Proteostasis and Cancer explores the intricate mechanisms of protein homeostasis and their critical roles in cancer progression and therapeutics. The book delves into the mechanisms that control proteins inside the cell to preserve the health of the cellular proteome and the organism itself. It covers key topics such as post-translational modifications, protein folding, proteolysis, and the unfolded protein response (UPR), with a specific focus on their roles in cancer. Detailed discussions on molecular chaperones, the ubiquitin-proteasome system, and autophagy pathways offer valuable insights into how these processes contribute to cancer progression and how they can be targeted for therapeutic interventions.
With clear explanations and well-labeled diagrams, the book makes complex concepts accessible to students and researchers alike. It also addresses the clinical implications of proteostasis in cancer, providing a foundation for developing innovative, therapeutic strategies. The book's multidisciplinary approach, combining insights from biochemistry, cancer biology, and medical sciences make it an essential resource for anyone seeking to understand the role of proteostasis in cancer.
1. An overview of Proteostasis or Protein Homeostasis
2. Post-translational modifications, protein folding and Proteolysis
3. Protein misfolding, Endoplamsic reticulum stress and Unfolded Protein
Response (UPR)
4. Proteostasis and Human diseases
5. Methodology to study Proteostasis
6. Molecular Chaperones in Cancer
7. Mitochondrial Proteostasis, UPR and Cancer
8. Ubiquitin-proteasome system and its role in Cancer
9. Proteostasis and Autophagy pathways in Cancer
10. Role of Proteostasis in Breast cancer
11. Proteostasis in solid tumors
12. Proteostasis and liquid or blood cancer
13. How Proteostasis can be targeted in cancer: therapeutic perspective.
14. Clinical implications of Proteostasis in Cancer
Dr. Buddhi Prakash Jain is an Assistant Professor at the Department of Zoology, Mahatma Gandhi Central University, Motihari, Bihar, India. He completed his doctoral studies at the School of Life Sciences, Jawaharlal Nehru University (JNU) New Delhi, India. His research interests include gene expression regulation and endoplasmic reticulum stress in cancer. He is the recipient of several awards including a gold medal in Master Programme (M.Sc.), EMBO travel award, DST (Department of Science and Technology) Govt of India, Young Scientist travel award, and has published several papers in reputed international journals and a number of books and book chapters.
