, drug delivery, 3D in vitro systems, bioreactor technology, and bioengineering stem cells technology. He has experience in both academia and industry in biomedical engineering research and development, which includes several years of basic science research experience in a number of premier institutions related to the structure and function of biomaterials, and in polymer-based and mineral-based medical implants development in the medical device industry.