The overall prognosis for patients with gastric cancer remains poor as tumors are often diagnosed at an advanced stage, despite new developments and technical advances in endoscopic diagnosis and therapy. This publication brings together leading experts in the fields of basic research and clinical management of gastric cancer, to share their expertise with the clinical community. State-of-the-art reviews discuss the pathogenesis of and the most important risk factors for the development of gastric cancer, potential benefits of chemoprevention and Helicobacter pylori eradication. Moreover, new diagnostic modalities and surgical therapy, including the potential benefits of neoadjuvant and adjuvant therapies, are presented. As most patients require palliative therapy because of locally advanced or metastasized cancers, several reviews are dedicated to advances in the chemotherapy of advanced gastric cancers and peritoneal metastasis. Finally, future approaches towards a molecular diagnosis and therapy are described. Those involved in the management of gastric cancer patients will find the information presented in this publication of utmost help and will benefit greatly for their daily routine.
Editorial: Ebert, M.; Malfertheiner, P.; Review Articles; Gastric
Cancer: Who Is at Risk? Zagari, R.M.; Bezzoli, F.; Pathogenesis of
Pre-Neoplastic Lesions of the Stomach: Targets for Prevention: Leung, W.K.;
Sung, J.J.Y.; Prevention of Gastric Cancer by Helicobacter pylori
Eradication: Leodolter, A.; Naumann, M.; Malfertheiner, P.; Chemoprevention
of Gastric Cancer: Role of COX-2 Inhibitors and Other Agents: Nardone, G.;
Rocco, A.; New Diagnostic Approaches for Early Detection of Gastric Cancer:
Sugano, K.; Sato, K.; Yao, K.; Novel Endoscopic Imaging Techniques toward in
vivo Observation of Living Cancer Cells in the Gastrointestinal Tract: Inoue,
H.; Kudo, S.; Shiokawa, A.; Update on Surgery of Gastric Cancer: New
Procedures versus Standard Technique: Katal, H.; Sano, T.; Sasako, M.;
Fukagawa, T.; Saka, M.; (Neo)Adjuvant Strategies of Advanced Gastric
Carcinoma: Time for a Change? Moahler, M.; Schlmanski, C.C.; Gockel, I.;
Junginger, T.; Galle, P.R.; Endoscopic Palliation and Nutritional Support in
Advanced Gastric Cancer: Dormann, A.J.; Recent Developments in Chemotherapy
of Advanced Gastric Cancer: Gotze, T.; Schutte, K.; Rocken, C.;
Malfertheiner, P.; Ebert, M.P.A.; Treatment of Peritoneal Carcinomatosis in
Gastric Cancers: Brigand, C.; Arvieux, C.; Gilly, F.N.; Glehen, O.; Gene
Therapy and Virotherapy of Gastric Cancer: Preclinical Results and Clinical
Developments: Heideman, D.A.M.; Recent Advances in Molecular Diagnosis and
Therapy of Gastric Cancer: Chen, J.; Rocken, C.; Malfertheiner, P.; Ebert,
M.P.A.; Original Papers; Helicobacter pylori Seropositivity and
Atherosclerosis Risk Factors: Koksal, A.; Ekmekci, Y.; Karadeniz, Y.; Koklu,
S.; Apan, T.; Yilmaz, M.; Sezikli, M.; Unal, B.; Demirel, T.; Yildiz, A.;
Down-Regulation of Secretory Leukocyte Protease Inhibitor Expression in
Gastric Mucosa is a General Phenomenon in Helicobacter pylori-Related
Gastroduodenal Diseases: Wex, T.; Sokic-Milutinovic, A.; Todorovic, V.;
Bjelovic, M.; Milosavljevic, T.; Pesko, P.; Malfertheiner, P.; Subtotal
Esophageal Resection in Motility Disorders of the Esophagus: Gockel, I.;
Kneist, W.; Eckardt, V.F.; Oberholzer, K.; Junginger, T.
