| Preface |
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ix | |
| Acknowledgments |
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xi | |
| Contributors |
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xiii | |
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1 Epidemiology and Etiology of Glioma: An Overview |
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1 | (3) |
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2 Descriptive Epidemiology of Glioma |
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4 | (10) |
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3 Familial Factors and Inherited Susceptibility to Glioma |
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14 | (4) |
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4 Chemical Exposures Mediated Through Occupation, Environment and Lifestyle, and Brain Tumor Risk |
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18 | (8) |
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5 Exposure to Ionizing Radiation and Glioma Risk |
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26 | (5) |
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6 Radiofrequency Fields and Glioma Risk |
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31 | (8) |
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7 Allergies and Glioma Risk |
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39 | (8) |
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8 Glioma Survival and Prognosis |
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47 | (10) |
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9 Epidemiology of Childhood Brain Tumors |
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57 | (14) |
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71 | (8) |
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Part II Molecular Biology |
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11 Molecular Neuro-Oncology: Why is it Essential? |
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79 | (2) |
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12 Brain Tumor Initiating Cells: History, New Advances, Therapeutic Promises, and Pitfalls |
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81 | (7) |
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13 Molecular Pathogenesis of Glioma: Overview and Therapeutic Implications |
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88 | (12) |
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14 Molecular Heterogeneity and Tumor Microenvironment |
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100 | (12) |
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15 Molecular Regulators of Glioma Invasion |
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112 | (10) |
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16 Molecular Basis of Glioma Neovascularization and Its Therapeutic Applications |
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122 | (23) |
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17 Mouse Models of Central Nervous System Tumors |
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145 | (13) |
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Part 1 Transgenic Mouse Models of Central Nervous System Tumors |
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145 | (8) |
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Part 2 Transplantation Mouse Models of Central Nervous System Tumors |
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153 | (5) |
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18 Pathology and Genetics of Meningiomas |
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158 | (9) |
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19 Histopathology and Molecular Pathogenesis of Schwannomas |
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167 | (7) |
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Anat O. Stemmer-Rachamimov |
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20 Histopathology and Molecular Pathogenesis of Pituitary Adenomas |
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174 | (11) |
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21 Histopathology and Molecular Pathogenesis of Neurofibromas and Malignant Peripheral Nerve Sheath Tumors |
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185 | (10) |
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22 The `Cell of Origin' for Common Pediatric Brain Tumors |
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195 | (9) |
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23 Histopathological Features of Common Pediatric Brain Tumors |
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204 | (11) |
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24 Molecular Genetics of Medulloblastoma and High-Grade Astrocytomas in Children |
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215 | (10) |
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25 Molecular Pathogenesis of Neuroblastomas |
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225 | (14) |
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26 Pediatric Brain Tumor Syndromes and Murine Models |
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239 | (10) |
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27 Predisposition Syndromes: Neurofibromatosis 1, Neurofibromatosis 2, and Tuberous Sclerosis Complex |
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249 | (8) |
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Part III Clinical Presentation And Supportive Care |
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28 Presentation and Clinical Features of Supratentorial Gliomas in Adults |
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257 | (5) |
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29 Presentation and Clinical Features of Brain Metastases |
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262 | (5) |
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30 Presentation and Clinical Features of Medulloblastoma |
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267 | (6) |
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31 Presentation and Clinical Features of Pediatric Gliomas |
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273 | (5) |
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32 Presentation and Clinical Features of Brainstem Tumors |
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278 | (4) |
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33 Presentation and Clinical Features of Tumours of the Skull Base and Cranial Nerves |
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282 | (9) |
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34 Presentation and Clinical Features of Tumors of the Pituitary and Sellar Region |
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291 | (6) |
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35 Presentation and Clinical Features of Spinal Cord Tumors |
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297 | (7) |
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Supportive Care and Quality of Life |
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36 Supportive Care in Neuro-Oncology |
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304 | (7) |
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37 Ethical Issues in Neuro-Oncology |
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311 | (5) |
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38 Role of Support Groups and Caregivers in Neuro-Oncology |
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316 | (4) |
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39 Neurocognitive Function and Quality of Life |
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320 | (6) |
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40 Neuropsychological Sequelae of Adult Brain Tumors |
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326 | (8) |
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41 Neuropsychological Sequelae Associated with Pediatric Brain Tumors: What We've Learned over the Past 40 Years |
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334 | (8) |
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42 Rehabilitation of Central Nervous System Tumors |
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342 | (7) |
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43 Palliative Care in Neuro-Oncology |
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349 | (4) |
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44 Imaging of Brain Tumors |
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353 | (18) |
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Volker Wilhelm Walter Stieber |
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Part IV Neuroanatomy And Neurosurgery |
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45 Functional Neuroanatomy |
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371 | (14) |
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46 Skull Base Anatomy, Pathology, and Approaches: An Overview |
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385 | (7) |
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Technology and Specialized Techniques |
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392 | (8) |
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48 Stereotactic Brain Biopsy |
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400 | (7) |
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49 Intraoperative Anatomical Imaging |
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407 | (14) |
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50 Intraoperative Molecular Imaging |
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421 | (7) |
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51 Intraoperative Functional Mapping |
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428 | (7) |
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435 | (10) |
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445 | (8) |
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453 | (12) |
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465 | (12) |
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477 | (8) |
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485 | (11) |
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58 Intraventricular Tumors |
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496 | (9) |
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505 | (13) |
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60 Pediatric Tumor Surgery |
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518 | (16) |
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61 Brachial Plexus Tumors |
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534 | (13) |
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547 | (9) |
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63 Medical Management of Supratentorial Gliomas in Adults |
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556 | (23) |
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64 Medical Management for Pediatric Gliomas |
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579 | (10) |
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65 Medical Management of Primitive Neuroectodermal Tumors |
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589 | (10) |
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66 Intracranial Meningiomas |
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599 | (9) |
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67 Medical Management for Brainstem Tumors |
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608 | (7) |
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68 Chemotherapy for Tumors of the Skull Base and Cranial Nerves |
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615 | (8) |
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69 Tumors of the Pituitary and Sellar Region |
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623 | (10) |
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70 Medical Treatment of Spinal Cord Tumors |
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633 | (5) |
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71 Brain Metastases and Leptomeningeal Disease |
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638 | (12) |
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72 Primary Central Nervous System Lymphoma |
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650 | (11) |
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73 Medical Treatment of Primary Central Nervous System Germ Cell Tumors |
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661 | (3) |
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74 Medical Management for Choroid Plexus Tumors |
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664 | (2) |
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75 General Principles of Targeted Therapies |
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666 | (3) |
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76 General Principles of Angiogenesis |
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669 | (7) |
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77 Inhibitors of Signal Transduction Pathways in Malignant Glioma Therapy |
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676 | (16) |
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692 | (12) |
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704 | (6) |
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710 | (9) |
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Part VI Radiaiton Therapy |
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81 Introduction to Radiation Therapy |
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719 | (25) |
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82 Radiation for Glioblastoma |
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744 | (8) |
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752 | (8) |
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84 Low-Grade Glioma Radiation Therapy |
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760 | (9) |
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769 | (2) |
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771 | (4) |
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87 The Current Role for Radiation Therapy in Pediatric Grade II-IV (Non-JPA) Gliomas |
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775 | (6) |
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88 Medulloblastoma and Primitive Neuroectodermal Tumors |
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781 | (14) |
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89 Adult and Pediatric Pilocytic Astrocytoma |
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795 | (4) |
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90 Ependymoma (Intracranial) |
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799 | (9) |
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808 | (10) |
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92 Hemangioblastoma and Hemangiopericytoma |
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818 | (2) |
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93 Radiation Therapy for Intracranial Meningiomas |
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820 | (22) |
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94 Adult and Pediatric Brainstem Glioma |
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842 | (4) |
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95 Tumors of the Base of Skull |
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846 | (15) |
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Tumors of the Pituitary and Sellar Region |
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96 Pituitary Tumors and Craniopharyngioma |
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861 | (13) |
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97 Primary Central Nervous System Germ Cell Tumors, Pineal Tumors, and Other Tumors of the Pineal and Sellar Regions |
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874 | (6) |
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98 Primary Central Nervous System Lymphoma |
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880 | (12) |
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892 | (2) |
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100 Radiation Therapy of Primary Spinal Cord Tumors |
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894 | (8) |
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Volker Wilhelm Walter Stieber |
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902 | (21) |
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| Index |
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923 | |
