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RNA Therapeutics: From siRNA to mRNA Innovations [Kõva köide]

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  • Formaat: Hardback, 369 pages, kõrgus x laius: 254x178 mm, 85 Illustrations, color; 21 Illustrations, black and white; VIII, 369 p. 106 illus., 85 illus. in color., 1 Hardback
  • Sari: Methods in Molecular Biology 2965
  • Ilmumisaeg: 14-Sep-2025
  • Kirjastus: Springer-Verlag New York Inc.
  • ISBN-10: 1071647415
  • ISBN-13: 9781071647417
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RNA Therapeutics: From siRNA to mRNA InnovationsSuurem pilt
  • Formaat: Hardback, 369 pages, kõrgus x laius: 254x178 mm, 85 Illustrations, color; 21 Illustrations, black and white; VIII, 369 p. 106 illus., 85 illus. in color., 1 Hardback
  • Sari: Methods in Molecular Biology 2965
  • Ilmumisaeg: 14-Sep-2025
  • Kirjastus: Springer-Verlag New York Inc.
  • ISBN-10: 1071647415
  • ISBN-13: 9781071647417
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9781071647417.html

This book provides an overview of RNA-based technologies, covering their mechanisms, therapeutic applications, and challenges. Chapters explore therapeutic RNAs, RNA stability, mRNA vaccine formulation, strategies to overcome immunogenicity, delivery hurdles, mRNA-based cancer immunotherapy, CAR and TCR T cell therapies, and RNA interference. Additional chapters examine RNA delivery systems such as lipid nanoparticles, nanotubular structures and extracellular vesicles. Written in the highly successful Methods in Molecular Biology series format, the chapters include brief introductions to the material, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and a Notes section which highlights tips on troubleshooting and avoiding known pitfalls.


Authoritative and cutting-edge, RNA Therapeutics: From siRNA to mRNA Innovations aims to be comprehensive guide for researchers in the field.

RNA therapeutics: Bridging discovery and clinical implementation.-
Molecular mechanisms of innate immune sensing of exogenous RNAs.- Chemical
modifications in nucleic acid therapeutic.- Effects of nucleoside
modifications on mRNA Translation: Choosing the right modifications.-
Generation of lipid nanoparticle mRNA vaccines and evaluation of antigen
specific CD8+ T cell responses.- Assessing the immunogenicity of synthetic
RNA using blood cells.- Lateral flow immunoassay for rapid and sensitive
detection of dsRNA contaminants in in vitro-transcribed mRNA products.-
Hydrophobic chromatography purification of linearized Plasmid DNA reduces
dsRNA formation during in vitro transcription.- Optimization of In vitro
transcription reaction for mRNA production using chromatographic at-line
monitoring.- Large scale production of unmodified mRNA for reprogramming
human dendritic cells and T cells.- Production of mRNA-loaded dendritic cell
cancer vaccines.- Enhancing cancer vaccine efficacy: siRNA-based modulation
of immune suppressive factors in dendritic cells.- mRNA-based engineering of
viral antigen-specific TCR-T cells.- Engineering mRNA CAR-T cells for cancer
immunotherapy.- Generating mRNA encoding anti-HBV designer epigenome
modifiers.- Lipid nanoparticles for the delivery of mRN.- Optimization of
DOTAP/cholesterol cationic lipid nanoparticles for nucleic acid delivery.-
Formulation and characterization of cationic bicelles for siRNA delivery.-
Bioinspired extracellular vesicles for enhanced delivery of siRNA to
tumours.- Construction of nanotube-shaped mRNA vehicles using self-assembling
peptides.- Nanoparticle-mediated siRNA delivery in human epithelial lung
cells cultured at the air-liquid interface.- Developing aptamer-targeted mRNA
for immunotherapy.- A facile method for assessing cellular stability and
co-localization of Cas9 mRNA and sgRNA using confocal microscopy.- siRMSD: A
structural parameter to reduce sequence-dependent off-target effects for
siRNA design with chemical modifications.- Chemical strategies to enhance
antisense strand selection and minimize off-target effect-mediated by
siRNAs.- In vivo fermentation production of RNA interference agents.