This book summarizes a wide range of recent developments in synthetic methodologies and strategies for the preparation of all possible structurally diverse types of saturated pyrimidine compounds, published in the literature during the last decade (from 2015 to May 2025). This book is divided into two parts based on the type of key strategies used to synthesize these compounds. The Strategy I is divided into five sections, each of which focuses on the synthesis of monocyclic and condensed compounds containing a specific structural type of saturated pyrimidines, including their spiro-fused and bridged derivatives according to Evans' classification, either via cyclization of the appropriate acyclic precursors or by skeletal editing of other heterocycles. In addition, each section presents compounds with biological activity synthesized during this period. The Strategy II includes two sections, which are devoted to the dearomatization of the pyrimidines and the transformation of partially saturated pyrimidine derivatives with retention or increase of their degree of saturation, respectively. It is especially necessary to emphasize that the review also discusses the mechanistic aspects of the synthesis of these interesting compounds.
Chapter 1 Introduction.
Chapter 2 Strategy I. Synthesis of saturated
pyrimidines via cyclization from the appropriate acyclic precursors or
skeletal editing of other heterocycles.
Chapter 3 Strategy II. Synthesis of
saturated pyrimidines via transformation of pyrimidine derivatives.
Chapter
4 Conclusions.
Grygoriy Remennikov was born in Kyiv, Ukraine, in 1951. He studied Chemistry at the University of Donetsk, where he obtained his B.Sc. degree in 1973. He received his Ph.D. degree in Organic Chemistry in 1982 (performed under the supervision of Prof. W. Cherkasov) from the Institute of Organic Chemistry, Kyiv, and DSci (1998) from the Institute of Bioorganic Chemistry, Kyiv, working in the field of chemistry of the saturated nitropyrimidines. From 1998 to 2020, he was a senior researcher at Ludwig Maximilian Universität and Firma Priaxon AG, München, Germany. Currently retired. His main research interests are in the area of the synthesis of pyrimidine derivatives.
