Nanosafety encompasses a spectrum of multidisciplinary studies, including nanotoxicology, immunotoxicology, genotoxicity, and epigenetic effects. Nanomaterials, with their unique properties and diverse applications, have revolutionized industries from medicine to electronics. However, the potential risks associated with their use demand meticulous investigation and understanding. This open access book serves as a crucial resource, bridging the gap between the burgeoning field of nanotechnology and the imperative need to ensure the safety of nanomaterials in various contexts. As nanotechnology continues to transform our world, this book provides invaluable insights and guidance for researchers, policymakers, and industries, ensuring the responsible and safe development of nanomaterials and their applications in the 21st century.
Nanotoxicology probing established paradigms using innovative
approaches.- Use of sensors to provide real time assessment of cellular
responses to nanomaterials in in vitro systems.- Recreating physi logical
events using advanced in vitro models.- Emerging strategies for nanosafety
assessment the power of multiplexing.- Genotoxicity and Epigenetics How
nanomaterials interact with DNA and gene expression.- Section Two Bridging in
vitro in vivo models Assessing nanomaterial hazard with lower tier organisms,
reducing reliance on rodent models and ensuring sustainability in nanosafety
approaches.- Caenorhabditis elegans as a model organism to probe nanosafety
from morphological to molecular approach.- Drosophila melanogaster a dynamic
in vivo model to study nano bio interactions.- Zebrafish embryos as a tool
for nanomaterials hazard assessment.- Daphnia as a model organism in
econanotoxicity assessment from individual to population effects.- Organ on a
chip and nanosafety The latest in vitro platforms to predict hazard and
streamline nanosafety assessment.- Skin on a chip.- Lung on a chip.- Gut on a
chip.- Systems on a chip.- Computational approaches to nanosafety From
traditional QSAR to Artificial Intelligence and Life Cycle Assessment.-
Leveraging Opportunities for Computer Aided Nanosafety Integrating Nano QSTR
with AI Generalized Read Across Models.- Advanced Structure Based Docking
Protocols for Complex Nano Mixtures Risk Assessment.- Building Multiple
Machine Learning Classifiers to Address Nanomaterial Risks Assessment.- Life
Cycle Assessment a broader view of nanomaterials beyond biological effects.
Dr. Ernesto Alfaro-Moreno obtained his Ph.D. in Biomedicals Sciences (2004). From 2006 to 2008 he was a postdoctoral fellow at the Lung Toxicology Unit of the K.U. Leuven, developing novel in vitro models to assess lung-vascular communication. From 2008 until 2015, he was head of the Environmental Health Laboratory at the National Cancer Institute of Mexico. From 2015, until 2020, he led a project on Inhaled Particles, at Swetox/Karolinska Institutet. Since June 2020, he leads the Nanosafety Group at the International Iberian Nanotechnology Laboratory (INL). He has published over 40 articles in the field of inhaled particles, air pollution and nanosafety, with over 2,600 citations.
Dr. Fiona Murphy is a Lecturer in Immunology and Pharmacology at the Strathclyde Institute of Pharmacy and Biomedical Sciences at University of Strathclyde. She received her Ph.D. in Particle Toxicology at the University of Edinburgh, under the supervision of Prof Ken Donaldson. From 2011-2014, she was a postdoctoral fellow at the MRC Toxicology Unit in Leicester, UK. From 2014-2018, she was a research assistant at the Centre for Inflammation Research at University of Edinburgh. From 2018-2022, she was a postdoctoral research associate at Heriot-Watt University in the NanoSafety group developing Integrated Approaches for Testing and Assessment to support grouping and read-across of nanomaterial hazard. Fionas current research focuses on the development of physiologically-relevant in vitro models to reduce the reliance on rodent models for hazard assessment of novel materials and to improve our understanding of the underlying mechanism of particle-related lung disease.
