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Patient-Derived Xenografts: Methods and Protocols 2024 ed. [Kõva köide]

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  • Formaat: Hardback, 244 pages, kõrgus x laius: 254x178 mm, 44 Illustrations, color; 5 Illustrations, black and white; XII, 244 p. 49 illus., 44 illus. in color., 1 Hardback
  • Sari: Methods in Molecular Biology 2806
  • Ilmumisaeg: 28-Apr-2024
  • Kirjastus: Springer-Verlag New York Inc.
  • ISBN-10: 1071638572
  • ISBN-13: 9781071638576
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  • Formaat: Hardback, 244 pages, kõrgus x laius: 254x178 mm, 44 Illustrations, color; 5 Illustrations, black and white; XII, 244 p. 49 illus., 44 illus. in color., 1 Hardback
  • Sari: Methods in Molecular Biology 2806
  • Ilmumisaeg: 28-Apr-2024
  • Kirjastus: Springer-Verlag New York Inc.
  • ISBN-10: 1071638572
  • ISBN-13: 9781071638576
Teised raamatud teemal:
This detailed volume explores the dynamic landscape of patient-derived xenograft (PDX) generation and applications. After a few chapters examining the evolution of PDXs, tracing their roots and contextualizing their significance in the broader narrative of cancer research, the book continues with methodologies for generating PDXs from diverse clinical tissue samples as well as for utilizing PDXs in various specific cancer types. From the development of humanized PDX models to the exploration of protein expression through advanced techniques including multiplex immunohistochemistry, Western blotting, and immunoprecipitation, the chapters offer a comprehensive toolkit for researchers and clinicians alike. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Patient-Derived Xenografts: Methods and Protocols serves as an ideal interdisciplinary guide for understanding the intricate processes that underscore translational cancer research.
Patient-Derived Xenografts: Historical Evolution, Immunocompromised Host
Models, and Translational Significance.- Patient-Derived Xenograft Models in
Cancer Research: Methodology, Applications, and Future Prospects.-
Patient-Derived Xenografts: A Valuable Preclinical Model for Drug Development
and Biomarker Discovery.- Patient-Derived Xenograft Models for Leukemias.-
Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain
Cancers.- Generation of Orthotopic and Subcutaneous Patient-Derived Xenograft
Models from Diverse Clinical Tissue Samples of Pediatric Extracranial Solid
Tumors.- Development of Orthotopic Patient-Derived Xenograft Models of
Pediatric Intracranial Tumors.- A Humanized Patient-Derived Xenograft Model
for Pancreatic Cancer.- Development and Expansion of Patient-Derived
Xenografts for Endometrial Cancer.- A Multiplexed Approach to Assess Small
Cell Lung Cancer Subtype Heterogeneity in Primary and Patient-Derived Tumor
Samples.- Generation of Metastatic Cholangiocarcinoma Patient-Derived
Xenograft Models.- Patient-Derived Xenograft Models for Translational
Prostate Cancer Research and Drug Development.- Patient-Derived Xenograft
Models for Ovarian Cancer.- Orthotopic MC-38 Allograft as a Robust
Preclinical Model of Colorectal Carcinoma.- Assessing Protein Expression in
Patient-Derived Xenografts Using Western Blotting.- Analysis of Protein
Interactions in Patient-Derived Xenografts Using Immunoprecipitation.- A
Semi-Automated Proteomics and Phosphoproteomics Protocol for the
Identification of Novel Therapeutic Targets and Predictive Biomarkers in In
Vivo Xenograft Models of Pediatric Cancers.