Protein-based Nanoparticles in Drug Delivery is a comprehensive book aimed at pharmaceutical scientists and researchers both in academia and corporate environments focused on nanotechnology drug delivery and pharmaceutical-related disciplines. The book covers the design and characterization of various protein nanoparticles, sheds light on the power of an endogenous substance as a drug delivery system, and highlights the possible future trends in the use of protein-based drug delivery. It covers in-depth novel applications of protein-based drug delivery from fundamental to most current use cases. The book comprises three parts. Part one is devoted to the foundations of protein-based drug delivery, including nanocarriers development, drug encapsulation, targetability, and in vivo properties. Part two explores the applications of protein-based nanoparticles in drug delivery, covering topics such as protein nanoparticles in cancer therapy, genetic material delivery, and nanocarriers based on milk protein, silk, and gliadin. Part three addresses recent advances and regulatory aspects of protein-based nanoparticles in drug delivery, including clinical translation, challenges, biological toxicity, and environmental hazards associated with protein-based nanoparticles. Protein-based Nanoparticles in Drug Delivery provides a complete journey of protein-based drug delivery, offers an in-depth understanding of the design and characterization of various protein nanoparticles, and highlights possible future trends in this field. Pharmaceutical scientists will benefit from the novel applications of protein-based nanoparticles drug delivery approaches in the biological field. Nanotechnologists, biologists, chemists, physicists, engineers, and clinicians will also benefit from the foundational content provided as a basis to support communication and tackle the multidisciplinary challenges associated with research in this exciting field.
Part I - Foundations of protein-based drug delivery
1. Fundamental of nanocarriers development: Drug encapsulation,
targetability, stimuli-response and in vivo properties
2. Unlocking the Potential of Protein-Based Drug Delivery: Discovery,
Characteristics, and Real-World Applications
3. History, introduction, properties, applications of protein-based drug
delivery
4. Methods of preparation, characterization parameters and pharmaceutical
application for protein-based nanoparticles
5.
5. Design, development and drug delivery applications of self-assembling
nanocarriers from engineered proteins
6. Mechanism of Protein-Based Nanoparticle Interactions
Part II - Applications of protein-based nanoparticles in drug delivery
7. Protein nanoparticles in cancer therapy
8. Protein nanoparticles in cancer imaging
9. Protein-based nanotechnologies as cancer theranostics
10. Protein-based nanoparticles for the delivery of genetic materials
11. Human serum albumin based nanocarriers for drug delivery
12. Bovine serum albumin based nanocarriers for drug delivery
13. Milk protein / casein based nanocarriers for drug delivery
14. Silk based nanocarriers for drug delivery
15. Zein based nanocarriers for drug delivery
16. Gliadin based nanocarriers for drug delivery
17. Lectin based nanocarriers for drug delivery
18. Elastin-Like Polypeptides (ELPs) based nanocarriers for drug delivery
19. Virus-Like Proteins (VLPs) based nanocarriers for drug delivery
20. The role of sol-gel routes in the nanoparticles-proteins interactions in
drug delivery system
Part III - Recent advances and regulatory aspects of protein-based
nanoparticles in drug delivery
21. Recent advancement in co-delivery of proteins and small molecule drugs
for targeted therapy
22. Antibody drug conjugated (ADC) nanoparticles for target-specific drug
delivery Nanocarriers in Drug Delivery
23. Recent updates in protein nanoparticle vaccine platforms
24. Recent advances in protein based nano delivery systems in overcoming the
challenges associated with metastatic cancers
25. Conclusion and future prospective of protein-based nanoparticles
Dr. Prashant Kesharwani is assistant professor of Pharmaceutics at Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya University, Sagar, Madhya Pradesh, India. He has more than 12 years of teaching, research, and industrial experience across various countries. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He has more than 350 international publications in well-reputed journals and more than 25 international books (Elsevier). He is a recipient of many research grants from various funding bodies. He is also the recipient of several internationally acclaimed awards, such as USERN Laureate award”, and SERB-Ramanujan Fellowship Award”. He has presented many invited talks and oral presentations at prestigious scientific peer-conferences, received international acclaims and awards for research contribution, supervised students/junior researchers and actively participated in outreach and scientific dissemination for the service of the wider community.
