This book is the first to summarize the progress of research on neural functions of the the delta opioid receptor (DOR) to date. This receptor, a member of the opioid receptor family, was traditionally thought to be primarily involved in pain modulation. Recent new findings have shown its unique role in neuroprotection and many other functions. Many scientists from a number of independent laboratories have now confirmed that DOR can provide neuroprotection against hypoxic/ischemic injuries. They have also found that it plays a role in a variety of physiological and pathophysiological events such as hypoxic encephalopathy, epilepsy, acupuncture, Parkinson's disease, etc. by regulating ionic homeostasis, glutamate transportation and signaling, and balancing intracellular survival/death signals. The book will provide a comprehensive overview of the current state of DOR research and provide a blueprint for future directions.
Arvustused
Recent development in research dedicated to the function of -opioid receptors (DORs) is reviewed in this book. Book may serve for graduated as well as undergraduated students who wish to get better insight into topics covered by individual chapters. It will be indispensable reference book for scientists working on any aspect of opioid research. (Lubica Lacinova, General Physiology and Biophysics, Vol. 35 (4), 2016)
Preface.- Current research on the -opioid receptor: From
neuroprotection against hypoxia/ischemia to broad neural functions.- Recent
history on delta opioid receptors and ligands: Biased mechanisms, and opioid
delta-mu and delta-kappa receptor heteromers.- Evolutionary distribution of
the -Opioid Receptor: from invertebrates to humans.- Developmental
distribution of the -opioid receptor in mammalian brains.- The Role of
-opioid receptors in brain ionic homeostasis under physiological
condition.- The -opioid receptor and stabilization of brain ionic
homeostasis in hypoxia/ischemia.- Regulation of membrane transporters by
delta-opioid receptors.- Neuroprotective interactions between delta-opioid
receptors and glutamatergic signaling mediate hypoxia-tolerance in
brain.- -Opioids and Neurogenesis.- Delta Opioid Receptor and Peptide:
Hibernation for Stroke Therapy.- An important role of the -opioid receptor
in electroacupuncture-induced protection against ischemic brain
injury.- Delta Opioid Receptor in Cerebral Preconditioning.- Delta-opioid
receptor-mediated protection and mitochondria.- The delta-opioid system in
the brain: A neglected element in Parkinsons disease?.- Are -opioid
receptors involved in deep brain stimulation?.- Acupuncture, opioid receptors
and Na+ channels: A novel insight into inhibition of epileptic
hyperexcitability.- Delta Opioids in Protection of the Heart and Brain.- The
Various Functions of Opioids in Pathophysiological Conditions.
Dr. Ying Xia is Professor and Vice-Chairman for Research of the Department of Neurosurgery at The University of Texas Medical School at Houston, and Professor of Neuroscience at The University of Texas at Houston Graduate School of Biomedical Sciences. He obtained his medical training at Soochow Medical College, China and his Master Degree of Medicine and Doctoral Degree of Medical Science (Ph.D.) in Neurobiology and Integrative Medicine at Shanghai Medical University, China. Dr. Xia joined Yale University School of Medicine for his postdoctoral training and established his laboratory at Yale. During his 22-year academic career at Yale University School of Medicine, he was appointed as a faculty member in 1993 and promoted to Associate Professor in 2002. He joined the University of Texas Medical School at Houston in May 2010.
Dr. Xias research has been consecutively supported by various funding agencies such as NIH, America Heart Association, March of Dimes Foundation, Cerebral Palsy Foundation and The Vivian L. Smith Neurologic Foundation since the establishment of his laboratory. He has been invited to deliver speeches by many academic institutions and international conferences. He is a reviewer for many international journals and serves as a grant reviewer for NIH, US National Science Foundation, other American and European foundations, Hong Kong University Grants Committees, and Natural Science Foundation of China.
