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Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary [Pehme köide]

  • Formaat: Paperback / softback, 176 pages, kõrgus x laius: 229x152 mm
  • Ilmumisaeg: 12-Mar-2016
  • Kirjastus: National Academies Press
  • ISBN-10: 0309378613
  • ISBN-13: 9780309378611
  • Formaat: Paperback / softback, 176 pages, kõrgus x laius: 229x152 mm
  • Ilmumisaeg: 12-Mar-2016
  • Kirjastus: National Academies Press
  • ISBN-10: 0309378613
  • ISBN-13: 9780309378611
Emerging infectious disease threats that may not have available treatments or vaccines can directly affect the security of the world's health since these diseases also know no boundaries and will easily cross borders. Sustaining public and private investment in the development of medical countermeasures (MCMs) before an emerging infectious disease becomes a public health emergency in the United States has been extremely challenging. Interest and momentum peak during a crisis and wane between events, and there is little interest in disease threats outside the United States until they impact people stateside.



On March 26 and 27, 2015, the Institute of Medicine convened a workshop in Washington, DC to discuss how to achieve rapid and nimble MCM capability for new and emerging threats. Public- and private-sector stakeholders examined recent efforts to prepare for and respond to outbreaks of Ebola Virus Disease, pandemic influenza, and coronaviruses from policy, budget, and operational standpoints. Participants discussed the need for rapid access to MCM to ensure national security and considered strategies and business models that could enhance stakeholder interest and investment in sustainable response capabilities. This report summarizes the presentations and discussions from this workshop.

Table of Contents



Front Matter 1 Introduction 2 A Wake-Up Call: The 2014 Ebola Outbreak Response 3 Preparedness as an Issue of National Security 4 Rapid Development of Ebola Vaccines 5 Influenza Risk Assessment and Pandemic Preparedness 6 Developing MCMs for Coronaviruses 7 Sustainable Business Models to Ensure Rapid and Nimble Responses 8 Supporting MCM Development Across Threats and Funding Cycles A References B Acronyms and Abbreviations C Statement of Task D Agenda E Biosketches of Invited Speakers and Facilitators
1 Introduction
1(8)
Achieving Rapid and Nimble MCM Capability
3(1)
Organization of the Report
4(1)
Overview of Topics Highlighted During Presentations and Discussion
4(5)
2 A Wake-Up Call: The 2014 Ebola Outbreak Response
9(8)
Identifying the Gaps
9(8)
3 Preparedness As An Issue Of National Security
17(14)
Economic Impacts
17(2)
Global Risk Analysis
19(2)
Leveraging the Department of Defense Mission
21(2)
Biosecurity Strategy
23(1)
Engaging Industry
24(2)
Ethical Considerations
26(1)
Capitalizing on the Current Momentum
27(4)
4 Rapid Development Of Ebola Vaccines
31(16)
Public Health Perspective
32(1)
Regulatory Perspective
33(3)
Values of Multistakeholder Partnerships: Large Company Perspective
36(2)
Engaging the Innovators: Small Biotechnology Company Perspective
38(1)
Pre-Positioned EUA for Diagnostics
38(1)
Lessons Learned
39(2)
Engaging Industry
41(2)
Chapter 4 Annex
43(4)
5 Influenza Risk Assessment And Pandemic Preparedness
47(16)
Influenza Risk Assessment Tool
48(2)
Industry Partners in Pandemic Preparedness and Rapid Response
50(4)
Developing and Sustaining New Vaccine Platforms
54(2)
Funding a Better Influenza Vaccine
56(2)
Chapter 5 Annex
58(5)
6 Developing MCMS For Corona Viruses
63(16)
Coronaviruses
64(4)
Response to the 2003 SARS Outbreak
68(3)
Sustaining Product Development
71(3)
Animal Vaccines
74(1)
Chapter 6 Annex
75(4)
7 Sustainable Business Models To Ensure Rapid And Nimble Responses
79(20)
Addressing "Market Failures" in Global Health and Biodefense
79(4)
What Motivates Companies?: Lessons from Antibacterial Drug Development
83(2)
U.S. Government Models for Incentivizing Development
85(4)
Viral Hemorrhagic Fever Consortium: A University-Based Model
89(2)
Critical Path to Tuberculosis Drug Regimens: A Public--Private Partnership Mode
91(3)
Creating Shared Value for Social Change
94(2)
Sustaining Capabilities
96(1)
A Discussion of Priorities Moving Forward
97(2)
8 Supporting Mcm Development Across Threats And Funding Cycles
99(6)
Preparedness as a National Security Imperative
99(1)
Responding to Emerging Infectious Disease Threats
100(2)
Sustainable Business Models
102(3)
APPENDIXES
A References
105(4)
B Acronyms and Abbreviations
109(4)
C Statement of Task
113(2)
D Agenda
115(14)
E Biosketches of Invited Speakers and Facilitators
129