Provides a multidisciplinary approach to the study of energetics of secretion responses by combining the knowledge and expertise of leading authorities from various fields.
1. Introduction
2. Cellular Energetics 3. PreStimulation Events:
Biosynthesis and Storage of Secretory Proteins
4. Transport and Storage of
Biogenic Amines in Adrenal Chromaffin Granules
5. Maintenance of Responsivity
6. Energy-Dependent Steps in Signal Processing: Ligand-Induced Surface
Receptor Movement and Transmembrane Interactions
7. The Role of Membrane
Potentials and of Intracellular pH in Secretory Cell Stimulation
8.
Phosphoinositide Metabolism. Index
Jan-Willem N. Akkerman PhD is the Director of the Laboratory of Haematology in the Department of Haematology at the University of Utrecht, The Netherlands. He received his Ph.D. degree in 1975 on a thesis entitled "Human Platelet Glycolysis" and was a visiting staff member at the Thrombosis Research Center at Temple University, Philadelphia, Pa. In 1978.
His research efforts are in the field of thrombosis and atherosclerosis, with special emphasis on the role of blood platelets and the mechanisms that make these cells responsive to platelet-activating agents. His current research interests are the energetics of platelet functions, mechanisms for signal transduction, and abnormal platelet behaviour in patients with bleeding disorders or hyperaggregability.
