Editors Preface v Gerard Bricogne Charles W. Carter, Jr. Symposium Presentations Structure Determination as a Sequential Bayesian Inference process. The Role of Entropy and Likelihood 1(14) G. Bricogne The MICE Program and its Applications to Direct Phase Determination for Powders, Electron Diffraction and Macromolecules 15(14) C.J. Gilmore Solution of Powder Structures by Entropy Maximization and Likelihood Ranking 29(12) K. Shankland Solving Macromolecular Crystal Structures using the Bayesian Paradigm 41(32) C.W. Carter, Jr. S. Xiang G. Bricogne C.J. Gilmore Maximum Entropy, Likelihood and the Large Ribosomal Subunit Of Thermus Thermophilus 73(12) N. Volkmann A Maximum-likelihood Parameter Refinement Program for MIR and MAD Phasing 85(14) Eric de La Fortelle Roger Fourme Gerard Bricogne The Multiwavelength Anomalous Solvent Contrast Method (MASC) in Macromolecular Crystallography 99(10) R. Fourme W. Shepard G. LHermite R. Kahn On the Solution of the Molecular Replacement Problem at Very Low Resolution: Application to a Ribosome Model 109(12) A.D. Podjarny A. Urzhumtsev Phasing at Low Resolution using Direct Methods in Protein Crystallographic Studies 121(10) Michel Roth Eva Pebay-Peyroula Low Resolution Reflections: Phases, Finding Solvent Molecules and Refinement. Rubredoxin as a Test Case 131(14) Ronald E. Stenkamp Low-Resolution Real-Space Envelopes: The Application of the Condensing Protocol approach to the ab initio Macromolecular Phase Problem of a Variety of Examples 145(8) P. David S. Subbiah Structure Determination of Shake-And-Bake with Tangent Refinement 153(10) Charles M. Weeks Herbert A. Hauptman Chun-Shi Chang Russ Miller The Way Ahead: An Expert System Based on Structure Factor Statistics with Built-in Steriochemistry 163 G. Bricogne