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Pathogenesis of Functional Bowel Disease [Kõva köide]

  • Formaat: Hardback, 388 pages, kõrgus: 230 mm, kaal: 850 g, 16 black & white illustrations, biography
  • Sari: Topics in Gastroenterology
  • Ilmumisaeg: 30-Sep-1989
  • Kirjastus: Kluwer Academic / Plenum Publishers
  • ISBN-10: 030643265X
  • ISBN-13: 9780306432651
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  • Formaat: Hardback, 388 pages, kõrgus: 230 mm, kaal: 850 g, 16 black & white illustrations, biography
  • Sari: Topics in Gastroenterology
  • Ilmumisaeg: 30-Sep-1989
  • Kirjastus: Kluwer Academic / Plenum Publishers
  • ISBN-10: 030643265X
  • ISBN-13: 9780306432651
Teised raamatud teemal:
In their second year in medical school, students begin to learn about the differences between "disease" and "illness." In their studies of pathology they learn to understand disease as pertubations of molecular biological events. And we clinicians can show disease to them by our scans, lay it out even on our genetic scrolls, and sometimes even point out the errant nucleotide. Disease satisfies them and us; at Yale, lectures on the gastrointestinal tract run from achalasia to proctitis. There is, alas, little mention of functional bowel disease or of the irritable or spastic colon, for that is not easy to show on hard copy. Functional bowel disease represents "illness," the response of the person to distress, to food, to the environment, and to the existential problems of living. In real life such matters are most important. Richard Cabot first found out at the Massachusetts General Hospital almost a century ago that 50% of the patients attending the outpatient clinic had "functional" complaints. The figure had grown to over 80% when the very same question was reexamined 60 years later.
1. Historical Perspectives of Functional Bowel Disease.-
1. Evolution of
Clinical Concepts.-
2. Life Events, Emotions, and Functional Disorders.- 2.1.
Critique.- 2.2. Alternative Models of a Mind-Body Interaction.- 2.3. Widening
Concepts of Mind-Body Interaction.-
3. Conclusion.- References.-
2. Role of
Neural Control in Gastrointestinal Motility and Visceral Pain..-
1.
Introduction.-
2. Role of the Autonomic Nervous System in GI Motility and
Visceral Sensation.- 2.1. Enteric Nervous System.- 2.2. Visceral Afferent
Mechanisms.- 2.3. Autonomic Efferent Innervation.- 2.4. Pain-Modulating
Mechanisms.-
3. Evidence for Alteration in Pain Perception (Visceral and
Somatic) and Colonic Motility in IBS.- 3.1. Colonic Motility.- 3.2. Visceral
Sensation.- 3.3. General Pain Perception.-
4. Proposed Model for Alterations
in Visceral Sensation and GI Motility in IBS.- References.-
3. Effects of
Psychological Factors on Gastrointestinal Function.-
1. Introduction.- 1.1.
Psychiatric Diagnoses.- 1.2. Psychometric Testing.- 1.3. Self-Selection
Hypothesis.-
2. Direct Effects of Psychological Stress on Gastrointestinal
Physiology.- 2.1. Esophageal Motility.- 2.2. Gastric Motility.- 2.3. Small
Intestine.- 2.4. Colon.-
3. Indirect Effects of Psychological Stress on
Gastrointestinal Physiology.-
4. Effects of Psychological Traits on the
Perception and Reporting of Bowel Symptoms.-
5. Social Learning Influences on
Gastrointestinal Symptoms and Physiology.-
6. Conclusions and Implications
for Treatment.- 6.1. Stress.- 6.2. Effects of Psychological Traits on
Perception and Reporting of Gastrointestinal Symptoms.- 6.3. Learned Illness
Behavior.- References.-
4. Central Control of Gastrointestinal Transit and
Motility by Brain-Gut Peptides.-
1. Introduction.-
2. Central Nervous
Structures Influencing Gastrointestinal Motility.- 2.1. Hypothalamus.- 2.2.
Medulla Oblongata.-
3. CNS Action of Peptides to Influence Gastrointestinal
Motility and Transit.- 3.1. CNS Action of TRH to Stimulate Gastrointestinal
Motor Function.- 3.2. CNS Action of Corticotropin-Releasing Factor (CRF) to
Alter Gastrointestinal Motor Function.- 3.3. CNS Action of Opioid Peptides to
Inhibit Gastrointestinal Motor Function.- 3.4. CNS Action of Bombesin to
Inhibit Gastrointestinal Motor Function.- 3.5. CNS Action of Calcitonin to
Inhibit Gastrointestinal Motor Function.- 3.6. CNS Action of Calcitonin
Gene-Related Peptide (CGRP) on Gastrointestinal Motor Function.- 3.7. CNS
Action of Neurotensin to Influence Gastrointestinal Motor Function.- 3.8. CNS
Action of Other Peptides to Influence Gastrointestinal Motility.-
4. Summary
and Conclusions.- 4.1. Brain Peptides and CNS Modulation of Gastrointestinal
Transit.- 4.2. Brain Peptides and Modulation of Gastrointestinal Motility.-
4.3. Conclusions.- References.-
5. Effect of Diet on Intestinal Function and
Dysfunction.-
1. Introduction.-
2. Effects of Eating on the Colon.-
3.
Carbohydrate.- 3.1. Simple Sugars.- 3.2. Starch.-
4. Dietary Fiber.- 4.1.
Definition and Classification.- 4.2. Actions of Wheat Bran and Ispaghula on
the Colon.- 4.3. Effects of Bran and Ispaghula on Symptoms of Irritable
Bowel.-
5. Other Dietary Factors.- 5.1. Food Allergy and Intolerance.- 5.2.
Protein and Fat.-
6. Conclusions.- References.-
6. Disorders of Intestinal
Motility Resulting from Drug Therapy.-
1. Introduction.-
2. Cholinergic
Agents.-
3. Adrenergic Agents.-
4. Dopaminergic Agents.-
5. Opiates.-
6.
Calcium Channel Blockers.-
7. Prostaglandins.-
8. Antibiotics.-
9.
Miscellaneous.-
10. Summary.- References.-
7. Functional Diseases of the
Esophagus.-
1. Introduction.-
2. Clinical Presentation.-
3. Classification of
EMDs.- 3.1. Disorders of the UES.- 3.2. Primary EMDs.- 3.3. Secondary EMDs.-
4. Diagnostic Studies.- 4.1. Radiology.- 4.2. Fiberoptic Endoscopy.- 4.3.
Radionuclide Transit Studies.- 4.4. Esophageal Manometry.- 4.5. Provocative
Tests.- 4.6. 24-hr Motility Testing.-
5. Approach to the Diagnosis of EMDs.-
6. Psychologic Abnormalities in EMDs.-
7. Medical and Surgical Therapies.-
7.1. Disorders of the UES.- 7.2. Achalasia.- 7.3. Painful EMDs.- 7.4.
Secondary EMDs.-
8. Future Perspectives.- References.-
8. Functional Causes
of Disturbed Gastric Function.-
1. Normal Physiology.- 1.1. Functional
Anatomy.- 1.2. Gastric Electrical and Motor Activity.- 1.3. Gastric Emptying
in Relation to Gastric Motility.- 1.4. Regulation of Gastric Motility.-
2.
Functional Disorders of Gastric Motility and Emptying.- 2.1. Diabetic
Gastroparesis.- 2.2. Collagen Diseases.- 2.3. Primary Anorexia Nervosa.- 2.4.
Dyspepsia.- 2.5. Gastric Dysrhythmia.-
3. General Conclusions.- References.-
9. Functional Disorders of the Small Intestine.-
1. Introduction.-
2. Motor
Activity of the Small Intestine in Health.- 2.1. Interdigestive Motility.-
2.2. Postprandial Motility.- 2.3. Control Mechanisms.-
3. Absorption and
Secretion in the Small Intestine.- 3.1. Water and Electrolyte Transport and
Nutrient Absorption.- 3.2. Control Mechanisms.-
4. Function of the Small
Intestine in IBS.- 4.1. Definition and Clinical Picture.- 4.2. Motility of
the Small Bowel.- 4.3. Altered Absorption and Secretion.-
5. Summary and
Interim Speculations.- References.-
10. Mechanisms and Management of Chronic
Constipation.-
1. Introduction.-
2. The Diagnosis of Colonic Motor
Dysfunction.- 2.1. The Initial Approach to the Patient.- 2.2. The Need for an
Objective Definition of Constipation.- 2.3. Subjective Definitions of
Constipation.- 2.4. Objective Variables of Colonic Function.- 2.5. A Working
Definition of Slowed Transit Constipation.-
3. Mechanisms of Chronic
Constipation.- 3.1. Normal Colonic Function.- 3.2. Mechanisms of Defecation.-
3.3. Secondary Causes of Constipation.- 3.4. Patterns of Chronic
Constipation.- 3.5. Colonic Outlet Obstruction.- 3.6. Impaired Colonic
Transit.- 3.7. Other Factors Contributing to Delayed Colonic Transit.-
4.
Complications of Chronic Constipation.-
5. Treatment.- 5.1. Therapeutic
Agents and Their Mechanisms of Action.- 5.2. Dietary Fiber.- 5.3. Laxatives
and Cathartics.- 5.4. Agents That Promote Neurally Mediated Propulsive
Colonic Contractions.- 5.5. The Use of Enemas.- 5.6. Surgery in the Treatment
of Chronic Constipation.- References.-
11. Irritable Colon Syndrome.-
1.
Epidemiology.-
2. Clinical Symptoms.-
3. Diagnosis.- 3.1. Differential
Diagnosis.- 3.2. Diagnostic Studies.-
4. General Pathophysiology.- 4.1.
Myogenic.- 4.2. Neural.- 4.3. Humoral.- 4.4. Gastrocolonic Response.-
5.
Pathophysiology of Specific Condition.- 5.1. Constipation.- 5.2. Spastic
Irritable Colon Syndrome.- 5.3. Painless Diarrhea.-
6. Treatment.- 6.1.
Constipation Associated with Increased Motility.- 6.2. Constipation
Associated with Decreased Motility.- 6.3. Diarrhea.-
7. Conclusion.-
References.-
12. Association between Disturbances in Gastrointestinal Transit
and Functional Bowel Disease.-
1. Esophageal Transit.-
2. Gastroduodenal
Transit.-
3. Small Bowel Transit.-
4. Colonic Transit.-
5. Stress- and
Meal-Related Alterations in GI Transit.-
6. Effects of Treatment on Altered
GI Transit.-
7. Summary.- References.-
13. Abdominal Pain and Biliary Tract
Dysmotility.-
1. Introduction.-
2. Bile Flow within the Biliary Tract.-
3.
Biliary-Type Pain-Referred versus Real.-
4. Biliary Tract Disorders of
Functional Nature.- 4.1. Gallbladder.- 4.2. Sphincter of Oddi.-
5. Sphincter
of Oddi Manometry.-
6. Clinical Classification of Patients with Suspected
Sphincter of Oddi Dysfunction.- 6.1. Biliary Type I.- 6.2. Biliary Type II.-
6.3. Biliary Type III.-
7. Primary Sphincter of Oddi Motor Dysfunction.-
References.-
14. Disorders of the Anal Sphincters.-
1. Anatomy.-
2. The
Incompetent Sphincter.- 2.1. Maintenance of Continence.- 2.2. Investigation
of Patients with Fecal Incontinence.- 2.3. Normal Records.- 2.4. Disturbances
in Sphincter Function in Patients with Fecal Incontinence.-
3. The Obstructed
Sphincter.- 3.1. Normal Defecation.- 3.2. Causes of Impaired Defecation.-
4.
The Irritable Anorectum.- References.-
15. Functional Bowel Disturbances in
Childhood.-
1. Infantile Colic.- 1.1. Pathophysiology.- 1.2. Treatment.-
2.
Gastroesophageal Reflux.- 2.1. Pathophysiology.- 2.2. Diagnosis.- 2.3.
Treatment.-
3. Chronic Nonspecific Diarrhea (Toddler's Diarrhea).- 3.1.
Pathophysiology.- 3.2. Diagnosis.- 3.3. Treatment.-
4. Constipation and
Functional Fecal Retention.- 4.1. Physiology of Childhood Constipation and
Functional Fecal Retention.- 4.2. Diagnosis.- 4.3. Treatment.-
5. Functional
Recurrent Abdominal Pain.- 5.1. Pathophysiology.- 5.2. Diagnosis.- 5.3.
Treatment.-
6. Chronic Intestinal Pseudoobstruction.- 6.1. Clinical Disease
in Childhood.- 6.2. Pathophysiology.- 6.3. Treatment.- References.-
16.
Surgical Approach to Functional Bowel Disease.-
1. Introduction.-
2. Motility
Disorders of the Esophagus.- 2.1. Diffuse Esophageal Spasm.- 2.2. Achalasia.-
2.3. Zenker's Diverticulum.- 2.4. Lower Esophageal (Epiphrenic)
Diverticulum.-
3. Motility Disorders of the Stomach.- 3.1. Gastric
Dysrhythmias.- 3.2. Postgastrectomy Syndromes.-
4. Biliary Dyskinesia.- 4.1.
Pathophysiology and Clinical Presentation.- 4.2. Surgical Management.-
5.
Intestinal Pseudoobstruction.- 5.1. Chronic Idiopathic Intestinal
Pseudoobstruction.- 5.2. Acute Colonic Pseudoobstruction.-
6. Colonic
Dysmotility Syndromes.- 6.1. Colonic Diverticular Disease.- 6.2. Chronic
Constipation.- 6.3. Hirschsprung's Disease.-
7. Summary.- References.