This volume provides a state-of-the-art overview of the role of phospholipase A2 (PLA2) in the pathophysiology of inflammatory diseases. Our knowledge about PLA2 has increased tremendously in the last two decades and investigations of the enzyme have revealed a whole family of different gene products. A rough distinction can be made between intracellular and secretory PLA2. The involvement of PLA2 in various life-threatening inflammatory diseases as well as in carcinomas is documented by many contributions to this volume. Recently developed transgenic and knockout mouse models are a powerful new tool for PLA2 research. A number of specific inhibitors of the various PLA2s offer new therapeutic approaches to control unwanted acute and chronic inflammatory responses and to intervene in malignant diseases. Due to the enzymes important role in these pathophysiological processes, this update of PLA2 research will interest basic scientists, physicians, oncologists, ICU specialists and surgeons.
Abbreviations viii(3) Preface xi Structure, Distribution and Function of Phospholipase A(2) 1(42) History, Classification, Structure and Function of Phospholipase A(2) 1(7) Dennis, E. A. (La Jolla, Calif) Expression of Group II Phospholipase A(2) in Human Tissues 8(9) Kallajoki, M. Nevalainen, T. J. (Turku) Determinants of the Antimicrobial Action of 14-kD Phospholipases A(2) 17(6) Elsbach, P. (New York, NY) Downregulation of Cytokine-Induced Synthesis and Secretion of Group II Phospholipase A(2) 23(8) van den Bosch, H. Vervoordeldonk, M.J.B.M. Schalkwijk, C.G. (Utrecht) Pfeilschifter, J. (Basel) Control of Phospholipase A(2) Gene Expression 31(7) Pfeilschifter, J. Walker, G. Kunz, D. Pignat, W. (Basel) van den Bosch, H. (Utrecht) Secretory Nonpancreatic Phospholipase A(2) (sPLA(2)) as a Mediator of Inflammation 38(5) Pruzanski, W. Vadas, P. (Toronto) Methods for Measuring Phospholipase A(2) 43(29) Catalytic Phospholipase A(2) Assays 43(6) Aufenanger, J. Bertsch, T. (Mannheim) Immunoassay for Type II Phospholipase A(2) 49(7) Massing, U. Kraft, A. (Freiburg) Stockinger, H. (Penzberg) Specific Quantitation of Activated Pancreatic Type Phospholipase A(2) by Measurement of Type 1 Prophospholipase A(2) Propeptide (PROP) 56(9) Schmidt, J. Eisold, S. (Heidelberg) Rae, D.; Sumar, N. Hermon-Taylor, J. (London) Secretory PLA(2)-Deficient and Transgenic Mice in Phospholipase A(2) Research 65(7) Kennedy, B. P. (Kirkland) Vadas, P. Pruzanski, W. (Toronto) Role of Phospholipase A(2) in Inflammation 72(51) Eicosanoids as Mediators and Modulators of Allergic Reactions 72(7) Hedqvist, P. Lindbom, L. Raud, J. (Stockholm) Phospholipase A(2) and Acute Respiratory Distress Syndrome 79(9) Arbibe, L. Vial, D. Touqui, L. (Paris) Phospholipase A(2) and Oxygen Radicals 88(6) Schoenberg, M. H. (Ulm) Phospholipase A(2) in Inflamed Tissues and Inflammatory Exudates 94(10) Koike, K. Yamamoto, Y. Otsuka, H. Murakami, M. Kudo, I. (Tokyo) Serum Phospholipase A(2) in Inflammatory Diseases 104(6) Nevalainen, T. J. Gronroos, J. M. (Turku) Phospholipase A(2) in Experimental Acute Pancreatitis 110(7) Schrag, H. -J. Uhl, W. Schmitter, N. Dervenis, C. Buchler, M. W. (Bern) Toxic Effects of Phospholipase A(2) in vitro 117(6) Nyman, K. M. Haggblom, J. -O. Nevalainen, T. J. (Turku) Inhibition of Phospholipase A(2) 123(53) Principles of Inhibition of Phospholipase A(2) and Other Interfacial Enzymes 123(7) Gelb, M. H. (Seattle, Wash.) Jain, M. K. (Newark, Del.) Berg, O. G. (Uppsala) New Type II Phospholipase A(2) Inhibitors Effective in Blocking an Ongoing Enzyme Reaction: Inability of Manoalide and Scalaradial to Exert an Inhibitory Capacity 130(10) Vondran, A. (Penzberg) Tibes, U. (Mannheim) Borowski, E. (Karlsruhe) Friebe, W. -G. (Mannheim) Scheuer, W. V. (Penzberg) Structure-Based Design and Therapeutic Potential of Phospholipase A(2) Inhibitors 140(6) Mihelich, E. D. Carlson, D. G. Fox, N. Song, M. Schevitz, R. W. Snyder, D. W. (Indianapolis, Ind.) Marine Natural Products as Phospholipase A(2) Inhibitors 146(7) Wylie, B. L. Ernst, N. B. Grace, K.J.S. Jacobs, R. S. (Santa Barbara, Calif.) Role of Cytosolic PLA(2), Secretory PLA(2) and Nitric Oxide Synthase in Inflammation 153(15) Tibes, U. (Mannheim) Scheuer, W. V. (Penzberg) Thierse, H. -J. (Mannheim) Burgermeister, E. (Penzberg) Schramm, S. Friebe, W. -G. Dietz, E. (Mannheim) Inhibition of Type II Phospholipase A(2) in Experimental Acute Pancreatitis: A New Specific Treatment Approach 168(8) Uhl, W. Schrag, H. -J. (Bern) Aufenanger, J. (Mannheim) Nevalainen, T. J. (Turku) Tibes, U. Scheuer, W. V. Friebe, W. -G. (Mannheim) Buchler, M. W. (Bern) Clinical Implications of Phospholipase A(2) 176(69) Inter-Relationship of Phospholipase A(2) and Lipid Peroxidation in Multisystem Organ Failure in Septic Shock 176(6) Vadas, P. Pruzanski, W. (Toronto) Phospholipase A(2) in Acute Pancreatitis: Clinical Value of Phospholipase A(2) Measurements 182(5) Gronroos, J. M. Nevalainen, T. J. (Turku) Phospholipase A(2) in Surgical Intensive Care Patients 187(13) Uhl, W. Buchler, M. W. (Bern) Group II Phospholipase A(2) in Neoplastic Diseases 200(5) Ogawa, M. (Kumamoto) Phospholipase A(2) in Chronic Inflammatory Disease of the Intestine 205(9) Minami, T. Tojo, H. (Osaka) Phospholipase A(2) in Arthritis 214(11) Winkler, J.D. Marshall, L. A. (King of Prussia, Pa.) Phospholipase A(2) in Psoriasis 225(7) Johansen, B. Andersen, S. Sjursen, W. Gundersen, P. Selbo, P. K. (Trondheim) Phospholipase A(2) in Normal and Pathological Pregnancies 232(13) Rice, G. E. (Melbourne) Author Index 245(1) Subject Index 246
