The availability of isotopic varieties of the chemical elements has had a strong impact on many branches of science. For some procedures isotopic tracers make possible methods that are simply easier or more accurate or more convenient than other methods. More importantly, however, there are some processes, particularly those involving steady-state conditions, that before the advent of isotopic tracers were considered to be not accessible to investigation, but which can be studied with these tracers. In biological studies the radioactive tracers have been especially useful because external detection methods can be employed in noninvasive or minimally invasive studies.
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Chapter 1 Historical Development |
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1 | (10) |
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Chapter 2 Basic Principles |
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11 | (18) |
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Chapter 3 Mathematical Methods |
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29 | (38) |
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Chapter 4 Application of Computers for Obtaining Numerical Solutions to Compartmental Models |
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67 | (6) |
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Chapter 5 The Use of Computers in Compartmental Analysis: The SAAM and CONSAM Programs |
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73 | (70) |
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Chapter 6 Some Statistical Principles in Compartmental Analysis |
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143 | (34) |
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177 | (10) |
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| Index |
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187 | |
James S. Robertson, M.D., Ph.D., is a consultant in the Diagnosic Nuclear Medicine Section of the Department of Laboratory Medicine at the Mayo Clinic and Professor of Laboratory Medicine in the Mayo Medical School, Rochester, Minnesota.
