Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. With contributions on topics such as PBPK modeling, cytochrome P-450 metabolism in skin, percutaneous absorption, adverse effects, new skin models, and the role of epidemiology in assessing the hazards of toxicants, Health Risk Assessment is essential for toxicologists, environmental chemists, pharmacologists, risk assessors, and managers working in industrial, pesticide, and pharmaceutical development.
Pharmacokinetics, Metabolism, And Percutaneous Penetration Of The Skin.
Physiologically-Based Pharmacokinetic Modeling to Predict Tissue Dose and
Cholinesterase Inhibition in Workers Exposed to Organophosphorus and
Carbamate Pesticides
J.B. Knaak, M.A. Al-Bayati, and O.G. Raabe
The Application of Pharmacokinetic Models to Predict Target Dose
Jerry N. Blancato and Kenneth B. Bischoff
Cytochrome P450-Dependent Metabolism of Drugs and Carcinogens in Skin
Hasan Mukhtar and Rajesh Agarwal
Percutaneous Absorption
Ronald C. Wester and Howard I. Maibach
In Vitro Skin Metabolism
Robert L. Bronaugh and Steven W. Collier
Animal Models for Percutaneous Absorption
Ronald C. Wester and Howard I. Maibach
A Comparative Study of the Kinetics and Bioavailability of Pure and
Soil-Absorbed Benzene, Toluene, and M-Xylene After Dermal Exposure
Mohamed S. Abdel-Rahman, Gloria A. Slowronski, and Rita M. Turkall
Prediction of Human Percutaneous Absorption with Physicochemical Data
Robert L. Bronaugh and Curtis N. Barton
Dermal Absorption of TCDD: Effect of Age
Yolanda B. Banks and Linda S. Birnbaum
Percutaneous Absorption of Chemicals from Water During Swimming and Bathing
Ronald C. Wester and Howard I. Maibach
Percutaneous Absorption of Chemicals from Soil
David A.W. Bucks and Howard I. Maibach
Route Of Exposure And Toxicological Response.
General Overview on Toxicological Responses and Routes of Chemical Exposure
Rhoda G.M. Wang
Acute Toxicity Testing by the Dermal Route
R.C. Myers and L.R. DePass
Subchronic Dermal Exposure Studies with Industrial Chemicals
David W. Hobson
The Dose Response of Percutaneous Absorption
Ronald C. Wester and Howard I. Maibach
Reproductive and Developmental Toxicity Studies by Cutaneous Administration
R. W. Tyl, R.G. York, and J.L. Schardein
Dermal Carcinogenicity Studies of Petroleum-Derived Materials
Richard H. McKee and James J. Freeman
Comparison of Results from Carcinogenicity Tests of Two Halogenated Compounds
by Oral, Dermal, and Inhalation Routes
Elizabeth K. Weisburger
The Objectives and Goals of Dermal Carcinogenicity Testing of Petroleum
Liquids
James J. Freeman and Richard H. McKee
Chemical Carcinogenesis in Skin: Causation, Mechanism, and Role of Oncogenes
Rajesh Agarwal and Hasan Mukhtar
Dose, Toxicity, And Risk Assessment.
Incorporating Biological Information into the Assessment of Cancer Risk to
Humans Under Various Exposure Conditions and Issues Related to High
Background Tumor Incidence Rates
Chao W. Chen and Kim-Chi Hoang
Phototoxicity of Topical and Systemic Agents
Francis N. Marzulli and Howard I. Maibach
Techniques for Assessing the Health Risks of Dermal Contact with Chemicals in
the Environment
Dennis J. Paustenbach and Hon-Wing Leung
Interspecies Extrapolation of Toxicological Data
Curtis C. Travis
New Models In Skin Research.
Human Skin Xenografts to Athymic Rodents as a System to Study Toxins
Delivered to or Through the Skin
Gerald G. Drueger and Lynn K. Pershing
The Isolated Perfused Porcine Skin Flap
J.E. Riviere
Epidemiologic Studies Of Route Of Exposure And Health Effects.
Perspectives on Assessment of Risk from Dermal Exposure to Polycyclic
Aromatic Hydrocarbons
Christopher J. Borgert et al.
The Paradox of Herbicide 2, 4-D Epidemiology
Gregory G. Bond and Ralph R. Cook
A Review of Epidemiologic Studies with Regard to Routes of Exposure to
Toxicants
Anthony P. Polednak
Rhoda G. M. Wang, Ph.D., is DABT Regulatory Toxicologist Department of Pesticide Regulation California Environmental Protection Agency, Sacramento, California, USA. James B. Knaak, Ph.D, is Product Stewardship Scientist Occidental Chemical Corporation, Niagara Falls, New York, USA. Howard I. Maibach, M.D., is Professor of Dermatology Department of Dermatology University of California, San Francisco, California, USA.
