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1 Pathophysiology of Allergic and Irritant Contact Dermatitis |
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3 | (8) |
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3 | (1) |
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1.2 Pathophysiology of Irritant and Allergic Skin Inflammation |
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4 | (2) |
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1.2.1 Irritant and/or Allergic Chemicals |
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5 | (1) |
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1.2.2 Skin Irritation: Activation of Innate Immunity |
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5 | (1) |
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1.3 Skin Allergy: The Role of Specific Immunity |
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6 | (1) |
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1.3.1 Antigen-Specific Immunity |
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6 | (1) |
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1.3.2 Skin Allergy: Mechanisms of Action |
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7 | (1) |
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1.3.3 Indirect Responsibility of Chemicals in Skin Irritation |
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7 | (1) |
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1.4 Pathophysiology of Skin Inflammation: The Connection Between Innate and Acquired Immunity |
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7 | (4) |
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9 | (2) |
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2 Diseases for Which Patch Testing Is Recommended: Patients Who Should Be Investigated |
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11 | (28) |
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2.1 Allergic Contact Dermatitis |
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11 | (3) |
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2.1.1 Clinical Signs and Symptoms |
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11 | (2) |
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2.1.2 Histopathological Features |
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13 | (1) |
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2.2 Allergic Contact Dermatitis Syndrome |
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14 | (11) |
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16 | (2) |
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18 | (3) |
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21 | (4) |
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2.3 Allergic Contact Dermatitis Versus Irritant Contact Dermatitis: Criteria for Differential Diagnosis |
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25 | (1) |
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2.4 Other Skin Diseases in Which Patch Testing Is of Major Interest |
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25 | (2) |
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2.5 Algorithmic Approach: Key Role of Patch Testing |
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27 | (1) |
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2.6 Hand Dermatitis: Definition and Procedures Applied in Differential Diagnosis |
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28 | (11) |
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2.6.1 Hand Dermatitis: Exogenous and Endogenous Factors |
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28 | (1) |
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2.6.2 A Classification of Hand Dermatitis |
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29 | (4) |
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2.6.3 Tools of Investigation |
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33 | (1) |
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2.6.4 Hand Dermatitis: Some Examples of an Algorithmic Approach |
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34 | (1) |
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2.6.5 Hand Eczema: A Controversial Issue |
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34 | (2) |
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36 | (3) |
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3 Patch Testing Methodology |
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39 | (46) |
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3.1 Historical Background |
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39 | (1) |
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40 | (1) |
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3.2.1 Requirements for an Ideal Patch Testing Procedure |
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40 | (1) |
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3.2.2 Is Patch Testing the "Gold Standard" to Investigate Patients with Allergic Contact Dermatitis? |
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41 | (1) |
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41 | (10) |
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3.3.1 Nonchamber Patch Tests |
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41 | (1) |
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3.3.2 Chamber Patch Tests |
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42 | (3) |
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3.3.3 Plastic Square Chambers |
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45 | (6) |
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3.3.4 Reinforcement of Patch Test Units |
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51 | (1) |
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3.4 A General Overview of Allergens |
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51 | (4) |
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51 | (1) |
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3.4.2 Bioavailability of Allergens |
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52 | (1) |
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3.4.3 Quality Control of Allergens |
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53 | (1) |
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3.4.4 Appropriate Amounts of Petrolatum to Be Applied at Patch Testing |
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53 | (1) |
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3.4.5 Appropriate Amounts of Liquids to Be Applied at Patch Testing |
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54 | (1) |
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3.5 Specific Recommendations When Considering Patch Testing Patients |
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55 | (2) |
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3.5.1 Patch Testing on Intact Skin Is Critical |
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55 | (1) |
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3.5.2 Medicaments and Patch Testing |
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55 | (2) |
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3.5.3 Pregnancy and Patch Testing |
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57 | (1) |
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3.5.4 Patch Testing in Children |
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57 | (1) |
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3.6 Application of Patch Tests on the Skin: Some Practical Suggestions |
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57 | (2) |
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58 | (1) |
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58 | (1) |
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3.6.3 Degreasing of Test Site |
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58 | (1) |
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3.6.4 Application of Test Strips |
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58 | (1) |
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3.6.5 Instructions to Patients |
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58 | (1) |
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59 | (4) |
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3.7.1 Standard Patch Test Occlusion and Reading Time |
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59 | (1) |
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3.7.2 Conventional Patch Test Reading Time |
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59 | (1) |
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3.7.3 Reading at Day 2, Day 3, and Day 4 |
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60 | (1) |
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60 | (1) |
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3.7.5 Single Reading Versus Multiple Reading |
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60 | (1) |
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3.7.6 Day 3 Versus Day 4 Reading |
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60 | (1) |
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3.7.7 One-Day Occlusion Versus Two-Day Occlusion |
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61 | (1) |
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61 | (1) |
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62 | (1) |
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3.7.10 Immediate Urticarial Reactions to Some Allergens |
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62 | (1) |
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3.8 Reading and Scoring Patch Test Results |
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63 | (5) |
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3.8.1 Scoring Codes According to the ICDRG |
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63 | (1) |
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3.8.2 Proposal for Modified Scoring Codes of Positive Patch Test Reactions, According to ESCD and EECDRG |
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63 | (2) |
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3.8.3 Rating Patch Test Reactions Based on Digital Images |
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65 | (1) |
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3.8.4 Bioengineering Methods for Evaluating Skin Irritation and Allergic Reactions: A Comparison with Visual Scoring |
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65 | (1) |
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3.8.5 Remarks About Reading and Scoring Patch Test Results |
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66 | (2) |
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3.9 Irritant Patch Test Reactions |
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68 | (2) |
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3.10 False-Positive Patch Test Reactions |
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70 | (1) |
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3.11 False-Negative Patch Test Reactions |
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71 | (1) |
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71 | (1) |
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3.13 Cross-Sensitization, Concomitant Sensitization, and Polysensitization |
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72 | (2) |
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3.13.1 Cross-Sensitization |
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72 | (1) |
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3.13.2 Concomitant Sensitization |
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73 | (1) |
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73 | (1) |
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3.14 Unwanted Adverse Reactions of Patch Testing |
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74 | (2) |
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3.14.1 Patch Test Sensitization ("Active Sensitization") |
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75 | (1) |
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3.14.2 Excited Skin Syndrome ("Angry Back") |
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75 | (1) |
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3.15 Patch Test Readings in Different Ethnic Populations |
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76 | (3) |
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3.15.1 Patch Test Reading in Oriental Populations |
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76 | (2) |
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3.15.2 Patch Test Reading in Black Populations |
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78 | (1) |
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3.16 Patch Testing Techniques in Different Climatic Environments |
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79 | (2) |
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3.16.1 Temperate Climates |
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79 | (1) |
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80 | (1) |
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3.16.3 Patch Testing Procedures in the Tropics |
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80 | (1) |
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3.17 Is Self-assessment of Allergic Contact Dermatitis by Patients Recommendable? |
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81 | (4) |
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3.17.1 Self-assessment by Questionnaires |
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81 | (1) |
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3.17.2 Self-readings of Patch Tests by Patients |
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81 | (1) |
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81 | (4) |
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4 Baseline Series of Patch Tests |
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85 | (20) |
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4.1 Historical Background |
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85 | (1) |
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4.2 Advantages and Disadvantages of Using a Baseline Series of Patch Tests |
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86 | (1) |
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86 | (1) |
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86 | (1) |
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4.3 The Different Baseline Series of Patch Tests |
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86 | (7) |
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4.3.1 ICDRG-Revised International Minimal Baseline Series of Patch Tests |
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87 | (1) |
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4.3.2 The Updated 2019 Baseline Series (Table 4.2) of the International Contact Dermatitis Research Group |
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87 | (2) |
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4.3.3 The Updated 2019 European Baseline Series (Tables 4.3 and 4.4) on Behalf of the ESCD and the EECDRG [ 8] |
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89 | (1) |
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4.3.4 The Updated 2019 North American Baseline Series (Table 4.5) on Behalf of the NACDG (Sasseville D, personal communication, 2019) |
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89 | (4) |
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4.3.5 The Updated 2019 Japanese Baseline Series (Table 4.6) on Behalf of the JCDS (Matsunaga K, personal communication, 2019) |
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93 | (1) |
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4.4 "Mixes" of Baseline Series |
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93 | (2) |
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4.5 Concise Information About Allergens Included in the Updated 2011 Minimal Baseline Series of the ICDRG |
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95 | (5) |
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4.6 Concise Information on Other Common Allergens Included in the Updated 2011 Minimal Baseline Series of the ICDRG |
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100 | (1) |
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4.7 Additional Series of Patch Tests |
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101 | (1) |
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4.8 The Preservative Methylisothiazolinone: The New Star of Allergic Contact Dermatitis |
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101 | (4) |
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102 | (3) |
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105 | (10) |
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105 | (1) |
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5.2 Photoallergy Contact Dermatitis |
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106 | (2) |
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5.3 Photoallergy Contact Dermatitis Versus Airborne Allergic Contact Dermatitis: Criteria for Differential Diagnosis |
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108 | (1) |
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5.4 Photoallergy Drug Eruptions |
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109 | (1) |
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5.5 Photopatch Testing Methodology |
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109 | (2) |
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111 | (1) |
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5.7 Proposal for a Photopatch Test Series |
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111 | (4) |
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112 | (3) |
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6 The T.R.U.E. Test® Methodology |
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115 | (10) |
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115 | (1) |
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6.2 The T.R.U.E. Test® Methodology |
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115 | (1) |
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6.3 More Practical Information About the Technology of The T.R.U.E. Test® |
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116 | (1) |
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6.4 Regulatory Information |
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116 | (2) |
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6.5 Standard The T.R.U.E. Test® Series |
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118 | (3) |
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121 | (1) |
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121 | (1) |
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6.8 Additional Information |
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122 | (1) |
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122 | (3) |
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122 | (3) |
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7 Additional Testing Procedures and Spot Tests |
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125 | (20) |
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125 | (1) |
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126 | (1) |
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7.3 Semi-open (or Semi-occlusive) Tests |
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127 | (1) |
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7.4 Repeated Open Application Test |
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127 | (4) |
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7.5 Testing Procedures with Unknown Substances |
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131 | (4) |
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131 | (1) |
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7.5.2 Steps Required Prior to Any Testing Procedure |
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131 | (1) |
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7.5.3 Testing Procedures with Solid Products and Extracts |
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132 | (2) |
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7.5.4 The Use of Ultrasonic Bath Extracts in the Search of the Culprit(s) Allergen(s) Present in Solid Products |
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134 | (1) |
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7.5.5 Testing Procedures with Cosmetics and Other Related Products |
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135 | (1) |
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7.6 Oral Provocation Test (Oral Challenge) |
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135 | (1) |
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136 | (5) |
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136 | (1) |
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136 | (5) |
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141 | (1) |
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7.8 Additional Remarks About Chemistry and Immunology in Relationship with Allergic Contact Dermatitis |
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141 | (4) |
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141 | (4) |
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8 Clinical Relevance of Patch Test Reactions |
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145 | (8) |
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145 | (1) |
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145 | (1) |
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8.3 Past and Current Relevance |
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146 | (1) |
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146 | (1) |
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147 | (4) |
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148 | (1) |
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8.5.2 Environmental Evaluation |
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149 | (1) |
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8.5.3 Further Correlations |
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150 | (1) |
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8.5.4 Additional Investigations |
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150 | (1) |
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8.6 Suggestions for Improved Evidence-Based Diagnosis of Relevance |
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151 | (1) |
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152 | (1) |
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152 | (1) |
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9 Atopic Dermatitis, Irritant Contact Dermatitis, and Allergic Contact Dermatitis |
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153 | (10) |
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153 | (1) |
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9.2 Etiopathogenic Advances |
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153 | (1) |
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9.3 Disruption of the Skin Barrier |
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154 | (1) |
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9.4 Increased Disruption of the Skin Barrier in AD |
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154 | (1) |
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155 | (1) |
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9.6 Other Skin Typical Locations of Lesions in AD |
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156 | (2) |
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9.7 Guidelines for the Practice of Patch Testing |
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158 | (5) |
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158 | (5) |
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10 Spectrum of Diseases for Which Prick Testing and Open (Non-prick) Testing Are Recommended: Patients Who Should Be Investigated |
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163 | (14) |
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10.1 Contact Urticaria Syndrome |
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163 | (8) |
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10.1.1 Clinical Symptoms and Stages of CUS |
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164 | (1) |
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10.1.2 Etiology and Mechanisms of CUS |
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164 | (6) |
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10.1.3 Contact Urticaria to Natural Rubber Latex |
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170 | (1) |
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10.2 Protein Contact Dermatitis |
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171 | (6) |
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174 | (3) |
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11 Methodology of Open (Non-prick) Testing, Prick Testing, and Its Variants |
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177 | (18) |
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11.1 Introductory Remarks |
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177 | (1) |
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11.2 Open (Non-prick) Testing |
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177 | (2) |
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11.3 Prick Test: Technical Modalities and Reading |
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179 | (4) |
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11.3.1 Technique of Puncture |
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179 | (1) |
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180 | (1) |
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181 | (1) |
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11.3.4 Reading Prick Test Results |
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181 | (1) |
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11.3.5 Medicaments and Prick Testing |
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182 | (1) |
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11.3.6 False-Negative Reactions |
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182 | (1) |
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11.3.7 False-Positive Reactions |
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182 | (1) |
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11.3.8 Prick Tests in Children and Babies |
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183 | (1) |
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183 | (1) |
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183 | (1) |
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11.6 Scratch-Chamber Test |
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183 | (1) |
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11.7 Comparative Indications of Open (Non-prick) Testing, Prick Testing, and Other Related Tests |
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184 | (1) |
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11.8 Intradermal Testing for Type 1 Hypersensitivity |
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185 | (1) |
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11.9 Prick Testing: Allergens of Interest for Skin Problems |
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185 | (10) |
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185 | (1) |
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11.9.2 Airborne Environmental per Annum Allergens |
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186 | (1) |
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11.9.3 Airborne Environmental Seasonal Allergens |
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186 | (1) |
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11.9.4 Food Allergens (Trophallergens) |
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187 | (2) |
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11.9.5 Occupational Allergens |
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189 | (1) |
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189 | (1) |
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11.9.7 Miscellaneous (Immunological and/or Non-immunological) Urticariogens |
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190 | (1) |
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190 | (5) |
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Part III Testing in Cutaneous Systemic Immune-Related Adverse Drug Reactions: Interest and Limitations |
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12 Testing Procedures in Cutaneous Systemic Immune-Related Adverse Drug Reactions |
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195 | (16) |
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12.1 General Considerations |
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195 | (2) |
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12.2 Proposal of a Classification of CADR |
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197 | (3) |
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12.3 Tools of Investigation in CADR |
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200 | (1) |
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12.4 Histopathological Limitations in Diagnosis of a CADR |
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200 | (2) |
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12.5 Patch Testing in CADR |
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202 | (5) |
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12.5.1 Spectrum of CADRs for Which Patch Testing Is Recommended |
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202 | (1) |
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12.5.2 Spectrum of CADRs for Which Patch Testing Can Be Performed (Being Still Controversial) |
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203 | (1) |
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12.5.3 Spectrum of CADRs for Which Patch Testing Is of No Interest |
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203 | (1) |
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12.5.4 Guidelines in Drug Patch Testing: General Rules |
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204 | (1) |
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12.5.5 Technical Aspects of Drug Patch Testing |
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204 | (1) |
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12.5.6 Readings of Drug Patch Tests |
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205 | (1) |
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12.5.7 False-Negative Patch Test Reactions |
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205 | (1) |
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12.5.8 False-Positive Patch Test Reactions |
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206 | (1) |
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12.6 Prick Testing in CADR |
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207 | (1) |
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12.7 Intradermal Testing in CADR |
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207 | (1) |
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12.8 Oral Provocation Test (Oral Challenge) in CADR |
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207 | (4) |
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208 | (3) |
Appendices |
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211 | (30) |
Index |
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241 | |